Details for gene set HSA04510_FOCAL

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_48h_repos
Upregulated in class	double_gel_8d
GeneSet	HSA04510_FOCAL_ADHESION
Enrichment Score (ES)	0.51997846
Normalized Enrichment Score (NES)	1.9594547
Nominal p-value	0.0
FDR q-value	0.0068198405
FWER p-Value	0.342

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	COL1A2	COL1A2 Entrez, Source	collagen, type I, alpha 2	6	1.154	0.0773	Yes
2	CCND2	CCND2 Entrez, Source	cyclin D2	10	0.885	0.1368	Yes
3	LAMC2	LAMC2 Entrez, Source	laminin, gamma 2	19	0.791	0.1895	Yes
4	COL3A1	COL3A1 Entrez, Source	collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)	21	0.785	0.2424	Yes
5	COL5A2	COL5A2 Entrez, Source	collagen, type V, alpha 2	34	0.714	0.2896	Yes
6	COL4A1	COL4A1 Entrez, Source	collagen, type IV, alpha 1	58	0.625	0.3300	Yes
7	ITGB4	ITGB4 Entrez, Source	integrin, beta 4	165	0.429	0.3509	Yes
8	LAMC1	LAMC1 Entrez, Source	laminin, gamma 1 (formerly LAMB2)	252	0.342	0.3675	Yes
9	PIP5K1C	PIP5K1C Entrez, Source	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	259	0.335	0.3896	Yes
10	PXN	PXN Entrez, Source	paxillin	425	0.252	0.3941	Yes
11	LAMB2	LAMB2 Entrez, Source	laminin, beta 2 (laminin S)	433	0.249	0.4103	Yes
12	PDGFA	PDGFA Entrez, Source	platelet-derived growth factor alpha polypeptide	544	0.218	0.4167	Yes
13	CCND3	CCND3 Entrez, Source	cyclin D3	643	0.198	0.4226	Yes
14	MAPK3	MAPK3 Entrez, Source	mitogen-activated protein kinase 3	646	0.197	0.4358	Yes
15	COL6A2	COL6A2 Entrez, Source	collagen, type VI, alpha 2	658	0.195	0.4481	Yes
16	COL1A1	COL1A1 Entrez, Source	collagen, type I, alpha 1	673	0.190	0.4599	Yes
17	ITGA9	ITGA9 Entrez, Source	integrin, alpha 9	767	0.175	0.4647	Yes
18	VEGFC	VEGFC Entrez, Source	vascular endothelial growth factor C	778	0.173	0.4756	Yes
19	FLT1	FLT1 Entrez, Source	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	789	0.172	0.4864	Yes
20	MAPK9	MAPK9 Entrez, Source	mitogen-activated protein kinase 9	828	0.165	0.4947	Yes
21	ERBB2	ERBB2 Entrez, Source	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	916	0.154	0.4985	Yes
22	PAK1	PAK1 Entrez, Source	p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)	1034	0.144	0.4993	Yes
23	ITGB6	ITGB6 Entrez, Source	integrin, beta 6	1054	0.141	0.5074	Yes
24	CAV2	CAV2 Entrez, Source	caveolin 2	1186	0.129	0.5062	Yes
25	VTN	VTN Entrez, Source	vitronectin	1239	0.124	0.5106	Yes
26	LAMA5	LAMA5 Entrez, Source	laminin, alpha 5	1466	0.110	0.5009	Yes
27	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	1663	0.099	0.4928	Yes
28	BIRC4	BIRC4 Entrez, Source	baculoviral IAP repeat-containing 4	1664	0.099	0.4995	Yes
29	COL11A1	COL11A1 Entrez, Source	collagen, type XI, alpha 1	1749	0.095	0.4996	Yes
30	SPP1	SPP1 Entrez, Source	secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	1776	0.094	0.5039	Yes
31	COL4A4	COL4A4 Entrez, Source	collagen, type IV, alpha 4	1802	0.093	0.5083	Yes
32	BRAF	BRAF Entrez, Source	v-raf murine sarcoma viral oncogene homolog B1	1804	0.093	0.5145	Yes
33	CAPN2	CAPN2 Entrez, Source	calpain 2, (m/II) large subunit	1925	0.088	0.5113	Yes
34	VEGFB	VEGFB Entrez, Source	vascular endothelial growth factor B	1934	0.087	0.5166	Yes
35	BAD	BAD Entrez, Source	BCL2-antagonist of cell death	1967	0.086	0.5200	Yes
36	ITGA1	ITGA1 Entrez, Source	integrin, alpha 1	2059	0.083	0.5187	No
37	MAPK10	MAPK10 Entrez, Source	mitogen-activated protein kinase 10	2176	0.078	0.5152	No
38	IGF1R	IGF1R Entrez, Source	insulin-like growth factor 1 receptor	2201	0.077	0.5186	No
39	SOS2	SOS2 Entrez, Source	son of sevenless homolog 2 (Drosophila)	2302	0.074	0.5160	No
40	PDGFRB	PDGFRB Entrez, Source	platelet-derived growth factor receptor, beta polypeptide	2644	0.064	0.4945	No
41	ZYX	ZYX Entrez, Source	zyxin	2654	0.063	0.4981	No
42	COL5A1	COL5A1 Entrez, Source	collagen, type V, alpha 1	2660	0.063	0.5020	No
43	CCND1	CCND1 Entrez, Source	cyclin D1	2668	0.063	0.5057	No
44	FN1	FN1 Entrez, Source	fibronectin 1	2715	0.062	0.5064	No
45	BIRC3	BIRC3 Entrez, Source	baculoviral IAP repeat-containing 3	2803	0.060	0.5039	No
46	JUN	JUN Entrez, Source	jun oncogene	3104	0.052	0.4847	No
47	RAP1B	RAP1B Entrez, Source	RAP1B, member of RAS oncogene family	3177	0.050	0.4826	No
48	ACTN1	ACTN1 Entrez, Source	actinin, alpha 1	3213	0.049	0.4833	No
49	ACTN3	ACTN3 Entrez, Source	actinin, alpha 3	3297	0.047	0.4802	No
50	ROCK1	ROCK1 Entrez, Source	Rho-associated, coiled-coil containing protein kinase 1	3389	0.045	0.4763	No
51	PDGFD	PDGFD Entrez, Source	platelet derived growth factor D	3442	0.044	0.4754	No
52	KDR	KDR Entrez, Source	kinase insert domain receptor (a type III receptor tyrosine kinase)	3567	0.041	0.4688	No
53	AKT1	AKT1 Entrez, Source	v-akt murine thymoma viral oncogene homolog 1	3582	0.041	0.4705	No
54	FYN	FYN Entrez, Source	FYN oncogene related to SRC, FGR, YES	3662	0.040	0.4672	No
55	RELN	RELN Entrez, Source	reelin	3719	0.038	0.4655	No
56	TLN1	TLN1 Entrez, Source	talin 1	3905	0.035	0.4539	No
57	ILK	ILK Entrez, Source	integrin-linked kinase	3923	0.034	0.4549	No
58	PIK3CA	PIK3CA Entrez, Source	phosphoinositide-3-kinase, catalytic, alpha polypeptide	3950	0.034	0.4552	No
59	HRAS	HRAS Entrez, Source	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	4055	0.032	0.4495	No
60	PAK3	PAK3 Entrez, Source	p21 (CDKN1A)-activated kinase 3	4196	0.029	0.4408	No
61	FLNC	FLNC Entrez, Source	filamin C, gamma (actin binding protein 280)	4230	0.029	0.4403	No
62	LAMA3	LAMA3 Entrez, Source	laminin, alpha 3	4300	0.027	0.4369	No
63	COL2A1	COL2A1 Entrez, Source	collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)	4726	0.020	0.4061	No
64	RAPGEF1	RAPGEF1 Entrez, Source	Rap guanine nucleotide exchange factor (GEF) 1	4844	0.018	0.3984	No
65	PPP1CA	PPP1CA Entrez, Source	protein phosphatase 1, catalytic subunit, alpha isoform	5008	0.015	0.3871	No
66	ACTB	ACTB Entrez, Source	actin, beta	5041	0.014	0.3856	No
67	MYLK2	MYLK2 Entrez, Source	myosin light chain kinase 2, skeletal muscle	5057	0.014	0.3854	No
68	BCAR1	BCAR1 Entrez, Source	breast cancer anti-estrogen resistance 1	5112	0.013	0.3822	No
69	PGF	PGF Entrez, Source	placental growth factor, vascular endothelial growth factor-related protein	5143	0.012	0.3808	No
70	SHC1	SHC1 Entrez, Source	SHC (Src homology 2 domain containing) transforming protein 1	5156	0.012	0.3807	No
71	PIK3R2	PIK3R2 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)	5237	0.011	0.3754	No
72	CDC42	CDC42 Entrez, Source	cell division cycle 42 (GTP binding protein, 25kDa)	5548	0.007	0.3524	No
73	PARVA	PARVA Entrez, Source	parvin, alpha	5605	0.006	0.3485	No
74	AKT3	AKT3 Entrez, Source	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	5706	0.004	0.3413	No
75	PAK2	PAK2 Entrez, Source	p21 (CDKN1A)-activated kinase 2	5985	0.000	0.3202	No
76	ROCK2	ROCK2 Entrez, Source	Rho-associated, coiled-coil containing protein kinase 2	6100	-0.002	0.3117	No
77	PDGFRA	PDGFRA Entrez, Source	platelet-derived growth factor receptor, alpha polypeptide	6101	-0.002	0.3118	No
78	BCL2	BCL2 Entrez, Source	B-cell CLL/lymphoma 2	6363	-0.006	0.2925	No
79	ACTN4	ACTN4 Entrez, Source	actinin, alpha 4	6539	-0.008	0.2798	No
80	BIRC2	BIRC2 Entrez, Source	baculoviral IAP repeat-containing 2	6621	-0.009	0.2743	No
81	PTK2	PTK2 Entrez, Source	PTK2 protein tyrosine kinase 2	6661	-0.010	0.2720	No
82	THBS2	THBS2 Entrez, Source	thrombospondin 2	6731	-0.011	0.2675	No
83	PDPK1	PDPK1 Entrez, Source	3-phosphoinositide dependent protein kinase-1	6739	-0.011	0.2678	No
84	ITGB1	ITGB1 Entrez, Source	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	6774	-0.012	0.2660	No
85	RAC1	RAC1 Entrez, Source	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	6834	-0.013	0.2624	No
86	IBSP	IBSP Entrez, Source	integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)	7019	-0.015	0.2495	No
87	SRC	SRC Entrez, Source	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	7020	-0.015	0.2505	No
88	CRK	CRK Entrez, Source	v-crk sarcoma virus CT10 oncogene homolog (avian)	7199	-0.018	0.2383	No
89	PPP1CB	PPP1CB Entrez, Source	protein phosphatase 1, catalytic subunit, beta isoform	7228	-0.019	0.2374	No
90	VAV1	VAV1 Entrez, Source	vav 1 oncogene	7315	-0.020	0.2322	No
91	RAC2	RAC2 Entrez, Source	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	7555	-0.023	0.2157	No
92	RHOA	RHOA Entrez, Source	ras homolog gene family, member A	7625	-0.025	0.2122	No
93	PIK3R1	PIK3R1 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)	7649	-0.025	0.2121	No
94	PPP1R12A	PPP1R12A Entrez, Source	protein phosphatase 1, regulatory (inhibitor) subunit 12A	7696	-0.026	0.2104	No
95	PPP1CC	PPP1CC Entrez, Source	protein phosphatase 1, catalytic subunit, gamma isoform	7701	-0.026	0.2118	No
96	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	7950	-0.030	0.1951	No
97	ARHGAP5	ARHGAP5 Entrez, Source	Rho GTPase activating protein 5	8103	-0.032	0.1857	No
98	COMP	COMP Entrez, Source	cartilage oligomeric matrix protein	8125	-0.033	0.1863	No
99	PIK3R3	PIK3R3 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)	8161	-0.033	0.1859	No
100	TNR	TNR Entrez, Source	tenascin R (restrictin, janusin)	8230	-0.034	0.1831	No
101	THBS4	THBS4 Entrez, Source	thrombospondin 4	8277	-0.035	0.1820	No
102	VWF	VWF Entrez, Source	von Willebrand factor	8376	-0.037	0.1771	No
103	MAPK1	MAPK1 Entrez, Source	mitogen-activated protein kinase 1	8472	-0.038	0.1725	No
104	ELK1	ELK1 Entrez, Source	ELK1, member of ETS oncogene family	8508	-0.039	0.1725	No
105	FLNB	FLNB Entrez, Source	filamin B, beta (actin binding protein 278)	8583	-0.040	0.1696	No
106	RAP1A	RAP1A Entrez, Source	RAP1A, member of RAS oncogene family	8724	-0.043	0.1619	No
107	GSK3B	GSK3B Entrez, Source	glycogen synthase kinase 3 beta	8958	-0.047	0.1474	No
108	CHAD	CHAD Entrez, Source	chondroadherin	9330	-0.053	0.1229	No
109	RAF1	RAF1 Entrez, Source	v-raf-1 murine leukemia viral oncogene homolog 1	9671	-0.059	0.1011	No
110	HGF	HGF Entrez, Source	hepatocyte growth factor (hepapoietin A; scatter factor)	9857	-0.063	0.0914	No
111	ITGA7	ITGA7 Entrez, Source	integrin, alpha 7	9876	-0.064	0.0943	No
112	CTNNB1	CTNNB1 Entrez, Source	catenin (cadherin-associated protein), beta 1, 88kDa	9886	-0.064	0.0980	No
113	ITGB5	ITGB5 Entrez, Source	integrin, beta 5	9946	-0.065	0.0979	No
114	FIGF	FIGF Entrez, Source	c-fos induced growth factor (vascular endothelial growth factor D)	10740	-0.084	0.0435	No
115	CAV3	CAV3 Entrez, Source	caveolin 3	10854	-0.087	0.0408	No
116	PIK3CB	PIK3CB Entrez, Source	phosphoinositide-3-kinase, catalytic, beta polypeptide	11031	-0.091	0.0337	No
117	PDGFC	PDGFC Entrez, Source	platelet derived growth factor C	11176	-0.095	0.0292	No
118	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	11192	-0.096	0.0345	No
119	ITGA6	ITGA6 Entrez, Source	integrin, alpha 6	11513	-0.106	0.0174	No
120	AKT2	AKT2 Entrez, Source	v-akt murine thymoma viral oncogene homolog 2	11527	-0.107	0.0236	No
121	PTEN	PTEN Entrez, Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	11578	-0.108	0.0271	No
122	ITGB7	ITGB7 Entrez, Source	integrin, beta 7	11584	-0.109	0.0341	No
123	GRB2	GRB2 Entrez, Source	growth factor receptor-bound protein 2	11888	-0.121	0.0193	No
124	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	12047	-0.129	0.0160	No
125	COL5A3	COL5A3 Entrez, Source	collagen, type V, alpha 3	12502	-0.155	-0.0079	No
126	LAMB3	LAMB3 Entrez, Source	laminin, beta 3	12600	-0.163	-0.0042	No
127	MET	MET Entrez, Source	met proto-oncogene (hepatocyte growth factor receptor)	12611	-0.164	0.0061	No
128	CRKL	CRKL Entrez, Source	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	12628	-0.166	0.0160	No
129	MAP2K1	MAP2K1 Entrez, Source	mitogen-activated protein kinase kinase 1	12766	-0.180	0.0178	No
130	EGF	EGF Entrez, Source	epidermal growth factor (beta-urogastrone)	12819	-0.188	0.0265	No
131	EGFR	EGFR Entrez, Source	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	12857	-0.193	0.0367	No