Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | UVB_NHEK1_C6 |
| Enrichment Score (ES) | -0.42038834 |
| Normalized Enrichment Score (NES) | -1.4751298 |
| Nominal p-value | 0.02455357 |
| FDR q-value | 0.2693357 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 411 | 0.256 | 0.0185 | No |
| 2 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 721 | 0.182 | 0.0304 | No |
| 3 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 778 | 0.173 | 0.0597 | No |
| 4 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 1155 | 0.132 | 0.0568 | No |
| 5 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 1392 | 0.114 | 0.0611 | No |
| 6 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 1841 | 0.091 | 0.0450 | No |
| 7 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 1977 | 0.086 | 0.0514 | No |
| 8 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 2137 | 0.079 | 0.0548 | No |
| 9 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 2686 | 0.063 | 0.0257 | No |
| 10 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 3264 | 0.048 | -0.0085 | No |
| 11 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 3662 | 0.040 | -0.0307 | No |
| 12 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 3727 | 0.038 | -0.0282 | No |
| 13 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3740 | 0.038 | -0.0218 | No |
| 14 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 4225 | 0.029 | -0.0526 | No |
| 15 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 4430 | 0.025 | -0.0632 | No |
| 16 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4433 | 0.025 | -0.0585 | No |
| 17 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 4720 | 0.020 | -0.0763 | No |
| 18 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 4938 | 0.016 | -0.0895 | No |
| 19 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 5090 | 0.014 | -0.0982 | No |
| 20 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5583 | 0.006 | -0.1341 | No |
| 21 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 5869 | 0.002 | -0.1552 | No |
| 22 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 6132 | -0.002 | -0.1745 | No |
| 23 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 6178 | -0.003 | -0.1773 | No |
| 24 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 6621 | -0.009 | -0.2088 | No |
| 25 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 6661 | -0.010 | -0.2098 | No |
| 26 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 7107 | -0.017 | -0.2400 | No |
| 27 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 7253 | -0.019 | -0.2473 | No |
| 28 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 7482 | -0.022 | -0.2602 | No |
| 29 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 7610 | -0.024 | -0.2650 | No |
| 30 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 7696 | -0.026 | -0.2664 | No |
| 31 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 7938 | -0.030 | -0.2788 | No |
| 32 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 9001 | -0.047 | -0.3496 | No |
| 33 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 9465 | -0.055 | -0.3738 | No |
| 34 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 9479 | -0.056 | -0.3640 | No |
| 35 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 9795 | -0.062 | -0.3757 | No |
| 36 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 10314 | -0.073 | -0.4006 | No |
| 37 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 10568 | -0.079 | -0.4044 | Yes |
| 38 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 10782 | -0.085 | -0.4040 | Yes |
| 39 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 10930 | -0.089 | -0.3979 | Yes |
| 40 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 11066 | -0.092 | -0.3903 | Yes |
| 41 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 11073 | -0.092 | -0.3729 | Yes |
| 42 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 11561 | -0.108 | -0.3887 | Yes |
| 43 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 11848 | -0.119 | -0.3871 | Yes |
| 44 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12025 | -0.128 | -0.3757 | Yes |
| 45 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 12206 | -0.137 | -0.3628 | Yes |
| 46 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 12329 | -0.144 | -0.3441 | Yes |
| 47 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 12364 | -0.147 | -0.3183 | Yes |
| 48 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 12592 | -0.163 | -0.3040 | Yes |
| 49 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 12624 | -0.165 | -0.2744 | Yes |
| 50 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 12770 | -0.180 | -0.2506 | Yes |
| 51 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 12801 | -0.185 | -0.2170 | Yes |
| 52 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 12952 | -0.209 | -0.1879 | Yes |
| 53 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 12993 | -0.216 | -0.1491 | Yes |
| 54 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 12994 | -0.216 | -0.1073 | Yes |
| 55 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 13039 | -0.228 | -0.0665 | Yes |
| 56 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 13303 | -0.462 | 0.0029 | Yes |
