Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | BRCA_BRCA1_NEG |
| Enrichment Score (ES) | 0.5306053 |
| Normalized Enrichment Score (NES) | 1.8858095 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.018200826 |
| FWER p-Value | 0.71 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 5 | 0.972 | 0.1022 | Yes |
| 2 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 15 | 0.737 | 0.1793 | Yes |
| 3 | HMGCS2 | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 66 | 0.519 | 0.2303 | Yes |
| 4 | BEXL1 | BEXL1 Entrez, Source | brain expressed X-linked-like 1 | 105 | 0.423 | 0.2721 | Yes |
| 5 | DCI | DCI Entrez, Source | dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase) | 164 | 0.350 | 0.3046 | Yes |
| 6 | AHNAK | AHNAK Entrez, Source | AHNAK nucleoprotein (desmoyokin) | 165 | 0.350 | 0.3415 | Yes |
| 7 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 196 | 0.324 | 0.3734 | Yes |
| 8 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 200 | 0.321 | 0.4071 | Yes |
| 9 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 234 | 0.297 | 0.4359 | Yes |
| 10 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 414 | 0.206 | 0.4442 | Yes |
| 11 | CPE | CPE Entrez, Source | carboxypeptidase E | 589 | 0.167 | 0.4486 | Yes |
| 12 | RETSAT | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 639 | 0.159 | 0.4616 | Yes |
| 13 | TSPAN8 | TSPAN8 Entrez, Source | tetraspanin 8 | 659 | 0.156 | 0.4767 | Yes |
| 14 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 825 | 0.137 | 0.4787 | Yes |
| 15 | STK39 | STK39 Entrez, Source | serine threonine kinase 39 (STE20/SPS1 homolog, yeast) | 864 | 0.133 | 0.4898 | Yes |
| 16 | EMP2 | EMP2 Entrez, Source | epithelial membrane protein 2 | 874 | 0.132 | 0.5030 | Yes |
| 17 | GPC1 | GPC1 Entrez, Source | glypican 1 | 929 | 0.127 | 0.5123 | Yes |
| 18 | PALMD | PALMD Entrez, Source | palmdelphin | 958 | 0.125 | 0.5234 | Yes |
| 19 | ENC1 | ENC1 Entrez, Source | ectodermal-neural cortex (with BTB-like domain) | 1029 | 0.119 | 0.5306 | Yes |
| 20 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 1389 | 0.099 | 0.5140 | No |
| 21 | CTSF | CTSF Entrez, Source | cathepsin F | 1408 | 0.098 | 0.5230 | No |
| 22 | ACOX2 | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 1711 | 0.084 | 0.5090 | No |
| 23 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 1781 | 0.081 | 0.5124 | No |
| 24 | BMPR2 | BMPR2 Entrez, Source | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 1820 | 0.080 | 0.5179 | No |
| 25 | DUSP4 | DUSP4 Entrez, Source | dual specificity phosphatase 4 | 2162 | 0.068 | 0.4994 | No |
| 26 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 2463 | 0.061 | 0.4832 | No |
| 27 | HDGFRP3 | HDGFRP3 Entrez, Source | - | 2508 | 0.059 | 0.4861 | No |
| 28 | GREM1 | GREM1 Entrez, Source | gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) | 2542 | 0.059 | 0.4898 | No |
| 29 | GPC4 | GPC4 Entrez, Source | glypican 4 | 2553 | 0.058 | 0.4952 | No |
| 30 | STXBP1 | STXBP1 Entrez, Source | syntaxin binding protein 1 | 2596 | 0.058 | 0.4981 | No |
| 31 | CXCR7 | CXCR7 Entrez, Source | chemokine (C-X-C motif) receptor 7 | 2822 | 0.052 | 0.4867 | No |
| 32 | NPTN | NPTN Entrez, Source | neuroplastin | 2925 | 0.050 | 0.4843 | No |
| 33 | PPT1 | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 2945 | 0.050 | 0.4881 | No |
| 34 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 2961 | 0.050 | 0.4922 | No |
| 35 | GALNT7 | GALNT7 Entrez, Source | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) | 2975 | 0.049 | 0.4964 | No |
| 36 | SLC9A2 | SLC9A2 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | 3277 | 0.043 | 0.4782 | No |
| 37 | PIB5PA | PIB5PA Entrez, Source | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A | 3373 | 0.041 | 0.4754 | No |
| 38 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 3714 | 0.035 | 0.4534 | No |
| 39 | HTRA1 | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 3790 | 0.034 | 0.4513 | No |
| 40 | NEO1 | NEO1 Entrez, Source | neogenin homolog 1 (chicken) | 3835 | 0.033 | 0.4514 | No |
| 41 | GLI3 | GLI3 Entrez, Source | GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) | 4066 | 0.029 | 0.4371 | No |
| 42 | PARVA | PARVA Entrez, Source | parvin, alpha | 4099 | 0.029 | 0.4378 | No |
| 43 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 4238 | 0.026 | 0.4301 | No |
| 44 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 4288 | 0.026 | 0.4291 | No |
| 45 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 4347 | 0.025 | 0.4274 | No |
| 46 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 4365 | 0.024 | 0.4286 | No |
| 47 | GOSR1 | GOSR1 Entrez, Source | golgi SNAP receptor complex member 1 | 4674 | 0.020 | 0.4075 | No |
| 48 | TMEM98 | TMEM98 Entrez, Source | transmembrane protein 98 | 4762 | 0.019 | 0.4029 | No |
| 49 | DNALI1 | DNALI1 Entrez, Source | dynein, axonemal, light intermediate chain 1 | 4808 | 0.018 | 0.4014 | No |
| 50 | PDE8B | PDE8B Entrez, Source | phosphodiesterase 8B | 5096 | 0.014 | 0.3813 | No |
| 51 | PNMT | PNMT Entrez, Source | phenylethanolamine N-methyltransferase | 5308 | 0.011 | 0.3665 | No |
| 52 | INPP4B | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5469 | 0.009 | 0.3553 | No |
| 53 | COL23A1 | COL23A1 Entrez, Source | collagen, type XXIII, alpha 1 | 5870 | 0.004 | 0.3256 | No |
| 54 | GPRC5C | GPRC5C Entrez, Source | G protein-coupled receptor, family C, group 5, member C | 5932 | 0.003 | 0.3213 | No |
| 55 | STARD10 | STARD10 Entrez, Source | START domain containing 10 | 6223 | -0.001 | 0.2995 | No |
| 56 | LASP1 | LASP1 Entrez, Source | LIM and SH3 protein 1 | 6500 | -0.004 | 0.2791 | No |
| 57 | PDLIM3 | PDLIM3 Entrez, Source | PDZ and LIM domain 3 | 6654 | -0.006 | 0.2682 | No |
| 58 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 6748 | -0.008 | 0.2620 | No |
| 59 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 6786 | -0.008 | 0.2601 | No |
| 60 | DNAJA4 | DNAJA4 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 4 | 7044 | -0.011 | 0.2419 | No |
| 61 | TXNDC13 | TXNDC13 Entrez, Source | thioredoxin domain containing 13 | 7101 | -0.012 | 0.2389 | No |
| 62 | CLEC11A | CLEC11A Entrez, Source | C-type lectin domain family 11, member A | 7198 | -0.013 | 0.2330 | No |
| 63 | CAMK2N1 | CAMK2N1 Entrez, Source | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 7381 | -0.015 | 0.2209 | No |
| 64 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 7678 | -0.019 | 0.2006 | No |
| 65 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 7809 | -0.021 | 0.1930 | No |
| 66 | SCAMP1 | SCAMP1 Entrez, Source | secretory carrier membrane protein 1 | 8093 | -0.025 | 0.1742 | No |
| 67 | ETFB | ETFB Entrez, Source | electron-transfer-flavoprotein, beta polypeptide | 8173 | -0.026 | 0.1710 | No |
| 68 | HEY1 | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 8303 | -0.028 | 0.1642 | No |
| 69 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 8396 | -0.029 | 0.1604 | No |
| 70 | UNC119 | UNC119 Entrez, Source | unc-119 homolog (C. elegans) | 8442 | -0.030 | 0.1601 | No |
| 71 | TEGT | TEGT Entrez, Source | testis enhanced gene transcript (BAX inhibitor 1) | 8519 | -0.031 | 0.1577 | No |
| 72 | DUSP13 | DUSP13 Entrez, Source | dual specificity phosphatase 13 | 8615 | -0.032 | 0.1539 | No |
| 73 | PLA2G10 | PLA2G10 Entrez, Source | phospholipase A2, group X | 8751 | -0.034 | 0.1474 | No |
| 74 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 8926 | -0.036 | 0.1381 | No |
| 75 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 9220 | -0.040 | 0.1202 | No |
| 76 | FMOD | FMOD Entrez, Source | fibromodulin | 9724 | -0.049 | 0.0874 | No |
| 77 | SPAG5 | SPAG5 Entrez, Source | sperm associated antigen 5 | 9793 | -0.050 | 0.0876 | No |
| 78 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 9919 | -0.052 | 0.0837 | No |
| 79 | BRD8 | BRD8 Entrez, Source | bromodomain containing 8 | 10036 | -0.054 | 0.0806 | No |
| 80 | PRKD1 | PRKD1 Entrez, Source | protein kinase D1 | 10693 | -0.066 | 0.0381 | No |
| 81 | CHGA | CHGA Entrez, Source | chromogranin A (parathyroid secretory protein 1) | 10811 | -0.069 | 0.0365 | No |
| 82 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 11121 | -0.076 | 0.0212 | No |
| 83 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 11183 | -0.078 | 0.0248 | No |
| 84 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 11283 | -0.081 | 0.0259 | No |
| 85 | TAOK1 | TAOK1 Entrez, Source | TAO kinase 1 | 11520 | -0.087 | 0.0173 | No |
| 86 | CRYM | CRYM Entrez, Source | crystallin, mu | 11562 | -0.088 | 0.0235 | No |
| 87 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 11589 | -0.089 | 0.0309 | No |
| 88 | SYNJ2BP | SYNJ2BP Entrez, Source | synaptojanin 2 binding protein | 11599 | -0.089 | 0.0396 | No |
| 89 | SORD | SORD Entrez, Source | sorbitol dehydrogenase | 11977 | -0.102 | 0.0219 | No |
| 90 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 12591 | -0.134 | -0.0102 | No |
| 91 | CA2 | CA2 Entrez, Source | carbonic anhydrase II | 13081 | -0.204 | -0.0256 | No |
| 92 | TSPYL4 | TSPYL4 Entrez, Source | TSPY-like 4 | 13090 | -0.207 | -0.0044 | No |
| 93 | MPDZ | MPDZ Entrez, Source | multiple PDZ domain protein | 13135 | -0.221 | 0.0156 | No |
