Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | AGEING_KIDNEY_SPECIFIC_UP |
| Enrichment Score (ES) | 0.5518031 |
| Normalized Enrichment Score (NES) | 2.0148933 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0047804704 |
| FWER p-Value | 0.169 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 3 | 1.046 | 0.0764 | Yes |
| 2 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 10 | 0.815 | 0.1357 | Yes |
| 3 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 15 | 0.737 | 0.1895 | Yes |
| 4 | BHLHB3 | BHLHB3 Entrez, Source | basic helix-loop-helix domain containing, class B, 3 | 23 | 0.682 | 0.2389 | Yes |
| 5 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 76 | 0.477 | 0.2699 | Yes |
| 6 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 104 | 0.424 | 0.2989 | Yes |
| 7 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 118 | 0.402 | 0.3274 | Yes |
| 8 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 140 | 0.372 | 0.3531 | Yes |
| 9 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 157 | 0.357 | 0.3781 | Yes |
| 10 | PKIB | PKIB Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 237 | 0.292 | 0.3935 | Yes |
| 11 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 414 | 0.206 | 0.3953 | Yes |
| 12 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 436 | 0.199 | 0.4083 | Yes |
| 13 | PROM1 | PROM1 Entrez, Source | prominin 1 | 448 | 0.196 | 0.4218 | Yes |
| 14 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 454 | 0.195 | 0.4357 | Yes |
| 15 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 483 | 0.185 | 0.4472 | Yes |
| 16 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 496 | 0.183 | 0.4597 | Yes |
| 17 | TPBG | TPBG Entrez, Source | trophoblast glycoprotein | 503 | 0.182 | 0.4725 | Yes |
| 18 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 504 | 0.181 | 0.4858 | Yes |
| 19 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 521 | 0.179 | 0.4977 | Yes |
| 20 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 618 | 0.162 | 0.5024 | Yes |
| 21 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 641 | 0.159 | 0.5123 | Yes |
| 22 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 696 | 0.150 | 0.5193 | Yes |
| 23 | VTCN1 | VTCN1 Entrez, Source | V-set domain containing T cell activation inhibitor 1 | 736 | 0.146 | 0.5270 | Yes |
| 24 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 738 | 0.146 | 0.5376 | Yes |
| 25 | WFDC2 | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 750 | 0.144 | 0.5474 | Yes |
| 26 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 825 | 0.137 | 0.5518 | Yes |
| 27 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 1137 | 0.113 | 0.5366 | No |
| 28 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 1169 | 0.111 | 0.5424 | No |
| 29 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 1234 | 0.108 | 0.5454 | No |
| 30 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 1389 | 0.099 | 0.5411 | No |
| 31 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 1404 | 0.098 | 0.5472 | No |
| 32 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 1496 | 0.094 | 0.5472 | No |
| 33 | MOXD1 | MOXD1 Entrez, Source | monooxygenase, DBH-like 1 | 1664 | 0.086 | 0.5409 | No |
| 34 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 1730 | 0.083 | 0.5421 | No |
| 35 | FEZ2 | FEZ2 Entrez, Source | fasciculation and elongation protein zeta 2 (zygin II) | 1737 | 0.083 | 0.5478 | No |
| 36 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 1825 | 0.079 | 0.5470 | No |
| 37 | SPARCL1 | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 1992 | 0.073 | 0.5398 | No |
| 38 | VSNL1 | VSNL1 Entrez, Source | visinin-like 1 | 2169 | 0.068 | 0.5315 | No |
| 39 | SMPD2 | SMPD2 Entrez, Source | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 2179 | 0.068 | 0.5358 | No |
| 40 | CTHRC1 | CTHRC1 Entrez, Source | collagen triple helix repeat containing 1 | 2341 | 0.063 | 0.5283 | No |
| 41 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 2463 | 0.061 | 0.5236 | No |
| 42 | FN1 | FN1 Entrez, Source | fibronectin 1 | 2637 | 0.057 | 0.5147 | No |
| 43 | DPP3 | DPP3 Entrez, Source | dipeptidyl-peptidase 3 | 2741 | 0.054 | 0.5108 | No |
| 44 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 2774 | 0.053 | 0.5123 | No |
| 45 | NFIX | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 2946 | 0.050 | 0.5031 | No |
| 46 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 2961 | 0.050 | 0.5056 | No |
| 47 | AMBP | AMBP Entrez, Source | alpha-1-microglobulin/bikunin precursor | 3026 | 0.048 | 0.5043 | No |
| 48 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 3082 | 0.047 | 0.5036 | No |
| 49 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 3256 | 0.044 | 0.4937 | No |
| 50 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 3304 | 0.042 | 0.4933 | No |
| 51 | HEXB | HEXB Entrez, Source | hexosaminidase B (beta polypeptide) | 3502 | 0.039 | 0.4812 | No |
| 52 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 3584 | 0.037 | 0.4778 | No |
| 53 | EBF1 | EBF1 Entrez, Source | early B-cell factor 1 | 3728 | 0.035 | 0.4695 | No |
| 54 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 3779 | 0.034 | 0.4682 | No |
| 55 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 3828 | 0.033 | 0.4670 | No |
| 56 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 4234 | 0.026 | 0.4384 | No |
| 57 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 4344 | 0.025 | 0.4319 | No |
| 58 | PRICKLE1 | PRICKLE1 Entrez, Source | prickle homolog 1 (Drosophila) | 4383 | 0.024 | 0.4308 | No |
| 59 | RAB34 | RAB34 Entrez, Source | RAB34, member RAS oncogene family | 4497 | 0.022 | 0.4239 | No |
| 60 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 4547 | 0.022 | 0.4218 | No |
| 61 | LUM | LUM Entrez, Source | lumican | 4728 | 0.019 | 0.4096 | No |
| 62 | SLC1A3 | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 5237 | 0.012 | 0.3721 | No |
| 63 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 5260 | 0.012 | 0.3713 | No |
| 64 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 5266 | 0.012 | 0.3718 | No |
| 65 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 5328 | 0.011 | 0.3680 | No |
| 66 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 5501 | 0.008 | 0.3556 | No |
| 67 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 5649 | 0.006 | 0.3449 | No |
| 68 | PLOD3 | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 5657 | 0.006 | 0.3448 | No |
| 69 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 5771 | 0.005 | 0.3367 | No |
| 70 | TMED3 | TMED3 Entrez, Source | transmembrane emp24 protein transport domain containing 3 | 5797 | 0.005 | 0.3351 | No |
| 71 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 5926 | 0.003 | 0.3257 | No |
| 72 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 6016 | 0.002 | 0.3191 | No |
| 73 | UBD | UBD Entrez, Source | ubiquitin D | 6622 | -0.006 | 0.2738 | No |
| 74 | CXCL14 | CXCL14 Entrez, Source | chemokine (C-X-C motif) ligand 14 | 6682 | -0.007 | 0.2698 | No |
| 75 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 6969 | -0.010 | 0.2490 | No |
| 76 | SYMPK | SYMPK Entrez, Source | symplekin | 7266 | -0.014 | 0.2276 | No |
| 77 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 7540 | -0.017 | 0.2083 | No |
| 78 | TSPAN1 | TSPAN1 Entrez, Source | tetraspanin 1 | 8574 | -0.032 | 0.1325 | No |
| 79 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 8582 | -0.032 | 0.1344 | No |
| 80 | C3 | C3 Entrez, Source | complement component 3 | 8749 | -0.034 | 0.1243 | No |
| 81 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 8753 | -0.034 | 0.1266 | No |
| 82 | RPN2 | RPN2 Entrez, Source | ribophorin II | 8906 | -0.036 | 0.1178 | No |
| 83 | UBE2Z | UBE2Z Entrez, Source | ubiquitin-conjugating enzyme E2Z (putative) | 9025 | -0.038 | 0.1116 | No |
| 84 | ABCC3 | ABCC3 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 9557 | -0.046 | 0.0749 | No |
| 85 | GGA2 | GGA2 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 9841 | -0.051 | 0.0572 | No |
| 86 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 10107 | -0.055 | 0.0412 | No |
| 87 | RPN1 | RPN1 Entrez, Source | ribophorin I | 10178 | -0.056 | 0.0401 | No |
| 88 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 10486 | -0.062 | 0.0214 | No |
| 89 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 10713 | -0.066 | 0.0092 | No |
| 90 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 10939 | -0.072 | -0.0026 | No |
| 91 | ASNS | ASNS Entrez, Source | asparagine synthetase | 11024 | -0.074 | -0.0035 | No |
| 92 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 11183 | -0.078 | -0.0097 | No |
| 93 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 11249 | -0.080 | -0.0088 | No |
| 94 | RPL35A | RPL35A Entrez, Source | ribosomal protein L35a | 11255 | -0.080 | -0.0033 | No |
| 95 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 11312 | -0.082 | -0.0015 | No |
| 96 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 11396 | -0.084 | -0.0017 | No |
| 97 | CFB | CFB Entrez, Source | complement factor B | 11731 | -0.093 | -0.0201 | No |
| 98 | RPL35 | RPL35 Entrez, Source | ribosomal protein L35 | 11865 | -0.098 | -0.0229 | No |
| 99 | SSR4 | SSR4 Entrez, Source | signal sequence receptor, delta (translocon-associated protein delta) | 12062 | -0.106 | -0.0300 | No |
| 100 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 12282 | -0.115 | -0.0381 | No |
| 101 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 12406 | -0.122 | -0.0385 | No |
| 102 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 12443 | -0.123 | -0.0322 | No |
| 103 | RPS25 | RPS25 Entrez, Source | ribosomal protein S25 | 12514 | -0.129 | -0.0280 | No |
| 104 | PHLDA3 | PHLDA3 Entrez, Source | pleckstrin homology-like domain, family A, member 3 | 12536 | -0.130 | -0.0200 | No |
| 105 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 12594 | -0.134 | -0.0145 | No |
| 106 | RBP1 | RBP1 Entrez, Source | retinol binding protein 1, cellular | 12674 | -0.139 | -0.0103 | No |
| 107 | COL27A1 | COL27A1 Entrez, Source | collagen, type XXVII, alpha 1 | 12813 | -0.154 | -0.0094 | No |
| 108 | CRELD2 | CRELD2 Entrez, Source | cysteine-rich with EGF-like domains 2 | 12917 | -0.167 | -0.0050 | No |
| 109 | VCAM1 | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 13085 | -0.205 | -0.0025 | No |
| 110 | RARRES1 | RARRES1 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 1 | 13250 | -0.299 | 0.0070 | No |
