Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | CHOLESTEROL_BIOSYNTHESIS |
| Enrichment Score (ES) | -0.62076205 |
| Normalized Enrichment Score (NES) | -1.5954862 |
| Nominal p-value | 0.03966597 |
| FDR q-value | 0.22141062 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 5077 | 0.014 | -0.3684 | No |
| 2 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 8441 | -0.030 | -0.5945 | Yes |
| 3 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 8632 | -0.033 | -0.5802 | Yes |
| 4 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 9103 | -0.039 | -0.5814 | Yes |
| 5 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 9455 | -0.044 | -0.5690 | Yes |
| 6 | SQLE | SQLE Entrez, Source | squalene epoxidase | 9644 | -0.048 | -0.5414 | Yes |
| 7 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 9919 | -0.052 | -0.5162 | Yes |
| 8 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 11182 | -0.078 | -0.5428 | Yes |
| 9 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 11576 | -0.088 | -0.4949 | Yes |
| 10 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 11716 | -0.093 | -0.4244 | Yes |
| 11 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 11844 | -0.097 | -0.3486 | Yes |
| 12 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 12159 | -0.110 | -0.2760 | Yes |
| 13 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 12335 | -0.118 | -0.1860 | Yes |
| 14 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 12678 | -0.140 | -0.0894 | Yes |
| 15 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 12854 | -0.159 | 0.0366 | Yes |
