Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | ELONGINA_KO_UP |
| Enrichment Score (ES) | 0.5243261 |
| Normalized Enrichment Score (NES) | 1.9047626 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.014968867 |
| FWER p-Value | 0.597 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 11 | 0.815 | 0.0741 | Yes |
| 2 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 50 | 0.578 | 0.1244 | Yes |
| 3 | CRYAB | CRYAB Entrez, Source | crystallin, alpha B | 141 | 0.371 | 0.1518 | Yes |
| 4 | CITED2 | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 145 | 0.367 | 0.1853 | Yes |
| 5 | SERPINH1 | SERPINH1 Entrez, Source | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 181 | 0.336 | 0.2135 | Yes |
| 6 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 200 | 0.321 | 0.2416 | Yes |
| 7 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 224 | 0.303 | 0.2677 | Yes |
| 8 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 234 | 0.297 | 0.2944 | Yes |
| 9 | ENPEP | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 338 | 0.234 | 0.3081 | Yes |
| 10 | DDAH1 | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 368 | 0.222 | 0.3263 | Yes |
| 11 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 406 | 0.208 | 0.3426 | Yes |
| 12 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 418 | 0.205 | 0.3606 | Yes |
| 13 | HERPUD1 | HERPUD1 Entrez, Source | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 430 | 0.201 | 0.3783 | Yes |
| 14 | CLIC1 | CLIC1 Entrez, Source | chloride intracellular channel 1 | 463 | 0.192 | 0.3935 | Yes |
| 15 | SGCE | SGCE Entrez, Source | sarcoglycan, epsilon | 484 | 0.185 | 0.4090 | Yes |
| 16 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 559 | 0.171 | 0.4191 | Yes |
| 17 | TAX1BP3 | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 791 | 0.140 | 0.4146 | Yes |
| 18 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 806 | 0.139 | 0.4263 | Yes |
| 19 | EFEMP2 | EFEMP2 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 2 | 824 | 0.137 | 0.4376 | Yes |
| 20 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 825 | 0.137 | 0.4502 | Yes |
| 21 | HS3ST1 | HS3ST1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 830 | 0.136 | 0.4624 | Yes |
| 22 | HSDL1 | HSDL1 Entrez, Source | hydroxysteroid dehydrogenase like 1 | 1053 | 0.117 | 0.4564 | Yes |
| 23 | PLOD1 | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 1057 | 0.117 | 0.4670 | Yes |
| 24 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 1130 | 0.113 | 0.4720 | Yes |
| 25 | NR4A1 | NR4A1 Entrez, Source | nuclear receptor subfamily 4, group A, member 1 | 1192 | 0.110 | 0.4775 | Yes |
| 26 | TYRO3 | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 1250 | 0.107 | 0.4830 | Yes |
| 27 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 1285 | 0.105 | 0.4901 | Yes |
| 28 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 1345 | 0.102 | 0.4950 | Yes |
| 29 | THBD | THBD Entrez, Source | thrombomodulin | 1364 | 0.100 | 0.5028 | Yes |
| 30 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 1496 | 0.094 | 0.5016 | Yes |
| 31 | RAMP2 | RAMP2 Entrez, Source | receptor (calcitonin) activity modifying protein 2 | 1641 | 0.087 | 0.4988 | Yes |
| 32 | SLC38A1 | SLC38A1 Entrez, Source | solute carrier family 38, member 1 | 1690 | 0.085 | 0.5030 | Yes |
| 33 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 1692 | 0.085 | 0.5107 | Yes |
| 34 | FBLN2 | FBLN2 Entrez, Source | fibulin 2 | 1714 | 0.084 | 0.5169 | Yes |
| 35 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 1825 | 0.079 | 0.5159 | Yes |
| 36 | VAMP8 | VAMP8 Entrez, Source | vesicle-associated membrane protein 8 (endobrevin) | 1893 | 0.077 | 0.5179 | Yes |
| 37 | NID2 | NID2 Entrez, Source | nidogen 2 (osteonidogen) | 1925 | 0.075 | 0.5225 | Yes |
| 38 | LGMN | LGMN Entrez, Source | legumain | 2054 | 0.071 | 0.5193 | Yes |
| 39 | P4HA1 | P4HA1 Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | 2075 | 0.071 | 0.5243 | Yes |
| 40 | FUT8 | FUT8 Entrez, Source | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 2270 | 0.065 | 0.5157 | No |
| 41 | TTR | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 2525 | 0.059 | 0.5019 | No |
| 42 | CYBASC3 | CYBASC3 Entrez, Source | cytochrome b, ascorbate dependent 3 | 2626 | 0.057 | 0.4996 | No |
| 43 | PSAP | PSAP Entrez, Source | prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) | 3033 | 0.048 | 0.4733 | No |
| 44 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 3298 | 0.043 | 0.4573 | No |
| 45 | CLU | CLU Entrez, Source | clusterin | 3299 | 0.043 | 0.4612 | No |
| 46 | PTHR1 | PTHR1 Entrez, Source | parathyroid hormone receptor 1 | 3437 | 0.040 | 0.4545 | No |
| 47 | MESDC1 | MESDC1 Entrez, Source | mesoderm development candidate 1 | 4058 | 0.029 | 0.4104 | No |
| 48 | GNS | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 4298 | 0.025 | 0.3947 | No |
| 49 | LMBRD1 | LMBRD1 Entrez, Source | LMBR1 domain containing 1 | 4305 | 0.025 | 0.3966 | No |
| 50 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 4345 | 0.025 | 0.3959 | No |
| 51 | ATP6AP1 | ATP6AP1 Entrez, Source | ATPase, H+ transporting, lysosomal accessory protein 1 | 4367 | 0.024 | 0.3965 | No |
| 52 | PGA5 | PGA5 Entrez, Source | pepsinogen 5, group I (pepsinogen A) | 4474 | 0.023 | 0.3906 | No |
| 53 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 4547 | 0.022 | 0.3872 | No |
| 54 | ARF4 | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 4680 | 0.020 | 0.3790 | No |
| 55 | ATP1B1 | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 4788 | 0.018 | 0.3727 | No |
| 56 | PDIA3 | PDIA3 Entrez, Source | protein disulfide isomerase family A, member 3 | 4843 | 0.018 | 0.3702 | No |
| 57 | GRINA | GRINA Entrez, Source | glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) | 4887 | 0.017 | 0.3685 | No |
| 58 | B2M | B2M Entrez, Source | beta-2-microglobulin | 4992 | 0.015 | 0.3621 | No |
| 59 | MYL3 | MYL3 Entrez, Source | myosin, light chain 3, alkali; ventricular, skeletal, slow | 5408 | 0.010 | 0.3316 | No |
| 60 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 5771 | 0.005 | 0.3047 | No |
| 61 | GNA12 | GNA12 Entrez, Source | guanine nucleotide binding protein (G protein) alpha 12 | 5992 | 0.002 | 0.2883 | No |
| 62 | CCNC | CCNC Entrez, Source | cyclin C | 5995 | 0.002 | 0.2884 | No |
| 63 | NID1 | NID1 Entrez, Source | nidogen 1 | 6133 | 0.000 | 0.2780 | No |
| 64 | STARD10 | STARD10 Entrez, Source | START domain containing 10 | 6223 | -0.001 | 0.2714 | No |
| 65 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 6253 | -0.001 | 0.2693 | No |
| 66 | PDE1B | PDE1B Entrez, Source | phosphodiesterase 1B, calmodulin-dependent | 6375 | -0.003 | 0.2605 | No |
| 67 | JUND | JUND Entrez, Source | jun D proto-oncogene | 6457 | -0.004 | 0.2547 | No |
| 68 | HSPA5 | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 6557 | -0.005 | 0.2477 | No |
| 69 | CD38 | CD38 Entrez, Source | CD38 molecule | 7086 | -0.012 | 0.2089 | No |
| 70 | SPOCK1 | SPOCK1 Entrez, Source | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 7173 | -0.013 | 0.2036 | No |
| 71 | ZYX | ZYX Entrez, Source | zyxin | 7461 | -0.016 | 0.1834 | No |
| 72 | CALM1 | CALM1 Entrez, Source | calmodulin 1 (phosphorylase kinase, delta) | 7735 | -0.020 | 0.1646 | No |
| 73 | CITED1 | CITED1 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | 7841 | -0.021 | 0.1586 | No |
| 74 | TXNDC4 | TXNDC4 Entrez, Source | thioredoxin domain containing 4 (endoplasmic reticulum) | 8300 | -0.028 | 0.1266 | No |
| 75 | STRA6 | STRA6 Entrez, Source | stimulated by retinoic acid gene 6 homolog (mouse) | 8551 | -0.031 | 0.1106 | No |
| 76 | TMED2 | TMED2 Entrez, Source | transmembrane emp24 domain trafficking protein 2 | 8814 | -0.035 | 0.0940 | No |
| 77 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 8852 | -0.035 | 0.0945 | No |
| 78 | KDELR2 | KDELR2 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 9192 | -0.040 | 0.0726 | No |
| 79 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 9243 | -0.041 | 0.0726 | No |
| 80 | FDX1 | FDX1 Entrez, Source | ferredoxin 1 | 9287 | -0.042 | 0.0731 | No |
| 81 | CTSZ | CTSZ Entrez, Source | cathepsin Z | 9975 | -0.053 | 0.0261 | No |
| 82 | FKBP9 | FKBP9 Entrez, Source | FK506 binding protein 9, 63 kDa | 10052 | -0.054 | 0.0254 | No |
| 83 | SRPRB | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 10554 | -0.063 | -0.0066 | No |
| 84 | GLUL | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 10574 | -0.064 | -0.0022 | No |
| 85 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 10686 | -0.066 | -0.0045 | No |
| 86 | SURF4 | SURF4 Entrez, Source | surfeit 4 | 10687 | -0.066 | 0.0016 | No |
| 87 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 10713 | -0.066 | 0.0058 | No |
| 88 | PTPRM | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 10978 | -0.073 | -0.0075 | No |
| 89 | LRPAP1 | LRPAP1 Entrez, Source | low density lipoprotein receptor-related protein associated protein 1 | 11802 | -0.096 | -0.0608 | No |
| 90 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 12024 | -0.104 | -0.0680 | No |
| 91 | SPINK1 | SPINK1 Entrez, Source | serine peptidase inhibitor, Kazal type 1 | 12063 | -0.106 | -0.0611 | No |
| 92 | SLC16A1 | SLC16A1 Entrez, Source | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) | 12082 | -0.106 | -0.0527 | No |
| 93 | GATA6 | GATA6 Entrez, Source | GATA binding protein 6 | 12352 | -0.119 | -0.0621 | No |
| 94 | CREB3L1 | CREB3L1 Entrez, Source | cAMP responsive element binding protein 3-like 1 | 12355 | -0.119 | -0.0514 | No |
| 95 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 12663 | -0.138 | -0.0618 | No |
| 96 | GHR | GHR Entrez, Source | growth hormone receptor | 12744 | -0.146 | -0.0545 | No |
| 97 | AQP8 | AQP8 Entrez, Source | aquaporin 8 | 12909 | -0.166 | -0.0516 | No |
| 98 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 13029 | -0.193 | -0.0429 | No |
| 99 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 13051 | -0.198 | -0.0263 | No |
| 100 | CYP26A1 | CYP26A1 Entrez, Source | cytochrome P450, family 26, subfamily A, polypeptide 1 | 13188 | -0.246 | -0.0139 | No |
| 101 | PSPH | PSPH Entrez, Source | phosphoserine phosphatase | 13229 | -0.277 | 0.0085 | No |
