Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HYPOXIA_REVIEW |
| Enrichment Score (ES) | 0.588661 |
| Normalized Enrichment Score (NES) | 1.9668573 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.00796392 |
| FWER p-Value | 0.315 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | VIM | VIM Entrez, Source | vimentin | 6 | 0.953 | 0.1079 | Yes |
| 2 | ADM | ADM Entrez, Source | adrenomedullin | 34 | 0.649 | 0.1796 | Yes |
| 3 | PFKP | PFKP Entrez, Source | phosphofructokinase, platelet | 52 | 0.576 | 0.2438 | Yes |
| 4 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 76 | 0.477 | 0.2963 | Yes |
| 5 | EDN1 | EDN1 Entrez, Source | endothelin 1 | 113 | 0.410 | 0.3402 | Yes |
| 6 | FOS | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 142 | 0.371 | 0.3802 | Yes |
| 7 | HK1 | HK1 Entrez, Source | hexokinase 1 | 197 | 0.323 | 0.4129 | Yes |
| 8 | TAGLN | TAGLN Entrez, Source | transgelin | 253 | 0.280 | 0.4405 | Yes |
| 9 | ENPEP | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 338 | 0.234 | 0.4608 | Yes |
| 10 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 418 | 0.205 | 0.4781 | Yes |
| 11 | JUN | JUN Entrez, Source | jun oncogene | 458 | 0.194 | 0.4971 | Yes |
| 12 | IGF2 | IGF2 Entrez, Source | insulin-like growth factor 2 (somatomedin A) | 480 | 0.186 | 0.5167 | Yes |
| 13 | IGFBP1 | IGFBP1 Entrez, Source | insulin-like growth factor binding protein 1 | 531 | 0.177 | 0.5330 | Yes |
| 14 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 567 | 0.170 | 0.5497 | Yes |
| 15 | FLT1 | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 699 | 0.150 | 0.5570 | Yes |
| 16 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 1105 | 0.114 | 0.5395 | Yes |
| 17 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 1177 | 0.111 | 0.5467 | Yes |
| 18 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 1212 | 0.109 | 0.5565 | Yes |
| 19 | L1CAM | L1CAM Entrez, Source | L1 cell adhesion molecule | 1321 | 0.103 | 0.5601 | Yes |
| 20 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 1327 | 0.103 | 0.5713 | Yes |
| 21 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 1345 | 0.102 | 0.5816 | Yes |
| 22 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 1404 | 0.098 | 0.5884 | Yes |
| 23 | BIK | BIK Entrez, Source | BCL2-interacting killer (apoptosis-inducing) | 1540 | 0.092 | 0.5887 | Yes |
| 24 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 1676 | 0.086 | 0.5882 | No |
| 25 | BNIP3L | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 1863 | 0.078 | 0.5831 | No |
| 26 | P4HA1 | P4HA1 Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | 2075 | 0.071 | 0.5752 | No |
| 27 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 2079 | 0.071 | 0.5830 | No |
| 28 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 2140 | 0.069 | 0.5863 | No |
| 29 | STC1 | STC1 Entrez, Source | stanniocalcin 1 | 3324 | 0.042 | 0.5020 | No |
| 30 | PFKL | PFKL Entrez, Source | phosphofructokinase, liver | 3325 | 0.042 | 0.5067 | No |
| 31 | CD99 | CD99 Entrez, Source | CD99 molecule | 3891 | 0.032 | 0.4678 | No |
| 32 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 3915 | 0.032 | 0.4696 | No |
| 33 | ANGPT2 | ANGPT2 Entrez, Source | angiopoietin 2 | 4649 | 0.020 | 0.4167 | No |
| 34 | GAPDH | GAPDH Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase | 4797 | 0.018 | 0.4078 | No |
| 35 | AK3 | AK3 Entrez, Source | adenylate kinase 3 | 4820 | 0.018 | 0.4081 | No |
| 36 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 4892 | 0.017 | 0.4047 | No |
| 37 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 4953 | 0.016 | 0.4020 | No |
| 38 | EPO | EPO Entrez, Source | erythropoietin | 5541 | 0.008 | 0.3586 | No |
| 39 | APEX1 | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 6464 | -0.004 | 0.2896 | No |
| 40 | TFRC | TFRC Entrez, Source | transferrin receptor (p90, CD71) | 6700 | -0.007 | 0.2728 | No |
| 41 | TH | TH Entrez, Source | tyrosine hydroxylase | 6779 | -0.008 | 0.2678 | No |
| 42 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 7317 | -0.014 | 0.2290 | No |
| 43 | HK2 | HK2 Entrez, Source | hexokinase 2 | 7823 | -0.021 | 0.1933 | No |
| 44 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 7852 | -0.021 | 0.1937 | No |
| 45 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 7976 | -0.023 | 0.1870 | No |
| 46 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 8663 | -0.033 | 0.1391 | No |
| 47 | TFF3 | TFF3 Entrez, Source | trefoil factor 3 (intestinal) | 8741 | -0.034 | 0.1372 | No |
| 48 | PGK1 | PGK1 Entrez, Source | phosphoglycerate kinase 1 | 9144 | -0.039 | 0.1114 | No |
| 49 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 9252 | -0.041 | 0.1080 | No |
| 50 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9350 | -0.043 | 0.1055 | No |
| 51 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 9694 | -0.049 | 0.0852 | No |
| 52 | SLC2A3 | SLC2A3 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 3 | 9985 | -0.053 | 0.0694 | No |
| 53 | MIF | MIF Entrez, Source | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 10013 | -0.054 | 0.0735 | No |
| 54 | CP | CP Entrez, Source | ceruloplasmin (ferroxidase) | 10079 | -0.055 | 0.0748 | No |
| 55 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 10192 | -0.057 | 0.0728 | No |
| 56 | XRCC5 | XRCC5 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) | 10199 | -0.057 | 0.0788 | No |
| 57 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 10486 | -0.062 | 0.0643 | No |
| 58 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 10686 | -0.066 | 0.0568 | No |
| 59 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 10957 | -0.072 | 0.0447 | No |
| 60 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 11121 | -0.076 | 0.0411 | No |
| 61 | EDN2 | EDN2 Entrez, Source | endothelin 2 | 11417 | -0.084 | 0.0284 | No |
| 62 | FGF3 | FGF3 Entrez, Source | fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog) | 11658 | -0.090 | 0.0206 | No |
| 63 | HMOX1 | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 12319 | -0.117 | -0.0158 | No |
| 64 | XRCC6 | XRCC6 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) | 12731 | -0.144 | -0.0303 | No |
| 65 | DDIT3 | DDIT3 Entrez, Source | DNA-damage-inducible transcript 3 | 13156 | -0.227 | -0.0365 | No |
| 66 | TF | TF Entrez, Source | transferrin | 13312 | -0.444 | 0.0023 | No |
