Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_48h_repos
Upregulated in class	double_gel_8d
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	0.5501092
Normalized Enrichment Score (NES)	2.0625482
Nominal p-value	0.0
FDR q-value	0.0019816272
FWER p-Value	0.067

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	IGFBP7	IGFBP7 Entrez, Source	insulin-like growth factor binding protein 7	2	1.254	0.0816	Yes
2	CCND2	CCND2 Entrez, Source	cyclin D2	10	0.885	0.1387	Yes
3	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	62	0.606	0.1743	Yes
4	RGS1	RGS1 Entrez, Source	regulator of G-protein signalling 1	75	0.565	0.2102	Yes
5	EMP1	EMP1 Entrez, Source	epithelial membrane protein 1	101	0.510	0.2415	Yes
6	TRPM4	TRPM4 Entrez, Source	transient receptor potential cation channel, subfamily M, member 4	137	0.461	0.2689	Yes
7	SERPINE2	SERPINE2 Entrez, Source	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	140	0.455	0.2984	Yes
8	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	173	0.414	0.3230	Yes
9	P2RX5	P2RX5 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 5	205	0.383	0.3456	Yes
10	LAMC1	LAMC1 Entrez, Source	laminin, gamma 1 (formerly LAMB2)	252	0.342	0.3644	Yes
11	TFPI	TFPI Entrez, Source	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	316	0.294	0.3788	Yes
12	SPARC	SPARC Entrez, Source	secreted protein, acidic, cysteine-rich (osteonectin)	317	0.293	0.3979	Yes
13	CD48	CD48 Entrez, Source	CD48 molecule	352	0.281	0.4136	Yes
14	CYP2E1	CYP2E1 Entrez, Source	cytochrome P450, family 2, subfamily E, polypeptide 1	389	0.265	0.4281	Yes
15	TMOD1	TMOD1 Entrez, Source	tropomodulin 1	395	0.263	0.4448	Yes
16	PTGER4	PTGER4 Entrez, Source	prostaglandin E receptor 4 (subtype EP4)	402	0.258	0.4612	Yes
17	DPYSL2	DPYSL2 Entrez, Source	dihydropyrimidinase-like 2	404	0.258	0.4780	Yes
18	FOXO1A	FOXO1A Entrez, Source	forkhead box O1A (rhabdomyosarcoma)	411	0.256	0.4942	Yes
19	GSN	GSN Entrez, Source	gelsolin (amyloidosis, Finnish type)	483	0.233	0.5040	Yes
20	ITM2C	ITM2C Entrez, Source	integral membrane protein 2C	491	0.231	0.5185	Yes
21	PROM1	PROM1 Entrez, Source	prominin 1	530	0.220	0.5299	Yes
22	EHD3	EHD3 Entrez, Source	EH-domain containing 3	559	0.215	0.5418	Yes
23	LMO4	LMO4 Entrez, Source	LIM domain only 4	808	0.169	0.5340	Yes
24	ASS1	ASS1 Entrez, Source	argininosuccinate synthetase 1	997	0.147	0.5294	Yes
25	SCRN1	SCRN1 Entrez, Source	secernin 1	1023	0.145	0.5370	Yes
26	NBL1	NBL1 Entrez, Source	neuroblastoma, suppression of tumorigenicity 1	1093	0.137	0.5407	Yes
27	SLC38A1	SLC38A1 Entrez, Source	solute carrier family 38, member 1	1109	0.135	0.5483	Yes
28	F2RL1	F2RL1 Entrez, Source	coagulation factor II (thrombin) receptor-like 1	1205	0.127	0.5494	Yes
29	MLLT3	MLLT3 Entrez, Source	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	1443	0.111	0.5388	Yes
30	B4GALT6	B4GALT6 Entrez, Source	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	1451	0.111	0.5454	Yes
31	TGFB1I1	TGFB1I1 Entrez, Source	transforming growth factor beta 1 induced transcript 1	1509	0.108	0.5481	Yes
32	GMPR	GMPR Entrez, Source	guanosine monophosphate reductase	1649	0.100	0.5441	Yes
33	RUNX3	RUNX3 Entrez, Source	runt-related transcription factor 3	1657	0.100	0.5501	Yes
34	OPTN	OPTN Entrez, Source	optineurin	1779	0.094	0.5471	No
35	APP	APP Entrez, Source	amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)	1890	0.089	0.5446	No
36	ALAS2	ALAS2 Entrez, Source	aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)	2058	0.083	0.5373	No
37	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	2181	0.078	0.5332	No
38	FCER1A	FCER1A Entrez, Source	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	2214	0.077	0.5358	No
39	LRP3	LRP3 Entrez, Source	low density lipoprotein receptor-related protein 3	2439	0.070	0.5234	No
40	VIL2	VIL2 Entrez, Source	villin 2 (ezrin)	2459	0.069	0.5264	No
41	PAM	PAM Entrez, Source	peptidylglycine alpha-amidating monooxygenase	2485	0.069	0.5290	No
42	SERPING1	SERPING1 Entrez, Source	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)	2524	0.067	0.5305	No
43	FZD2	FZD2 Entrez, Source	frizzled homolog 2 (Drosophila)	2586	0.065	0.5301	No
44	UGCG	UGCG Entrez, Source	UDP-glucose ceramide glucosyltransferase	2779	0.061	0.5195	No
45	CCR2	CCR2 Entrez, Source	chemokine (C-C motif) receptor 2	2793	0.060	0.5225	No
46	BAALC	BAALC Entrez, Source	brain and acute leukemia, cytoplasmic	2819	0.060	0.5245	No
47	ERG	ERG Entrez, Source	v-ets erythroblastosis virus E26 oncogene homolog (avian)	2935	0.057	0.5195	No
48	ALDH2	ALDH2 Entrez, Source	aldehyde dehydrogenase 2 family (mitochondrial)	3245	0.048	0.4992	No
49	IL5RA	IL5RA Entrez, Source	interleukin 5 receptor, alpha	3305	0.047	0.4979	No
50	MST1	MST1 Entrez, Source	macrophage stimulating 1 (hepatocyte growth factor-like)	3594	0.041	0.4787	No
51	ISG20	ISG20 Entrez, Source	interferon stimulated exonuclease gene 20kDa	3732	0.038	0.4708	No
52	GPM6B	GPM6B Entrez, Source	glycoprotein M6B	4058	0.032	0.4483	No
53	CD69	CD69 Entrez, Source	CD69 molecule	4095	0.031	0.4476	No
54	FHL1	FHL1 Entrez, Source	four and a half LIM domains 1	4269	0.028	0.4364	No
55	DLK1	DLK1 Entrez, Source	delta-like 1 homolog (Drosophila)	4323	0.027	0.4341	No
56	NRXN2	NRXN2 Entrez, Source	neurexin 2	4340	0.026	0.4346	No
57	BPGM	BPGM Entrez, Source	2,3-bisphosphoglycerate mutase	4344	0.026	0.4361	No
58	TRH	TRH Entrez, Source	thyrotropin-releasing hormone	4399	0.025	0.4337	No
59	RPS6KA2	RPS6KA2 Entrez, Source	ribosomal protein S6 kinase, 90kDa, polypeptide 2	4460	0.024	0.4307	No
60	WASF1	WASF1 Entrez, Source	WAS protein family, member 1	4524	0.023	0.4274	No
61	SERPINF1	SERPINF1 Entrez, Source	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	4697	0.020	0.4157	No
62	GATA3	GATA3 Entrez, Source	GATA binding protein 3	5124	0.013	0.3843	No
63	NARFL	NARFL Entrez, Source	nuclear prelamin A recognition factor-like	5169	0.012	0.3818	No
64	LCN2	LCN2 Entrez, Source	lipocalin 2 (oncogene 24p3)	5175	0.012	0.3822	No
65	TGFBI	TGFBI Entrez, Source	transforming growth factor, beta-induced, 68kDa	5439	0.008	0.3628	No
66	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	5497	0.007	0.3590	No
67	TPSAB1	TPSAB1 Entrez, Source	tryptase alpha/beta 1	5716	0.004	0.3428	No
68	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	5728	0.004	0.3422	No
69	SERINC5	SERINC5 Entrez, Source	serine incorporator 5	6205	-0.003	0.3064	No
70	PDE4B	PDE4B Entrez, Source	phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)	6239	-0.004	0.3041	No
71	SH3BP4	SH3BP4 Entrez, Source	SH3-domain binding protein 4	6416	-0.007	0.2913	No
72	PALM	PALM Entrez, Source	paralemmin	6470	-0.007	0.2877	No
73	JUP	JUP Entrez, Source	junction plakoglobin	6593	-0.009	0.2791	No
74	FZD6	FZD6 Entrez, Source	frizzled homolog 6 (Drosophila)	6625	-0.009	0.2773	No
75	MSLN	MSLN Entrez, Source	mesothelin	6641	-0.010	0.2768	No
76	PTPRM	PTPRM Entrez, Source	protein tyrosine phosphatase, receptor type, M	6655	-0.010	0.2765	No
77	PDE3B	PDE3B Entrez, Source	phosphodiesterase 3B, cGMP-inhibited	6687	-0.011	0.2748	No
78	EVL	EVL Entrez, Source	Enah/Vasp-like	6806	-0.012	0.2667	No
79	CHI3L1	CHI3L1 Entrez, Source	chitinase 3-like 1 (cartilage glycoprotein-39)	6833	-0.013	0.2656	No
80	KIT	KIT Entrez, Source	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	6856	-0.013	0.2647	No
81	CIITA	CIITA Entrez, Source	class II, major histocompatibility complex, transactivator	6886	-0.013	0.2634	No
82	MX1	MX1 Entrez, Source	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	7189	-0.018	0.2417	No
83	CD2	CD2 Entrez, Source	CD2 molecule	7323	-0.020	0.2330	No
84	TMEM158	TMEM158 Entrez, Source	transmembrane protein 158	7384	-0.021	0.2298	No
85	NCAM1	NCAM1 Entrez, Source	neural cell adhesion molecule 1	7426	-0.021	0.2281	No
86	CD200	CD200 Entrez, Source	CD200 molecule	7585	-0.024	0.2177	No
87	NT5E	NT5E Entrez, Source	5'-nucleotidase, ecto (CD73)	7715	-0.026	0.2096	No
88	SNCA	SNCA Entrez, Source	synuclein, alpha (non A4 component of amyloid precursor)	7742	-0.026	0.2094	No
89	BZRAP1	BZRAP1 Entrez, Source	benzodiazapine receptor (peripheral) associated protein 1	7874	-0.029	0.2013	No
90	SPON1	SPON1 Entrez, Source	spondin 1, extracellular matrix protein	8114	-0.032	0.1854	No
91	RAP2A	RAP2A Entrez, Source	RAP2A, member of RAS oncogene family	8557	-0.040	0.1545	No
92	FLNB	FLNB Entrez, Source	filamin B, beta (actin binding protein 278)	8583	-0.040	0.1552	No
93	EGFL7	EGFL7 Entrez, Source	EGF-like-domain, multiple 7	8671	-0.041	0.1514	No
94	SCCPDH	SCCPDH Entrez, Source	saccharopine dehydrogenase (putative)	9045	-0.048	0.1263	No
95	AK3L1	AK3L1 Entrez, Source	adenylate kinase 3-like 1	9110	-0.049	0.1246	No
96	PRODH	PRODH Entrez, Source	proline dehydrogenase (oxidase) 1	9179	-0.050	0.1227	No
97	ST18	ST18 Entrez, Source	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	9316	-0.053	0.1159	No
98	ELA2	ELA2 Entrez, Source	elastase 2, neutrophil	9637	-0.058	0.0955	No
99	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	9836	-0.063	0.0846	No
100	HGF	HGF Entrez, Source	hepatocyte growth factor (hepapoietin A; scatter factor)	9857	-0.063	0.0872	No
101	CD38	CD38 Entrez, Source	CD38 molecule	9966	-0.066	0.0833	No
102	MYH11	MYH11 Entrez, Source	myosin, heavy chain 11, smooth muscle	10036	-0.067	0.0825	No
103	HSPB1	HSPB1 Entrez, Source	heat shock 27kDa protein 1	10057	-0.068	0.0854	No
104	POU4F1	POU4F1 Entrez, Source	POU domain, class 4, transcription factor 1	10099	-0.068	0.0867	No
105	ADCY3	ADCY3 Entrez, Source	adenylate cyclase 3	10657	-0.081	0.0499	No
106	BLNK	BLNK Entrez, Source	B-cell linker	10728	-0.083	0.0500	No
107	FGFR1	FGFR1 Entrez, Source	fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)	10976	-0.090	0.0372	No
108	TACSTD2	TACSTD2 Entrez, Source	tumor-associated calcium signal transducer 2	11118	-0.094	0.0327	No
109	VEGF	VEGF Entrez, Source	vascular endothelial growth factor	11386	-0.102	0.0191	No
110	SYNGR1	SYNGR1 Entrez, Source	synaptogyrin 1	11408	-0.103	0.0242	No
111	ITGA6	ITGA6 Entrez, Source	integrin, alpha 6	11513	-0.106	0.0232	No
112	DHRS3	DHRS3 Entrez, Source	dehydrogenase/reductase (SDR family) member 3	11541	-0.107	0.0282	No
113	SNRPN /// SNURF			11623	-0.110	0.0292	No
114	GNAI1	GNAI1 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	11660	-0.111	0.0337	No
115	CD3D	CD3D Entrez, Source	CD3d molecule, delta (CD3-TCR complex)	11751	-0.115	0.0344	No
116	FGF13	FGF13 Entrez, Source	fibroblast growth factor 13	11831	-0.118	0.0361	No
117	VLDLR	VLDLR Entrez, Source	very low density lipoprotein receptor	12037	-0.128	0.0290	No
118	NPR3	NPR3 Entrez, Source	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	12092	-0.131	0.0335	No
119	ROBO1	ROBO1 Entrez, Source	roundabout, axon guidance receptor, homolog 1 (Drosophila)	12116	-0.133	0.0404	No
120	MMP9	MMP9 Entrez, Source	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	12150	-0.134	0.0466	No
121	IFI44	IFI44 Entrez, Source	interferon-induced protein 44	12405	-0.149	0.0371	No
122	C1ORF24	C1ORF24 Entrez, Source	chromosome 1 open reading frame 24	12569	-0.160	0.0351	No
123	ARHGEF12	ARHGEF12 Entrez, Source	Rho guanine nucleotide exchange factor (GEF) 12	12615	-0.164	0.0425	No
124	H1F0	H1F0 Entrez, Source	H1 histone family, member 0	12841	-0.191	0.0379	No