Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | ET743_SARCOMA_48HRS_DN |
| Enrichment Score (ES) | -0.3167159 |
| Normalized Enrichment Score (NES) | -1.2348261 |
| Nominal p-value | 0.098280095 |
| FDR q-value | 0.62805635 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 32 | 0.660 | 0.1080 | No |
| 2 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 496 | 0.183 | 0.1036 | No |
| 3 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 618 | 0.162 | 0.1216 | No |
| 4 | PLAG1 | PLAG1 Entrez, Source | pleiomorphic adenoma gene 1 | 756 | 0.144 | 0.1354 | No |
| 5 | WNT5B | WNT5B Entrez, Source | wingless-type MMTV integration site family, member 5B | 1064 | 0.116 | 0.1317 | No |
| 6 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 1212 | 0.109 | 0.1389 | No |
| 7 | RNF14 | RNF14 Entrez, Source | ring finger protein 14 | 1452 | 0.096 | 0.1369 | No |
| 8 | CLCN7 | CLCN7 Entrez, Source | chloride channel 7 | 1973 | 0.074 | 0.1100 | No |
| 9 | CYHR1 | CYHR1 Entrez, Source | cysteine/histidine-rich 1 | 2706 | 0.055 | 0.0640 | No |
| 10 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 2961 | 0.050 | 0.0531 | No |
| 11 | RAP1B | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 3115 | 0.046 | 0.0493 | No |
| 12 | GTF2B | GTF2B Entrez, Source | general transcription factor IIB | 3140 | 0.046 | 0.0551 | No |
| 13 | HERC4 | HERC4 Entrez, Source | hect domain and RLD 4 | 3688 | 0.035 | 0.0197 | No |
| 14 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 3699 | 0.035 | 0.0249 | No |
| 15 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 4270 | 0.026 | -0.0138 | No |
| 16 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 4471 | 0.023 | -0.0251 | No |
| 17 | HSPA8 | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 4537 | 0.022 | -0.0264 | No |
| 18 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 4639 | 0.020 | -0.0306 | No |
| 19 | RAB1A | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 4681 | 0.020 | -0.0304 | No |
| 20 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 4863 | 0.017 | -0.0411 | No |
| 21 | FZD1 | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 4872 | 0.017 | -0.0388 | No |
| 22 | FNTA | FNTA Entrez, Source | farnesyltransferase, CAAX box, alpha | 4985 | 0.015 | -0.0447 | No |
| 23 | NCOA6 | NCOA6 Entrez, Source | nuclear receptor coactivator 6 | 5196 | 0.013 | -0.0584 | No |
| 24 | PJA2 | PJA2 Entrez, Source | praja 2, RING-H2 motif containing | 5198 | 0.013 | -0.0564 | No |
| 25 | ELOVL6 | ELOVL6 Entrez, Source | ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 5229 | 0.012 | -0.0566 | No |
| 26 | ERCC3 | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 5284 | 0.011 | -0.0588 | No |
| 27 | PPP2R1B | PPP2R1B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform | 5470 | 0.009 | -0.0713 | No |
| 28 | CRLF3 | CRLF3 Entrez, Source | cytokine receptor-like factor 3 | 5514 | 0.008 | -0.0732 | No |
| 29 | PSMB1 | PSMB1 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 1 | 5654 | 0.006 | -0.0827 | No |
| 30 | NBN | NBN Entrez, Source | nibrin | 5769 | 0.005 | -0.0904 | No |
| 31 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 5898 | 0.003 | -0.0995 | No |
| 32 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 5938 | 0.003 | -0.1020 | No |
| 33 | HSPH1 | HSPH1 Entrez, Source | heat shock 105kDa/110kDa protein 1 | 6127 | 0.000 | -0.1161 | No |
| 34 | TOP1 | TOP1 Entrez, Source | topoisomerase (DNA) I | 6189 | -0.000 | -0.1207 | No |
| 35 | STK17B | STK17B Entrez, Source | serine/threonine kinase 17b (apoptosis-inducing) | 6193 | -0.000 | -0.1208 | No |
| 36 | TMPO | TMPO Entrez, Source | thymopoietin | 6281 | -0.002 | -0.1271 | No |
| 37 | DNAJA2 | DNAJA2 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 2 | 6450 | -0.004 | -0.1391 | No |
| 38 | PSMA4 | PSMA4 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 6523 | -0.005 | -0.1438 | No |
| 39 | PSMC2 | PSMC2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 6594 | -0.006 | -0.1481 | No |
| 40 | PPP1CC | PPP1CC Entrez, Source | protein phosphatase 1, catalytic subunit, gamma isoform | 6696 | -0.007 | -0.1546 | No |
| 41 | THRAP3 | THRAP3 Entrez, Source | thyroid hormone receptor associated protein 3 | 6772 | -0.008 | -0.1589 | No |
| 42 | SFRS9 | SFRS9 Entrez, Source | splicing factor, arginine/serine-rich 9 | 7120 | -0.012 | -0.1831 | No |
| 43 | RAB5A | RAB5A Entrez, Source | RAB5A, member RAS oncogene family | 7248 | -0.014 | -0.1904 | No |
| 44 | CDC5L | CDC5L Entrez, Source | CDC5 cell division cycle 5-like (S. pombe) | 7287 | -0.014 | -0.1909 | No |
| 45 | SON | SON Entrez, Source | SON DNA binding protein | 7481 | -0.016 | -0.2027 | No |
| 46 | MCTS1 | MCTS1 Entrez, Source | malignant T cell amplified sequence 1 | 7486 | -0.017 | -0.2002 | No |
| 47 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 7602 | -0.018 | -0.2059 | No |
| 48 | HSPE1 | HSPE1 Entrez, Source | heat shock 10kDa protein 1 (chaperonin 10) | 7672 | -0.019 | -0.2079 | No |
| 49 | PSMC6 | PSMC6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 8252 | -0.027 | -0.2470 | No |
| 50 | FOSL1 | FOSL1 Entrez, Source | FOS-like antigen 1 | 8279 | -0.028 | -0.2444 | No |
| 51 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 8396 | -0.029 | -0.2483 | No |
| 52 | EIF3S10 | EIF3S10 Entrez, Source | eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa | 8792 | -0.035 | -0.2722 | No |
| 53 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 8858 | -0.036 | -0.2712 | No |
| 54 | CCT4 | CCT4 Entrez, Source | chaperonin containing TCP1, subunit 4 (delta) | 9088 | -0.039 | -0.2820 | No |
| 55 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9154 | -0.040 | -0.2803 | No |
| 56 | ATF1 | ATF1 Entrez, Source | activating transcription factor 1 | 9168 | -0.040 | -0.2746 | No |
| 57 | RAB2 | RAB2 Entrez, Source | RAB2, member RAS oncogene family | 9314 | -0.042 | -0.2785 | No |
| 58 | JMJD1C | JMJD1C Entrez, Source | jumonji domain containing 1C | 9316 | -0.042 | -0.2716 | No |
| 59 | PSMA5 | PSMA5 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 9533 | -0.046 | -0.2802 | No |
| 60 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 9687 | -0.048 | -0.2837 | No |
| 61 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9826 | -0.051 | -0.2856 | No |
| 62 | PSME3 | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 9831 | -0.051 | -0.2774 | No |
| 63 | FBXL3 | FBXL3 Entrez, Source | F-box and leucine-rich repeat protein 3 | 10049 | -0.054 | -0.2847 | No |
| 64 | CXXC5 | CXXC5 Entrez, Source | CXXC finger 5 | 10086 | -0.055 | -0.2783 | No |
| 65 | RABGGTB | RABGGTB Entrez, Source | Rab geranylgeranyltransferase, beta subunit | 10378 | -0.060 | -0.2902 | No |
| 66 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 10730 | -0.067 | -0.3055 | Yes |
| 67 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 10765 | -0.068 | -0.2968 | Yes |
| 68 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 10785 | -0.068 | -0.2868 | Yes |
| 69 | SNIP1 | SNIP1 Entrez, Source | Smad nuclear interacting protein 1 | 10836 | -0.069 | -0.2790 | Yes |
| 70 | TXNRD1 | TXNRD1 Entrez, Source | thioredoxin reductase 1 | 10870 | -0.070 | -0.2698 | Yes |
| 71 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 10899 | -0.071 | -0.2601 | Yes |
| 72 | RBM17 | RBM17 Entrez, Source | RNA binding motif protein 17 | 10968 | -0.073 | -0.2530 | Yes |
| 73 | CCNH | CCNH Entrez, Source | cyclin H | 10973 | -0.073 | -0.2412 | Yes |
| 74 | PRIM2A | PRIM2A Entrez, Source | primase, polypeptide 2A, 58kDa | 10979 | -0.073 | -0.2294 | Yes |
| 75 | NUFIP1 | NUFIP1 Entrez, Source | nuclear fragile X mental retardation protein interacting protein 1 | 11003 | -0.073 | -0.2188 | Yes |
| 76 | DDX20 | DDX20 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 | 11083 | -0.075 | -0.2122 | Yes |
| 77 | ARFGAP1 | ARFGAP1 Entrez, Source | ADP-ribosylation factor GTPase activating protein 1 | 11345 | -0.083 | -0.2181 | Yes |
| 78 | PANX1 | PANX1 Entrez, Source | pannexin 1 | 11458 | -0.085 | -0.2123 | Yes |
| 79 | MTIF2 | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 11529 | -0.087 | -0.2029 | Yes |
| 80 | LBR | LBR Entrez, Source | lamin B receptor | 11547 | -0.088 | -0.1895 | Yes |
| 81 | SIRPA | SIRPA Entrez, Source | signal-regulatory protein alpha | 11784 | -0.095 | -0.1914 | Yes |
| 82 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 11925 | -0.100 | -0.1853 | Yes |
| 83 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 11974 | -0.102 | -0.1719 | Yes |
| 84 | CRSP6 | CRSP6 Entrez, Source | cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa | 11987 | -0.102 | -0.1556 | Yes |
| 85 | MAPK14 | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 12051 | -0.105 | -0.1428 | Yes |
| 86 | OGT | OGT Entrez, Source | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | 12390 | -0.121 | -0.1481 | Yes |
| 87 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 12402 | -0.121 | -0.1287 | Yes |
| 88 | SUPV3L1 | SUPV3L1 Entrez, Source | suppressor of var1, 3-like 1 (S. cerevisiae) | 12423 | -0.123 | -0.1097 | Yes |
| 89 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 12591 | -0.134 | -0.0998 | Yes |
| 90 | XBP1 | XBP1 Entrez, Source | X-box binding protein 1 | 12661 | -0.138 | -0.0819 | Yes |
| 91 | USP3 | USP3 Entrez, Source | ubiquitin specific peptidase 3 | 12845 | -0.158 | -0.0692 | Yes |
| 92 | TDG | TDG Entrez, Source | thymine-DNA glycosylase | 12879 | -0.162 | -0.0446 | Yes |
| 93 | MAT2A | MAT2A Entrez, Source | methionine adenosyltransferase II, alpha | 13317 | -0.475 | 0.0019 | Yes |
