Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_double_gel_48h.class.cls
#double_gel_8d_versus_double_gel_48h_repos
Phenotypeclass.cls#double_gel_8d_versus_double_gel_48h_repos
Upregulated in classdouble_gel_8d
GeneSetHSIAO_LIVER_SPECIFIC_GENES
Enrichment Score (ES)0.46148807
Normalized Enrichment Score (NES)1.8209456
Nominal p-value0.0
FDR q-value0.022751817
FWER p-Value0.928
Table: GSEA Results Summary



Fig 1: Enrichment plot: HSIAO_LIVER_SPECIFIC_GENES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAB2DAB2
Entrez,  Source
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)180.7970.0274Yes
2PCK1PCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)350.7110.0519Yes
3SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1560.6280.0731Yes
4G6PCG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit570.6280.0958Yes
5HMGCS2HMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)830.5520.1138Yes
6AGTR1AGTR1
Entrez,  Source
angiotensin II receptor, type 11390.4570.1261Yes
7HGDHGD
Entrez,  Source
homogentisate 1,2-dioxygenase (homogentisate oxidase)1460.4490.1419Yes
8APOC1APOC1
Entrez,  Source
apolipoprotein C-I1510.4450.1577Yes
9FSTFST
Entrez,  Source
follistatin1690.4230.1717Yes
10LIPCLIPC
Entrez,  Source
lipase, hepatic1930.3970.1843Yes
11CES2CES2
Entrez,  Source
carboxylesterase 2 (intestine, liver)2270.3650.1949Yes
12FMO3FMO3
Entrez,  Source
flavin containing monooxygenase 32810.3220.2025Yes
13GYS2GYS2
Entrez,  Source
glycogen synthase 2 (liver)2960.3110.2127Yes
14CBSCBS
Entrez,  Source
cystathionine-beta-synthase3130.2970.2222Yes
15TFPITFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)3160.2940.2327Yes
16TM4SF4TM4SF4
Entrez,  Source
transmembrane 4 L six family member 43390.2860.2414Yes
17PORPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase3540.2800.2504Yes
18AZGP1AZGP1
Entrez,  Source
alpha-2-glycoprotein 1, zinc3770.2700.2585Yes
19DECR1DECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial3780.2690.2682Yes
20ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain3790.2690.2779Yes
21CYP2E1CYP2E1
Entrez,  Source
cytochrome P450, family 2, subfamily E, polypeptide 13890.2650.2868Yes
22CYP27A1CYP27A1
Entrez,  Source
cytochrome P450, family 27, subfamily A, polypeptide 13940.2630.2960Yes
23RGL2RGL2
Entrez,  Source
ral guanine nucleotide dissociation stimulator-like 24390.2470.3016Yes
24AGXTAGXT
Entrez,  Source
alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)4420.2470.3103Yes
25RBP4RBP4
Entrez,  Source
retinol binding protein 4, plasma4580.2420.3179Yes
26ACAA2ACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)4700.2380.3257Yes
27NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 24850.2320.3330Yes
28ABCB4ABCB4
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 44870.2310.3413Yes
29TDO2TDO2
Entrez,  Source
tryptophan 2,3-dioxygenase5140.2230.3474Yes
30F9F9
Entrez,  Source
coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)5720.2120.3507Yes
31FABP1FABP1
Entrez,  Source
fatty acid binding protein 1, liver5800.2100.3578Yes
32IGFBP1IGFBP1
Entrez,  Source
insulin-like growth factor binding protein 15840.2090.3651Yes
33FMO5FMO5
Entrez,  Source
flavin containing monooxygenase 56350.2000.3685Yes
34BHMTBHMT
Entrez,  Source
betaine-homocysteine methyltransferase6690.1920.3729Yes
35ARG1ARG1
Entrez,  Source
arginase, liver7040.1850.3770Yes
36FBP1FBP1
Entrez,  Source
fructose-1,6-bisphosphatase 17200.1820.3825Yes
37GPTGPT
Entrez,  Source
glutamic-pyruvate transaminase (alanine aminotransferase)7330.1800.3880Yes
38ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A17390.1780.3941Yes
39LBPLBP
Entrez,  Source
lipopolysaccharide binding protein7900.1710.3965Yes
40ACAT1ACAT1
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)8090.1680.4012Yes
41CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)8170.1670.4067Yes
42CPS1CPS1
Entrez,  Source
carbamoyl-phosphate synthetase 1, mitochondrial8770.1590.4080Yes
43BAATBAAT
Entrez,  Source
bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)9060.1560.4115Yes
44TATTAT
Entrez,  Source
tyrosine aminotransferase9070.1560.4171Yes
45KYNUKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)9340.1530.4206Yes
46APOBAPOB
Entrez,  Source
apolipoprotein B (including Ag(x) antigen)9630.1510.4240Yes
47NAT2NAT2
Entrez,  Source
N-acetyltransferase 2 (arylamine N-acetyltransferase)9810.1490.4280Yes
48ASS1ASS1
Entrez,  Source
argininosuccinate synthetase 19970.1470.4322Yes
49GGCXGGCX
Entrez,  Source
gamma-glutamyl carboxylase10270.1440.4352Yes
50OTCOTC
Entrez,  Source
ornithine carbamoyltransferase10380.1430.4396Yes
51HRGHRG
Entrez,  Source
histidine-rich glycoprotein10390.1420.4448Yes
52SDSSDS
Entrez,  Source
serine dehydratase11360.1330.4423Yes
53VTNVTN
Entrez,  Source
vitronectin12390.1240.4390Yes
54F12F12
Entrez,  Source
coagulation factor XII (Hageman factor)12430.1240.4433Yes
55SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 513140.1190.4423Yes
56FAHFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)13150.1190.4466Yes
57SERPINA4SERPINA4
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 413650.1150.4470Yes
58HSD17B4HSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 413810.1150.4500Yes
59ITIH3ITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H314240.1120.4508Yes
60HRSP12HRSP12
Entrez,  Source
heat-responsive protein 1214830.1090.4504Yes
61RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 415250.1070.4511Yes
62ALDH6A1ALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A115850.1030.4504Yes
63APOA2APOA2
Entrez,  Source
apolipoprotein A-II15960.1030.4533Yes
64ADFPADFP
Entrez,  Source
adipose differentiation-related protein16260.1010.4548Yes
65APOHAPOH
Entrez,  Source
apolipoprotein H (beta-2-glycoprotein I)17120.0970.4518Yes
66HSD11B1HSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 117200.0960.4548Yes
67LAMP2LAMP2
Entrez,  Source
lysosomal-associated membrane protein 217440.0950.4565Yes
68SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 218550.0900.4514Yes
69GJB1GJB1
Entrez,  Source
gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)18710.0900.4535Yes
70DPYSDPYS
Entrez,  Source
dihydropyrimidinase18770.0890.4563Yes
71APOA1APOA1
Entrez,  Source
apolipoprotein A-I18860.0890.4589Yes
72GLUD1GLUD1
Entrez,  Source
glutamate dehydrogenase 119620.0870.4564Yes
73PCSK6PCSK6
Entrez,  Source
proprotein convertase subtilisin/kexin type 619790.0860.4582Yes
74CYP2C9CYP2C9
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 919840.0850.4610Yes
75CPB2CPB2
Entrez,  Source
carboxypeptidase B2 (plasma, carboxypeptidase U)20480.0830.4592Yes
76ABCC6ABCC6
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 620730.0820.4604Yes
77GHRGHR
Entrez,  Source
growth hormone receptor20980.0810.4615Yes
78HPNHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)21410.0790.4612No
79PZPPZP
Entrez,  Source
pregnancy-zone protein22080.0770.4589No
80ACSL1ACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 123550.0720.4504No
81SERPING1SERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)25240.0670.4401No
82MTTPMTTP
Entrez,  Source
microsomal triglyceride transfer protein25960.0650.4370No
83IL8RBIL8RB
Entrez,  Source
interleukin 8 receptor, beta26110.0650.4383No
84PROCPROC
Entrez,  Source
protein C (inactivator of coagulation factors Va and VIIIa)26360.0640.4388No
85FN1FN1
Entrez,  Source
fibronectin 127150.0620.4351No
86HMGCLHMGCL
Entrez,  Source
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)27390.0620.4356No
87SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 328890.0580.4263No
88PCCBPCCB
Entrez,  Source
propionyl Coenzyme A carboxylase, beta polypeptide29770.0550.4217No
89PYGLPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)29950.0540.4224No
90ASLASL
Entrez,  Source
argininosuccinate lyase30410.0530.4209No
91PON3PON3
Entrez,  Source
paraoxonase 330570.0530.4217No
92HNMTHNMT
Entrez,  Source
histamine N-methyltransferase30980.0520.4205No
93CYP3A4CYP3A4
Entrez,  Source
cytochrome P450, family 3, subfamily A, polypeptide 431490.0510.4185No
94APOC3APOC3
Entrez,  Source
apolipoprotein C-III31720.0500.4187No
95ALDH2ALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)32450.0480.4149No
96ALDOBALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate32530.0480.4162No
97LSRLSR
Entrez,  Source
lipolysis stimulated lipoprotein receptor33740.0460.4087No
98MST1MST1
Entrez,  Source
macrophage stimulating 1 (hepatocyte growth factor-like)35940.0410.3935No
99SEPP1SEPP1
Entrez,  Source
selenoprotein P, plasma, 136250.0400.3927No
100MGST1MGST1
Entrez,  Source
microsomal glutathione S-transferase 139320.0340.3706No
101AHSGAHSG
Entrez,  Source
alpha-2-HS-glycoprotein39810.0330.3682No
102SAA4SAA4
Entrez,  Source
serum amyloid A4, constitutive40170.0330.3667No
103SEPHS2SEPHS2
Entrez,  Source
selenophosphate synthetase 241810.0290.3554No
104SULT2A1SULT2A1
Entrez,  Source
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 143520.0260.3434No
105HPHP
Entrez,  Source
haptoglobin43920.0260.3414No
106SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 146970.0200.3190No
107HPDHPD
Entrez,  Source
4-hydroxyphenylpyruvate dioxygenase48850.0170.3054No
108ALAS1ALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 150590.0140.2927No
109HGFACHGFAC
Entrez,  Source
HGF activator50730.0140.2923No
110CFBCFB
Entrez,  Source
complement factor B52510.0110.2792No
111AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)52600.0110.2790No
112F2F2
Entrez,  Source
coagulation factor II (thrombin)52890.0100.2772No
113C3C3
Entrez,  Source
complement component 353330.0100.2743No
114ORM1ORM1
Entrez,  Source
orosomucoid 153480.0090.2736No
115ASGR1ASGR1
Entrez,  Source
asialoglycoprotein receptor 157920.0030.2400No
116CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I6103-0.0020.2165No
117ADH4ADH4
Entrez,  Source
alcohol dehydrogenase 4 (class II), pi polypeptide6171-0.0030.2115No
118CFICFI
Entrez,  Source
complement factor I6257-0.0040.2052No
119ALBALB
Entrez,  Source
albumin6276-0.0040.2039No
120CATCAT
Entrez,  Source
catalase6311-0.0050.2015No
121LGALS4LGALS4
Entrez,  Source
lectin, galactoside-binding, soluble, 4 (galectin 4)6339-0.0050.1997No
122SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16493-0.0080.1883No
123CRHBPCRHBP
Entrez,  Source
corticotropin releasing hormone binding protein6512-0.0080.1872No
124SERPIND1SERPIND1
Entrez,  Source
serpin peptidase inhibitor, clade D (heparin cofactor), member 16527-0.0080.1865No
125SPP2SPP2
Entrez,  Source
secreted phosphoprotein 2, 24kDa6617-0.0090.1800No
126SERPINF2SERPINF2
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 26956-0.0140.1548No
127CRPCRP
Entrez,  Source
C-reactive protein, pentraxin-related7104-0.0170.1443No
128CDH2CDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)7290-0.0190.1309No
129SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))7545-0.0230.1124No
130SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 17581-0.0240.1106No
131PGRMC1PGRMC1
Entrez,  Source
progesterone receptor membrane component 17638-0.0250.1073No
132TAF6TAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa7744-0.0270.1003No
133DHCR24DHCR24
Entrez,  Source
24-dehydrocholesterol reductase7755-0.0270.1005No
134C2C2
Entrez,  Source
complement component 27795-0.0270.0985No
135PCBD1PCBD1
Entrez,  Source
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)7839-0.0280.0962No
136F10F10
Entrez,  Source
coagulation factor X7895-0.0290.0931No
137PROS1PROS1
Entrez,  Source
protein S (alpha)7951-0.0300.0900No
138IL13IL13
Entrez,  Source
interleukin 137984-0.0310.0887No
139LCATLCAT
Entrez,  Source
lecithin-cholesterol acyltransferase8062-0.0320.0840No
140DDTDDT
Entrez,  Source
D-dopachrome tautomerase8250-0.0350.0710No
141CPCP
Entrez,  Source
ceruloplasmin (ferroxidase)8305-0.0360.0682No
142AGTAGT
Entrez,  Source
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)8544-0.0390.0515No
143PRDX4PRDX4
Entrez,  Source
peroxiredoxin 48646-0.0410.0453No
144ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 28688-0.0420.0437No
145C1RC1R
Entrez,  Source
complement component 1, r subcomponent8819-0.0440.0354No
146KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 29256-0.0520.0042No
147SSRP1SSRP1
Entrez,  Source
structure specific recognition protein 19266-0.0520.0054No
148HPXHPX
Entrez,  Source
hemopexin9338-0.0530.0019No
149APCSAPCS
Entrez,  Source
amyloid P component, serum9703-0.060-0.0236No
150GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)9836-0.063-0.0314No
151FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 49846-0.063-0.0298No
152FGGFGG
Entrez,  Source
fibrinogen gamma chain9982-0.066-0.0377No
153ASGR2ASGR2
Entrez,  Source
asialoglycoprotein receptor 210332-0.073-0.0616No
154TSTTST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)10520-0.078-0.0729No
155ACADSBACADSB
Entrez,  Source
acyl-Coenzyme A dehydrogenase, short/branched chain10528-0.078-0.0706No
156CYP4F2CYP4F2
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 210574-0.079-0.0712No
157AADACAADAC
Entrez,  Source
arylacetamide deacetylase (esterase)10775-0.085-0.0833No
158C4BPAC4BPA
Entrez,  Source
complement component 4 binding protein, alpha10785-0.085-0.0810No
159FGAFGA
Entrez,  Source
fibrinogen alpha chain10802-0.085-0.0791No
160PLGPLG
Entrez,  Source
plasminogen10845-0.087-0.0792No
161SERPINC1SERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 110857-0.087-0.0769No
162SORDSORD
Entrez,  Source
sorbitol dehydrogenase11046-0.092-0.0878No
163PBEF1PBEF1
Entrez,  Source
pre-B-cell colony enhancing factor 111072-0.092-0.0864No
164BZW1BZW1
Entrez,  Source
basic leucine zipper and W2 domains 111133-0.094-0.0876No
165MTHFD1MTHFD1
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase11221-0.096-0.0907No
166SHMT1SHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)11350-0.100-0.0968No
167IL13RA1IL13RA1
Entrez,  Source
interleukin 13 receptor, alpha 111405-0.102-0.0972No
168NR1H4NR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 411597-0.109-0.1078No
169TOMM40TOMM40
Entrez,  Source
translocase of outer mitochondrial membrane 40 homolog (yeast)11720-0.114-0.1129No
170FGL1FGL1
Entrez,  Source
fibrinogen-like 111767-0.116-0.1123No
171CASC3CASC3
Entrez,  Source
cancer susceptibility candidate 311825-0.118-0.1123No
172SC4MOLSC4MOL
Entrez,  Source
sterol-C4-methyl oxidase-like11986-0.126-0.1200No
173HALHAL
Entrez,  Source
histidine ammonia-lyase12080-0.131-0.1223No
174CFHR1CFHR1
Entrez,  Source
complement factor H-related 112082-0.131-0.1177No
175GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)12523-0.156-0.1455No
176GSTO1GSTO1
Entrez,  Source
glutathione S-transferase omega 112585-0.162-0.1443No
177FGBFGB
Entrez,  Source
fibrinogen beta chain12598-0.163-0.1393No
178EPHX1EPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)12715-0.175-0.1418No
179ACAT2ACAT2
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)12971-0.213-0.1535No
180BDH1BDH1
Entrez,  Source
3-hydroxybutyrate dehydrogenase, type 113033-0.226-0.1499No
181MBL2MBL2
Entrez,  Source
mannose-binding lectin (protein C) 2, soluble (opsonic defect)13116-0.257-0.1469No
182TFTF
Entrez,  Source
transferrin13216-0.315-0.1430No
183ACSM3ACSM3
Entrez,  Source
acyl-CoA synthetase medium-chain family member 313235-0.330-0.1324No
184LTB4DHLTB4DH
Entrez,  Source
leukotriene B4 12-hydroxydehydrogenase13237-0.330-0.1206No
185AOX1AOX1
Entrez,  Source
aldehyde oxidase 113251-0.347-0.1090No
186CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)13281-0.399-0.0968No
187KLKB1KLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 113310-0.480-0.0816No
188GSTA2GSTA2
Entrez,  Source
glutathione S-transferase A213321-0.590-0.0610No
189RGNRGN
Entrez,  Source
regucalcin (senescence marker protein-30)13331-0.718-0.0358No
190SERPINA7SERPINA7
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 713340-1.0120.0002No
Table: GSEA details [plain text format]



Fig 2: HSIAO_LIVER_SPECIFIC_GENES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HSIAO_LIVER_SPECIFIC_GENES: Random ES distribution   
Gene set null distribution of ES for HSIAO_LIVER_SPECIFIC_GENES