Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | HSA00230_PURINE_METABOLISM |
| Enrichment Score (ES) | -0.36056215 |
| Normalized Enrichment Score (NES) | -1.3799914 |
| Nominal p-value | 0.032098766 |
| FDR q-value | 0.4914742 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | AMPD3 | AMPD3 Entrez, Source | adenosine monophosphate deaminase (isoform E) | 180 | 0.337 | 0.0389 | No |
| 2 | GDA | GDA Entrez, Source | guanine deaminase | 342 | 0.233 | 0.0630 | No |
| 3 | AMPD1 | AMPD1 Entrez, Source | adenosine monophosphate deaminase 1 (isoform M) | 667 | 0.155 | 0.0628 | No |
| 4 | GUCY1B3 | GUCY1B3 Entrez, Source | guanylate cyclase 1, soluble, beta 3 | 801 | 0.140 | 0.0745 | No |
| 5 | PDE4C | PDE4C Entrez, Source | phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) | 941 | 0.126 | 0.0836 | No |
| 6 | POLA2 | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 1021 | 0.119 | 0.0962 | No |
| 7 | PDE10A | PDE10A Entrez, Source | phosphodiesterase 10A | 1495 | 0.094 | 0.0752 | No |
| 8 | GUK1 | GUK1 Entrez, Source | guanylate kinase 1 | 1568 | 0.091 | 0.0839 | No |
| 9 | PDE6H | PDE6H Entrez, Source | phosphodiesterase 6H, cGMP-specific, cone, gamma | 1673 | 0.086 | 0.0894 | No |
| 10 | NUDT2 | NUDT2 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 2 | 2160 | 0.068 | 0.0634 | No |
| 11 | NME7 | NME7 Entrez, Source | non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) | 2386 | 0.062 | 0.0562 | No |
| 12 | POLR2G | POLR2G Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide G | 2604 | 0.057 | 0.0487 | No |
| 13 | GMPR | GMPR Entrez, Source | guanosine monophosphate reductase | 2611 | 0.057 | 0.0572 | No |
| 14 | ENTPD3 | ENTPD3 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 3 | 2795 | 0.053 | 0.0516 | No |
| 15 | GUCY1A3 | GUCY1A3 Entrez, Source | guanylate cyclase 1, soluble, alpha 3 | 3107 | 0.046 | 0.0354 | No |
| 16 | FHIT | FHIT Entrez, Source | fragile histidine triad gene | 3384 | 0.041 | 0.0209 | No |
| 17 | PDE1C | PDE1C Entrez, Source | phosphodiesterase 1C, calmodulin-dependent 70kDa | 3643 | 0.036 | 0.0071 | No |
| 18 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 3699 | 0.035 | 0.0085 | No |
| 19 | PDE2A | PDE2A Entrez, Source | phosphodiesterase 2A, cGMP-stimulated | 3968 | 0.031 | -0.0070 | No |
| 20 | ENTPD2 | ENTPD2 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 2 | 4219 | 0.027 | -0.0217 | No |
| 21 | PDE7A | PDE7A Entrez, Source | phosphodiesterase 7A | 4231 | 0.027 | -0.0184 | No |
| 22 | AK1 | AK1 Entrez, Source | adenylate kinase 1 | 4876 | 0.017 | -0.0643 | No |
| 23 | ADCY2 | ADCY2 Entrez, Source | adenylate cyclase 2 (brain) | 4922 | 0.016 | -0.0652 | No |
| 24 | PDE8B | PDE8B Entrez, Source | phosphodiesterase 8B | 5096 | 0.014 | -0.0760 | No |
| 25 | ENTPD6 | ENTPD6 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 6 (putative function) | 5107 | 0.014 | -0.0746 | No |
| 26 | GUCY2C | GUCY2C Entrez, Source | guanylate cyclase 2C (heat stable enterotoxin receptor) | 5109 | 0.014 | -0.0725 | No |
| 27 | PDE4A | PDE4A Entrez, Source | phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) | 5171 | 0.013 | -0.0751 | No |
| 28 | PDE11A | PDE11A Entrez, Source | phosphodiesterase 11A | 5203 | 0.013 | -0.0755 | No |
| 29 | ENTPD5 | ENTPD5 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 5 | 5338 | 0.011 | -0.0839 | No |
| 30 | ZNRD1 | ZNRD1 Entrez, Source | zinc ribbon domain containing 1 | 5543 | 0.008 | -0.0981 | No |
| 31 | POLR2F | POLR2F Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide F | 5958 | 0.003 | -0.1290 | No |
| 32 | ADCY6 | ADCY6 Entrez, Source | adenylate cyclase 6 | 6028 | 0.002 | -0.1339 | No |
| 33 | GUCY2D | GUCY2D Entrez, Source | guanylate cyclase 2D, membrane (retina-specific) | 6484 | -0.004 | -0.1675 | No |
| 34 | ADCY5 | ADCY5 Entrez, Source | adenylate cyclase 5 | 6683 | -0.007 | -0.1814 | No |
| 35 | PDE8A | PDE8A Entrez, Source | phosphodiesterase 8A | 6843 | -0.009 | -0.1921 | No |
| 36 | GART | GART Entrez, Source | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 6946 | -0.010 | -0.1982 | No |
| 37 | NPR1 | NPR1 Entrez, Source | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) | 7769 | -0.020 | -0.2570 | No |
| 38 | ADK | ADK Entrez, Source | adenosine kinase | 7944 | -0.023 | -0.2666 | No |
| 39 | ADA | ADA Entrez, Source | adenosine deaminase | 8062 | -0.024 | -0.2716 | No |
| 40 | ADCY8 | ADCY8 Entrez, Source | adenylate cyclase 8 (brain) | 8194 | -0.026 | -0.2774 | No |
| 41 | NPR2 | NPR2 Entrez, Source | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) | 8412 | -0.030 | -0.2892 | No |
| 42 | ADCY3 | ADCY3 Entrez, Source | adenylate cyclase 3 | 8531 | -0.031 | -0.2932 | No |
| 43 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 8663 | -0.033 | -0.2979 | No |
| 44 | ATIC | ATIC Entrez, Source | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 8726 | -0.034 | -0.2973 | No |
| 45 | POLR2C | POLR2C Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa | 8936 | -0.037 | -0.3074 | No |
| 46 | POLD4 | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 9014 | -0.038 | -0.3073 | No |
| 47 | NME2 | NME2 Entrez, Source | non-metastatic cells 2, protein (NM23B) expressed in | 9131 | -0.039 | -0.3099 | No |
| 48 | POLE3 | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 9201 | -0.040 | -0.3089 | No |
| 49 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 9276 | -0.041 | -0.3080 | No |
| 50 | GMPR2 | GMPR2 Entrez, Source | guanosine monophosphate reductase 2 | 9397 | -0.043 | -0.3103 | No |
| 51 | PDE4B | PDE4B Entrez, Source | phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | 9537 | -0.046 | -0.3137 | No |
| 52 | AK2 | AK2 Entrez, Source | adenylate kinase 2 | 9770 | -0.050 | -0.3234 | No |
| 53 | HPRT1 | HPRT1 Entrez, Source | hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) | 9884 | -0.052 | -0.3239 | No |
| 54 | GMPS | GMPS Entrez, Source | guanine monphosphate synthetase | 10172 | -0.056 | -0.3368 | No |
| 55 | PDE4D | PDE4D Entrez, Source | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) | 10269 | -0.058 | -0.3350 | No |
| 56 | PNPT1 | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 10541 | -0.063 | -0.3456 | No |
| 57 | POLR1A | POLR1A Entrez, Source | polymerase (RNA) I polypeptide A, 194kDa | 10562 | -0.063 | -0.3373 | No |
| 58 | GUCY1A2 | GUCY1A2 Entrez, Source | guanylate cyclase 1, soluble, alpha 2 | 10872 | -0.070 | -0.3496 | Yes |
| 59 | CANT1 | CANT1 Entrez, Source | calcium activated nucleotidase 1 | 10903 | -0.071 | -0.3409 | Yes |
| 60 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 10927 | -0.072 | -0.3314 | Yes |
| 61 | PAICS | PAICS Entrez, Source | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 10929 | -0.072 | -0.3204 | Yes |
| 62 | ENTPD1 | ENTPD1 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 1 | 10967 | -0.073 | -0.3119 | Yes |
| 63 | NUDT9 | NUDT9 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 11254 | -0.080 | -0.3209 | Yes |
| 64 | NT5E | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 11299 | -0.081 | -0.3116 | Yes |
| 65 | ENPP1 | ENPP1 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 11362 | -0.083 | -0.3033 | Yes |
| 66 | PDE3B | PDE3B Entrez, Source | phosphodiesterase 3B, cGMP-inhibited | 11375 | -0.083 | -0.2913 | Yes |
| 67 | PDE5A | PDE5A Entrez, Source | phosphodiesterase 5A, cGMP-specific | 11495 | -0.086 | -0.2868 | Yes |
| 68 | GUCY2F | GUCY2F Entrez, Source | guanylate cyclase 2F, retinal | 11508 | -0.087 | -0.2742 | Yes |
| 69 | PDE9A | PDE9A Entrez, Source | phosphodiesterase 9A | 11700 | -0.092 | -0.2743 | Yes |
| 70 | NME1 | NME1 Entrez, Source | non-metastatic cells 1, protein (NM23A) expressed in | 11914 | -0.100 | -0.2749 | Yes |
| 71 | ADCY4 | ADCY4 Entrez, Source | adenylate cyclase 4 | 12124 | -0.108 | -0.2738 | Yes |
| 72 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 12141 | -0.109 | -0.2580 | Yes |
| 73 | NME6 | NME6 Entrez, Source | non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) | 12375 | -0.120 | -0.2569 | Yes |
| 74 | PDE1A | PDE1A Entrez, Source | phosphodiesterase 1A, calmodulin-dependent | 12401 | -0.121 | -0.2399 | Yes |
| 75 | IMPDH2 | IMPDH2 Entrez, Source | IMP (inosine monophosphate) dehydrogenase 2 | 12451 | -0.124 | -0.2244 | Yes |
| 76 | NUDT5 | NUDT5 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 5 | 12497 | -0.127 | -0.2079 | Yes |
| 77 | POLR1B | POLR1B Entrez, Source | polymerase (RNA) I polypeptide B, 128kDa | 12576 | -0.133 | -0.1931 | Yes |
| 78 | DCK | DCK Entrez, Source | deoxycytidine kinase | 12784 | -0.151 | -0.1852 | Yes |
| 79 | ENPP3 | ENPP3 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 3 | 12806 | -0.153 | -0.1630 | Yes |
| 80 | PPAT | PPAT Entrez, Source | phosphoribosyl pyrophosphate amidotransferase | 12816 | -0.154 | -0.1396 | Yes |
| 81 | AK3L1 | AK3L1 Entrez, Source | adenylate kinase 3-like 1 | 12819 | -0.155 | -0.1157 | Yes |
| 82 | PRPS2 | PRPS2 Entrez, Source | phosphoribosyl pyrophosphate synthetase 2 | 12857 | -0.160 | -0.0936 | Yes |
| 83 | PDE7B | PDE7B Entrez, Source | phosphodiesterase 7B | 12940 | -0.171 | -0.0732 | Yes |
| 84 | XDH | XDH Entrez, Source | xanthine dehydrogenase | 13126 | -0.217 | -0.0533 | Yes |
| 85 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 13313 | -0.446 | 0.0022 | Yes |
