Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | TAKEDA_NUP8_HOXA9_8D_DN |
| Enrichment Score (ES) | 0.56854755 |
| Normalized Enrichment Score (NES) | 2.0964272 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.001161254 |
| FWER p-Value | 0.031 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DAB2 | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 18 | 0.797 | 0.0607 | Yes |
| 2 | CD24 | CD24 Entrez, Source | CD24 molecule | 26 | 0.771 | 0.1202 | Yes |
| 3 | MAF | MAF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | 43 | 0.675 | 0.1715 | Yes |
| 4 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 84 | 0.549 | 0.2113 | Yes |
| 5 | IL1R2 | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 89 | 0.531 | 0.2524 | Yes |
| 6 | RNASE1 | RNASE1 Entrez, Source | ribonuclease, RNase A family, 1 (pancreatic) | 94 | 0.529 | 0.2932 | Yes |
| 7 | RAB30 | RAB30 Entrez, Source | RAB30, member RAS oncogene family | 98 | 0.518 | 0.3334 | Yes |
| 8 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 101 | 0.510 | 0.3729 | Yes |
| 9 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 141 | 0.455 | 0.4054 | Yes |
| 10 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 200 | 0.388 | 0.4313 | Yes |
| 11 | CD9 | CD9 Entrez, Source | CD9 molecule | 283 | 0.320 | 0.4500 | Yes |
| 12 | TSPAN2 | TSPAN2 Entrez, Source | tetraspanin 2 | 311 | 0.298 | 0.4712 | Yes |
| 13 | TDO2 | TDO2 Entrez, Source | tryptophan 2,3-dioxygenase | 514 | 0.223 | 0.4733 | Yes |
| 14 | CUTL1 | CUTL1 Entrez, Source | cut-like 1, CCAAT displacement protein (Drosophila) | 531 | 0.219 | 0.4892 | Yes |
| 15 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 550 | 0.217 | 0.5047 | Yes |
| 16 | IFNGR1 | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 611 | 0.205 | 0.5161 | Yes |
| 17 | RAB3C | RAB3C Entrez, Source | RAB3C, member RAS oncogene family | 830 | 0.165 | 0.5125 | Yes |
| 18 | IL10 | IL10 Entrez, Source | interleukin 10 | 842 | 0.163 | 0.5244 | Yes |
| 19 | SLC16A6 | SLC16A6 Entrez, Source | solute carrier family 16, member 6 (monocarboxylic acid transporter 7) | 855 | 0.162 | 0.5361 | Yes |
| 20 | S100A8 | S100A8 Entrez, Source | S100 calcium binding protein A8 | 960 | 0.151 | 0.5400 | Yes |
| 21 | IL3RA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 1013 | 0.146 | 0.5474 | Yes |
| 22 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 1041 | 0.142 | 0.5564 | Yes |
| 23 | ST8SIA1 | ST8SIA1 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 1042 | 0.142 | 0.5675 | Yes |
| 24 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 1220 | 0.126 | 0.5639 | Yes |
| 25 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 1321 | 0.118 | 0.5656 | Yes |
| 26 | CLEC4A | CLEC4A Entrez, Source | C-type lectin domain family 4, member A | 1400 | 0.114 | 0.5685 | Yes |
| 27 | MS4A2 | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 1571 | 0.104 | 0.5638 | No |
| 28 | HSD11B1 | HSD11B1 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 1 | 1720 | 0.096 | 0.5602 | No |
| 29 | AKAP13 | AKAP13 Entrez, Source | A kinase (PRKA) anchor protein 13 | 1725 | 0.096 | 0.5674 | No |
| 30 | LGMN | LGMN Entrez, Source | legumain | 1864 | 0.090 | 0.5639 | No |
| 31 | LCP2 | LCP2 Entrez, Source | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 1958 | 0.087 | 0.5637 | No |
| 32 | ITGAM | ITGAM Entrez, Source | integrin, alpha M (complement component 3 receptor 3 subunit) | 2219 | 0.077 | 0.5500 | No |
| 33 | ENC1 | ENC1 Entrez, Source | ectodermal-neural cortex (with BTB-like domain) | 2392 | 0.071 | 0.5425 | No |
| 34 | CD200R1 | CD200R1 Entrez, Source | CD200 receptor 1 | 2497 | 0.068 | 0.5400 | No |
| 35 | PADI4 | PADI4 Entrez, Source | peptidyl arginine deiminase, type IV | 2700 | 0.063 | 0.5296 | No |
| 36 | C7ORF10 | C7ORF10 Entrez, Source | chromosome 7 open reading frame 10 | 2833 | 0.059 | 0.5242 | No |
| 37 | HTRA1 | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 2880 | 0.058 | 0.5253 | No |
| 38 | ME1 | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 2902 | 0.057 | 0.5282 | No |
| 39 | PYGL | PYGL Entrez, Source | phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) | 2995 | 0.054 | 0.5255 | No |
| 40 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 3017 | 0.054 | 0.5281 | No |
| 41 | JUN | JUN Entrez, Source | jun oncogene | 3104 | 0.052 | 0.5256 | No |
| 42 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 3245 | 0.048 | 0.5188 | No |
| 43 | MMP12 | MMP12 Entrez, Source | matrix metallopeptidase 12 (macrophage elastase) | 3285 | 0.048 | 0.5196 | No |
| 44 | IL5RA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 3305 | 0.047 | 0.5218 | No |
| 45 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 3388 | 0.045 | 0.5191 | No |
| 46 | CLU | CLU Entrez, Source | clusterin | 3739 | 0.038 | 0.4957 | No |
| 47 | CAPZA2 | CAPZA2 Entrez, Source | capping protein (actin filament) muscle Z-line, alpha 2 | 3840 | 0.036 | 0.4909 | No |
| 48 | HRH4 | HRH4 Entrez, Source | histamine receptor H4 | 3986 | 0.033 | 0.4825 | No |
| 49 | UTS2 | UTS2 Entrez, Source | urotensin 2 | 4034 | 0.032 | 0.4815 | No |
| 50 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 4328 | 0.027 | 0.4614 | No |
| 51 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 4460 | 0.024 | 0.4534 | No |
| 52 | PPP1R1B | PPP1R1B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) | 4556 | 0.022 | 0.4480 | No |
| 53 | ALOX5 | ALOX5 Entrez, Source | arachidonate 5-lipoxygenase | 4658 | 0.021 | 0.4420 | No |
| 54 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 4730 | 0.020 | 0.4381 | No |
| 55 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 4808 | 0.018 | 0.4338 | No |
| 56 | ADORA3 | ADORA3 Entrez, Source | adenosine A3 receptor | 5346 | 0.009 | 0.3939 | No |
| 57 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 5439 | 0.008 | 0.3876 | No |
| 58 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 5548 | 0.007 | 0.3800 | No |
| 59 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 5599 | 0.006 | 0.3766 | No |
| 60 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 5691 | 0.004 | 0.3701 | No |
| 61 | CDH8 | CDH8 Entrez, Source | cadherin 8, type 2 | 6277 | -0.004 | 0.3263 | No |
| 62 | ADAM19 | ADAM19 Entrez, Source | ADAM metallopeptidase domain 19 (meltrin beta) | 6281 | -0.004 | 0.3264 | No |
| 63 | PADI2 | PADI2 Entrez, Source | peptidyl arginine deiminase, type II | 6353 | -0.006 | 0.3214 | No |
| 64 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 6363 | -0.006 | 0.3212 | No |
| 65 | LFNG | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 6457 | -0.007 | 0.3147 | No |
| 66 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 6493 | -0.008 | 0.3127 | No |
| 67 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 6833 | -0.013 | 0.2880 | No |
| 68 | GJA4 | GJA4 Entrez, Source | gap junction protein, alpha 4, 37kDa (connexin 37) | 6909 | -0.014 | 0.2835 | No |
| 69 | ABP1 | ABP1 Entrez, Source | amiloride binding protein 1 (amine oxidase (copper-containing)) | 7051 | -0.016 | 0.2740 | No |
| 70 | CORO2A | CORO2A Entrez, Source | coronin, actin binding protein, 2A | 7122 | -0.017 | 0.2701 | No |
| 71 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 7208 | -0.018 | 0.2651 | No |
| 72 | PPBP | PPBP Entrez, Source | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 7274 | -0.019 | 0.2617 | No |
| 73 | OLIG1 | OLIG1 Entrez, Source | oligodendrocyte transcription factor 1 | 7444 | -0.022 | 0.2506 | No |
| 74 | RHOH | RHOH Entrez, Source | ras homolog gene family, member H | 7559 | -0.024 | 0.2438 | No |
| 75 | ETS1 | ETS1 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 7566 | -0.024 | 0.2452 | No |
| 76 | CYBB | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 8263 | -0.035 | 0.1954 | No |
| 77 | ENTPD1 | ENTPD1 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 1 | 8353 | -0.037 | 0.1915 | No |
| 78 | RAP2A | RAP2A Entrez, Source | RAP2A, member of RAS oncogene family | 8557 | -0.040 | 0.1793 | No |
| 79 | ABI1 | ABI1 Entrez, Source | abl-interactor 1 | 8608 | -0.041 | 0.1787 | No |
| 80 | CD14 | CD14 Entrez, Source | CD14 molecule | 8706 | -0.042 | 0.1746 | No |
| 81 | RAP1A | RAP1A Entrez, Source | RAP1A, member of RAS oncogene family | 8724 | -0.043 | 0.1767 | No |
| 82 | ZDHHC19 | ZDHHC19 Entrez, Source | zinc finger, DHHC-type containing 19 | 8859 | -0.045 | 0.1700 | No |
| 83 | S100B | S100B Entrez, Source | S100 calcium binding protein B | 8923 | -0.046 | 0.1689 | No |
| 84 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 9192 | -0.050 | 0.1525 | No |
| 85 | SLC25A27 | SLC25A27 Entrez, Source | solute carrier family 25, member 27 | 9626 | -0.058 | 0.1244 | No |
| 86 | S100A9 | S100A9 Entrez, Source | S100 calcium binding protein A9 | 9785 | -0.062 | 0.1172 | No |
| 87 | NIPBL | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 9875 | -0.064 | 0.1155 | No |
| 88 | CEBPE | CEBPE Entrez, Source | CCAAT/enhancer binding protein (C/EBP), epsilon | 10021 | -0.067 | 0.1097 | No |
| 89 | KCNMA1 | KCNMA1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 10077 | -0.068 | 0.1109 | No |
| 90 | COLEC12 | COLEC12 Entrez, Source | collectin sub-family member 12 | 10217 | -0.071 | 0.1059 | No |
| 91 | SRPX | SRPX Entrez, Source | sushi-repeat-containing protein, X-linked | 10360 | -0.074 | 0.1009 | No |
| 92 | CTSB | CTSB Entrez, Source | cathepsin B | 10843 | -0.086 | 0.0712 | No |
| 93 | UHMK1 | UHMK1 Entrez, Source | U2AF homology motif (UHM) kinase 1 | 10896 | -0.088 | 0.0742 | No |
| 94 | HTR2C | HTR2C Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2C | 10920 | -0.088 | 0.0793 | No |
| 95 | PPP1R3B | PPP1R3B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3B | 11091 | -0.093 | 0.0737 | No |
| 96 | PCSK5 | PCSK5 Entrez, Source | proprotein convertase subtilisin/kexin type 5 | 11725 | -0.114 | 0.0348 | No |
| 97 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 12150 | -0.134 | 0.0132 | No |
| 98 | NDRG2 | NDRG2 Entrez, Source | NDRG family member 2 | 12174 | -0.135 | 0.0220 | No |
| 99 | FCGR2B | FCGR2B Entrez, Source | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 12366 | -0.147 | 0.0190 | No |
| 100 | SLC30A7 | SLC30A7 Entrez, Source | solute carrier family 30 (zinc transporter), member 7 | 12382 | -0.148 | 0.0294 | No |
| 101 | SLCO2B1 | SLCO2B1 Entrez, Source | solute carrier organic anion transporter family, member 2B1 | 12485 | -0.154 | 0.0337 | No |
| 102 | C1ORF24 | C1ORF24 Entrez, Source | chromosome 1 open reading frame 24 | 12569 | -0.160 | 0.0398 | No |
| 103 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 13061 | -0.237 | 0.0212 | No |
