Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | LVAD_HEARTFAILURE_UP |
| Enrichment Score (ES) | 0.56859714 |
| Normalized Enrichment Score (NES) | 1.9001037 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.012614135 |
| FWER p-Value | 0.61 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 27 | 0.757 | 0.0926 | Yes |
| 2 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 56 | 0.628 | 0.1689 | Yes |
| 3 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 84 | 0.549 | 0.2355 | Yes |
| 4 | ANKRD1 | ANKRD1 Entrez, Source | ankyrin repeat domain 1 (cardiac muscle) | 93 | 0.529 | 0.3011 | Yes |
| 5 | AGTR1 | AGTR1 Entrez, Source | angiotensin II receptor, type 1 | 139 | 0.457 | 0.3548 | Yes |
| 6 | TSC22D3 | TSC22D3 Entrez, Source | TSC22 domain family, member 3 | 286 | 0.317 | 0.3834 | Yes |
| 7 | SLC38A2 | SLC38A2 Entrez, Source | solute carrier family 38, member 2 | 300 | 0.310 | 0.4212 | Yes |
| 8 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 310 | 0.299 | 0.4580 | Yes |
| 9 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 329 | 0.291 | 0.4929 | Yes |
| 10 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 600 | 0.206 | 0.4984 | Yes |
| 11 | FKBP5 | FKBP5 Entrez, Source | FK506 binding protein 5 | 666 | 0.194 | 0.5179 | Yes |
| 12 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 754 | 0.176 | 0.5334 | Yes |
| 13 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 880 | 0.159 | 0.5438 | Yes |
| 14 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 998 | 0.147 | 0.5534 | Yes |
| 15 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1210 | 0.127 | 0.5534 | Yes |
| 16 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 1218 | 0.126 | 0.5686 | Yes |
| 17 | ADFP | ADFP Entrez, Source | adipose differentiation-related protein | 1626 | 0.101 | 0.5506 | No |
| 18 | PER1 | PER1 Entrez, Source | period homolog 1 (Drosophila) | 1956 | 0.087 | 0.5367 | No |
| 19 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 1977 | 0.086 | 0.5459 | No |
| 20 | RERE | RERE Entrez, Source | arginine-glutamic acid dipeptide (RE) repeats | 2695 | 0.063 | 0.4998 | No |
| 21 | RRAS2 | RRAS2 Entrez, Source | related RAS viral (r-ras) oncogene homolog 2 | 2790 | 0.060 | 0.5003 | No |
| 22 | CHST3 | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 2922 | 0.057 | 0.4975 | No |
| 23 | JUN | JUN Entrez, Source | jun oncogene | 3104 | 0.052 | 0.4904 | No |
| 24 | MFAP4 | MFAP4 Entrez, Source | microfibrillar-associated protein 4 | 3105 | 0.052 | 0.4968 | No |
| 25 | PPAP2A | PPAP2A Entrez, Source | phosphatidic acid phosphatase type 2A | 3216 | 0.049 | 0.4947 | No |
| 26 | HYAL2 | HYAL2 Entrez, Source | hyaluronoglucosaminidase 2 | 3368 | 0.046 | 0.4890 | No |
| 27 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3506 | 0.043 | 0.4841 | No |
| 28 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 3612 | 0.041 | 0.4812 | No |
| 29 | CLU | CLU Entrez, Source | clusterin | 3739 | 0.038 | 0.4765 | No |
| 30 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 3937 | 0.034 | 0.4659 | No |
| 31 | RGC32 | RGC32 Entrez, Source | - | 4104 | 0.031 | 0.4573 | No |
| 32 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 4230 | 0.029 | 0.4514 | No |
| 33 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 4269 | 0.028 | 0.4521 | No |
| 34 | CDC37L1 | CDC37L1 Entrez, Source | CDC37 cell division cycle 37 homolog (S. cerevisiae)-like 1 | 4571 | 0.022 | 0.4322 | No |
| 35 | ZBTB16 | ZBTB16 Entrez, Source | zinc finger and BTB domain containing 16 | 5042 | 0.014 | 0.3986 | No |
| 36 | CSDC2 | CSDC2 Entrez, Source | cold shock domain containing C2, RNA binding | 5203 | 0.012 | 0.3880 | No |
| 37 | NID1 | NID1 Entrez, Source | nidogen 1 | 5553 | 0.007 | 0.3626 | No |
| 38 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 5970 | 0.001 | 0.3313 | No |
| 39 | NFIL3 | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 6595 | -0.009 | 0.2855 | No |
| 40 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 7649 | -0.025 | 0.2094 | No |
| 41 | FSTL3 | FSTL3 Entrez, Source | follistatin-like 3 (secreted glycoprotein) | 7760 | -0.027 | 0.2044 | No |
| 42 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 8198 | -0.034 | 0.1758 | No |
| 43 | IER5 | IER5 Entrez, Source | immediate early response 5 | 8527 | -0.039 | 0.1560 | No |
| 44 | SLCO4A1 | SLCO4A1 Entrez, Source | solute carrier organic anion transporter family, member 4A1 | 8782 | -0.043 | 0.1423 | No |
| 45 | MYOM1 | MYOM1 Entrez, Source | myomesin 1 (skelemin) 185kDa | 9156 | -0.050 | 0.1205 | No |
| 46 | DIXDC1 | DIXDC1 Entrez, Source | DIX domain containing 1 | 9318 | -0.053 | 0.1150 | No |
| 47 | CNN1 | CNN1 Entrez, Source | calponin 1, basic, smooth muscle | 10018 | -0.067 | 0.0707 | No |
| 48 | INSR | INSR Entrez, Source | insulin receptor | 11168 | -0.095 | -0.0039 | No |
| 49 | AREG | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 11612 | -0.110 | -0.0235 | No |
| 50 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 11645 | -0.111 | -0.0120 | No |
| 51 | GLUL | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 12268 | -0.141 | -0.0412 | No |
| 52 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 12376 | -0.147 | -0.0309 | No |
| 53 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 12801 | -0.185 | -0.0396 | No |
| 54 | CYP4B1 | CYP4B1 Entrez, Source | cytochrome P450, family 4, subfamily B, polypeptide 1 | 12818 | -0.188 | -0.0174 | No |
| 55 | GADD45G | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 13302 | -0.454 | 0.0030 | No |
