Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | HSA00100_BIOSYNTHESIS_OF_STEROIDS |
| Enrichment Score (ES) | -0.5835573 |
| Normalized Enrichment Score (NES) | -1.6953639 |
| Nominal p-value | 0.004454343 |
| FDR q-value | 0.16586223 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 2123 | 0.069 | -0.1207 | No |
| 2 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 5077 | 0.014 | -0.3344 | No |
| 3 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 7128 | -0.012 | -0.4815 | No |
| 4 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 8441 | -0.030 | -0.5632 | Yes |
| 5 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 8632 | -0.033 | -0.5592 | Yes |
| 6 | VKORC1 | VKORC1 Entrez, Source | vitamin K epoxide reductase complex, subunit 1 | 8958 | -0.037 | -0.5628 | Yes |
| 7 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 9103 | -0.039 | -0.5518 | Yes |
| 8 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 9220 | -0.040 | -0.5379 | Yes |
| 9 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 9455 | -0.044 | -0.5306 | Yes |
| 10 | SQLE | SQLE Entrez, Source | squalene epoxidase | 9644 | -0.048 | -0.5181 | Yes |
| 11 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 9919 | -0.052 | -0.5094 | Yes |
| 12 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 10795 | -0.068 | -0.5369 | Yes |
| 13 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 11182 | -0.078 | -0.5223 | Yes |
| 14 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 11716 | -0.093 | -0.5105 | Yes |
| 15 | TM7SF2 | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 11819 | -0.096 | -0.4642 | Yes |
| 16 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 11844 | -0.097 | -0.4115 | Yes |
| 17 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 11949 | -0.101 | -0.3629 | Yes |
| 18 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 12159 | -0.110 | -0.3171 | Yes |
| 19 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 12335 | -0.118 | -0.2642 | Yes |
| 20 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 12656 | -0.138 | -0.2110 | Yes |
| 21 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 12678 | -0.140 | -0.1344 | Yes |
| 22 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 12854 | -0.159 | -0.0585 | Yes |
| 23 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 12934 | -0.170 | 0.0306 | Yes |
