Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | GLYCINE_SERINE_AND_THREONINE_METABOLISM |
| Enrichment Score (ES) | -0.4541876 |
| Normalized Enrichment Score (NES) | -1.3831128 |
| Nominal p-value | 0.07656612 |
| FDR q-value | 0.49799147 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CHDH | CHDH Entrez, Source | choline dehydrogenase | 760 | 0.144 | 0.0006 | No |
| 2 | PLCG2 | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 1116 | 0.114 | 0.0196 | No |
| 3 | DMGDH | DMGDH Entrez, Source | dimethylglycine dehydrogenase | 1276 | 0.105 | 0.0499 | No |
| 4 | ALAS2 | ALAS2 Entrez, Source | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 2100 | 0.070 | 0.0161 | No |
| 5 | CBS | CBS Entrez, Source | cystathionine-beta-synthase | 2663 | 0.056 | -0.0037 | No |
| 6 | MAOA | MAOA Entrez, Source | monoamine oxidase A | 3833 | 0.033 | -0.0783 | No |
| 7 | AGXT | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 4309 | 0.025 | -0.1038 | No |
| 8 | CHKB | CHKB Entrez, Source | choline kinase beta | 5538 | 0.008 | -0.1930 | No |
| 9 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 6337 | -0.002 | -0.2520 | No |
| 10 | ALAS1 | ALAS1 Entrez, Source | aminolevulinate, delta-, synthase 1 | 6928 | -0.010 | -0.2924 | No |
| 11 | AOC3 | AOC3 Entrez, Source | amine oxidase, copper containing 3 (vascular adhesion protein 1) | 7106 | -0.012 | -0.3009 | No |
| 12 | BHMT | BHMT Entrez, Source | betaine-homocysteine methyltransferase | 8485 | -0.031 | -0.3921 | No |
| 13 | SARDH | SARDH Entrez, Source | sarcosine dehydrogenase | 8785 | -0.035 | -0.4006 | No |
| 14 | PLCG1 | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 8898 | -0.036 | -0.3945 | No |
| 15 | PLCB2 | PLCB2 Entrez, Source | phospholipase C, beta 2 | 9233 | -0.041 | -0.4033 | No |
| 16 | AMT | AMT Entrez, Source | aminomethyltransferase | 9912 | -0.052 | -0.4333 | Yes |
| 17 | AGXT2 | AGXT2 Entrez, Source | alanine-glyoxylate aminotransferase 2 | 10038 | -0.054 | -0.4209 | Yes |
| 18 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 10295 | -0.058 | -0.4167 | Yes |
| 19 | PEMT | PEMT Entrez, Source | phosphatidylethanolamine N-methyltransferase | 10459 | -0.061 | -0.4043 | Yes |
| 20 | CHKA | CHKA Entrez, Source | choline kinase alpha | 10678 | -0.066 | -0.3942 | Yes |
| 21 | ABP1 | ABP1 Entrez, Source | amiloride binding protein 1 (amine oxidase (copper-containing)) | 11324 | -0.082 | -0.4097 | Yes |
| 22 | TARS | TARS Entrez, Source | threonyl-tRNA synthetase | 11414 | -0.084 | -0.3825 | Yes |
| 23 | GARS | GARS Entrez, Source | glycyl-tRNA synthetase | 11841 | -0.097 | -0.3755 | Yes |
| 24 | SHMT2 | SHMT2 Entrez, Source | serine hydroxymethyltransferase 2 (mitochondrial) | 12164 | -0.110 | -0.3555 | Yes |
| 25 | CTH | CTH Entrez, Source | cystathionase (cystathionine gamma-lyase) | 12543 | -0.131 | -0.3312 | Yes |
| 26 | SHMT1 | SHMT1 Entrez, Source | serine hydroxymethyltransferase 1 (soluble) | 12628 | -0.136 | -0.2828 | Yes |
| 27 | GAMT | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 12960 | -0.175 | -0.2375 | Yes |
| 28 | MAOB | MAOB Entrez, Source | monoamine oxidase B | 12987 | -0.180 | -0.1670 | Yes |
| 29 | GCAT | GCAT Entrez, Source | glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) | 13084 | -0.205 | -0.0919 | Yes |
| 30 | PSPH | PSPH Entrez, Source | phosphoserine phosphatase | 13229 | -0.277 | 0.0085 | Yes |
