Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | ORGANIC_ACID_METABOLIC_PROCESS |
| Enrichment Score (ES) | 0.466028 |
| Normalized Enrichment Score (NES) | 1.7714771 |
| Nominal p-value | 0.0016233766 |
| FDR q-value | 0.03048865 |
| FWER p-Value | 0.987 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CPT1A | CPT1A Entrez, Source | carnitine palmitoyltransferase 1A (liver) | 47 | 0.660 | 0.0360 | Yes |
| 2 | HAO2 | HAO2 Entrez, Source | hydroxyacid oxidase 2 (long chain) | 54 | 0.630 | 0.0732 | Yes |
| 3 | PFKFB1 | PFKFB1 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 133 | 0.466 | 0.0953 | Yes |
| 4 | GOT1 | GOT1 Entrez, Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 144 | 0.453 | 0.1216 | Yes |
| 5 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 146 | 0.449 | 0.1484 | Yes |
| 6 | ECH1 | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 181 | 0.405 | 0.1701 | Yes |
| 7 | FTCD | FTCD Entrez, Source | formiminotransferase cyclodeaminase | 215 | 0.374 | 0.1900 | Yes |
| 8 | BCKDHA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 272 | 0.326 | 0.2053 | Yes |
| 9 | GGT1 | GGT1 Entrez, Source | gamma-glutamyltransferase 1 | 276 | 0.323 | 0.2244 | Yes |
| 10 | BBOX1 | BBOX1 Entrez, Source | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 309 | 0.300 | 0.2399 | Yes |
| 11 | SLC3A1 | SLC3A1 Entrez, Source | 1 | 374 | 0.271 | 0.2513 | Yes |
| 12 | ACOX2 | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 379 | 0.269 | 0.2671 | Yes |
| 13 | DDAH1 | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 421 | 0.254 | 0.2792 | Yes |
| 14 | AGXT | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 442 | 0.247 | 0.2924 | Yes |
| 15 | SLC25A15 | SLC25A15 Entrez, Source | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | 478 | 0.235 | 0.3039 | Yes |
| 16 | DDAH2 | DDAH2 Entrez, Source | dimethylarginine dimethylaminohydrolase 2 | 501 | 0.227 | 0.3158 | Yes |
| 17 | BCAT1 | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 558 | 0.215 | 0.3244 | Yes |
| 18 | PAH | PAH Entrez, Source | phenylalanine hydroxylase | 573 | 0.211 | 0.3360 | Yes |
| 19 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 585 | 0.209 | 0.3477 | Yes |
| 20 | ARG1 | ARG1 Entrez, Source | arginase, liver | 704 | 0.185 | 0.3498 | Yes |
| 21 | ADI1 | ADI1 Entrez, Source | acireductone dioxygenase 1 | 712 | 0.183 | 0.3603 | Yes |
| 22 | MLYCD | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 713 | 0.183 | 0.3712 | Yes |
| 23 | MAT1A | MAT1A Entrez, Source | methionine adenosyltransferase I, alpha | 734 | 0.180 | 0.3805 | Yes |
| 24 | MSRA | MSRA Entrez, Source | methionine sulfoxide reductase A | 738 | 0.179 | 0.3910 | Yes |
| 25 | GLS2 | GLS2 Entrez, Source | glutaminase 2 (liver, mitochondrial) | 833 | 0.165 | 0.3937 | Yes |
| 26 | HACL1 | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 839 | 0.164 | 0.4032 | Yes |
| 27 | ACOT2 | ACOT2 Entrez, Source | acyl-CoA thioesterase 2 | 876 | 0.159 | 0.4100 | Yes |
| 28 | PECI | PECI Entrez, Source | peroxisomal D3,D2-enoyl-CoA isomerase | 894 | 0.157 | 0.4181 | Yes |
| 29 | BAAT | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 906 | 0.156 | 0.4266 | Yes |
| 30 | ACADS | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 1025 | 0.145 | 0.4263 | Yes |
| 31 | LYPLA3 | LYPLA3 Entrez, Source | lysophospholipase 3 (lysosomal phospholipase A2) | 1075 | 0.138 | 0.4309 | Yes |
| 32 | AS3MT | AS3MT Entrez, Source | arsenic (+3 oxidation state) methyltransferase | 1104 | 0.136 | 0.4369 | Yes |
| 33 | SDS | SDS Entrez, Source | serine dehydratase | 1136 | 0.133 | 0.4425 | Yes |
| 34 | FARS2 | FARS2 Entrez, Source | phenylalanine-tRNA synthetase 2 (mitochondrial) | 1142 | 0.133 | 0.4501 | Yes |
| 35 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 1181 | 0.130 | 0.4550 | Yes |
| 36 | BCKDHB | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 1252 | 0.124 | 0.4571 | Yes |
| 37 | FAH | FAH Entrez, Source | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 1315 | 0.119 | 0.4595 | Yes |
| 38 | SLC6A6 | SLC6A6 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 1323 | 0.118 | 0.4660 | Yes |
| 39 | ALDH6A1 | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 1585 | 0.103 | 0.4525 | No |
| 40 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 1621 | 0.101 | 0.4559 | No |
| 41 | PLOD1 | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 1639 | 0.101 | 0.4606 | No |
| 42 | ACO2 | ACO2 Entrez, Source | aconitase 2, mitochondrial | 1737 | 0.096 | 0.4590 | No |
| 43 | FADS1 | FADS1 Entrez, Source | fatty acid desaturase 1 | 1887 | 0.089 | 0.4531 | No |
| 44 | GLUD1 | GLUD1 Entrez, Source | glutamate dehydrogenase 1 | 1962 | 0.087 | 0.4526 | No |
| 45 | MCCC2 | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 2111 | 0.080 | 0.4463 | No |
| 46 | ADIPOR1 | ADIPOR1 Entrez, Source | adiponectin receptor 1 | 2181 | 0.078 | 0.4457 | No |
| 47 | ALDH5A1 | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 2210 | 0.077 | 0.4482 | No |
| 48 | LTA4H | LTA4H Entrez, Source | leukotriene A4 hydrolase | 2256 | 0.075 | 0.4493 | No |
| 49 | FAAH | FAAH Entrez, Source | fatty acid amide hydrolase | 2484 | 0.069 | 0.4362 | No |
| 50 | CPT1B | CPT1B Entrez, Source | carnitine palmitoyltransferase 1B (muscle) | 2591 | 0.065 | 0.4321 | No |
| 51 | AGPAT1 | AGPAT1 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) | 2813 | 0.060 | 0.4189 | No |
| 52 | ME1 | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 2902 | 0.057 | 0.4157 | No |
| 53 | ASL | ASL Entrez, Source | argininosuccinate lyase | 3041 | 0.053 | 0.4085 | No |
| 54 | ACO1 | ACO1 Entrez, Source | aconitase 1, soluble | 3097 | 0.052 | 0.4074 | No |
| 55 | GLYAT | GLYAT Entrez, Source | glycine-N-acyltransferase | 3145 | 0.051 | 0.4069 | No |
| 56 | ABCD2 | ABCD2 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 2 | 3159 | 0.051 | 0.4089 | No |
| 57 | ADIPOR2 | ADIPOR2 Entrez, Source | adiponectin receptor 2 | 3261 | 0.048 | 0.4042 | No |
| 58 | ASPA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 3681 | 0.039 | 0.3748 | No |
| 59 | BCKDK | BCKDK Entrez, Source | branched chain ketoacid dehydrogenase kinase | 3853 | 0.036 | 0.3640 | No |
| 60 | ATF4 | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 3861 | 0.035 | 0.3656 | No |
| 61 | ACADVL | ACADVL Entrez, Source | acyl-Coenzyme A dehydrogenase, very long chain | 4485 | 0.024 | 0.3198 | No |
| 62 | ALDH1L1 | ALDH1L1 Entrez, Source | aldehyde dehydrogenase 1 family, member L1 | 4510 | 0.023 | 0.3194 | No |
| 63 | SLC7A2 | SLC7A2 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 4675 | 0.020 | 0.3082 | No |
| 64 | NFS1 | NFS1 Entrez, Source | NFS1 nitrogen fixation 1 (S. cerevisiae) | 4759 | 0.019 | 0.3031 | No |
| 65 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 4761 | 0.019 | 0.3041 | No |
| 66 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 4825 | 0.018 | 0.3004 | No |
| 67 | HPD | HPD Entrez, Source | 4-hydroxyphenylpyruvate dioxygenase | 4885 | 0.017 | 0.2970 | No |
| 68 | ACADM | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 4941 | 0.016 | 0.2938 | No |
| 69 | CROT | CROT Entrez, Source | carnitine O-octanoyltransferase | 5009 | 0.015 | 0.2896 | No |
| 70 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 5090 | 0.014 | 0.2844 | No |
| 71 | IDH1 | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 5182 | 0.012 | 0.2782 | No |
| 72 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 5260 | 0.011 | 0.2730 | No |
| 73 | MPST | MPST Entrez, Source | mercaptopyruvate sulfurtransferase | 5279 | 0.010 | 0.2723 | No |
| 74 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 5370 | 0.009 | 0.2660 | No |
| 75 | AMT | AMT Entrez, Source | aminomethyltransferase | 5396 | 0.009 | 0.2647 | No |
| 76 | HPGD | HPGD Entrez, Source | hydroxyprostaglandin dehydrogenase 15-(NAD) | 5728 | 0.004 | 0.2398 | No |
| 77 | CYP7B1 | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 5862 | 0.002 | 0.2299 | No |
| 78 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 6084 | -0.001 | 0.2132 | No |
| 79 | ACOT12 | ACOT12 Entrez, Source | acyl-CoA thioesterase 12 | 6086 | -0.001 | 0.2132 | No |
| 80 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 6103 | -0.002 | 0.2121 | No |
| 81 | ARPP-19 | ARPP-19 Entrez, Source | - | 6321 | -0.005 | 0.1960 | No |
| 82 | PTGS1 | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 6341 | -0.005 | 0.1949 | No |
| 83 | PTGES | PTGES Entrez, Source | prostaglandin E synthase | 6358 | -0.006 | 0.1940 | No |
| 84 | HADHB | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 6362 | -0.006 | 0.1941 | No |
| 85 | GCSH | GCSH Entrez, Source | glycine cleavage system protein H (aminomethyl carrier) | 6406 | -0.006 | 0.1913 | No |
| 86 | ACN9 | ACN9 Entrez, Source | ACN9 homolog (S. cerevisiae) | 6645 | -0.010 | 0.1738 | No |
| 87 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 6790 | -0.012 | 0.1637 | No |
| 88 | PTS | PTS Entrez, Source | 6-pyruvoyltetrahydropterin synthase | 7010 | -0.015 | 0.1480 | No |
| 89 | SLC7A9 | SLC7A9 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 7340 | -0.020 | 0.1243 | No |
| 90 | NANP | NANP Entrez, Source | N-acetylneuraminic acid phosphatase | 7472 | -0.022 | 0.1157 | No |
| 91 | SLC7A8 | SLC7A8 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 | 7714 | -0.026 | 0.0990 | No |
| 92 | ACLY | ACLY Entrez, Source | ATP citrate lyase | 7774 | -0.027 | 0.0962 | No |
| 93 | IGF1 | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 7950 | -0.030 | 0.0847 | No |
| 94 | PTGDS | PTGDS Entrez, Source | prostaglandin D2 synthase 21kDa (brain) | 8146 | -0.033 | 0.0719 | No |
| 95 | SCLY | SCLY Entrez, Source | selenocysteine lyase | 8389 | -0.037 | 0.0558 | No |
| 96 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 8497 | -0.039 | 0.0501 | No |
| 97 | ASRGL1 | ASRGL1 Entrez, Source | asparaginase like 1 | 8649 | -0.041 | 0.0411 | No |
| 98 | INDO | INDO Entrez, Source | indoleamine-pyrrole 2,3 dioxygenase | 8856 | -0.045 | 0.0282 | No |
| 99 | GSS | GSS Entrez, Source | glutathione synthetase | 8876 | -0.045 | 0.0294 | No |
| 100 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 9075 | -0.048 | 0.0174 | No |
| 101 | FADS2 | FADS2 Entrez, Source | fatty acid desaturase 2 | 9436 | -0.055 | -0.0066 | No |
| 102 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 9836 | -0.063 | -0.0330 | No |
| 103 | HDC | HDC Entrez, Source | histidine decarboxylase | 10195 | -0.070 | -0.0559 | No |
| 104 | IDH3B | IDH3B Entrez, Source | isocitrate dehydrogenase 3 (NAD+) beta | 10442 | -0.076 | -0.0700 | No |
| 105 | GAMT | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 10494 | -0.078 | -0.0692 | No |
| 106 | SMS | SMS Entrez, Source | spermine synthase | 10501 | -0.078 | -0.0650 | No |
| 107 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 10520 | -0.078 | -0.0617 | No |
| 108 | ACADSB | ACADSB Entrez, Source | acyl-Coenzyme A dehydrogenase, short/branched chain | 10528 | -0.078 | -0.0575 | No |
| 109 | CYP4F2 | CYP4F2 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 2 | 10574 | -0.079 | -0.0562 | No |
| 110 | SLC25A10 | SLC25A10 Entrez, Source | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | 10638 | -0.081 | -0.0561 | No |
| 111 | ACOX3 | ACOX3 Entrez, Source | acyl-Coenzyme A oxidase 3, pristanoyl | 11075 | -0.092 | -0.0836 | No |
| 112 | GAD2 | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 11228 | -0.096 | -0.0893 | No |
| 113 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 11300 | -0.099 | -0.0888 | No |
| 114 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 11445 | -0.104 | -0.0934 | No |
| 115 | KARS | KARS Entrez, Source | lysyl-tRNA synthetase | 11525 | -0.107 | -0.0930 | No |
| 116 | NR1H4 | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 11597 | -0.109 | -0.0919 | No |
| 117 | YARS | YARS Entrez, Source | tyrosyl-tRNA synthetase | 11607 | -0.110 | -0.0860 | No |
| 118 | MIF | MIF Entrez, Source | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 11668 | -0.112 | -0.0838 | No |
| 119 | QDPR | QDPR Entrez, Source | quinoid dihydropteridine reductase | 11673 | -0.112 | -0.0774 | No |
| 120 | SCYE1 | SCYE1 Entrez, Source | small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) | 11779 | -0.116 | -0.0784 | No |
| 121 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 11986 | -0.126 | -0.0865 | No |
| 122 | DARS | DARS Entrez, Source | aspartyl-tRNA synthetase | 12158 | -0.134 | -0.0914 | No |
| 123 | GCLM | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 12248 | -0.139 | -0.0898 | No |
| 124 | AARS | AARS Entrez, Source | alanyl-tRNA synthetase | 12282 | -0.141 | -0.0838 | No |
| 125 | PPARA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 12287 | -0.141 | -0.0756 | No |
| 126 | GNPAT | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 12982 | -0.215 | -0.1153 | No |
| 127 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 13061 | -0.237 | -0.1070 | No |
| 128 | UGDH | UGDH Entrez, Source | UDP-glucose dehydrogenase | 13081 | -0.242 | -0.0939 | No |
| 129 | GCK | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 13135 | -0.263 | -0.0822 | No |
| 130 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 13151 | -0.271 | -0.0671 | No |
| 131 | SLC7A5 | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 13201 | -0.300 | -0.0528 | No |
| 132 | SLC27A5 | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 13297 | -0.441 | -0.0336 | No |
| 133 | CD74 | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 13325 | -0.617 | 0.0013 | No |
