Details for gene set REGULATION_OF_SIGNAL

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_48h_repos
Upregulated in class	double_gel_8d
GeneSet	REGULATION_OF_SIGNAL_TRANSDUCTION
Enrichment Score (ES)	0.4800541
Normalized Enrichment Score (NES)	1.8117306
Nominal p-value	0.0
FDR q-value	0.023096235
FWER p-Value	0.95

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	RGS2	RGS2 Entrez, Source	regulator of G-protein signalling 2, 24kDa	25	0.771	0.0526	Yes
2	CD24	CD24 Entrez, Source	CD24 molecule	26	0.771	0.1071	Yes
3	LGALS1	LGALS1 Entrez, Source	lectin, galactoside-binding, soluble, 1 (galectin 1)	60	0.614	0.1480	Yes
4	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	62	0.606	0.1907	Yes
5	RGS16	RGS16 Entrez, Source	regulator of G-protein signalling 16	103	0.505	0.2234	Yes
6	GRK5	GRK5 Entrez, Source	G protein-coupled receptor kinase 5	115	0.484	0.2568	Yes
7	F2R	F2R Entrez, Source	coagulation factor II (thrombin) receptor	142	0.455	0.2870	Yes
8	SLC35B2	SLC35B2 Entrez, Source	solute carrier family 35, member B2	170	0.420	0.3146	Yes
9	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	173	0.414	0.3438	Yes
10	PLCE1	PLCE1 Entrez, Source	phospholipase C, epsilon 1	203	0.384	0.3687	Yes
11	CDH13	CDH13 Entrez, Source	cadherin 13, H-cadherin (heart)	223	0.366	0.3931	Yes
12	CITED2	CITED2 Entrez, Source	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	297	0.311	0.4096	Yes
13	RGS3	RGS3 Entrez, Source	regulator of G-protein signalling 3	338	0.287	0.4268	Yes
14	RGS4	RGS4 Entrez, Source	regulator of G-protein signalling 4	454	0.244	0.4353	Yes
15	SLC20A1	SLC20A1 Entrez, Source	solute carrier family 20 (phosphate transporter), member 1	484	0.232	0.4496	Yes
16	RGS5	RGS5 Entrez, Source	regulator of G-protein signalling 5	513	0.224	0.4633	Yes
17	CFLAR	CFLAR Entrez, Source	CASP8 and FADD-like apoptosis regulator	523	0.222	0.4783	Yes
18	CD40	CD40 Entrez, Source	CD40 molecule, TNF receptor superfamily member 5	758	0.176	0.4730	Yes
19	TGFB1	TGFB1 Entrez, Source	transforming growth factor, beta 1 (Camurati-Engelmann disease)	821	0.166	0.4801	Yes
20	TAX1BP3	TAX1BP3 Entrez, Source	Tax1 (human T-cell leukemia virus type I) binding protein 3	1166	0.131	0.4633	No
21	PTPRC	PTPRC Entrez, Source	protein tyrosine phosphatase, receptor type, C	1207	0.127	0.4692	No
22	NDFIP1	NDFIP1 Entrez, Source	Nedd4 family interacting protein 1	1388	0.114	0.4637	No
23	LGALS9	LGALS9 Entrez, Source	lectin, galactoside-binding, soluble, 9 (galectin 9)	1440	0.111	0.4677	No
24	PLK2	PLK2 Entrez, Source	polo-like kinase 2 (Drosophila)	1523	0.107	0.4690	No
25	AMBP	AMBP Entrez, Source	alpha-1-microglobulin/bikunin precursor	1630	0.101	0.4681	No
26	RALBP1	RALBP1 Entrez, Source	ralA binding protein 1	1792	0.093	0.4625	No
27	LTBR	LTBR Entrez, Source	lymphotoxin beta receptor (TNFR superfamily, member 3)	1914	0.088	0.4596	No
28	OTX2	OTX2 Entrez, Source	orthodenticle homolog 2 (Drosophila)	2173	0.078	0.4456	No
29	TRADD	TRADD Entrez, Source	TNFRSF1A-associated via death domain	2264	0.075	0.4441	No
30	MYD88	MYD88 Entrez, Source	myeloid differentiation primary response gene (88)	2332	0.073	0.4442	No
31	ABRA	ABRA Entrez, Source	actin-binding Rho activating protein	2417	0.070	0.4428	No
32	TGFA	TGFA Entrez, Source	transforming growth factor, alpha	2430	0.070	0.4468	No
33	GIT1	GIT1 Entrez, Source	G protein-coupled receptor kinase interactor 1	2623	0.064	0.4368	No
34	EDG2	EDG2 Entrez, Source	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2	2690	0.063	0.4362	No
35	LITAF	LITAF Entrez, Source	lipopolysaccharide-induced TNF factor	2826	0.059	0.4302	No
36	CLCF1	CLCF1 Entrez, Source	cardiotrophin-like cytokine factor 1	2926	0.057	0.4267	No
37	EREG	EREG Entrez, Source	epiregulin	3011	0.054	0.4242	No
38	IL17F	IL17F Entrez, Source	interleukin 17F	3733	0.038	0.3723	No
39	ECM1	ECM1 Entrez, Source	extracellular matrix protein 1	3867	0.035	0.3647	No
40	CBLC	CBLC Entrez, Source	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	3927	0.034	0.3627	No
41	GRK1	GRK1 Entrez, Source	G protein-coupled receptor kinase 1	3952	0.034	0.3632	No
42	MFN2	MFN2 Entrez, Source	mitofusin 2	3996	0.033	0.3623	No
43	HCLS1	HCLS1 Entrez, Source	hematopoietic cell-specific Lyn substrate 1	4075	0.031	0.3586	No
44	CARD9	CARD9 Entrez, Source	caspase recruitment domain family, member 9	4448	0.024	0.3322	No
45	TSC1	TSC1 Entrez, Source	tuberous sclerosis 1	4477	0.024	0.3318	No
46	RELA	RELA Entrez, Source	v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)	4483	0.024	0.3331	No
47	CDKN2B	CDKN2B Entrez, Source	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	4592	0.022	0.3264	No
48	ZIC1	ZIC1 Entrez, Source	Zic family member 1 (odd-paired homolog, Drosophila)	4619	0.021	0.3260	No
49	ADRB3	ADRB3 Entrez, Source	adrenergic, beta-3-, receptor	4672	0.021	0.3235	No
50	SMAD3	SMAD3 Entrez, Source	SMAD, mothers against DPP homolog 3 (Drosophila)	4720	0.020	0.3213	No
51	ADRB2	ADRB2 Entrez, Source	adrenergic, beta-2-, receptor, surface	4733	0.020	0.3218	No
52	SOCS1	SOCS1 Entrez, Source	suppressor of cytokine signaling 1	4762	0.019	0.3210	No
53	TAOK2	TAOK2 Entrez, Source	TAO kinase 2	4780	0.019	0.3210	No
54	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	4825	0.018	0.3190	No
55	GRM4	GRM4 Entrez, Source	glutamate receptor, metabotropic 4	4831	0.018	0.3199	No
56	BCL10	BCL10 Entrez, Source	B-cell CLL/lymphoma 10	4947	0.016	0.3123	No
57	INHBA	INHBA Entrez, Source	inhibin, beta A (activin A, activin AB alpha polypeptide)	5081	0.014	0.3032	No
58	PPP5C	PPP5C Entrez, Source	protein phosphatase 5, catalytic subunit	5131	0.013	0.3004	No
59	SHC1	SHC1 Entrez, Source	SHC (Src homology 2 domain containing) transforming protein 1	5156	0.012	0.2994	No
60	RASGRP4	RASGRP4 Entrez, Source	RAS guanyl releasing protein 4	5408	0.009	0.2810	No
61	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	5497	0.007	0.2749	No
62	RIC8B	RIC8B Entrez, Source	resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)	5515	0.007	0.2741	No
63	CASP8	CASP8 Entrez, Source	caspase 8, apoptosis-related cysteine peptidase	5583	0.006	0.2695	No
64	ATP2C1	ATP2C1 Entrez, Source	ATPase, Ca++ transporting, type 2C, member 1	5638	0.005	0.2658	No
65	FGD1	FGD1 Entrez, Source	FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia)	5692	0.004	0.2621	No
66	SIGIRR	SIGIRR Entrez, Source	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	5702	0.004	0.2617	No
67	CDKN1C	CDKN1C Entrez, Source	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	5704	0.004	0.2619	No
68	CDC42BPA	CDC42BPA Entrez, Source	CDC42 binding protein kinase alpha (DMPK-like)	5723	0.004	0.2608	No
69	ENG	ENG Entrez, Source	endoglin (Osler-Rendu-Weber syndrome 1)	5761	0.003	0.2582	No
70	ATP6AP2	ATP6AP2 Entrez, Source	ATPase, H+ transporting, lysosomal accessory protein 2	5915	0.001	0.2468	No
71	ACVR2A	ACVR2A Entrez, Source	activin A receptor, type IIA	5960	0.001	0.2435	No
72	SQSTM1	SQSTM1 Entrez, Source	sequestosome 1	6184	-0.003	0.2268	No
73	PLEKHG5	PLEKHG5 Entrez, Source	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	6237	-0.004	0.2231	No
74	GLI1	GLI1 Entrez, Source	glioma-associated oncogene homolog 1 (zinc finger protein)	6332	-0.005	0.2164	No
75	TFG	TFG Entrez, Source	TRK-fused gene	6388	-0.006	0.2126	No
76	BIRC2	BIRC2 Entrez, Source	baculoviral IAP repeat-containing 2	6621	-0.009	0.1957	No
77	FKBP1A	FKBP1A Entrez, Source	FK506 binding protein 1A, 12kDa	6681	-0.010	0.1920	No
78	CXXC5	CXXC5 Entrez, Source	CXXC finger 5	6698	-0.011	0.1915	No
79	RAC1	RAC1 Entrez, Source	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	6834	-0.013	0.1822	No
80	IL22RA2	IL22RA2 Entrez, Source	interleukin 22 receptor, alpha 2	6898	-0.014	0.1784	No
81	RGS12	RGS12 Entrez, Source	regulator of G-protein signalling 12	6916	-0.014	0.1781	No
82	MAPK8IP2	MAPK8IP2 Entrez, Source	mitogen-activated protein kinase 8 interacting protein 2	6981	-0.015	0.1743	No
83	GRK4	GRK4 Entrez, Source	G protein-coupled receptor kinase 4	6984	-0.015	0.1752	No
84	SMAD4	SMAD4 Entrez, Source	SMAD, mothers against DPP homolog 4 (Drosophila)	7113	-0.017	0.1667	No
85	TAOK3	TAOK3 Entrez, Source	TAO kinase 3	7131	-0.017	0.1666	No
86	VAPA	VAPA Entrez, Source	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	7181	-0.018	0.1642	No
87	RGS9	RGS9 Entrez, Source	regulator of G-protein signalling 9	7456	-0.022	0.1450	No
88	UBE2N	UBE2N Entrez, Source	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	7534	-0.023	0.1408	No
89	RHOH	RHOH Entrez, Source	ras homolog gene family, member H	7559	-0.024	0.1406	No
90	RHOA	RHOA Entrez, Source	ras homolog gene family, member A	7625	-0.025	0.1375	No
91	IL12A	IL12A Entrez, Source	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	7646	-0.025	0.1377	No
92	GIT2	GIT2 Entrez, Source	G protein-coupled receptor kinase interactor 2	7717	-0.026	0.1343	No
93	CENTD2	CENTD2 Entrez, Source	centaurin, delta 2	7725	-0.026	0.1356	No
94	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	7950	-0.030	0.1207	No
95	ACVR1	ACVR1 Entrez, Source	activin A receptor, type I	7971	-0.030	0.1214	No
96	GRK6	GRK6 Entrez, Source	G protein-coupled receptor kinase 6	8007	-0.031	0.1209	No
97	ZDHHC13	ZDHHC13 Entrez, Source	zinc finger, DHHC-type containing 13	8050	-0.032	0.1200	No
98	NUP62	NUP62 Entrez, Source	nucleoporin 62kDa	8059	-0.032	0.1216	No
99	MAP3K7IP2	MAP3K7IP2 Entrez, Source	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	8296	-0.036	0.1063	No
100	CANT1	CANT1 Entrez, Source	calcium activated nucleotidase 1	8366	-0.037	0.1037	No
101	ALS2	ALS2 Entrez, Source	amyotrophic lateral sclerosis 2 (juvenile)	8397	-0.037	0.1040	No
102	SMAD2	SMAD2 Entrez, Source	SMAD, mothers against DPP homolog 2 (Drosophila)	8430	-0.038	0.1043	No
103	TMEM101	TMEM101 Entrez, Source	transmembrane protein 101	8563	-0.040	0.0971	No
104	ARHGAP27	ARHGAP27 Entrez, Source	Rho GTPase activating protein 27	8729	-0.043	0.0876	No
105	NEK6	NEK6 Entrez, Source	NIMA (never in mitosis gene a)-related kinase 6	8774	-0.043	0.0873	No
106	LYN	LYN Entrez, Source	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	9007	-0.047	0.0731	No
107	NF2	NF2 Entrez, Source	neurofibromin 2 (bilateral acoustic neuroma)	9310	-0.053	0.0540	No
108	HGS	HGS Entrez, Source	hepatocyte growth factor-regulated tyrosine kinase substrate	9370	-0.054	0.0533	No
109	SECTM1	SECTM1 Entrez, Source	secreted and transmembrane 1	9756	-0.061	0.0285	No
110	FASLG	FASLG Entrez, Source	Fas ligand (TNF superfamily, member 6)	9771	-0.061	0.0318	No
111	CDC42BPB	CDC42BPB Entrez, Source	CDC42 binding protein kinase beta (DMPK-like)	9816	-0.062	0.0328	No
112	RPL17	RPL17 Entrez, Source	ribosomal protein L17	9826	-0.063	0.0366	No
113	FRZB	FRZB Entrez, Source	frizzled-related protein	9829	-0.063	0.0409	No
114	MAPK8IP3	MAPK8IP3 Entrez, Source	mitogen-activated protein kinase 8 interacting protein 3	10124	-0.069	0.0235	No
115	ARF6	ARF6 Entrez, Source	ADP-ribosylation factor 6	10133	-0.069	0.0277	No
116	CASP1	CASP1 Entrez, Source	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	10182	-0.070	0.0291	No
117	FGD4	FGD4 Entrez, Source	FYVE, RhoGEF and PH domain containing 4	10187	-0.070	0.0337	No
118	NF1	NF1 Entrez, Source	neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)	10739	-0.084	-0.0021	No
119	HTR2B	HTR2B Entrez, Source	5-hydroxytryptamine (serotonin) receptor 2B	10954	-0.089	-0.0119	No
120	PPM1A	PPM1A Entrez, Source	protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform	11053	-0.092	-0.0129	No
121	SOST	SOST Entrez, Source	sclerosteosis	11309	-0.099	-0.0252	No
122	THY1	THY1 Entrez, Source	Thy-1 cell surface antigen	11400	-0.102	-0.0248	No
123	FADD	FADD Entrez, Source	Fas (TNFRSF6)-associated via death domain	11436	-0.104	-0.0201	No
124	RGS14	RGS14 Entrez, Source	regulator of G-protein signalling 14	11575	-0.108	-0.0229	No
125	PTEN	PTEN Entrez, Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	11578	-0.108	-0.0154	No
126	EEF1D	EEF1D Entrez, Source	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	11614	-0.110	-0.0103	No
127	ACVR2B	ACVR2B Entrez, Source	activin A receptor, type IIB	12018	-0.127	-0.0318	No
128	RIPK2	RIPK2 Entrez, Source	receptor-interacting serine-threonine kinase 2	12163	-0.135	-0.0331	No
129	TSPAN6	TSPAN6 Entrez, Source	tetraspanin 6	12255	-0.140	-0.0301	No
130	NOTCH2	NOTCH2 Entrez, Source	Notch homolog 2 (Drosophila)	12769	-0.180	-0.0563	No
131	HMOX1	HMOX1 Entrez, Source	heme oxygenase (decycling) 1	12788	-0.183	-0.0447	No
132	EGF	EGF Entrez, Source	epidermal growth factor (beta-urogastrone)	12819	-0.188	-0.0337	No
133	BST2	BST2 Entrez, Source	bone marrow stromal cell antigen 2	13220	-0.317	-0.0416	No
134	RGN	RGN Entrez, Source	regucalcin (senescence marker protein-30)	13331	-0.718	0.0008	No