Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | UVB_NHEK1_DN |
| Enrichment Score (ES) | -0.3859163 |
| Normalized Enrichment Score (NES) | -1.5236129 |
| Nominal p-value | 0.002538071 |
| FDR q-value | 0.20959201 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RAPGEF5 | RAPGEF5 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 5 | 384 | 0.267 | -0.0025 | No |
| 2 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 411 | 0.256 | 0.0209 | No |
| 3 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 721 | 0.182 | 0.0157 | No |
| 4 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 778 | 0.173 | 0.0286 | No |
| 5 | CCDC131 | CCDC131 Entrez, Source | coiled-coil domain containing 131 | 935 | 0.153 | 0.0320 | No |
| 6 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 998 | 0.147 | 0.0420 | No |
| 7 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 1155 | 0.132 | 0.0433 | No |
| 8 | PSCD1 | PSCD1 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) | 1237 | 0.125 | 0.0495 | No |
| 9 | AKAP9 | AKAP9 Entrez, Source | A kinase (PRKA) anchor protein (yotiao) 9 | 1346 | 0.117 | 0.0529 | No |
| 10 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 1392 | 0.114 | 0.0609 | No |
| 11 | PER2 | PER2 Entrez, Source | period homolog 2 (Drosophila) | 1454 | 0.110 | 0.0672 | No |
| 12 | CEP170 | CEP170 Entrez, Source | centrosomal protein 170kDa | 1823 | 0.092 | 0.0485 | No |
| 13 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 1841 | 0.091 | 0.0563 | No |
| 14 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 1977 | 0.086 | 0.0546 | No |
| 15 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 2137 | 0.079 | 0.0505 | No |
| 16 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 2364 | 0.072 | 0.0405 | No |
| 17 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2499 | 0.068 | 0.0372 | No |
| 18 | PHC2 | PHC2 Entrez, Source | polyhomeotic homolog 2 (Drosophila) | 2559 | 0.066 | 0.0393 | No |
| 19 | CBLB | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 2684 | 0.063 | 0.0361 | No |
| 20 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 2686 | 0.063 | 0.0423 | No |
| 21 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 2722 | 0.062 | 0.0458 | No |
| 22 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 3264 | 0.048 | 0.0097 | No |
| 23 | DTX2 | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 3529 | 0.042 | -0.0061 | No |
| 24 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 3662 | 0.040 | -0.0121 | No |
| 25 | ADORA2B | ADORA2B Entrez, Source | adenosine A2b receptor | 3693 | 0.039 | -0.0105 | No |
| 26 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 3727 | 0.038 | -0.0092 | No |
| 27 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3740 | 0.038 | -0.0064 | No |
| 28 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 3824 | 0.036 | -0.0091 | No |
| 29 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 4225 | 0.029 | -0.0364 | No |
| 30 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 4430 | 0.025 | -0.0494 | No |
| 31 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4433 | 0.025 | -0.0471 | No |
| 32 | SH2B3 | SH2B3 Entrez, Source | SH2B adaptor protein 3 | 4523 | 0.023 | -0.0515 | No |
| 33 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 4687 | 0.020 | -0.0618 | No |
| 34 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 4720 | 0.020 | -0.0623 | No |
| 35 | ADRB2 | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 4733 | 0.020 | -0.0613 | No |
| 36 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 4938 | 0.016 | -0.0751 | No |
| 37 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 5090 | 0.014 | -0.0851 | No |
| 38 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 5565 | 0.006 | -0.1203 | No |
| 39 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5583 | 0.006 | -0.1210 | No |
| 40 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 5869 | 0.002 | -0.1424 | No |
| 41 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 5905 | 0.001 | -0.1449 | No |
| 42 | ZNF148 | ZNF148 Entrez, Source | zinc finger protein 148 | 5916 | 0.001 | -0.1455 | No |
| 43 | KEAP1 | KEAP1 Entrez, Source | kelch-like ECH-associated protein 1 | 6022 | -0.000 | -0.1534 | No |
| 44 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 6092 | -0.002 | -0.1585 | No |
| 45 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 6132 | -0.002 | -0.1612 | No |
| 46 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 6178 | -0.003 | -0.1643 | No |
| 47 | BAZ1B | BAZ1B Entrez, Source | bromodomain adjacent to zinc finger domain, 1B | 6516 | -0.008 | -0.1890 | No |
| 48 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 6621 | -0.009 | -0.1960 | No |
| 49 | DMTF1 | DMTF1 Entrez, Source | cyclin D binding myb-like transcription factor 1 | 6628 | -0.009 | -0.1955 | No |
| 50 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 6661 | -0.010 | -0.1969 | No |
| 51 | CTCF | CTCF Entrez, Source | CCCTC-binding factor (zinc finger protein) | 6862 | -0.013 | -0.2107 | No |
| 52 | CEP350 | CEP350 Entrez, Source | centrosomal protein 350kDa | 7098 | -0.017 | -0.2268 | No |
| 53 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 7107 | -0.017 | -0.2258 | No |
| 54 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 7253 | -0.019 | -0.2348 | No |
| 55 | NAGK | NAGK Entrez, Source | N-acetylglucosamine kinase | 7266 | -0.019 | -0.2338 | No |
| 56 | ATRX | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 7295 | -0.019 | -0.2340 | No |
| 57 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 7482 | -0.022 | -0.2459 | No |
| 58 | TAF5L | TAF5L Entrez, Source | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | 7536 | -0.023 | -0.2476 | No |
| 59 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 7557 | -0.023 | -0.2468 | No |
| 60 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 7610 | -0.024 | -0.2483 | No |
| 61 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 7696 | -0.026 | -0.2521 | No |
| 62 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 7938 | -0.030 | -0.2674 | No |
| 63 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 8198 | -0.034 | -0.2836 | No |
| 64 | TAF11 | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 8562 | -0.040 | -0.3071 | No |
| 65 | NFE2L2 | NFE2L2 Entrez, Source | nuclear factor (erythroid-derived 2)-like 2 | 8944 | -0.046 | -0.3313 | No |
| 66 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 9001 | -0.047 | -0.3308 | No |
| 67 | PTPN3 | PTPN3 Entrez, Source | protein tyrosine phosphatase, non-receptor type 3 | 9054 | -0.048 | -0.3300 | No |
| 68 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 9465 | -0.055 | -0.3555 | No |
| 69 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 9479 | -0.056 | -0.3509 | No |
| 70 | UBE2G1 | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 9631 | -0.058 | -0.3565 | No |
| 71 | AHR | AHR Entrez, Source | aryl hydrocarbon receptor | 9715 | -0.060 | -0.3568 | No |
| 72 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 9795 | -0.062 | -0.3566 | No |
| 73 | NIPBL | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 9875 | -0.064 | -0.3563 | No |
| 74 | BRD8 | BRD8 Entrez, Source | bromodomain containing 8 | 9887 | -0.064 | -0.3507 | No |
| 75 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 10314 | -0.073 | -0.3757 | No |
| 76 | PUM2 | PUM2 Entrez, Source | pumilio homolog 2 (Drosophila) | 10315 | -0.073 | -0.3685 | No |
| 77 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 10547 | -0.079 | -0.3781 | Yes |
| 78 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 10568 | -0.079 | -0.3717 | Yes |
| 79 | ANKRD15 | ANKRD15 Entrez, Source | ankyrin repeat domain 15 | 10705 | -0.083 | -0.3738 | Yes |
| 80 | SERTAD2 | SERTAD2 Entrez, Source | SERTA domain containing 2 | 10758 | -0.084 | -0.3693 | Yes |
| 81 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 10782 | -0.085 | -0.3626 | Yes |
| 82 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 10930 | -0.089 | -0.3649 | Yes |
| 83 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 11066 | -0.092 | -0.3660 | Yes |
| 84 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 11073 | -0.092 | -0.3572 | Yes |
| 85 | NUP153 | NUP153 Entrez, Source | nucleoporin 153kDa | 11338 | -0.100 | -0.3673 | Yes |
| 86 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 11561 | -0.108 | -0.3733 | Yes |
| 87 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 11645 | -0.111 | -0.3685 | Yes |
| 88 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 11848 | -0.119 | -0.3720 | Yes |
| 89 | NCOA3 | NCOA3 Entrez, Source | nuclear receptor coactivator 3 | 11864 | -0.120 | -0.3612 | Yes |
| 90 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12025 | -0.128 | -0.3606 | Yes |
| 91 | SKAP2 | SKAP2 Entrez, Source | src kinase associated phosphoprotein 2 | 12042 | -0.128 | -0.3490 | Yes |
| 92 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 12206 | -0.137 | -0.3478 | Yes |
| 93 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 12329 | -0.144 | -0.3426 | Yes |
| 94 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 12364 | -0.147 | -0.3306 | Yes |
| 95 | MTM1 | MTM1 Entrez, Source | myotubularin 1 | 12542 | -0.158 | -0.3283 | Yes |
| 96 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 12592 | -0.163 | -0.3159 | Yes |
| 97 | MTIF2 | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 12601 | -0.163 | -0.3003 | Yes |
| 98 | ADNP | ADNP Entrez, Source | activity-dependent neuroprotector | 12610 | -0.164 | -0.2846 | Yes |
| 99 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 12624 | -0.165 | -0.2691 | Yes |
| 100 | AURKA | AURKA Entrez, Source | aurora kinase A | 12673 | -0.170 | -0.2558 | Yes |
| 101 | SMAD5 | SMAD5 Entrez, Source | SMAD, mothers against DPP homolog 5 (Drosophila) | 12719 | -0.175 | -0.2418 | Yes |
| 102 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 12770 | -0.180 | -0.2277 | Yes |
| 103 | DYRK1A | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 12773 | -0.181 | -0.2099 | Yes |
| 104 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 12801 | -0.185 | -0.1935 | Yes |
| 105 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 12952 | -0.209 | -0.1841 | Yes |
| 106 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 12993 | -0.216 | -0.1656 | Yes |
| 107 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 12994 | -0.216 | -0.1441 | Yes |
| 108 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 13039 | -0.228 | -0.1248 | Yes |
| 109 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 13151 | -0.271 | -0.1062 | Yes |
| 110 | USP1 | USP1 Entrez, Source | ubiquitin specific peptidase 1 | 13158 | -0.275 | -0.0793 | Yes |
| 111 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 13303 | -0.462 | -0.0443 | Yes |
| 112 | PPP1R3C | PPP1R3C Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 13309 | -0.475 | 0.0025 | Yes |
