Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | CORDERO_KRAS_KD_VS_CONTROL_UP |
| Enrichment Score (ES) | 0.7880159 |
| Normalized Enrichment Score (NES) | 2.4854279 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 5 | 0.972 | 0.1131 | Yes |
| 2 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 12 | 0.803 | 0.2065 | Yes |
| 3 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 27 | 0.668 | 0.2835 | Yes |
| 4 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 50 | 0.578 | 0.3493 | Yes |
| 5 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 76 | 0.477 | 0.4032 | Yes |
| 6 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 104 | 0.424 | 0.4506 | Yes |
| 7 | WASPIP | WASPIP Entrez, Source | Wiskott-Aldrich syndrome protein interacting protein | 203 | 0.319 | 0.4805 | Yes |
| 8 | SLC22A5 | SLC22A5 Entrez, Source | solute carrier family 22 (organic cation transporter), member 5 | 204 | 0.319 | 0.5178 | Yes |
| 9 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 234 | 0.297 | 0.5503 | Yes |
| 10 | TAGLN | TAGLN Entrez, Source | transgelin | 253 | 0.280 | 0.5816 | Yes |
| 11 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 258 | 0.276 | 0.6136 | Yes |
| 12 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 330 | 0.237 | 0.6359 | Yes |
| 13 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 367 | 0.223 | 0.6593 | Yes |
| 14 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 406 | 0.208 | 0.6807 | Yes |
| 15 | JUN | JUN Entrez, Source | jun oncogene | 458 | 0.194 | 0.6995 | Yes |
| 16 | IGSF4 | IGSF4 Entrez, Source | immunoglobulin superfamily, member 4 | 517 | 0.180 | 0.7161 | Yes |
| 17 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 567 | 0.170 | 0.7323 | Yes |
| 18 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 738 | 0.146 | 0.7366 | Yes |
| 19 | JUNB | JUNB Entrez, Source | jun B proto-oncogene | 866 | 0.132 | 0.7425 | Yes |
| 20 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 920 | 0.127 | 0.7533 | Yes |
| 21 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1045 | 0.118 | 0.7578 | Yes |
| 22 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 1084 | 0.116 | 0.7684 | Yes |
| 23 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 1130 | 0.113 | 0.7783 | Yes |
| 24 | GLIPR1 | GLIPR1 Entrez, Source | GLI pathogenesis-related 1 (glioma) | 1283 | 0.105 | 0.7791 | Yes |
| 25 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 1404 | 0.098 | 0.7815 | Yes |
| 26 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 1467 | 0.095 | 0.7880 | Yes |
| 27 | DKK3 | DKK3 Entrez, Source | dickkopf homolog 3 (Xenopus laevis) | 1742 | 0.083 | 0.7771 | No |
| 28 | ECE1 | ECE1 Entrez, Source | endothelin converting enzyme 1 | 2048 | 0.071 | 0.7625 | No |
| 29 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 2429 | 0.061 | 0.7411 | No |
| 30 | WISP2 | WISP2 Entrez, Source | WNT1 inducible signaling pathway protein 2 | 2901 | 0.051 | 0.7116 | No |
| 31 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 3006 | 0.048 | 0.7094 | No |
| 32 | CHST3 | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 3649 | 0.036 | 0.6653 | No |
| 33 | ATP2B4 | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 4265 | 0.026 | 0.6221 | No |
| 34 | INPP4B | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5469 | 0.009 | 0.5327 | No |
| 35 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 5892 | 0.004 | 0.5014 | No |
| 36 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 5926 | 0.003 | 0.4992 | No |
| 37 | EVL | EVL Entrez, Source | Enah/Vasp-like | 6399 | -0.003 | 0.4641 | No |
| 38 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 6410 | -0.003 | 0.4637 | No |
| 39 | ADAM19 | ADAM19 Entrez, Source | ADAM metallopeptidase domain 19 (meltrin beta) | 7040 | -0.011 | 0.4177 | No |
| 40 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 7852 | -0.021 | 0.3593 | No |
| 41 | MGEA5 | MGEA5 Entrez, Source | meningioma expressed antigen 5 (hyaluronidase) | 8871 | -0.036 | 0.2869 | No |
| 42 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 11240 | -0.080 | 0.1181 | No |
| 43 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 12282 | -0.115 | 0.0533 | No |
| 44 | DICER1 | DICER1 Entrez, Source | Dicer1, Dcr-1 homolog (Drosophila) | 13152 | -0.225 | 0.0143 | No |
