Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HSA00620_PYRUVATE_METABOLISM |
| Enrichment Score (ES) | 0.62780577 |
| Normalized Enrichment Score (NES) | 1.8229374 |
| Nominal p-value | 0.0058252425 |
| FDR q-value | 0.022517782 |
| FWER p-Value | 0.923 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 22 | 0.785 | 0.2047 | Yes |
| 2 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 35 | 0.711 | 0.3908 | Yes |
| 3 | PC | PC Entrez, Source | pyruvate carboxylase | 292 | 0.313 | 0.4540 | Yes |
| 4 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 444 | 0.246 | 0.5073 | Yes |
| 5 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 517 | 0.223 | 0.5607 | Yes |
| 6 | ALDH3A2 | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 798 | 0.170 | 0.5843 | Yes |
| 7 | ACAT1 | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 809 | 0.168 | 0.6278 | Yes |
| 8 | ME1 | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 2902 | 0.057 | 0.4857 | No |
| 9 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 3245 | 0.048 | 0.4728 | No |
| 10 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 3365 | 0.046 | 0.4759 | No |
| 11 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 3467 | 0.044 | 0.4798 | No |
| 12 | ALDH1B1 | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 3480 | 0.043 | 0.4903 | No |
| 13 | ALDH7A1 | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 3592 | 0.041 | 0.4927 | No |
| 14 | LDHC | LDHC Entrez, Source | lactate dehydrogenase C | 3672 | 0.039 | 0.4971 | No |
| 15 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 3755 | 0.037 | 0.5008 | No |
| 16 | MDH1 | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 4125 | 0.030 | 0.4811 | No |
| 17 | LDHD | LDHD Entrez, Source | lactate dehydrogenase D | 5147 | 0.012 | 0.4076 | No |
| 18 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 5536 | 0.007 | 0.3803 | No |
| 19 | ACACA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 5939 | 0.001 | 0.3504 | No |
| 20 | ACOT12 | ACOT12 Entrez, Source | acyl-CoA thioesterase 12 | 6086 | -0.001 | 0.3398 | No |
| 21 | ACACB | ACACB Entrez, Source | acetyl-Coenzyme A carboxylase beta | 6400 | -0.006 | 0.3179 | No |
| 22 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 6818 | -0.012 | 0.2899 | No |
| 23 | MDH2 | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 7022 | -0.015 | 0.2787 | No |
| 24 | HAGHL | HAGHL Entrez, Source | hydroxyacylglutathione hydrolase-like | 8224 | -0.034 | 0.1975 | No |
| 25 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 8536 | -0.039 | 0.1845 | No |
| 26 | GLO1 | GLO1 Entrez, Source | glyoxalase I | 9243 | -0.051 | 0.1450 | No |
| 27 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 9409 | -0.054 | 0.1469 | No |
| 28 | LDHAL6B | LDHAL6B Entrez, Source | lactate dehydrogenase A-like 6B | 11134 | -0.094 | 0.0421 | No |
| 29 | ACAT2 | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12971 | -0.213 | -0.0398 | No |
| 30 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 13114 | -0.257 | 0.0171 | No |
