Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | PYRUVATE_METABOLISM |
| Enrichment Score (ES) | 0.6639849 |
| Normalized Enrichment Score (NES) | 1.8594767 |
| Nominal p-value | 0.0018691589 |
| FDR q-value | 0.017948838 |
| FWER p-Value | 0.809 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 22 | 0.785 | 0.2017 | Yes |
| 2 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 35 | 0.711 | 0.3851 | Yes |
| 3 | PC | PC Entrez, Source | pyruvate carboxylase | 292 | 0.313 | 0.4470 | Yes |
| 4 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 444 | 0.246 | 0.4995 | Yes |
| 5 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 517 | 0.223 | 0.5519 | Yes |
| 6 | ALDH1A1 | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 739 | 0.178 | 0.5815 | Yes |
| 7 | ALDH3A2 | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 798 | 0.170 | 0.6211 | Yes |
| 8 | ACAT1 | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 809 | 0.168 | 0.6640 | Yes |
| 9 | ME1 | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 2902 | 0.057 | 0.5217 | No |
| 10 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 3245 | 0.048 | 0.5086 | No |
| 11 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 3365 | 0.046 | 0.5115 | No |
| 12 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 3467 | 0.044 | 0.5152 | No |
| 13 | ALDH1B1 | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 3480 | 0.043 | 0.5256 | No |
| 14 | LDHC | LDHC Entrez, Source | lactate dehydrogenase C | 3672 | 0.039 | 0.5214 | No |
| 15 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 3755 | 0.037 | 0.5250 | No |
| 16 | MDH1 | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 4125 | 0.030 | 0.5051 | No |
| 17 | LDHD | LDHD Entrez, Source | lactate dehydrogenase D | 5147 | 0.012 | 0.4317 | No |
| 18 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 5536 | 0.007 | 0.4043 | No |
| 19 | ACACA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 5939 | 0.001 | 0.3744 | No |
| 20 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 6818 | -0.012 | 0.3116 | No |
| 21 | MDH2 | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 7022 | -0.015 | 0.3004 | No |
| 22 | ALDH1A2 | ALDH1A2 Entrez, Source | aldehyde dehydrogenase 1 family, member A2 | 7402 | -0.021 | 0.2773 | No |
| 23 | HAGHL | HAGHL Entrez, Source | hydroxyacylglutathione hydrolase-like | 8224 | -0.034 | 0.2246 | No |
| 24 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 8536 | -0.039 | 0.2114 | No |
| 25 | GLO1 | GLO1 Entrez, Source | glyoxalase I | 9243 | -0.051 | 0.1717 | No |
| 26 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 9409 | -0.054 | 0.1734 | No |
| 27 | ACAT2 | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12971 | -0.213 | -0.0388 | No |
| 28 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 13114 | -0.257 | 0.0171 | No |
