Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | PENG_RAPAMYCIN_DN |
| Enrichment Score (ES) | -0.39286587 |
| Normalized Enrichment Score (NES) | -1.612076 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.13269016 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 22 | 0.785 | 0.0595 | No |
| 2 | P2RX5 | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 205 | 0.383 | 0.0755 | No |
| 3 | HSPA4 | HSPA4 Entrez, Source | heat shock 70kDa protein 4 | 305 | 0.303 | 0.0916 | No |
| 4 | PTPN1 | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 599 | 0.207 | 0.0855 | No |
| 5 | EMP3 | EMP3 Entrez, Source | epithelial membrane protein 3 | 755 | 0.176 | 0.0874 | No |
| 6 | HADH2 | HADH2 Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase, type II | 782 | 0.173 | 0.0989 | No |
| 7 | S100A4 | S100A4 Entrez, Source | S100 calcium binding protein A4 | 962 | 0.151 | 0.0971 | No |
| 8 | EIF2B2 | EIF2B2 Entrez, Source | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | 975 | 0.149 | 0.1078 | No |
| 9 | ACVRL1 | ACVRL1 Entrez, Source | activin A receptor type II-like 1 | 1574 | 0.104 | 0.0706 | No |
| 10 | IDH3A | IDH3A Entrez, Source | isocitrate dehydrogenase 3 (NAD+) alpha | 1728 | 0.096 | 0.0665 | No |
| 11 | PRDX3 | PRDX3 Entrez, Source | peroxiredoxin 3 | 1788 | 0.093 | 0.0693 | No |
| 12 | SCD | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 1854 | 0.090 | 0.0714 | No |
| 13 | SLC1A5 | SLC1A5 Entrez, Source | solute carrier family 1 (neutral amino acid transporter), member 5 | 2604 | 0.065 | 0.0197 | No |
| 14 | COX7B | COX7B Entrez, Source | cytochrome c oxidase subunit VIIb | 2748 | 0.061 | 0.0137 | No |
| 15 | HBB | HBB Entrez, Source | hemoglobin, beta | 2898 | 0.057 | 0.0069 | No |
| 16 | EXTL3 | EXTL3 Entrez, Source | exostoses (multiple)-like 3 | 3040 | 0.053 | 0.0003 | No |
| 17 | INPP5E | INPP5E Entrez, Source | inositol polyphosphate-5-phosphatase, 72 kDa | 3078 | 0.052 | 0.0016 | No |
| 18 | SQLE | SQLE Entrez, Source | squalene epoxidase | 3091 | 0.052 | 0.0048 | No |
| 19 | CD47 | CD47 Entrez, Source | CD47 molecule | 3700 | 0.039 | -0.0383 | No |
| 20 | PSMD8 | PSMD8 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 3796 | 0.037 | -0.0426 | No |
| 21 | CAPZA2 | CAPZA2 Entrez, Source | capping protein (actin filament) muscle Z-line, alpha 2 | 3840 | 0.036 | -0.0431 | No |
| 22 | ATP6V0C | ATP6V0C Entrez, Source | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | 4083 | 0.031 | -0.0590 | No |
| 23 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 4301 | 0.027 | -0.0733 | No |
| 24 | PPIF | PPIF Entrez, Source | peptidylprolyl isomerase F (cyclophilin F) | 4337 | 0.027 | -0.0739 | No |
| 25 | ETFA | ETFA Entrez, Source | electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) | 4385 | 0.026 | -0.0754 | No |
| 26 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 4389 | 0.026 | -0.0737 | No |
| 27 | ADRM1 | ADRM1 Entrez, Source | adhesion regulating molecule 1 | 4443 | 0.025 | -0.0758 | No |
| 28 | RAB1A | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 4611 | 0.021 | -0.0868 | No |
| 29 | COPB2 | COPB2 Entrez, Source | coatomer protein complex, subunit beta 2 (beta prime) | 4784 | 0.019 | -0.0983 | No |
| 30 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 4888 | 0.017 | -0.1048 | No |
| 31 | ATF5 | ATF5 Entrez, Source | activating transcription factor 5 | 4937 | 0.016 | -0.1072 | No |
| 32 | ARF1 | ARF1 Entrez, Source | ADP-ribosylation factor 1 | 5149 | 0.012 | -0.1222 | No |
| 33 | GORASP2 | GORASP2 Entrez, Source | golgi reassembly stacking protein 2, 55kDa | 5178 | 0.012 | -0.1234 | No |
| 34 | JTB | JTB Entrez, Source | jumping translocation breakpoint | 5233 | 0.011 | -0.1266 | No |
| 35 | PPIB | PPIB Entrez, Source | peptidylprolyl isomerase B (cyclophilin B) | 5253 | 0.011 | -0.1272 | No |
| 36 | POLR2F | POLR2F Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide F | 5278 | 0.010 | -0.1282 | No |
| 37 | MAPKAPK3 | MAPKAPK3 Entrez, Source | mitogen-activated protein kinase-activated protein kinase 3 | 5339 | 0.009 | -0.1320 | No |
| 38 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 5540 | 0.007 | -0.1466 | No |
| 39 | PICALM | PICALM Entrez, Source | phosphatidylinositol binding clathrin assembly protein | 5636 | 0.005 | -0.1534 | No |
| 40 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 5738 | 0.004 | -0.1608 | No |
| 41 | LIMK2 | LIMK2 Entrez, Source | LIM domain kinase 2 | 5743 | 0.004 | -0.1608 | No |
| 42 | NMT1 | NMT1 Entrez, Source | N-myristoyltransferase 1 | 5907 | 0.001 | -0.1731 | No |
| 43 | ATP5G3 | ATP5G3 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) | 5923 | 0.001 | -0.1741 | No |
| 44 | CDC25A | CDC25A Entrez, Source | cell division cycle 25A | 6002 | 0.000 | -0.1800 | No |
| 45 | PTMS | PTMS Entrez, Source | parathymosin | 6405 | -0.006 | -0.2100 | No |
| 46 | NUP98 | NUP98 Entrez, Source | nucleoporin 98kDa | 6561 | -0.008 | -0.2210 | No |
| 47 | HSPA8 | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 6613 | -0.009 | -0.2242 | No |
| 48 | PITPNB | PITPNB Entrez, Source | phosphatidylinositol transfer protein, beta | 6631 | -0.010 | -0.2247 | No |
| 49 | PPP2R2A | PPP2R2A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform | 6690 | -0.011 | -0.2283 | No |
| 50 | GTF2A2 | GTF2A2 Entrez, Source | general transcription factor IIA, 2, 12kDa | 6756 | -0.012 | -0.2323 | No |
| 51 | BCAP31 | BCAP31 Entrez, Source | B-cell receptor-associated protein 31 | 6822 | -0.012 | -0.2363 | No |
| 52 | VCP | VCP Entrez, Source | valosin-containing protein | 7037 | -0.016 | -0.2513 | No |
| 53 | CCNC | CCNC Entrez, Source | cyclin C | 7174 | -0.018 | -0.2602 | No |
| 54 | RTN4 | RTN4 Entrez, Source | reticulon 4 | 7528 | -0.023 | -0.2851 | No |
| 55 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 7755 | -0.027 | -0.3002 | No |
| 56 | EIF2B4 | EIF2B4 Entrez, Source | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | 7792 | -0.027 | -0.3008 | No |
| 57 | PGAM1 | PGAM1 Entrez, Source | phosphoglycerate mutase 1 (brain) | 7875 | -0.029 | -0.3047 | No |
| 58 | RTCD1 | RTCD1 Entrez, Source | RNA terminal phosphate cyclase domain 1 | 8083 | -0.032 | -0.3179 | No |
| 59 | DNAJA1 | DNAJA1 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 1 | 8213 | -0.034 | -0.3250 | No |
| 60 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 8298 | -0.036 | -0.3286 | No |
| 61 | PSMC2 | PSMC2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 8346 | -0.037 | -0.3293 | No |
| 62 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 8497 | -0.039 | -0.3377 | No |
| 63 | ASNS | ASNS Entrez, Source | asparagine synthetase | 8596 | -0.040 | -0.3419 | No |
| 64 | NDUFA9 | NDUFA9 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | 8712 | -0.042 | -0.3473 | No |
| 65 | PIP5K1A | PIP5K1A Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 8843 | -0.044 | -0.3537 | No |
| 66 | RNASEH1 | RNASEH1 Entrez, Source | ribonuclease H1 | 8861 | -0.045 | -0.3515 | No |
| 67 | MORF4L2 | MORF4L2 Entrez, Source | mortality factor 4 like 2 | 9092 | -0.049 | -0.3652 | No |
| 68 | ATP1B3 | ATP1B3 Entrez, Source | ATPase, Na+/K+ transporting, beta 3 polypeptide | 9230 | -0.051 | -0.3715 | No |
| 69 | GLO1 | GLO1 Entrez, Source | glyoxalase I | 9243 | -0.051 | -0.3684 | No |
| 70 | CTSC | CTSC Entrez, Source | cathepsin C | 9429 | -0.055 | -0.3782 | No |
| 71 | PHB | PHB Entrez, Source | prohibitin | 9567 | -0.057 | -0.3841 | No |
| 72 | SREBF1 | SREBF1 Entrez, Source | sterol regulatory element binding transcription factor 1 | 9603 | -0.058 | -0.3823 | No |
| 73 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 9744 | -0.061 | -0.3881 | Yes |
| 74 | EIF4G2 | EIF4G2 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 2 | 9796 | -0.062 | -0.3872 | Yes |
| 75 | HSPE1 | HSPE1 Entrez, Source | heat shock 10kDa protein 1 (chaperonin 10) | 9837 | -0.063 | -0.3853 | Yes |
| 76 | PGK1 | PGK1 Entrez, Source | phosphoglycerate kinase 1 | 9880 | -0.064 | -0.3835 | Yes |
| 77 | PSMB5 | PSMB5 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 5 | 9898 | -0.064 | -0.3798 | Yes |
| 78 | DDX3X | DDX3X Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | 9904 | -0.064 | -0.3752 | Yes |
| 79 | WDR18 | WDR18 Entrez, Source | WD repeat domain 18 | 9985 | -0.066 | -0.3761 | Yes |
| 80 | PTBP1 | PTBP1 Entrez, Source | polypyrimidine tract binding protein 1 | 10104 | -0.068 | -0.3797 | Yes |
| 81 | RAE1 | RAE1 Entrez, Source | RAE1 RNA export 1 homolog (S. pombe) | 10200 | -0.071 | -0.3814 | Yes |
| 82 | TCP1 | TCP1 Entrez, Source | t-complex 1 | 10212 | -0.071 | -0.3767 | Yes |
| 83 | TARS | TARS Entrez, Source | threonyl-tRNA synthetase | 10249 | -0.072 | -0.3739 | Yes |
| 84 | CCT6A | CCT6A Entrez, Source | chaperonin containing TCP1, subunit 6A (zeta 1) | 10250 | -0.072 | -0.3683 | Yes |
| 85 | MRPL12 | MRPL12 Entrez, Source | mitochondrial ribosomal protein L12 | 10333 | -0.073 | -0.3688 | Yes |
| 86 | CCT2 | CCT2 Entrez, Source | chaperonin containing TCP1, subunit 2 (beta) | 10334 | -0.073 | -0.3631 | Yes |
| 87 | RBBP6 | RBBP6 Entrez, Source | retinoblastoma binding protein 6 | 10335 | -0.073 | -0.3574 | Yes |
| 88 | AK2 | AK2 Entrez, Source | adenylate kinase 2 | 10352 | -0.074 | -0.3528 | Yes |
| 89 | RAB14 | RAB14 Entrez, Source | RAB14, member RAS oncogene family | 10401 | -0.075 | -0.3507 | Yes |
| 90 | IDH3B | IDH3B Entrez, Source | isocitrate dehydrogenase 3 (NAD+) beta | 10442 | -0.076 | -0.3478 | Yes |
| 91 | NARS | NARS Entrez, Source | asparaginyl-tRNA synthetase | 10470 | -0.077 | -0.3438 | Yes |
| 92 | GSPT1 | GSPT1 Entrez, Source | G1 to S phase transition 1 | 10533 | -0.079 | -0.3424 | Yes |
| 93 | FKBP4 | FKBP4 Entrez, Source | FK506 binding protein 4, 59kDa | 10541 | -0.079 | -0.3368 | Yes |
| 94 | DAP3 | DAP3 Entrez, Source | death associated protein 3 | 10562 | -0.079 | -0.3322 | Yes |
| 95 | NXF1 | NXF1 Entrez, Source | nuclear RNA export factor 1 | 10576 | -0.079 | -0.3270 | Yes |
| 96 | RABGGTB | RABGGTB Entrez, Source | Rab geranylgeranyltransferase, beta subunit | 10595 | -0.080 | -0.3221 | Yes |
| 97 | TIMM17A | TIMM17A Entrez, Source | translocase of inner mitochondrial membrane 17 homolog A (yeast) | 10631 | -0.081 | -0.3185 | Yes |
| 98 | USP10 | USP10 Entrez, Source | ubiquitin specific peptidase 10 | 10721 | -0.083 | -0.3188 | Yes |
| 99 | KPNA3 | KPNA3 Entrez, Source | karyopherin alpha 3 (importin alpha 4) | 10744 | -0.084 | -0.3139 | Yes |
| 100 | RPS26 | RPS26 Entrez, Source | ribosomal protein S26 | 10813 | -0.086 | -0.3124 | Yes |
| 101 | HSPA5 | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 10956 | -0.089 | -0.3162 | Yes |
| 102 | C1QBP | C1QBP Entrez, Source | complement component 1, q subcomponent binding protein | 10991 | -0.090 | -0.3117 | Yes |
| 103 | UCHL1 | UCHL1 Entrez, Source | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 11042 | -0.092 | -0.3084 | Yes |
| 104 | GTF3C1 | GTF3C1 Entrez, Source | general transcription factor IIIC, polypeptide 1, alpha 220kDa | 11181 | -0.095 | -0.3114 | Yes |
| 105 | PTDSS1 | PTDSS1 Entrez, Source | phosphatidylserine synthase 1 | 11318 | -0.099 | -0.3140 | Yes |
| 106 | EIF3S9 | EIF3S9 Entrez, Source | eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa | 11339 | -0.100 | -0.3077 | Yes |
| 107 | CCT5 | CCT5 Entrez, Source | chaperonin containing TCP1, subunit 5 (epsilon) | 11472 | -0.105 | -0.3095 | Yes |
| 108 | CCT4 | CCT4 Entrez, Source | chaperonin containing TCP1, subunit 4 (delta) | 11590 | -0.109 | -0.3099 | Yes |
| 109 | YARS | YARS Entrez, Source | tyrosyl-tRNA synthetase | 11607 | -0.110 | -0.3026 | Yes |
| 110 | BYSL | BYSL Entrez, Source | bystin-like | 11704 | -0.113 | -0.3011 | Yes |
| 111 | TOMM40 | TOMM40 Entrez, Source | translocase of outer mitochondrial membrane 40 homolog (yeast) | 11720 | -0.114 | -0.2933 | Yes |
| 112 | SSBP1 | SSBP1 Entrez, Source | single-stranded DNA binding protein 1 | 11852 | -0.119 | -0.2939 | Yes |
| 113 | EIF4G1 | EIF4G1 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 1 | 11911 | -0.122 | -0.2888 | Yes |
| 114 | SAFB | SAFB Entrez, Source | scaffold attachment factor B | 11983 | -0.126 | -0.2844 | Yes |
| 115 | GM2A | GM2A Entrez, Source | GM2 ganglioside activator | 12057 | -0.129 | -0.2799 | Yes |
| 116 | FASN | FASN Entrez, Source | fatty acid synthase | 12064 | -0.130 | -0.2702 | Yes |
| 117 | SF3A3 | SF3A3 Entrez, Source | splicing factor 3a, subunit 3, 60kDa | 12128 | -0.133 | -0.2647 | Yes |
| 118 | XBP1 | XBP1 Entrez, Source | X-box binding protein 1 | 12147 | -0.134 | -0.2556 | Yes |
| 119 | NME1 | NME1 Entrez, Source | non-metastatic cells 1, protein (NM23A) expressed in | 12324 | -0.144 | -0.2577 | Yes |
| 120 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 12376 | -0.147 | -0.2501 | Yes |
| 121 | TIMM44 | TIMM44 Entrez, Source | translocase of inner mitochondrial membrane 44 homolog (yeast) | 12404 | -0.149 | -0.2406 | Yes |
| 122 | NOL5A | NOL5A Entrez, Source | nucleolar protein 5A (56kDa with KKE/D repeat) | 12500 | -0.155 | -0.2357 | Yes |
| 123 | XPO6 | XPO6 Entrez, Source | exportin 6 | 12526 | -0.156 | -0.2255 | Yes |
| 124 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 12532 | -0.157 | -0.2136 | Yes |
| 125 | TRIP13 | TRIP13 Entrez, Source | thyroid hormone receptor interactor 13 | 12670 | -0.170 | -0.2107 | Yes |
| 126 | ETF1 | ETF1 Entrez, Source | eukaryotic translation termination factor 1 | 12680 | -0.171 | -0.1981 | Yes |
| 127 | SYNCRIP | SYNCRIP Entrez, Source | synaptotagmin binding, cytoplasmic RNA interacting protein | 12730 | -0.176 | -0.1881 | Yes |
| 128 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 12777 | -0.181 | -0.1775 | Yes |
| 129 | EBNA1BP2 | EBNA1BP2 Entrez, Source | EBNA1 binding protein 2 | 12803 | -0.186 | -0.1649 | Yes |
| 130 | BCS1L | BCS1L Entrez, Source | BCS1-like (yeast) | 12828 | -0.189 | -0.1520 | Yes |
| 131 | SRM | SRM Entrez, Source | spermidine synthase | 12882 | -0.197 | -0.1406 | Yes |
| 132 | TDG | TDG Entrez, Source | thymine-DNA glycosylase | 12893 | -0.199 | -0.1259 | Yes |
| 133 | SLC29A1 | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 12934 | -0.205 | -0.1130 | Yes |
| 134 | HYOU1 | HYOU1 Entrez, Source | hypoxia up-regulated 1 | 12962 | -0.212 | -0.0985 | Yes |
| 135 | ACAT2 | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12971 | -0.213 | -0.0825 | Yes |
| 136 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 13019 | -0.222 | -0.0688 | Yes |
| 137 | PA2G4 | PA2G4 Entrez, Source | proliferation-associated 2G4, 38kDa | 13074 | -0.242 | -0.0541 | Yes |
| 138 | TFRC | TFRC Entrez, Source | transferrin receptor (p90, CD71) | 13197 | -0.299 | -0.0400 | Yes |
| 139 | SLC7A5 | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 13201 | -0.300 | -0.0169 | Yes |
| 140 | SLC3A2 | SLC3A2 Entrez, Source | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 13255 | -0.353 | 0.0066 | Yes |
