Details for gene set HSA04510_FOCAL

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_72h_repos
Upregulated in class	double_gel_8d
GeneSet	HSA04510_FOCAL_ADHESION
Enrichment Score (ES)	0.54557836
Normalized Enrichment Score (NES)	2.0564349
Nominal p-value	0.0
FDR q-value	0.003146083
FWER p-Value	0.078

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	COL1A2	COL1A2 Entrez, Source	collagen, type I, alpha 2	3	1.046	0.0785	Yes
2	CCND2	CCND2 Entrez, Source	cyclin D2	11	0.815	0.1393	Yes
3	LAMC2	LAMC2 Entrez, Source	laminin, gamma 2	14	0.770	0.1971	Yes
4	COL3A1	COL3A1 Entrez, Source	collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)	15	0.737	0.2526	Yes
5	COL5A2	COL5A2 Entrez, Source	collagen, type V, alpha 2	28	0.668	0.3019	Yes
6	COL4A1	COL4A1 Entrez, Source	collagen, type IV, alpha 1	50	0.578	0.3438	Yes
7	ITGB4	ITGB4 Entrez, Source	integrin, beta 4	121	0.401	0.3686	Yes
8	LAMC1	LAMC1 Entrez, Source	laminin, gamma 1 (formerly LAMB2)	224	0.303	0.3837	Yes
9	LAMB2	LAMB2 Entrez, Source	laminin, beta 2 (laminin S)	351	0.229	0.3914	Yes
10	PIP5K1C	PIP5K1C Entrez, Source	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	407	0.208	0.4029	Yes
11	JUN	JUN Entrez, Source	jun oncogene	458	0.194	0.4137	Yes
12	COL6A2	COL6A2 Entrez, Source	collagen, type VI, alpha 2	460	0.193	0.4281	Yes
13	VEGFC	VEGFC Entrez, Source	vascular endothelial growth factor C	496	0.183	0.4392	Yes
14	PXN	PXN Entrez, Source	paxillin	617	0.163	0.4424	Yes
15	PDGFA	PDGFA Entrez, Source	platelet-derived growth factor alpha polypeptide	619	0.162	0.4545	Yes
16	BIRC4	BIRC4 Entrez, Source	baculoviral IAP repeat-containing 4	630	0.161	0.4658	Yes
17	MAPK3	MAPK3 Entrez, Source	mitogen-activated protein kinase 3	631	0.160	0.4779	Yes
18	ITGA9	ITGA9 Entrez, Source	integrin, alpha 9	643	0.158	0.4890	Yes
19	FLT1	FLT1 Entrez, Source	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	699	0.150	0.4961	Yes
20	VEGFB	VEGFB Entrez, Source	vascular endothelial growth factor B	715	0.149	0.5062	Yes
21	COL1A1	COL1A1 Entrez, Source	collagen, type I, alpha 1	738	0.146	0.5155	Yes
22	ITGA1	ITGA1 Entrez, Source	integrin, alpha 1	936	0.126	0.5101	Yes
23	ERBB2	ERBB2 Entrez, Source	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	1072	0.116	0.5086	Yes
24	SPP1	SPP1 Entrez, Source	secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	1105	0.114	0.5148	Yes
25	ACTN1	ACTN1 Entrez, Source	actinin, alpha 1	1268	0.106	0.5105	Yes
26	COL4A4	COL4A4 Entrez, Source	collagen, type IV, alpha 4	1373	0.100	0.5101	Yes
27	ITGB6	ITGB6 Entrez, Source	integrin, beta 6	1389	0.099	0.5164	Yes
28	COL5A1	COL5A1 Entrez, Source	collagen, type V, alpha 1	1404	0.098	0.5228	Yes
29	PPP1R12A	PPP1R12A Entrez, Source	protein phosphatase 1, regulatory (inhibitor) subunit 12A	1434	0.097	0.5278	Yes
30	ROCK1	ROCK1 Entrez, Source	Rho-associated, coiled-coil containing protein kinase 1	1513	0.093	0.5290	Yes
31	PDPK1	PDPK1 Entrez, Source	3-phosphoinositide dependent protein kinase-1	1565	0.091	0.5319	Yes
32	MAPK9	MAPK9 Entrez, Source	mitogen-activated protein kinase 9	1621	0.088	0.5344	Yes
33	CAPN2	CAPN2 Entrez, Source	calpain 2, (m/II) large subunit	1726	0.084	0.5328	Yes
34	ROCK2	ROCK2 Entrez, Source	Rho-associated, coiled-coil containing protein kinase 2	1731	0.083	0.5388	Yes
35	BAD	BAD Entrez, Source	BCL2-antagonist of cell death	1750	0.083	0.5436	Yes
36	PAK1	PAK1 Entrez, Source	p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)	1975	0.074	0.5322	Yes
37	SOS2	SOS2 Entrez, Source	son of sevenless homolog 2 (Drosophila)	2013	0.073	0.5349	Yes
38	RAPGEF1	RAPGEF1 Entrez, Source	Rap guanine nucleotide exchange factor (GEF) 1	2101	0.070	0.5335	Yes
39	CCND3	CCND3 Entrez, Source	cyclin D3	2106	0.069	0.5385	Yes
40	FYN	FYN Entrez, Source	FYN oncogene related to SRC, FGR, YES	2118	0.069	0.5428	Yes
41	CAV2	CAV2 Entrez, Source	caveolin 2	2151	0.069	0.5456	Yes
42	BCL2	BCL2 Entrez, Source	B-cell CLL/lymphoma 2	2324	0.064	0.5374	No
43	COL11A1	COL11A1 Entrez, Source	collagen, type XI, alpha 1	2472	0.060	0.5308	No
44	GSK3B	GSK3B Entrez, Source	glycogen synthase kinase 3 beta	2479	0.060	0.5349	No
45	FN1	FN1 Entrez, Source	fibronectin 1	2637	0.057	0.5272	No
46	THBS4	THBS4 Entrez, Source	thrombospondin 4	2746	0.054	0.5231	No
47	PDGFRB	PDGFRB Entrez, Source	platelet-derived growth factor receptor, beta polypeptide	2871	0.051	0.5176	No
48	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	2895	0.051	0.5197	No
49	RAP1B	RAP1B Entrez, Source	RAP1B, member of RAS oncogene family	3115	0.046	0.5066	No
50	RHOA	RHOA Entrez, Source	ras homolog gene family, member A	3147	0.045	0.5077	No
51	IGF1R	IGF1R Entrez, Source	insulin-like growth factor 1 receptor	3414	0.040	0.4905	No
52	AKT3	AKT3 Entrez, Source	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	3449	0.040	0.4910	No
53	PDGFC	PDGFC Entrez, Source	platelet derived growth factor C	3584	0.037	0.4836	No
54	ITGB5	ITGB5 Entrez, Source	integrin, beta 5	3714	0.035	0.4765	No
55	SRC	SRC Entrez, Source	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	3782	0.034	0.4739	No
56	IBSP	IBSP Entrez, Source	integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)	3929	0.031	0.4652	No
57	PARVA	PARVA Entrez, Source	parvin, alpha	4099	0.029	0.4546	No
58	PIK3R3	PIK3R3 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)	4251	0.026	0.4452	No
59	BRAF	BRAF Entrez, Source	v-raf murine sarcoma viral oncogene homolog B1	4295	0.026	0.4438	No
60	PIK3CA	PIK3CA Entrez, Source	phosphoinositide-3-kinase, catalytic, alpha polypeptide	4457	0.023	0.4334	No
61	MAPK1	MAPK1 Entrez, Source	mitogen-activated protein kinase 1	4608	0.021	0.4236	No
62	KDR	KDR Entrez, Source	kinase insert domain receptor (a type III receptor tyrosine kinase)	4694	0.020	0.4186	No
63	ACTB	ACTB Entrez, Source	actin, beta	4714	0.019	0.4186	No
64	MYLK2	MYLK2 Entrez, Source	myosin light chain kinase 2, skeletal muscle	4719	0.019	0.4198	No
65	FIGF	FIGF Entrez, Source	c-fos induced growth factor (vascular endothelial growth factor D)	4855	0.017	0.4109	No
66	PPP1CA	PPP1CA Entrez, Source	protein phosphatase 1, catalytic subunit, alpha isoform	5040	0.015	0.3981	No
67	ILK	ILK Entrez, Source	integrin-linked kinase	5046	0.015	0.3988	No
68	VTN	VTN Entrez, Source	vitronectin	5129	0.014	0.3936	No
69	MAPK10	MAPK10 Entrez, Source	mitogen-activated protein kinase 10	5148	0.013	0.3933	No
70	ACTN4	ACTN4 Entrez, Source	actinin, alpha 4	5181	0.013	0.3918	No
71	CDC42	CDC42 Entrez, Source	cell division cycle 42 (GTP binding protein, 25kDa)	5202	0.013	0.3912	No
72	PAK3	PAK3 Entrez, Source	p21 (CDKN1A)-activated kinase 3	5292	0.011	0.3853	No
73	RELN	RELN Entrez, Source	reelin	5458	0.009	0.3735	No
74	TLN1	TLN1 Entrez, Source	talin 1	5544	0.008	0.3677	No
75	COL2A1	COL2A1 Entrez, Source	collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)	5569	0.007	0.3664	No
76	CTNNB1	CTNNB1 Entrez, Source	catenin (cadherin-associated protein), beta 1, 88kDa	6001	0.002	0.3339	No
77	RAC1	RAC1 Entrez, Source	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	6128	0.000	0.3244	No
78	FLNC	FLNC Entrez, Source	filamin C, gamma (actin binding protein 280)	6220	-0.001	0.3176	No
79	ITGB1	ITGB1 Entrez, Source	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	6253	-0.001	0.3153	No
80	LAMB3	LAMB3 Entrez, Source	laminin, beta 3	6323	-0.002	0.3102	No
81	LAMA3	LAMA3 Entrez, Source	laminin, alpha 3	6404	-0.003	0.3044	No
82	ITGB7	ITGB7 Entrez, Source	integrin, beta 7	6475	-0.004	0.2994	No
83	PPP1CB	PPP1CB Entrez, Source	protein phosphatase 1, catalytic subunit, beta isoform	6632	-0.006	0.2881	No
84	PPP1CC	PPP1CC Entrez, Source	protein phosphatase 1, catalytic subunit, gamma isoform	6696	-0.007	0.2839	No
85	PIK3R1	PIK3R1 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)	6769	-0.008	0.2790	No
86	ITGA6	ITGA6 Entrez, Source	integrin, alpha 6	6967	-0.010	0.2649	No
87	RAP1A	RAP1A Entrez, Source	RAP1A, member of RAS oncogene family	7119	-0.012	0.2543	No
88	LAMA5	LAMA5 Entrez, Source	laminin, alpha 5	7254	-0.014	0.2452	No
89	SHC1	SHC1 Entrez, Source	SHC (Src homology 2 domain containing) transforming protein 1	7269	-0.014	0.2452	No
90	PDGFRA	PDGFRA Entrez, Source	platelet-derived growth factor receptor, alpha polypeptide	7343	-0.015	0.2408	No
91	ZYX	ZYX Entrez, Source	zyxin	7461	-0.016	0.2331	No
92	RAF1	RAF1 Entrez, Source	v-raf-1 murine leukemia viral oncogene homolog 1	7552	-0.017	0.2276	No
93	HRAS	HRAS Entrez, Source	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	7568	-0.018	0.2278	No
94	PAK2	PAK2 Entrez, Source	p21 (CDKN1A)-activated kinase 2	8198	-0.027	0.1822	No
95	PTK2	PTK2 Entrez, Source	PTK2 protein tyrosine kinase 2	8235	-0.027	0.1815	No
96	BIRC3	BIRC3 Entrez, Source	baculoviral IAP repeat-containing 3	8408	-0.029	0.1707	No
97	CCND1	CCND1 Entrez, Source	cyclin D1	8524	-0.031	0.1644	No
98	FLNB	FLNB Entrez, Source	filamin B, beta (actin binding protein 278)	8603	-0.032	0.1609	No
99	CRKL	CRKL Entrez, Source	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	8950	-0.037	0.1375	No
100	CAV3	CAV3 Entrez, Source	caveolin 3	8955	-0.037	0.1399	No
101	VWF	VWF Entrez, Source	von Willebrand factor	9242	-0.041	0.1214	No
102	THBS2	THBS2 Entrez, Source	thrombospondin 2	9270	-0.041	0.1224	No
103	PGF	PGF Entrez, Source	placental growth factor, vascular endothelial growth factor-related protein	9350	-0.043	0.1196	No
104	ITGA7	ITGA7 Entrez, Source	integrin, alpha 7	9373	-0.043	0.1212	No
105	BIRC2	BIRC2 Entrez, Source	baculoviral IAP repeat-containing 2	9826	-0.051	0.0908	No
106	PIK3R2	PIK3R2 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)	9995	-0.053	0.0821	No
107	MAP2K1	MAP2K1 Entrez, Source	mitogen-activated protein kinase kinase 1	10278	-0.058	0.0651	No
108	CRK	CRK Entrez, Source	v-crk sarcoma virus CT10 oncogene homolog (avian)	10328	-0.059	0.0659	No
109	COMP	COMP Entrez, Source	cartilage oligomeric matrix protein	10344	-0.059	0.0692	No
110	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	10373	-0.060	0.0715	No
111	ARHGAP5	ARHGAP5 Entrez, Source	Rho GTPase activating protein 5	10392	-0.060	0.0747	No
112	HGF	HGF Entrez, Source	hepatocyte growth factor (hepapoietin A; scatter factor)	10486	-0.062	0.0723	No
113	PIK3CB	PIK3CB Entrez, Source	phosphoinositide-3-kinase, catalytic, beta polypeptide	10639	-0.065	0.0657	No
114	BCAR1	BCAR1 Entrez, Source	breast cancer anti-estrogen resistance 1	10680	-0.066	0.0676	No
115	PTEN	PTEN Entrez, Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	10692	-0.066	0.0718	No
116	AKT1	AKT1 Entrez, Source	v-akt murine thymoma viral oncogene homolog 1	10838	-0.069	0.0660	No
117	PDGFD	PDGFD Entrez, Source	platelet derived growth factor D	10958	-0.072	0.0624	No
118	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	10982	-0.073	0.0662	No
119	TNR	TNR Entrez, Source	tenascin R (restrictin, janusin)	11126	-0.076	0.0611	No
120	GRB2	GRB2 Entrez, Source	growth factor receptor-bound protein 2	11132	-0.077	0.0665	No
121	EGFR	EGFR Entrez, Source	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	11286	-0.081	0.0610	No
122	CHAD	CHAD Entrez, Source	chondroadherin	11454	-0.085	0.0548	No
123	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	11531	-0.087	0.0556	No
124	RAC2	RAC2 Entrez, Source	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	11635	-0.090	0.0546	No
125	VAV1	VAV1 Entrez, Source	vav 1 oncogene	11668	-0.091	0.0590	No
126	ELK1	ELK1 Entrez, Source	ELK1, member of ETS oncogene family	12168	-0.110	0.0295	No
127	AKT2	AKT2 Entrez, Source	v-akt murine thymoma viral oncogene homolog 2	12338	-0.118	0.0256	No
128	MET	MET Entrez, Source	met proto-oncogene (hepatocyte growth factor receptor)	12396	-0.121	0.0304	No
129	EGF	EGF Entrez, Source	epidermal growth factor (beta-urogastrone)	12737	-0.145	0.0155	No
130	ACTN3	ACTN3 Entrez, Source	actinin, alpha 3	12811	-0.154	0.0216	No
131	COL5A3	COL5A3 Entrez, Source	collagen, type V, alpha 3	13187	-0.246	0.0117	No