Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | MANALO_HYPOXIA_UP |
| Enrichment Score (ES) | 0.55742526 |
| Normalized Enrichment Score (NES) | 1.9408953 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.008228211 |
| FWER p-Value | 0.422 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 6 | 1.154 | 0.1421 | Yes |
| 2 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 58 | 0.625 | 0.2154 | Yes |
| 3 | ADM | ADM Entrez, Source | adrenomedullin | 96 | 0.523 | 0.2772 | Yes |
| 4 | GRK5 | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 115 | 0.484 | 0.3356 | Yes |
| 5 | LOX | LOX Entrez, Source | lysyl oxidase | 154 | 0.441 | 0.3873 | Yes |
| 6 | EDN1 | EDN1 Entrez, Source | endothelin 1 | 326 | 0.291 | 0.4104 | Yes |
| 7 | RGS3 | RGS3 Entrez, Source | regulator of G-protein signalling 3 | 338 | 0.287 | 0.4450 | Yes |
| 8 | LEPR | LEPR Entrez, Source | leptin receptor | 471 | 0.237 | 0.4643 | Yes |
| 9 | ANGPTL4 | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 493 | 0.230 | 0.4911 | Yes |
| 10 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 571 | 0.212 | 0.5115 | Yes |
| 11 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 778 | 0.173 | 0.5174 | Yes |
| 12 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 837 | 0.164 | 0.5333 | Yes |
| 13 | PLCG2 | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 1161 | 0.131 | 0.5252 | Yes |
| 14 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1210 | 0.127 | 0.5373 | Yes |
| 15 | HIF3A | HIF3A Entrez, Source | hypoxia inducible factor 3, alpha subunit | 1332 | 0.117 | 0.5427 | Yes |
| 16 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 1373 | 0.115 | 0.5539 | Yes |
| 17 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 1504 | 0.108 | 0.5574 | Yes |
| 18 | HES1 | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 1677 | 0.098 | 0.5566 | No |
| 19 | COL18A1 | COL18A1 Entrez, Source | collagen, type XVIII, alpha 1 | 1942 | 0.087 | 0.5475 | No |
| 20 | AK3 | AK3 Entrez, Source | adenylate kinase 3 | 2456 | 0.069 | 0.5174 | No |
| 21 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 2485 | 0.069 | 0.5238 | No |
| 22 | EGLN1 | EGLN1 Entrez, Source | egl nine homolog 1 (C. elegans) | 2652 | 0.064 | 0.5191 | No |
| 23 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 2660 | 0.063 | 0.5264 | No |
| 24 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 3235 | 0.049 | 0.4892 | No |
| 25 | COL9A1 | COL9A1 Entrez, Source | collagen, type IX, alpha 1 | 3413 | 0.045 | 0.4814 | No |
| 26 | NOTCH4 | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 3964 | 0.033 | 0.4441 | No |
| 27 | PTPRF | PTPRF Entrez, Source | protein tyrosine phosphatase, receptor type, F | 4202 | 0.029 | 0.4298 | No |
| 28 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 4348 | 0.026 | 0.4222 | No |
| 29 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 4460 | 0.024 | 0.4168 | No |
| 30 | GDF10 | GDF10 Entrez, Source | growth differentiation factor 10 | 4564 | 0.022 | 0.4118 | No |
| 31 | PTGIS | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 4653 | 0.021 | 0.4077 | No |
| 32 | NFATC4 | NFATC4 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 4838 | 0.018 | 0.3960 | No |
| 33 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 5081 | 0.014 | 0.3795 | No |
| 34 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 5143 | 0.012 | 0.3764 | No |
| 35 | TNFRSF14 | TNFRSF14 Entrez, Source | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 5269 | 0.011 | 0.3683 | No |
| 36 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 5560 | 0.006 | 0.3473 | No |
| 37 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 5704 | 0.004 | 0.3371 | No |
| 38 | STC2 | STC2 Entrez, Source | stanniocalcin 2 | 5955 | 0.001 | 0.3183 | No |
| 39 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 5981 | 0.000 | 0.3165 | No |
| 40 | PTGS1 | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 6341 | -0.005 | 0.2901 | No |
| 41 | RLN1 | RLN1 Entrez, Source | relaxin 1 | 6670 | -0.010 | 0.2666 | No |
| 42 | ITPR2 | ITPR2 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 2 | 6675 | -0.010 | 0.2676 | No |
| 43 | STC1 | STC1 Entrez, Source | stanniocalcin 1 | 6986 | -0.015 | 0.2461 | No |
| 44 | CUBN | CUBN Entrez, Source | cubilin (intrinsic factor-cobalamin receptor) | 7059 | -0.016 | 0.2426 | No |
| 45 | CDH2 | CDH2 Entrez, Source | cadherin 2, type 1, N-cadherin (neuronal) | 7290 | -0.019 | 0.2277 | No |
| 46 | PPARG | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 7396 | -0.021 | 0.2224 | No |
| 47 | HIVEP2 | HIVEP2 Entrez, Source | human immunodeficiency virus type I enhancer binding protein 2 | 7650 | -0.025 | 0.2064 | No |
| 48 | PTPRR | PTPRR Entrez, Source | protein tyrosine phosphatase, receptor type, R | 8038 | -0.031 | 0.1812 | No |
| 49 | ADORA2A | ADORA2A Entrez, Source | adenosine A2a receptor | 8048 | -0.032 | 0.1844 | No |
| 50 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 8667 | -0.041 | 0.1430 | No |
| 51 | TCF8 | TCF8 Entrez, Source | transcription factor 8 (represses interleukin 2 expression) | 8965 | -0.047 | 0.1264 | No |
| 52 | FKBP9 | FKBP9 Entrez, Source | FK506 binding protein 9, 63 kDa | 9467 | -0.055 | 0.0955 | No |
| 53 | EPOR | EPOR Entrez, Source | erythropoietin receptor | 9512 | -0.056 | 0.0991 | No |
| 54 | ERO1L | ERO1L Entrez, Source | ERO1-like (S. cerevisiae) | 9559 | -0.057 | 0.1027 | No |
| 55 | ZBTB1 | ZBTB1 Entrez, Source | zinc finger and BTB domain containing 1 | 9994 | -0.066 | 0.0781 | No |
| 56 | ZNF292 | ZNF292 Entrez, Source | zinc finger protein 292 | 10656 | -0.081 | 0.0384 | No |
| 57 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 10782 | -0.085 | 0.0395 | No |
| 58 | NPR1 | NPR1 Entrez, Source | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) | 10893 | -0.088 | 0.0420 | No |
| 59 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 10960 | -0.089 | 0.0481 | No |
| 60 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 11137 | -0.094 | 0.0465 | No |
| 61 | INSR | INSR Entrez, Source | insulin receptor | 11168 | -0.095 | 0.0560 | No |
| 62 | ENPP1 | ENPP1 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 11335 | -0.100 | 0.0558 | No |
| 63 | SHOX2 | SHOX2 Entrez, Source | short stature homeobox 2 | 11372 | -0.101 | 0.0656 | No |
| 64 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 11386 | -0.102 | 0.0771 | No |
| 65 | VLDLR | VLDLR Entrez, Source | very low density lipoprotein receptor | 12037 | -0.128 | 0.0440 | No |
| 66 | CASK | CASK Entrez, Source | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 12562 | -0.159 | 0.0242 | No |
| 67 | TRIO | TRIO Entrez, Source | triple functional domain (PTPRF interacting) | 13166 | -0.279 | 0.0133 | No |
