Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | HSA00100_BIOSYNTHESIS_OF_STEROIDS |
| Enrichment Score (ES) | -0.56217086 |
| Normalized Enrichment Score (NES) | -1.6197888 |
| Nominal p-value | 0.008528785 |
| FDR q-value | 0.12813403 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 1027 | 0.144 | -0.0160 | No |
| 2 | VKORC1 | VKORC1 Entrez, Source | vitamin K epoxide reductase complex, subunit 1 | 2811 | 0.060 | -0.1245 | No |
| 3 | SQLE | SQLE Entrez, Source | squalene epoxidase | 3091 | 0.052 | -0.1235 | No |
| 4 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 3902 | 0.035 | -0.1696 | No |
| 5 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 4179 | 0.030 | -0.1778 | No |
| 6 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 5315 | 0.010 | -0.2588 | No |
| 7 | TM7SF2 | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 6881 | -0.013 | -0.3707 | No |
| 8 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 7755 | -0.027 | -0.4249 | No |
| 9 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 7967 | -0.030 | -0.4279 | No |
| 10 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 8601 | -0.041 | -0.4583 | No |
| 11 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 9744 | -0.061 | -0.5183 | No |
| 12 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 9978 | -0.066 | -0.5078 | No |
| 13 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 10490 | -0.077 | -0.5134 | No |
| 14 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 11141 | -0.094 | -0.5223 | Yes |
| 15 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 11376 | -0.101 | -0.4970 | Yes |
| 16 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 11893 | -0.121 | -0.4844 | Yes |
| 17 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 11986 | -0.126 | -0.4380 | Yes |
| 18 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 12263 | -0.140 | -0.3993 | Yes |
| 19 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 12532 | -0.157 | -0.3529 | Yes |
| 20 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 12750 | -0.178 | -0.2939 | Yes |
| 21 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 12932 | -0.205 | -0.2207 | Yes |
| 22 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 12984 | -0.215 | -0.1334 | Yes |
| 23 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 13270 | -0.378 | 0.0054 | Yes |
