Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | TGF_BETA_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.59714377 |
| Normalized Enrichment Score (NES) | 1.8869449 |
| Nominal p-value | 0.0036101083 |
| FDR q-value | 0.014014705 |
| FWER p-Value | 0.675 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOS | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 9 | 0.936 | 0.1845 | Yes |
| 2 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 56 | 0.628 | 0.3051 | Yes |
| 3 | FST | FST Entrez, Source | follistatin | 169 | 0.423 | 0.3804 | Yes |
| 4 | LTBP1 | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 525 | 0.222 | 0.3976 | Yes |
| 5 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 646 | 0.197 | 0.4276 | Yes |
| 6 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 821 | 0.166 | 0.4474 | Yes |
| 7 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 828 | 0.165 | 0.4796 | Yes |
| 8 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 1054 | 0.141 | 0.4906 | Yes |
| 9 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 1094 | 0.137 | 0.5147 | Yes |
| 10 | LIF | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 1203 | 0.127 | 0.5318 | Yes |
| 11 | BMP4 | BMP4 Entrez, Source | bone morphogenetic protein 4 | 1506 | 0.108 | 0.5304 | Yes |
| 12 | IFNG | IFNG Entrez, Source | interferon, gamma | 1653 | 0.100 | 0.5392 | Yes |
| 13 | RUNX3 | RUNX3 Entrez, Source | runt-related transcription factor 3 | 1657 | 0.100 | 0.5587 | Yes |
| 14 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 1776 | 0.094 | 0.5684 | Yes |
| 15 | LEF1 | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 1812 | 0.092 | 0.5840 | Yes |
| 16 | RUNX2 | RUNX2 Entrez, Source | runt-related transcription factor 2 | 1874 | 0.090 | 0.5971 | Yes |
| 17 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 2722 | 0.062 | 0.5457 | No |
| 18 | TGFBR3 | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 3034 | 0.054 | 0.5329 | No |
| 19 | ZFHX1B | ZFHX1B Entrez, Source | zinc finger homeobox 1b | 3081 | 0.052 | 0.5398 | No |
| 20 | JUN | JUN Entrez, Source | jun oncogene | 3104 | 0.052 | 0.5484 | No |
| 21 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3740 | 0.038 | 0.5081 | No |
| 22 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 4055 | 0.032 | 0.4908 | No |
| 23 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 5081 | 0.014 | 0.4164 | No |
| 24 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 5682 | 0.005 | 0.3722 | No |
| 25 | SMAD1 | SMAD1 Entrez, Source | SMAD, mothers against DPP homolog 1 (Drosophila) | 5731 | 0.004 | 0.3694 | No |
| 26 | ENG | ENG Entrez, Source | endoglin (Osler-Rendu-Weber syndrome 1) | 5761 | 0.003 | 0.3678 | No |
| 27 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 5914 | 0.001 | 0.3567 | No |
| 28 | FKBP1A | FKBP1A Entrez, Source | FK506 binding protein 1A, 12kDa | 6681 | -0.010 | 0.3011 | No |
| 29 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 6946 | -0.014 | 0.2841 | No |
| 30 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 7113 | -0.017 | 0.2750 | No |
| 31 | NOG | NOG Entrez, Source | noggin | 8217 | -0.034 | 0.1988 | No |
| 32 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 8430 | -0.038 | 0.1903 | No |
| 33 | SMAD9 | SMAD9 Entrez, Source | SMAD, mothers against DPP homolog 9 (Drosophila) | 8442 | -0.038 | 0.1970 | No |
| 34 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 8660 | -0.041 | 0.1889 | No |
| 35 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 9886 | -0.064 | 0.1094 | No |
| 36 | SMAD6 | SMAD6 Entrez, Source | SMAD, mothers against DPP homolog 6 (Drosophila) | 10518 | -0.078 | 0.0775 | No |
| 37 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 10575 | -0.079 | 0.0890 | No |
| 38 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 10602 | -0.080 | 0.1028 | No |
| 39 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12538 | -0.158 | -0.0115 | No |
| 40 | SMAD5 | SMAD5 Entrez, Source | SMAD, mothers against DPP homolog 5 (Drosophila) | 12719 | -0.175 | 0.0096 | No |
| 41 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 12819 | -0.188 | 0.0393 | No |
