Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | VERHAAK_AML_NPM1_MUT_VS_WT_UP |
| Enrichment Score (ES) | 0.5028864 |
| Normalized Enrichment Score (NES) | 1.8323312 |
| Nominal p-value | 0.0016051364 |
| FDR q-value | 0.021155728 |
| FWER p-Value | 0.894 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CCL20 | CCL20 Entrez, Source | chemokine (C-C motif) ligand 20 | 50 | 0.641 | 0.0450 | Yes |
| 2 | VNN1 | VNN1 Entrez, Source | vanin 1 | 97 | 0.522 | 0.0813 | Yes |
| 3 | LGALS2 | LGALS2 Entrez, Source | lectin, galactoside-binding, soluble, 2 (galectin 2) | 132 | 0.466 | 0.1142 | Yes |
| 4 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 138 | 0.458 | 0.1487 | Yes |
| 5 | PRKAR2B | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 160 | 0.434 | 0.1802 | Yes |
| 6 | BCL2A1 | BCL2A1 Entrez, Source | BCL2-related protein A1 | 177 | 0.408 | 0.2100 | Yes |
| 7 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 222 | 0.366 | 0.2346 | Yes |
| 8 | SCHIP1 | SCHIP1 Entrez, Source | schwannomin interacting protein 1 | 231 | 0.364 | 0.2617 | Yes |
| 9 | DEFB1 | DEFB1 Entrez, Source | defensin, beta 1 | 234 | 0.360 | 0.2889 | Yes |
| 10 | GGT1 | GGT1 Entrez, Source | gamma-glutamyltransferase 1 | 276 | 0.323 | 0.3104 | Yes |
| 11 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 288 | 0.316 | 0.3337 | Yes |
| 12 | S100A6 | S100A6 Entrez, Source | S100 calcium binding protein A6 | 365 | 0.274 | 0.3488 | Yes |
| 13 | GDF15 | GDF15 Entrez, Source | growth differentiation factor 15 | 385 | 0.267 | 0.3676 | Yes |
| 14 | FGR | FGR Entrez, Source | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 390 | 0.264 | 0.3875 | Yes |
| 15 | IER3 | IER3 Entrez, Source | immediate early response 3 | 392 | 0.264 | 0.4074 | Yes |
| 16 | TMEM176B | TMEM176B Entrez, Source | transmembrane protein 176B | 403 | 0.258 | 0.4264 | Yes |
| 17 | PF4 | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 506 | 0.226 | 0.4358 | Yes |
| 18 | LTBP1 | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 525 | 0.222 | 0.4514 | Yes |
| 19 | CCR1 | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 564 | 0.213 | 0.4647 | Yes |
| 20 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 720 | 0.182 | 0.4669 | Yes |
| 21 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 754 | 0.176 | 0.4778 | Yes |
| 22 | CAST | CAST Entrez, Source | calpastatin | 1090 | 0.137 | 0.4630 | Yes |
| 23 | BASP1 | BASP1 Entrez, Source | brain abundant, membrane attached signal protein 1 | 1105 | 0.136 | 0.4722 | Yes |
| 24 | LGALS3BP | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 1132 | 0.134 | 0.4805 | Yes |
| 25 | IL1B | IL1B Entrez, Source | interleukin 1, beta | 1197 | 0.128 | 0.4854 | Yes |
| 26 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 1220 | 0.126 | 0.4933 | Yes |
| 27 | PHLDA1 | PHLDA1 Entrez, Source | pleckstrin homology-like domain, family A, member 1 | 1221 | 0.126 | 0.5029 | Yes |
| 28 | NGFRAP1 | NGFRAP1 Entrez, Source | nerve growth factor receptor (TNFRSF16) associated protein 1 | 1421 | 0.112 | 0.4964 | No |
| 29 | PELI1 | PELI1 Entrez, Source | pellino homolog 1 (Drosophila) | 1568 | 0.104 | 0.4933 | No |
| 30 | SLC16A3 | SLC16A3 Entrez, Source | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) | 1690 | 0.098 | 0.4916 | No |
| 31 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 1839 | 0.091 | 0.4874 | No |
| 32 | GNS | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 1850 | 0.091 | 0.4935 | No |
| 33 | SMPDL3A | SMPDL3A Entrez, Source | sphingomyelin phosphodiesterase, acid-like 3A | 1863 | 0.090 | 0.4994 | No |
| 34 | SCPEP1 | SCPEP1 Entrez, Source | serine carboxypeptidase 1 | 2022 | 0.084 | 0.4939 | No |
| 35 | TBXAS1 | TBXAS1 Entrez, Source | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) | 2191 | 0.078 | 0.4871 | No |
| 36 | TLR4 | TLR4 Entrez, Source | toll-like receptor 4 | 2287 | 0.074 | 0.4856 | No |
| 37 | SORT1 | SORT1 Entrez, Source | sortilin 1 | 2329 | 0.073 | 0.4881 | No |
| 38 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 2355 | 0.072 | 0.4917 | No |
| 39 | CAMK1 | CAMK1 Entrez, Source | calcium/calmodulin-dependent protein kinase I | 2617 | 0.064 | 0.4769 | No |
| 40 | C3AR1 | C3AR1 Entrez, Source | complement component 3a receptor 1 | 2746 | 0.061 | 0.4719 | No |
| 41 | TRIB1 | TRIB1 Entrez, Source | tribbles homolog 1 (Drosophila) | 2792 | 0.060 | 0.4731 | No |
| 42 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 2983 | 0.055 | 0.4629 | No |
| 43 | EREG | EREG Entrez, Source | epiregulin | 3011 | 0.054 | 0.4650 | No |
| 44 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 3017 | 0.054 | 0.4687 | No |
| 45 | HNMT | HNMT Entrez, Source | histamine N-methyltransferase | 3098 | 0.052 | 0.4666 | No |
| 46 | MAFB | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 3122 | 0.051 | 0.4688 | No |
| 47 | PDGFD | PDGFD Entrez, Source | platelet derived growth factor D | 3442 | 0.044 | 0.4480 | No |
| 48 | SEPP1 | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 3625 | 0.040 | 0.4373 | No |
| 49 | RHAG | RHAG Entrez, Source | Rh-associated glycoprotein | 3718 | 0.038 | 0.4333 | No |
| 50 | CLU | CLU Entrez, Source | clusterin | 3739 | 0.038 | 0.4347 | No |
| 51 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 3824 | 0.036 | 0.4311 | No |
| 52 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 3854 | 0.036 | 0.4316 | No |
| 53 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 4301 | 0.027 | 0.4000 | No |
| 54 | CARD9 | CARD9 Entrez, Source | caspase recruitment domain family, member 9 | 4448 | 0.024 | 0.3908 | No |
| 55 | PLA2G4A | PLA2G4A Entrez, Source | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 4688 | 0.020 | 0.3743 | No |
| 56 | FGL2 | FGL2 Entrez, Source | fibrinogen-like 2 | 5086 | 0.014 | 0.3454 | No |
| 57 | CTSL | CTSL Entrez, Source | cathepsin L | 5451 | 0.008 | 0.3185 | No |
| 58 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 5691 | 0.004 | 0.3008 | No |
| 59 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 5780 | 0.003 | 0.2943 | No |
| 60 | HOXA4 | HOXA4 Entrez, Source | homeobox A4 | 5806 | 0.003 | 0.2926 | No |
| 61 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 5914 | 0.001 | 0.2847 | No |
| 62 | CD86 | CD86 Entrez, Source | CD86 molecule | 6302 | -0.005 | 0.2558 | No |
| 63 | CAT | CAT Entrez, Source | catalase | 6311 | -0.005 | 0.2556 | No |
| 64 | LMNA | LMNA Entrez, Source | lamin A/C | 6342 | -0.005 | 0.2537 | No |
| 65 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 6493 | -0.008 | 0.2429 | No |
| 66 | CCL4 | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 6591 | -0.009 | 0.2363 | No |
| 67 | HIP1 | HIP1 Entrez, Source | huntingtin interacting protein 1 | 7039 | -0.016 | 0.2037 | No |
| 68 | QPRT | QPRT Entrez, Source | quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) | 7045 | -0.016 | 0.2045 | No |
| 69 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 7208 | -0.018 | 0.1937 | No |
| 70 | PPBP | PPBP Entrez, Source | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 7274 | -0.019 | 0.1903 | No |
| 71 | ADCY2 | ADCY2 Entrez, Source | adenylate cyclase 2 (brain) | 7570 | -0.024 | 0.1698 | No |
| 72 | DPEP2 | DPEP2 Entrez, Source | dipeptidase 2 | 7712 | -0.026 | 0.1611 | No |
| 73 | SERPINB2 | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 7731 | -0.026 | 0.1618 | No |
| 74 | C2 | C2 Entrez, Source | complement component 2 | 7795 | -0.027 | 0.1591 | No |
| 75 | CX3CR1 | CX3CR1 Entrez, Source | chemokine (C-X3-C motif) receptor 1 | 7909 | -0.029 | 0.1528 | No |
| 76 | CYP1B1 | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 7989 | -0.031 | 0.1491 | No |
| 77 | PLEK | PLEK Entrez, Source | pleckstrin | 7997 | -0.031 | 0.1510 | No |
| 78 | LAPTM4B | LAPTM4B Entrez, Source | lysosomal associated protein transmembrane 4 beta | 8069 | -0.032 | 0.1480 | No |
| 79 | PTAFR | PTAFR Entrez, Source | platelet-activating factor receptor | 8264 | -0.035 | 0.1360 | No |
| 80 | TCIRG1 | TCIRG1 Entrez, Source | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 8560 | -0.040 | 0.1168 | No |
| 81 | CD14 | CD14 Entrez, Source | CD14 molecule | 8706 | -0.042 | 0.1091 | No |
| 82 | EMR1 | EMR1 Entrez, Source | egf-like module containing, mucin-like, hormone receptor-like 1 | 8911 | -0.046 | 0.0971 | No |
| 83 | MARCKS | MARCKS Entrez, Source | myristoylated alanine-rich protein kinase C substrate | 8955 | -0.047 | 0.0974 | No |
| 84 | SNX10 | SNX10 Entrez, Source | sorting nexin 10 | 9028 | -0.048 | 0.0956 | No |
| 85 | MVP | MVP Entrez, Source | major vault protein | 9188 | -0.050 | 0.0874 | No |
| 86 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 9267 | -0.052 | 0.0855 | No |
| 87 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 9690 | -0.060 | 0.0582 | No |
| 88 | SECTM1 | SECTM1 Entrez, Source | secreted and transmembrane 1 | 9756 | -0.061 | 0.0579 | No |
| 89 | HCK | HCK Entrez, Source | hemopoietic cell kinase | 9848 | -0.063 | 0.0558 | No |
| 90 | KCNJ2 | KCNJ2 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 2 | 9974 | -0.066 | 0.0514 | No |
| 91 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 10174 | -0.070 | 0.0417 | No |
| 92 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 10182 | -0.070 | 0.0465 | No |
| 93 | RUNX1 | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 11329 | -0.100 | -0.0325 | No |
| 94 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 11445 | -0.104 | -0.0333 | No |
| 95 | NINJ1 | NINJ1 Entrez, Source | ninjurin 1 | 11455 | -0.104 | -0.0260 | No |
| 96 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 11710 | -0.114 | -0.0366 | No |
| 97 | SLC15A3 | SLC15A3 Entrez, Source | solute carrier family 15, member 3 | 11905 | -0.122 | -0.0419 | No |
| 98 | HOXA5 | HOXA5 Entrez, Source | homeobox A5 | 12360 | -0.146 | -0.0651 | No |
| 99 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 12364 | -0.147 | -0.0542 | No |
| 100 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 12523 | -0.156 | -0.0542 | No |
| 101 | AQP9 | AQP9 Entrez, Source | aquaporin 9 | 12727 | -0.176 | -0.0561 | No |
| 102 | HMOX1 | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 12788 | -0.183 | -0.0468 | No |
| 103 | G0S2 | G0S2 Entrez, Source | G0/G1switch 2 | 13137 | -0.265 | -0.0529 | No |
| 104 | ABCC4 | ABCC4 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 13299 | -0.446 | -0.0311 | No |
| 105 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 13301 | -0.450 | 0.0031 | No |
