Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | TGFBETA_ALL_UP |
| Enrichment Score (ES) | 0.62459165 |
| Normalized Enrichment Score (NES) | 1.9944792 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004844312 |
| FWER p-Value | 0.22 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 6 | 1.154 | 0.1625 | Yes |
| 2 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 21 | 0.785 | 0.2724 | Yes |
| 3 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 56 | 0.628 | 0.3585 | Yes |
| 4 | MARCKSL1 | MARCKSL1 Entrez, Source | MARCKS-like 1 | 166 | 0.428 | 0.4108 | Yes |
| 5 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 230 | 0.365 | 0.4576 | Yes |
| 6 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 317 | 0.293 | 0.4925 | Yes |
| 7 | PXN | PXN Entrez, Source | paxillin | 425 | 0.252 | 0.5201 | Yes |
| 8 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 533 | 0.219 | 0.5430 | Yes |
| 9 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 571 | 0.212 | 0.5701 | Yes |
| 10 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 709 | 0.184 | 0.5858 | Yes |
| 11 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 759 | 0.176 | 0.6070 | Yes |
| 12 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 1034 | 0.144 | 0.6067 | Yes |
| 13 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 1078 | 0.138 | 0.6229 | Yes |
| 14 | WNT2B | WNT2B Entrez, Source | wingless-type MMTV integration site family, member 2B | 1284 | 0.121 | 0.6246 | Yes |
| 15 | RHOG | RHOG Entrez, Source | ras homolog gene family, member G (rho G) | 1566 | 0.104 | 0.6182 | No |
| 16 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 1859 | 0.090 | 0.6090 | No |
| 17 | ZYX | ZYX Entrez, Source | zyxin | 2654 | 0.063 | 0.5582 | No |
| 18 | FN1 | FN1 Entrez, Source | fibronectin 1 | 2715 | 0.062 | 0.5625 | No |
| 19 | BSG | BSG Entrez, Source | basigin (Ok blood group) | 2772 | 0.061 | 0.5669 | No |
| 20 | EFNA5 | EFNA5 Entrez, Source | ephrin-A5 | 2911 | 0.057 | 0.5645 | No |
| 21 | SMO | SMO Entrez, Source | smoothened homolog (Drosophila) | 3242 | 0.049 | 0.5466 | No |
| 22 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 3530 | 0.042 | 0.5309 | No |
| 23 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 3937 | 0.034 | 0.5052 | No |
| 24 | DSP | DSP Entrez, Source | desmoplakin | 4079 | 0.031 | 0.4990 | No |
| 25 | IGFBP5 | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 4507 | 0.023 | 0.4701 | No |
| 26 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 4808 | 0.018 | 0.4501 | No |
| 27 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 4825 | 0.018 | 0.4515 | No |
| 28 | NID1 | NID1 Entrez, Source | nidogen 1 | 5553 | 0.007 | 0.3977 | No |
| 29 | DVL1 | DVL1 Entrez, Source | dishevelled, dsh homolog 1 (Drosophila) | 5611 | 0.005 | 0.3942 | No |
| 30 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 5692 | 0.004 | 0.3888 | No |
| 31 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 5770 | 0.003 | 0.3835 | No |
| 32 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 5780 | 0.003 | 0.3832 | No |
| 33 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 5985 | 0.000 | 0.3679 | No |
| 34 | CDH6 | CDH6 Entrez, Source | cadherin 6, type 2, K-cadherin (fetal kidney) | 6129 | -0.002 | 0.3574 | No |
| 35 | JUP | JUP Entrez, Source | junction plakoglobin | 6593 | -0.009 | 0.3238 | No |
| 36 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 6731 | -0.011 | 0.3151 | No |
| 37 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 6834 | -0.013 | 0.3092 | No |
| 38 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 7208 | -0.018 | 0.2837 | No |
| 39 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 7625 | -0.025 | 0.2559 | No |
| 40 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 8238 | -0.035 | 0.2148 | No |
| 41 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 9082 | -0.049 | 0.1582 | No |
| 42 | NEO1 | NEO1 Entrez, Source | neogenin homolog 1 (chicken) | 9160 | -0.050 | 0.1594 | No |
| 43 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 9690 | -0.060 | 0.1280 | No |
| 44 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 9886 | -0.064 | 0.1224 | No |
| 45 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 9946 | -0.065 | 0.1272 | No |
| 46 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 10103 | -0.068 | 0.1251 | No |
| 47 | ITGB2 | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 10432 | -0.076 | 0.1111 | No |
| 48 | ARHGDIA | ARHGDIA Entrez, Source | Rho GDP dissociation inhibitor (GDI) alpha | 10450 | -0.076 | 0.1206 | No |
| 49 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 10770 | -0.085 | 0.1086 | No |
| 50 | RHOQ | RHOQ Entrez, Source | ras homolog gene family, member Q | 11646 | -0.111 | 0.0584 | No |
| 51 | MTA1 | MTA1 Entrez, Source | metastasis associated 1 | 11924 | -0.123 | 0.0549 | No |
| 52 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 12769 | -0.180 | 0.0168 | No |
| 53 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 12802 | -0.185 | 0.0406 | No |
