Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | LIGASE_ACTIVITY |
| Enrichment Score (ES) | -0.41452867 |
| Normalized Enrichment Score (NES) | -1.3861905 |
| Nominal p-value | 0.046875 |
| FDR q-value | 0.49946135 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | XRCC4 | XRCC4 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 4 | 586 | 0.167 | 0.0047 | No |
| 2 | BTD | BTD Entrez, Source | biotinidase | 670 | 0.155 | 0.0438 | No |
| 3 | PC | PC Entrez, Source | pyruvate carboxylase | 895 | 0.130 | 0.0648 | No |
| 4 | RNF14 | RNF14 Entrez, Source | ring finger protein 14 | 1452 | 0.096 | 0.0511 | No |
| 5 | FBXL6 | FBXL6 Entrez, Source | F-box and leucine-rich repeat protein 6 | 1517 | 0.093 | 0.0735 | No |
| 6 | FARS2 | FARS2 Entrez, Source | phenylalanine-tRNA synthetase 2 (mitochondrial) | 1738 | 0.083 | 0.0812 | No |
| 7 | CTPS2 | CTPS2 Entrez, Source | CTP synthase II | 2446 | 0.061 | 0.0459 | No |
| 8 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 3216 | 0.044 | 0.0010 | No |
| 9 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 3507 | 0.039 | -0.0095 | No |
| 10 | PCCB | PCCB Entrez, Source | propionyl Coenzyme A carboxylase, beta polypeptide | 3873 | 0.032 | -0.0276 | No |
| 11 | ANAPC2 | ANAPC2 Entrez, Source | anaphase promoting complex subunit 2 | 3939 | 0.031 | -0.0233 | No |
| 12 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 4865 | 0.017 | -0.0878 | No |
| 13 | WWP1 | WWP1 Entrez, Source | WW domain containing E3 ubiquitin protein ligase 1 | 4986 | 0.015 | -0.0923 | No |
| 14 | CPS1 | CPS1 Entrez, Source | carbamoyl-phosphate synthetase 1, mitochondrial | 5149 | 0.013 | -0.1007 | No |
| 15 | RTCD1 | RTCD1 Entrez, Source | RNA terminal phosphate cyclase domain 1 | 5993 | 0.002 | -0.1634 | No |
| 16 | FBXO2 | FBXO2 Entrez, Source | F-box protein 2 | 6030 | 0.002 | -0.1656 | No |
| 17 | FBXO22 | FBXO22 Entrez, Source | F-box protein 22 | 6553 | -0.005 | -0.2034 | No |
| 18 | ACSL4 | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 7452 | -0.016 | -0.2662 | No |
| 19 | UBE2L6 | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 7569 | -0.018 | -0.2697 | No |
| 20 | GSS | GSS Entrez, Source | glutathione synthetase | 7964 | -0.023 | -0.2927 | No |
| 21 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 8408 | -0.029 | -0.3173 | No |
| 22 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 8858 | -0.036 | -0.3407 | No |
| 23 | FBXO7 | FBXO7 Entrez, Source | F-box protein 7 | 9502 | -0.045 | -0.3759 | No |
| 24 | NARS | NARS Entrez, Source | asparaginyl-tRNA synthetase | 10017 | -0.054 | -0.3988 | Yes |
| 25 | GMPS | GMPS Entrez, Source | guanine monphosphate synthetase | 10172 | -0.056 | -0.3939 | Yes |
| 26 | ARIH1 | ARIH1 Entrez, Source | ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) | 10214 | -0.057 | -0.3804 | Yes |
| 27 | DARS | DARS Entrez, Source | aspartyl-tRNA synthetase | 10246 | -0.057 | -0.3659 | Yes |
| 28 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 10785 | -0.068 | -0.3865 | Yes |
| 29 | PAICS | PAICS Entrez, Source | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 10929 | -0.072 | -0.3763 | Yes |
| 30 | KARS | KARS Entrez, Source | lysyl-tRNA synthetase | 11005 | -0.073 | -0.3605 | Yes |
| 31 | ASNS | ASNS Entrez, Source | asparagine synthetase | 11024 | -0.074 | -0.3403 | Yes |
| 32 | MTHFD1 | MTHFD1 Entrez, Source | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 11282 | -0.081 | -0.3361 | Yes |
| 33 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 11312 | -0.082 | -0.3143 | Yes |
| 34 | ACACA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 11328 | -0.082 | -0.2915 | Yes |
| 35 | PARK2 | PARK2 Entrez, Source | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 11750 | -0.094 | -0.2958 | Yes |
| 36 | GARS | GARS Entrez, Source | glycyl-tRNA synthetase | 11841 | -0.097 | -0.2741 | Yes |
| 37 | SYVN1 | SYVN1 Entrez, Source | synovial apoptosis inhibitor 1, synoviolin | 11899 | -0.099 | -0.2494 | Yes |
| 38 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 11974 | -0.102 | -0.2253 | Yes |
| 39 | GCLM | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 12046 | -0.105 | -0.2000 | Yes |
| 40 | YARS | YARS Entrez, Source | tyrosyl-tRNA synthetase | 12233 | -0.113 | -0.1811 | Yes |
| 41 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 12866 | -0.161 | -0.1816 | Yes |
| 42 | TRIM23 | TRIM23 Entrez, Source | tripartite motif-containing 23 | 13053 | -0.198 | -0.1377 | Yes |
| 43 | SLC27A5 | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 13326 | -0.545 | 0.0012 | Yes |
