Details for gene set SMOOTH_MUSCLE

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_48h_repos
Upregulated in class	double_gel_8d
GeneSet	SMOOTH_MUSCLE_CONTRACTION
Enrichment Score (ES)	0.5728633
Normalized Enrichment Score (NES)	2.1261237
Nominal p-value	0.0
FDR q-value	0.0010079363
FWER p-Value	0.02

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FOS	FOS Entrez, Source	v-fos FBJ murine osteosarcoma viral oncogene homolog	9	0.936	0.0701	Yes
2	RGS2	RGS2 Entrez, Source	regulator of G-protein signalling 2, 24kDa	25	0.771	0.1273	Yes
3	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	62	0.606	0.1704	Yes
4	RGS1	RGS1 Entrez, Source	regulator of G-protein signalling 1	75	0.565	0.2122	Yes
5	ADM	ADM Entrez, Source	adrenomedullin	96	0.523	0.2502	Yes
6	RGS16	RGS16 Entrez, Source	regulator of G-protein signalling 16	103	0.505	0.2879	Yes
7	GRK5	GRK5 Entrez, Source	G protein-coupled receptor kinase 5	115	0.484	0.3237	Yes
8	PRKAR2B	PRKAR2B Entrez, Source	protein kinase, cAMP-dependent, regulatory, type II, beta	160	0.434	0.3531	Yes
9	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	173	0.414	0.3836	Yes
10	ATF3	ATF3 Entrez, Source	activating transcription factor 3	310	0.299	0.3959	Yes
11	RGS3	RGS3 Entrez, Source	regulator of G-protein signalling 3	338	0.287	0.4155	Yes
12	PRKAR1B	PRKAR1B Entrez, Source	protein kinase, cAMP-dependent, regulatory, type I, beta	369	0.272	0.4339	Yes
13	RGS10	RGS10 Entrez, Source	regulator of G-protein signalling 10	370	0.272	0.4545	Yes
14	RAMP3	RAMP3 Entrez, Source	receptor (calcitonin) activity modifying protein 3	429	0.251	0.4690	Yes
15	PKIB	PKIB Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor beta	446	0.246	0.4864	Yes
16	RGS4	RGS4 Entrez, Source	regulator of G-protein signalling 4	454	0.244	0.5043	Yes
17	RGS5	RGS5 Entrez, Source	regulator of G-protein signalling 5	513	0.224	0.5168	Yes
18	IGFBP3	IGFBP3 Entrez, Source	insulin-like growth factor binding protein 3	571	0.212	0.5286	Yes
19	IGFBP1	IGFBP1 Entrez, Source	insulin-like growth factor binding protein 1	584	0.209	0.5434	Yes
20	ITPR1	ITPR1 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 1	816	0.167	0.5386	Yes
21	CREB3	CREB3 Entrez, Source	cAMP responsive element binding protein 3	970	0.150	0.5384	Yes
22	PLCG2	PLCG2 Entrez, Source	phospholipase C, gamma 2 (phosphatidylinositol-specific)	1161	0.131	0.5340	Yes
23	IL1B	IL1B Entrez, Source	interleukin 1, beta	1197	0.128	0.5410	Yes
24	ACTA1	ACTA1 Entrez, Source	actin, alpha 1, skeletal muscle	1218	0.126	0.5490	Yes
25	YWHAQ	YWHAQ Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	1294	0.120	0.5524	Yes
26	PKIA	PKIA Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	1340	0.117	0.5579	Yes
27	ATP2A3	ATP2A3 Entrez, Source	ATPase, Ca++ transporting, ubiquitous	1390	0.114	0.5628	Yes
28	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	1663	0.099	0.5498	Yes
29	NOS3	NOS3 Entrez, Source	nitric oxide synthase 3 (endothelial cell)	1705	0.097	0.5540	Yes
30	IGFBP2	IGFBP2 Entrez, Source	insulin-like growth factor binding protein 2, 36kDa	1859	0.090	0.5492	Yes
31	GNB5	GNB5 Entrez, Source	guanine nucleotide binding protein (G protein), beta 5	1878	0.089	0.5546	Yes
32	PKIG	PKIG Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	1880	0.089	0.5613	Yes
33	GUCA2B	GUCA2B Entrez, Source	guanylate cyclase activator 2B (uroguanylin)	1912	0.088	0.5656	Yes
34	PLCD1	PLCD1 Entrez, Source	phospholipase C, delta 1	1926	0.088	0.5713	Yes
35	RAMP2	RAMP2 Entrez, Source	receptor (calcitonin) activity modifying protein 2	1999	0.085	0.5723	Yes
36	ACTA2	ACTA2 Entrez, Source	actin, alpha 2, smooth muscle, aorta	2074	0.082	0.5729	Yes
37	ADMR	ADMR Entrez, Source	adrenomedullin receptor	2330	0.073	0.5591	No
38	IGFBP6	IGFBP6 Entrez, Source	insulin-like growth factor binding protein 6	2356	0.072	0.5627	No
39	ADCY6	ADCY6 Entrez, Source	adenylate cyclase 6	2414	0.070	0.5637	No
40	PRKAR1A	PRKAR1A Entrez, Source	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	2585	0.065	0.5557	No
41	CRH	CRH Entrez, Source	corticotropin releasing hormone	2685	0.063	0.5530	No
42	EDG2	EDG2 Entrez, Source	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2	2690	0.063	0.5575	No
43	GNAQ	GNAQ Entrez, Source	guanine nucleotide binding protein (G protein), q polypeptide	2897	0.057	0.5462	No
44	ITPR3	ITPR3 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 3	2923	0.057	0.5486	No
45	ARRB1	ARRB1 Entrez, Source	arrestin, beta 1	3016	0.054	0.5457	No
46	JUN	JUN Entrez, Source	jun oncogene	3104	0.052	0.5431	No
47	PLCB3	PLCB3 Entrez, Source	phospholipase C, beta 3 (phosphatidylinositol-specific)	3154	0.051	0.5432	No
48	OXT	OXT Entrez, Source	oxytocin, prepro- (neurophysin I)	3271	0.048	0.5380	No
49	CALM3	CALM3 Entrez, Source	calmodulin 3 (phosphorylase kinase, delta)	3289	0.048	0.5404	No
50	RCP9	RCP9 Entrez, Source	-	3316	0.047	0.5419	No
51	GNB4	GNB4 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 4	3549	0.042	0.5276	No
52	CAMK2A	CAMK2A Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha	3720	0.038	0.5176	No
53	NFKB1	NFKB1 Entrez, Source	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)	3740	0.038	0.5190	No
54	CACNB3	CACNB3 Entrez, Source	calcium channel, voltage-dependent, beta 3 subunit	3774	0.037	0.5193	No
55	PRKCD	PRKCD Entrez, Source	protein kinase C, delta	3824	0.036	0.5183	No
56	IL6	IL6 Entrez, Source	interleukin 6 (interferon, beta 2)	3854	0.036	0.5188	No
57	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	3861	0.035	0.5211	No
58	CREBL1	CREBL1 Entrez, Source	cAMP responsive element binding protein-like 1	3874	0.035	0.5228	No
59	CRHR1	CRHR1 Entrez, Source	corticotropin releasing hormone receptor 1	3942	0.034	0.5203	No
60	RYR2	RYR2 Entrez, Source	ryanodine receptor 2 (cardiac)	4005	0.033	0.5181	No
61	GNG5	GNG5 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 5	4174	0.030	0.5076	No
62	GNB2	GNB2 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 2	4175	0.030	0.5099	No
63	YWHAB	YWHAB Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	4394	0.025	0.4953	No
64	PRKCZ	PRKCZ Entrez, Source	protein kinase C, zeta	4529	0.023	0.4869	No
65	RGS7	RGS7 Entrez, Source	regulator of G-protein signalling 7	4582	0.022	0.4846	No
66	ADCY5	ADCY5 Entrez, Source	adenylate cyclase 5	4781	0.019	0.4710	No
67	ATF5	ATF5 Entrez, Source	activating transcription factor 5	4937	0.016	0.4605	No
68	PRKCH	PRKCH Entrez, Source	protein kinase C, eta	4972	0.016	0.4591	No
69	MYLK2	MYLK2 Entrez, Source	myosin light chain kinase 2, skeletal muscle	5057	0.014	0.4539	No
70	GUCY1A3	GUCY1A3 Entrez, Source	guanylate cyclase 1, soluble, alpha 3	5232	0.011	0.4416	No
71	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	5370	0.009	0.4319	No
72	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	5497	0.007	0.4229	No
73	ARRB2	ARRB2 Entrez, Source	arrestin, beta 2	5791	0.003	0.4010	No
74	CAMK2G	CAMK2G Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma	5913	0.001	0.3919	No
75	GNB3	GNB3 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 3	6067	-0.001	0.3804	No
76	OXTR	OXTR Entrez, Source	oxytocin receptor	6165	-0.002	0.3733	No
77	PDE4B	PDE4B Entrez, Source	phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)	6239	-0.004	0.3680	No
78	CALCA	CALCA Entrez, Source	calcitonin/calcitonin-related polypeptide, alpha	6370	-0.006	0.3586	No
79	PRKACA	PRKACA Entrez, Source	protein kinase, cAMP-dependent, catalytic, alpha	6428	-0.007	0.3548	No
80	RYR1	RYR1 Entrez, Source	ryanodine receptor 1 (skeletal)	6453	-0.007	0.3536	No
81	GUCA2A	GUCA2A Entrez, Source	guanylate cyclase activator 2A (guanylin)	6469	-0.007	0.3530	No
82	SP1	SP1 Entrez, Source	Sp1 transcription factor	6622	-0.009	0.3422	No
83	YWHAH	YWHAH Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	6649	-0.010	0.3409	No
84	RLN1	RLN1 Entrez, Source	relaxin 1	6670	-0.010	0.3402	No
85	ITPR2	ITPR2 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 2	6675	-0.010	0.3407	No
86	RGS6	RGS6 Entrez, Source	regulator of G-protein signalling 6	6832	-0.013	0.3298	No
87	GRK4	GRK4 Entrez, Source	G protein-coupled receptor kinase 4	6984	-0.015	0.3195	No
88	CALM2	CALM2 Entrez, Source	calmodulin 2 (phosphorylase kinase, delta)	7147	-0.017	0.3086	No
89	SLC8A1	SLC8A1 Entrez, Source	solute carrier family 8 (sodium/calcium exchanger), member 1	7449	-0.022	0.2875	No
90	RGS9	RGS9 Entrez, Source	regulator of G-protein signalling 9	7456	-0.022	0.2887	No
91	GNG3	GNG3 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 3	7522	-0.023	0.2855	No
92	PLCG1	PLCG1 Entrez, Source	phospholipase C, gamma 1	7527	-0.023	0.2869	No
93	ADCY2	ADCY2 Entrez, Source	adenylate cyclase 2 (brain)	7570	-0.024	0.2855	No
94	CORIN	CORIN Entrez, Source	corin, serine peptidase	7574	-0.024	0.2871	No
95	PRKAR2A	PRKAR2A Entrez, Source	protein kinase, cAMP-dependent, regulatory, type II, alpha	7798	-0.027	0.2723	No
96	CAMK2D	CAMK2D Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II delta	7932	-0.030	0.2645	No
97	ATP2A2	ATP2A2 Entrez, Source	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	7943	-0.030	0.2660	No
98	PDE4D	PDE4D Entrez, Source	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	7982	-0.030	0.2654	No
99	GRK6	GRK6 Entrez, Source	G protein-coupled receptor kinase 6	8007	-0.031	0.2660	No
100	PRKCE	PRKCE Entrez, Source	protein kinase C, epsilon	8210	-0.034	0.2532	No
101	NOS1	NOS1 Entrez, Source	nitric oxide synthase 1 (neuronal)	8645	-0.041	0.2235	No
102	CAMK2B	CAMK2B Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II beta	8673	-0.041	0.2246	No
103	ADCY8	ADCY8 Entrez, Source	adenylate cyclase 8 (brain)	8892	-0.045	0.2116	No
104	IGFBP4	IGFBP4 Entrez, Source	insulin-like growth factor binding protein 4	9082	-0.049	0.2010	No
105	PRKCQ	PRKCQ Entrez, Source	protein kinase C, theta	9522	-0.056	0.1720	No
106	GNG12	GNG12 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 12	9681	-0.059	0.1645	No
107	CNN1	CNN1 Entrez, Source	calponin 1, basic, smooth muscle	10018	-0.067	0.1442	No
108	CALM1	CALM1 Entrez, Source	calmodulin 1 (phosphorylase kinase, delta)	10213	-0.071	0.1349	No
109	DGKZ	DGKZ Entrez, Source	diacylglycerol kinase, zeta 104kDa	10326	-0.073	0.1319	No
110	ATF1	ATF1 Entrez, Source	activating transcription factor 1	10486	-0.077	0.1257	No
111	ADCY3	ADCY3 Entrez, Source	adenylate cyclase 3	10657	-0.081	0.1190	No
112	RGS19	RGS19 Entrez, Source	regulator of G-protein signalling 19	10872	-0.087	0.1095	No
113	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	11192	-0.096	0.0926	No
114	RGS14	RGS14 Entrez, Source	regulator of G-protein signalling 14	11575	-0.108	0.0719	No
115	PRKD1	PRKD1 Entrez, Source	protein kinase D1	11594	-0.109	0.0788	No
116	GNB1	GNB1 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 1	11712	-0.114	0.0785	No
117	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	12047	-0.129	0.0630	No
118	ATF2	ATF2 Entrez, Source	activating transcription factor 2	12206	-0.137	0.0614	No
119	ADCY4	ADCY4 Entrez, Source	adenylate cyclase 4	12581	-0.161	0.0453	No
120	GSTO1	GSTO1 Entrez, Source	glutathione S-transferase omega 1	12585	-0.162	0.0572	No