Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HYPOPHYSECTOMY_RAT_DN |
| Enrichment Score (ES) | 0.571715 |
| Normalized Enrichment Score (NES) | 1.7820511 |
| Nominal p-value | 0.007029877 |
| FDR q-value | 0.0347664 |
| FWER p-Value | 0.99 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 15 | 0.737 | 0.1493 | Yes |
| 2 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 22 | 0.685 | 0.2885 | Yes |
| 3 | MGP | MGP Entrez, Source | matrix Gla protein | 62 | 0.533 | 0.3942 | Yes |
| 4 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 234 | 0.297 | 0.4419 | Yes |
| 5 | ECH1 | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 241 | 0.289 | 0.5004 | Yes |
| 6 | DECR1 | DECR1 Entrez, Source | 2,4-dienoyl CoA reductase 1, mitochondrial | 304 | 0.247 | 0.5462 | Yes |
| 7 | ACAA2 | ACAA2 Entrez, Source | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 528 | 0.177 | 0.5656 | Yes |
| 8 | PIM3 | PIM3 Entrez, Source | pim-3 oncogene | 965 | 0.124 | 0.5581 | Yes |
| 9 | MEP1B | MEP1B Entrez, Source | meprin A, beta | 1097 | 0.115 | 0.5717 | Yes |
| 10 | HADH | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 1791 | 0.081 | 0.5361 | No |
| 11 | PADI4 | PADI4 Entrez, Source | peptidyl arginine deiminase, type IV | 2199 | 0.067 | 0.5192 | No |
| 12 | FN1 | FN1 Entrez, Source | fibronectin 1 | 2637 | 0.057 | 0.4979 | No |
| 13 | GLUD1 | GLUD1 Entrez, Source | glutamate dehydrogenase 1 | 2843 | 0.052 | 0.4930 | No |
| 14 | DCN | DCN Entrez, Source | decorin | 3029 | 0.048 | 0.4888 | No |
| 15 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 3216 | 0.044 | 0.4839 | No |
| 16 | DDC | DDC Entrez, Source | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 3391 | 0.041 | 0.4791 | No |
| 17 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 3915 | 0.032 | 0.4462 | No |
| 18 | NPPA | NPPA Entrez, Source | natriuretic peptide precursor A | 4177 | 0.028 | 0.4322 | No |
| 19 | ARF4 | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 4680 | 0.020 | 0.3985 | No |
| 20 | AHSG | AHSG Entrez, Source | alpha-2-HS-glycoprotein | 4733 | 0.019 | 0.3985 | No |
| 21 | PDIA3 | PDIA3 Entrez, Source | protein disulfide isomerase family A, member 3 | 4843 | 0.018 | 0.3939 | No |
| 22 | B2M | B2M Entrez, Source | beta-2-microglobulin | 4992 | 0.015 | 0.3859 | No |
| 23 | SCD | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 5035 | 0.015 | 0.3857 | No |
| 24 | PPGB | PPGB Entrez, Source | protective protein for beta-galactosidase (galactosialidosis) | 5068 | 0.014 | 0.3863 | No |
| 25 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 5077 | 0.014 | 0.3886 | No |
| 26 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 5519 | 0.008 | 0.3570 | No |
| 27 | FTH1 | FTH1 Entrez, Source | ferritin, heavy polypeptide 1 | 5816 | 0.004 | 0.3357 | No |
| 28 | ODC1 | ODC1 Entrez, Source | ornithine decarboxylase 1 | 5974 | 0.002 | 0.3244 | No |
| 29 | PEX19 | PEX19 Entrez, Source | peroxisomal biogenesis factor 19 | 5980 | 0.002 | 0.3245 | No |
| 30 | ALAS1 | ALAS1 Entrez, Source | aminolevulinate, delta-, synthase 1 | 6928 | -0.010 | 0.2553 | No |
| 31 | FBLN5 | FBLN5 Entrez, Source | fibulin 5 | 6975 | -0.010 | 0.2539 | No |
| 32 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 7433 | -0.016 | 0.2228 | No |
| 33 | DAD1 | DAD1 Entrez, Source | defender against cell death 1 | 7549 | -0.017 | 0.2177 | No |
| 34 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 7678 | -0.019 | 0.2119 | No |
| 35 | IDH1 | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 7828 | -0.021 | 0.2050 | No |
| 36 | CYB5B | CYB5B Entrez, Source | cytochrome b5 type B (outer mitochondrial membrane) | 8415 | -0.030 | 0.1670 | No |
| 37 | CALR | CALR Entrez, Source | calreticulin | 8727 | -0.034 | 0.1505 | No |
| 38 | TFF3 | TFF3 Entrez, Source | trefoil factor 3 (intestinal) | 8741 | -0.034 | 0.1565 | No |
| 39 | AKR1A1 | AKR1A1 Entrez, Source | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 9857 | -0.051 | 0.0830 | No |
| 40 | ATP2A2 | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 9899 | -0.052 | 0.0905 | No |
| 41 | OAT | OAT Entrez, Source | ornithine aminotransferase (gyrate atrophy) | 11140 | -0.077 | 0.0129 | No |
| 42 | SLC9A1 | SLC9A1 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) | 11386 | -0.084 | 0.0116 | No |
| 43 | TKT | TKT Entrez, Source | transketolase (Wernicke-Korsakoff syndrome) | 12039 | -0.104 | -0.0161 | No |
| 44 | AQP8 | AQP8 Entrez, Source | aquaporin 8 | 12909 | -0.166 | -0.0476 | No |
| 45 | LIMS2 | LIMS2 Entrez, Source | LIM and senescent cell antigen-like domains 2 | 13040 | -0.196 | -0.0175 | No |
| 46 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 13048 | -0.197 | 0.0221 | No |
