Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | NETPATH_NOTCH_PATHWAY_UP |
| Enrichment Score (ES) | 0.5713168 |
| Normalized Enrichment Score (NES) | 1.7794207 |
| Nominal p-value | 0.0037243948 |
| FDR q-value | 0.029211508 |
| FWER p-Value | 0.982 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 58 | 0.625 | 0.1767 | Yes |
| 2 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 165 | 0.429 | 0.2929 | Yes |
| 3 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 222 | 0.366 | 0.3949 | Yes |
| 4 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 523 | 0.222 | 0.4367 | Yes |
| 5 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 916 | 0.154 | 0.4519 | Yes |
| 6 | VTN | VTN Entrez, Source | vitronectin | 1239 | 0.124 | 0.4638 | Yes |
| 7 | PTPN2 | PTPN2 Entrez, Source | protein tyrosine phosphatase, non-receptor type 2 | 1414 | 0.113 | 0.4833 | Yes |
| 8 | HES1 | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 1677 | 0.098 | 0.4921 | Yes |
| 9 | LCP2 | LCP2 Entrez, Source | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 1958 | 0.087 | 0.4961 | Yes |
| 10 | DCXR | DCXR Entrez, Source | dicarbonyl/L-xylulose reductase | 2333 | 0.073 | 0.4891 | Yes |
| 11 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2499 | 0.068 | 0.4964 | Yes |
| 12 | CSF1R | CSF1R Entrez, Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 2552 | 0.066 | 0.5116 | Yes |
| 13 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 2668 | 0.063 | 0.5213 | Yes |
| 14 | FN1 | FN1 Entrez, Source | fibronectin 1 | 2715 | 0.062 | 0.5359 | Yes |
| 15 | EGR3 | EGR3 Entrez, Source | early growth response 3 | 2754 | 0.061 | 0.5508 | Yes |
| 16 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 2803 | 0.060 | 0.5646 | Yes |
| 17 | ABCA2 | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 3022 | 0.054 | 0.5638 | Yes |
| 18 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 3166 | 0.050 | 0.5676 | Yes |
| 19 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 3300 | 0.047 | 0.5713 | Yes |
| 20 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3506 | 0.043 | 0.5683 | No |
| 21 | MAG | MAG Entrez, Source | myelin associated glycoprotein | 3969 | 0.033 | 0.5432 | No |
| 22 | EIF2B1 | EIF2B1 Entrez, Source | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa | 4466 | 0.024 | 0.5129 | No |
| 23 | TCF1 | TCF1 Entrez, Source | transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor | 4517 | 0.023 | 0.5158 | No |
| 24 | NOTCH3 | NOTCH3 Entrez, Source | Notch homolog 3 (Drosophila) | 4689 | 0.020 | 0.5088 | No |
| 25 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 4825 | 0.018 | 0.5039 | No |
| 26 | RARB | RARB Entrez, Source | retinoic acid receptor, beta | 4926 | 0.016 | 0.5011 | No |
| 27 | ACADM | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 4941 | 0.016 | 0.5047 | No |
| 28 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 5124 | 0.013 | 0.4948 | No |
| 29 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 5237 | 0.011 | 0.4896 | No |
| 30 | TCF2 | TCF2 Entrez, Source | transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor | 5337 | 0.010 | 0.4849 | No |
| 31 | ICAM2 | ICAM2 Entrez, Source | intercellular adhesion molecule 2 | 5448 | 0.008 | 0.4790 | No |
| 32 | ZNF148 | ZNF148 Entrez, Source | zinc finger protein 148 | 5916 | 0.001 | 0.4442 | No |
| 33 | RNF2 | RNF2 Entrez, Source | ring finger protein 2 | 5936 | 0.001 | 0.4431 | No |
| 34 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 6856 | -0.013 | 0.3777 | No |
| 35 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 7649 | -0.025 | 0.3254 | No |
| 36 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 7751 | -0.027 | 0.3256 | No |
| 37 | SYT11 | SYT11 Entrez, Source | synaptotagmin XI | 7754 | -0.027 | 0.3331 | No |
| 38 | ABCC8 | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 7808 | -0.027 | 0.3371 | No |
| 39 | NOTCH1 | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 7842 | -0.028 | 0.3427 | No |
| 40 | HES5 | HES5 Entrez, Source | hairy and enhancer of split 5 (Drosophila) | 7910 | -0.029 | 0.3462 | No |
| 41 | CTSK | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 8117 | -0.032 | 0.3401 | No |
| 42 | RARA | RARA Entrez, Source | retinoic acid receptor, alpha | 9679 | -0.059 | 0.2399 | No |
| 43 | HEY1 | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 11915 | -0.122 | 0.1073 | No |
