Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | STEROID_METABOLIC_PROCESS |
| Enrichment Score (ES) | 0.66401464 |
| Normalized Enrichment Score (NES) | 2.075154 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0016555135 |
| FWER p-Value | 0.053 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SOAT1 | SOAT1 Entrez, Source | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 | 85 | 0.548 | 0.1076 | Yes |
| 2 | ADM | ADM Entrez, Source | adrenomedullin | 96 | 0.523 | 0.2155 | Yes |
| 3 | ABCG1 | ABCG1 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 1 | 187 | 0.400 | 0.2919 | Yes |
| 4 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 288 | 0.316 | 0.3501 | Yes |
| 5 | HSD3B1 | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 302 | 0.308 | 0.4131 | Yes |
| 6 | ACOX2 | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 379 | 0.269 | 0.4633 | Yes |
| 7 | NR0B2 | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 485 | 0.232 | 0.5036 | Yes |
| 8 | SCARB1 | SCARB1 Entrez, Source | scavenger receptor class B, member 1 | 620 | 0.203 | 0.5357 | Yes |
| 9 | TSPO | TSPO Entrez, Source | translocator protein (18kDa) | 644 | 0.198 | 0.5751 | Yes |
| 10 | SCP2 | SCP2 Entrez, Source | sterol carrier protein 2 | 726 | 0.181 | 0.6066 | Yes |
| 11 | NR1I2 | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 891 | 0.157 | 0.6270 | Yes |
| 12 | BAAT | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 906 | 0.156 | 0.6583 | Yes |
| 13 | CLN8 | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 1188 | 0.129 | 0.6640 | Yes |
| 14 | DHRS9 | DHRS9 Entrez, Source | dehydrogenase/reductase (SDR family) member 9 | 2037 | 0.084 | 0.6176 | No |
| 15 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 2460 | 0.069 | 0.6003 | No |
| 16 | CEL | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 2522 | 0.067 | 0.6096 | No |
| 17 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 3902 | 0.035 | 0.5132 | No |
| 18 | SULT2A1 | SULT2A1 Entrez, Source | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 4352 | 0.026 | 0.4849 | No |
| 19 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 4498 | 0.023 | 0.4788 | No |
| 20 | CYP11A1 | CYP11A1 Entrez, Source | cytochrome P450, family 11, subfamily A, polypeptide 1 | 5093 | 0.014 | 0.4370 | No |
| 21 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 5260 | 0.011 | 0.4267 | No |
| 22 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 5315 | 0.010 | 0.4247 | No |
| 23 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 5370 | 0.009 | 0.4226 | No |
| 24 | CYP7B1 | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 5862 | 0.002 | 0.3861 | No |
| 25 | MBTPS2 | MBTPS2 Entrez, Source | membrane-bound transcription factor peptidase, site 2 | 5965 | 0.001 | 0.3785 | No |
| 26 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 6084 | -0.001 | 0.3700 | No |
| 27 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 6444 | -0.007 | 0.3444 | No |
| 28 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 6649 | -0.010 | 0.3311 | No |
| 29 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 6935 | -0.014 | 0.3126 | No |
| 30 | SHH | SHH Entrez, Source | sonic hedgehog homolog (Drosophila) | 6999 | -0.015 | 0.3110 | No |
| 31 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 7264 | -0.019 | 0.2951 | No |
| 32 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7545 | -0.023 | 0.2789 | No |
| 33 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 7755 | -0.027 | 0.2687 | No |
| 34 | AKR1B10 | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 8074 | -0.032 | 0.2515 | No |
| 35 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 9075 | -0.048 | 0.1863 | No |
| 36 | HDLBP | HDLBP Entrez, Source | high density lipoprotein binding protein (vigilin) | 9866 | -0.064 | 0.1402 | No |
| 37 | NR0B1 | NR0B1 Entrez, Source | nuclear receptor subfamily 0, group B, member 1 | 10457 | -0.077 | 0.1117 | No |
| 38 | ACOX3 | ACOX3 Entrez, Source | acyl-Coenzyme A oxidase 3, pristanoyl | 11075 | -0.092 | 0.0845 | No |
| 39 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 11141 | -0.094 | 0.0992 | No |
| 40 | IL4 | IL4 Entrez, Source | interleukin 4 | 11204 | -0.096 | 0.1145 | No |
| 41 | NR1H4 | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 11597 | -0.109 | 0.1077 | No |
| 42 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 11687 | -0.113 | 0.1244 | No |
