Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | MANALO_HYPOXIA_DN |
| Enrichment Score (ES) | -0.66594285 |
| Normalized Enrichment Score (NES) | -2.227633 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.4086194E-4 |
| FWER p-Value | 0.0010 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | POLG | POLG Entrez, Source | polymerase (DNA directed), gamma | 1028 | 0.144 | -0.0466 | No |
| 2 | BARD1 | BARD1 Entrez, Source | BRCA1 associated RING domain 1 | 1344 | 0.117 | -0.0454 | No |
| 3 | MFN2 | MFN2 Entrez, Source | mitofusin 2 | 3996 | 0.033 | -0.2377 | No |
| 4 | CCNF | CCNF Entrez, Source | cyclin F | 5366 | 0.009 | -0.3387 | No |
| 5 | MRPL40 | MRPL40 Entrez, Source | mitochondrial ribosomal protein L40 | 5748 | 0.003 | -0.3666 | No |
| 6 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 6092 | -0.002 | -0.3920 | No |
| 7 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 6790 | -0.012 | -0.4419 | No |
| 8 | DHFR | DHFR Entrez, Source | dihydrofolate reductase | 6938 | -0.014 | -0.4499 | No |
| 9 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 7557 | -0.023 | -0.4914 | No |
| 10 | ZWINT | ZWINT Entrez, Source | ZW10 interactor | 8148 | -0.033 | -0.5287 | No |
| 11 | ELK1 | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 8508 | -0.039 | -0.5474 | No |
| 12 | HNRPDL | HNRPDL Entrez, Source | heterogeneous nuclear ribonucleoprotein D-like | 8663 | -0.041 | -0.5501 | No |
| 13 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 9017 | -0.048 | -0.5666 | No |
| 14 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 9075 | -0.048 | -0.5605 | No |
| 15 | GTPBP4 | GTPBP4 Entrez, Source | GTP binding protein 4 | 10400 | -0.075 | -0.6441 | No |
| 16 | SFRS2 | SFRS2 Entrez, Source | splicing factor, arginine/serine-rich 2 | 10691 | -0.082 | -0.6484 | Yes |
| 17 | ATIC | ATIC Entrez, Source | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 10742 | -0.084 | -0.6343 | Yes |
| 18 | UMPS | UMPS Entrez, Source | uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) | 10783 | -0.085 | -0.6192 | Yes |
| 19 | PSME4 | PSME4 Entrez, Source | proteasome (prosome, macropain) activator subunit 4 | 10789 | -0.085 | -0.6015 | Yes |
| 20 | MLLT10 | MLLT10 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 10881 | -0.088 | -0.5897 | Yes |
| 21 | UCHL5 | UCHL5 Entrez, Source | ubiquitin carboxyl-terminal hydrolase L5 | 11355 | -0.100 | -0.6038 | Yes |
| 22 | MRPL46 | MRPL46 Entrez, Source | mitochondrial ribosomal protein L46 | 11443 | -0.104 | -0.5882 | Yes |
| 23 | HNRPD | HNRPD Entrez, Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 11613 | -0.110 | -0.5775 | Yes |
| 24 | BOP1 | BOP1 Entrez, Source | block of proliferation 1 | 11761 | -0.115 | -0.5640 | Yes |
| 25 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 11832 | -0.118 | -0.5440 | Yes |
| 26 | NEK4 | NEK4 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 4 | 11892 | -0.121 | -0.5227 | Yes |
| 27 | DDX18 | DDX18 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 11900 | -0.122 | -0.4973 | Yes |
| 28 | TFAM | TFAM Entrez, Source | transcription factor A, mitochondrial | 12117 | -0.133 | -0.4852 | Yes |
| 29 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 12204 | -0.137 | -0.4625 | Yes |
| 30 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 12251 | -0.140 | -0.4362 | Yes |
| 31 | ORC6L | ORC6L Entrez, Source | origin recognition complex, subunit 6 like (yeast) | 12293 | -0.142 | -0.4090 | Yes |
| 32 | RPL39 | RPL39 Entrez, Source | ribosomal protein L39 | 12390 | -0.148 | -0.3847 | Yes |
| 33 | PSME3 | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 12468 | -0.152 | -0.3580 | Yes |
| 34 | NOL5A | NOL5A Entrez, Source | nucleolar protein 5A (56kDa with KKE/D repeat) | 12500 | -0.155 | -0.3274 | Yes |
| 35 | TRIP13 | TRIP13 Entrez, Source | thyroid hormone receptor interactor 13 | 12670 | -0.170 | -0.3039 | Yes |
| 36 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 12846 | -0.192 | -0.2762 | Yes |
| 37 | HNRPU | HNRPU Entrez, Source | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 12874 | -0.196 | -0.2364 | Yes |
| 38 | NOLC1 | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 13015 | -0.221 | -0.1998 | Yes |
| 39 | ILF3 | ILF3 Entrez, Source | interleukin enhancer binding factor 3, 90kDa | 13043 | -0.231 | -0.1526 | Yes |
| 40 | PA2G4 | PA2G4 Entrez, Source | proliferation-associated 2G4, 38kDa | 13074 | -0.242 | -0.1034 | Yes |
| 41 | USP1 | USP1 Entrez, Source | ubiquitin specific peptidase 1 | 13158 | -0.275 | -0.0509 | Yes |
| 42 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 13204 | -0.304 | 0.0104 | Yes |
