Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | NETPATH_IL_1_PATHWAY_UP |
| Enrichment Score (ES) | 0.4921541 |
| Normalized Enrichment Score (NES) | 1.8237987 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.022362186 |
| FWER p-Value | 0.917 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 22 | 0.785 | 0.0624 | Yes |
| 2 | CCL20 | CCL20 Entrez, Source | chemokine (C-C motif) ligand 20 | 50 | 0.641 | 0.1126 | Yes |
| 3 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 56 | 0.628 | 0.1635 | Yes |
| 4 | TNFAIP6 | TNFAIP6 Entrez, Source | tumor necrosis factor, alpha-induced protein 6 | 116 | 0.483 | 0.1984 | Yes |
| 5 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 138 | 0.458 | 0.2343 | Yes |
| 6 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 141 | 0.455 | 0.2713 | Yes |
| 7 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 145 | 0.452 | 0.3079 | Yes |
| 8 | LOX | LOX Entrez, Source | lysyl oxidase | 154 | 0.441 | 0.3433 | Yes |
| 9 | AMPD3 | AMPD3 Entrez, Source | adenosine monophosphate deaminase (isoform E) | 167 | 0.426 | 0.3772 | Yes |
| 10 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 316 | 0.294 | 0.3899 | Yes |
| 11 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 454 | 0.244 | 0.3995 | Yes |
| 12 | RGS5 | RGS5 Entrez, Source | regulator of G-protein signalling 5 | 513 | 0.224 | 0.4134 | Yes |
| 13 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 709 | 0.184 | 0.4136 | Yes |
| 14 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 754 | 0.176 | 0.4247 | Yes |
| 15 | GUCY1B3 | GUCY1B3 Entrez, Source | guanylate cyclase 1, soluble, beta 3 | 766 | 0.175 | 0.4381 | Yes |
| 16 | CCL7 | CCL7 Entrez, Source | chemokine (C-C motif) ligand 7 | 860 | 0.161 | 0.4442 | Yes |
| 17 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 1041 | 0.142 | 0.4422 | Yes |
| 18 | ANXA3 | ANXA3 Entrez, Source | annexin A3 | 1170 | 0.131 | 0.4432 | Yes |
| 19 | IL1B | IL1B Entrez, Source | interleukin 1, beta | 1197 | 0.128 | 0.4517 | Yes |
| 20 | LIF | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 1203 | 0.127 | 0.4617 | Yes |
| 21 | ZFP36 | ZFP36 Entrez, Source | zinc finger protein 36, C3H type, homolog (mouse) | 1260 | 0.123 | 0.4675 | Yes |
| 22 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 1504 | 0.108 | 0.4580 | Yes |
| 23 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 1523 | 0.107 | 0.4653 | Yes |
| 24 | ARSA | ARSA Entrez, Source | arylsulfatase A | 1524 | 0.107 | 0.4741 | Yes |
| 25 | IFNG | IFNG Entrez, Source | interferon, gamma | 1653 | 0.100 | 0.4725 | Yes |
| 26 | HSD11B1 | HSD11B1 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 1 | 1720 | 0.096 | 0.4754 | Yes |
| 27 | HBEGF | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 1849 | 0.091 | 0.4731 | Yes |
| 28 | GJB1 | GJB1 Entrez, Source | gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) | 1871 | 0.090 | 0.4789 | Yes |
| 29 | GNB5 | GNB5 Entrez, Source | guanine nucleotide binding protein (G protein), beta 5 | 1878 | 0.089 | 0.4857 | Yes |
| 30 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 1890 | 0.089 | 0.4922 | Yes |
| 31 | STK39 | STK39 Entrez, Source | serine threonine kinase 39 (STE20/SPS1 homolog, yeast) | 2034 | 0.084 | 0.4882 | No |
| 32 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 2176 | 0.078 | 0.4839 | No |
| 33 | AK3 | AK3 Entrez, Source | adenylate kinase 3 | 2456 | 0.069 | 0.4685 | No |
| 34 | CSF3 | CSF3 Entrez, Source | colony stimulating factor 3 (granulocyte) | 2483 | 0.069 | 0.4721 | No |
| 35 | CSF2 | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 2558 | 0.066 | 0.4719 | No |
| 36 | CCL11 | CCL11 Entrez, Source | chemokine (C-C motif) ligand 11 | 2565 | 0.066 | 0.4768 | No |
| 37 | HMGCL | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 2739 | 0.062 | 0.4688 | No |
| 38 | LCP1 | LCP1 Entrez, Source | lymphocyte cytosolic protein 1 (L-plastin) | 2802 | 0.060 | 0.4690 | No |
| 39 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 2803 | 0.060 | 0.4739 | No |
| 40 | PTTG1 | PTTG1 Entrez, Source | pituitary tumor-transforming 1 | 2806 | 0.060 | 0.4786 | No |
| 41 | HNMT | HNMT Entrez, Source | histamine N-methyltransferase | 3098 | 0.052 | 0.4609 | No |
| 42 | JUN | JUN Entrez, Source | jun oncogene | 3104 | 0.052 | 0.4647 | No |
| 43 | MMP12 | MMP12 Entrez, Source | matrix metallopeptidase 12 (macrophage elastase) | 3285 | 0.048 | 0.4550 | No |
| 44 | DCN | DCN Entrez, Source | decorin | 3405 | 0.045 | 0.4497 | No |
| 45 | NR4A3 | NR4A3 Entrez, Source | nuclear receptor subfamily 4, group A, member 3 | 3417 | 0.045 | 0.4525 | No |
| 46 | SEPP1 | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 3625 | 0.040 | 0.4402 | No |
| 47 | SERPINB3 | SERPINB3 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 3699 | 0.039 | 0.4378 | No |
| 48 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3740 | 0.038 | 0.4379 | No |
| 49 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 3824 | 0.036 | 0.4345 | No |
| 50 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 3854 | 0.036 | 0.4353 | No |
| 51 | ST3GAL4 | ST3GAL4 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 4235 | 0.029 | 0.4089 | No |
| 52 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 4389 | 0.026 | 0.3994 | No |
| 53 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 4483 | 0.024 | 0.3943 | No |
| 54 | PRKCZ | PRKCZ Entrez, Source | protein kinase C, zeta | 4529 | 0.023 | 0.3928 | No |
| 55 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 4808 | 0.018 | 0.3733 | No |
| 56 | GAPDH | GAPDH Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase | 5074 | 0.014 | 0.3544 | No |
| 57 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 5081 | 0.014 | 0.3550 | No |
| 58 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 5156 | 0.012 | 0.3504 | No |
| 59 | LCN2 | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 5175 | 0.012 | 0.3501 | No |
| 60 | CFB | CFB Entrez, Source | complement factor B | 5251 | 0.011 | 0.3453 | No |
| 61 | C3 | C3 Entrez, Source | complement component 3 | 5333 | 0.010 | 0.3400 | No |
| 62 | LYPD3 | LYPD3 Entrez, Source | LY6/PLAUR domain containing 3 | 5376 | 0.009 | 0.3375 | No |
| 63 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 5599 | 0.006 | 0.3212 | No |
| 64 | SMAD1 | SMAD1 Entrez, Source | SMAD, mothers against DPP homolog 1 (Drosophila) | 5731 | 0.004 | 0.3116 | No |
| 65 | PTPN21 | PTPN21 Entrez, Source | protein tyrosine phosphatase, non-receptor type 21 | 6317 | -0.005 | 0.2678 | No |
| 66 | PTGES | PTGES Entrez, Source | prostaglandin E synthase | 6358 | -0.006 | 0.2653 | No |
| 67 | ACPP | ACPP Entrez, Source | acid phosphatase, prostate | 6543 | -0.008 | 0.2521 | No |
| 68 | CCL4 | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 6591 | -0.009 | 0.2492 | No |
| 69 | MMP10 | MMP10 Entrez, Source | matrix metallopeptidase 10 (stromelysin 2) | 6646 | -0.010 | 0.2459 | No |
| 70 | CDK10 | CDK10 Entrez, Source | cyclin-dependent kinase (CDC2-like) 10 | 6722 | -0.011 | 0.2412 | No |
| 71 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 6833 | -0.013 | 0.2339 | No |
| 72 | IL1A | IL1A Entrez, Source | interleukin 1, alpha | 7552 | -0.023 | 0.1816 | No |
| 73 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 7557 | -0.023 | 0.1832 | No |
| 74 | HSP90AB1 | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 7690 | -0.026 | 0.1753 | No |
| 75 | SERPINB2 | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 7731 | -0.026 | 0.1744 | No |
| 76 | PDE4D | PDE4D Entrez, Source | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) | 7982 | -0.030 | 0.1580 | No |
| 77 | UBD | UBD Entrez, Source | ubiquitin D | 8096 | -0.032 | 0.1521 | No |
| 78 | TMLHE | TMLHE Entrez, Source | trimethyllysine hydroxylase, epsilon | 8186 | -0.034 | 0.1481 | No |
| 79 | GRAP2 | GRAP2 Entrez, Source | GRB2-related adaptor protein 2 | 8492 | -0.039 | 0.1283 | No |
| 80 | DNMT1 | DNMT1 Entrez, Source | DNA (cytosine-5-)-methyltransferase 1 | 8570 | -0.040 | 0.1257 | No |
| 81 | HPRT1 | HPRT1 Entrez, Source | hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) | 8796 | -0.044 | 0.1123 | No |
| 82 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 8819 | -0.044 | 0.1142 | No |
| 83 | PIP5K1A | PIP5K1A Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 8843 | -0.044 | 0.1161 | No |
| 84 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 8937 | -0.046 | 0.1128 | No |
| 85 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 10004 | -0.066 | 0.0377 | No |
| 86 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 10056 | -0.067 | 0.0394 | No |
| 87 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 10103 | -0.068 | 0.0415 | No |
| 88 | RPS21 | RPS21 Entrez, Source | ribosomal protein S21 | 10215 | -0.071 | 0.0389 | No |
| 89 | GSTA3 | GSTA3 Entrez, Source | glutathione S-transferase A3 | 10304 | -0.073 | 0.0381 | No |
| 90 | SOD3 | SOD3 Entrez, Source | superoxide dismutase 3, extracellular | 10312 | -0.073 | 0.0435 | No |
| 91 | AK2 | AK2 Entrez, Source | adenylate kinase 2 | 10352 | -0.074 | 0.0466 | No |
| 92 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 10443 | -0.076 | 0.0460 | No |
| 93 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 10547 | -0.079 | 0.0447 | No |
| 94 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 10770 | -0.085 | 0.0348 | No |
| 95 | GTF2F1 | GTF2F1 Entrez, Source | general transcription factor IIF, polypeptide 1, 74kDa | 10980 | -0.090 | 0.0263 | No |
| 96 | PBEF1 | PBEF1 Entrez, Source | pre-B-cell colony enhancing factor 1 | 11072 | -0.092 | 0.0270 | No |
| 97 | RUNX1 | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 11329 | -0.100 | 0.0158 | No |
| 98 | GARS | GARS Entrez, Source | glycyl-tRNA synthetase | 11341 | -0.100 | 0.0231 | No |
| 99 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 11445 | -0.104 | 0.0238 | No |
| 100 | SULT4A1 | SULT4A1 Entrez, Source | sulfotransferase family 4A, member 1 | 11515 | -0.106 | 0.0273 | No |
| 101 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 11710 | -0.114 | 0.0219 | No |
| 102 | FOSL1 | FOSL1 Entrez, Source | FOS-like antigen 1 | 11938 | -0.123 | 0.0148 | No |
| 103 | GLUL | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 12268 | -0.141 | 0.0014 | No |
| 104 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 12376 | -0.147 | 0.0053 | No |
| 105 | CS | CS Entrez, Source | citrate synthase | 12739 | -0.177 | -0.0076 | No |
| 106 | TXNRD1 | TXNRD1 Entrez, Source | thioredoxin reductase 1 | 12775 | -0.181 | 0.0045 | No |
| 107 | IMPDH2 | IMPDH2 Entrez, Source | IMP (inosine monophosphate) dehydrogenase 2 | 12899 | -0.199 | 0.0115 | No |
| 108 | ARNT | ARNT Entrez, Source | aryl hydrocarbon receptor nuclear translocator | 13148 | -0.269 | 0.0147 | No |
