Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | LVAD_HEARTFAILURE_UP |
| Enrichment Score (ES) | 0.63373893 |
| Normalized Enrichment Score (NES) | 2.0709462 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0030263725 |
| FWER p-Value | 0.063 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 12 | 0.803 | 0.1001 | Yes |
| 2 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 22 | 0.685 | 0.1855 | Yes |
| 3 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 32 | 0.660 | 0.2678 | Yes |
| 4 | ANKRD1 | ANKRD1 Entrez, Source | ankyrin repeat domain 1 (cardiac muscle) | 63 | 0.532 | 0.3324 | Yes |
| 5 | AGTR1 | AGTR1 Entrez, Source | angiotensin II receptor, type 1 | 184 | 0.332 | 0.3651 | Yes |
| 6 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 218 | 0.309 | 0.4015 | Yes |
| 7 | TSC22D3 | TSC22D3 Entrez, Source | TSC22 domain family, member 3 | 276 | 0.263 | 0.4303 | Yes |
| 8 | SLC38A2 | SLC38A2 Entrez, Source | solute carrier family 38, member 2 | 302 | 0.248 | 0.4597 | Yes |
| 9 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 326 | 0.238 | 0.4879 | Yes |
| 10 | FKBP5 | FKBP5 Entrez, Source | FK506 binding protein 5 | 335 | 0.235 | 0.5168 | Yes |
| 11 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 350 | 0.230 | 0.5447 | Yes |
| 12 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 406 | 0.208 | 0.5667 | Yes |
| 13 | JUN | JUN Entrez, Source | jun oncogene | 458 | 0.194 | 0.5872 | Yes |
| 14 | ADFP | ADFP Entrez, Source | adipose differentiation-related protein | 550 | 0.172 | 0.6020 | Yes |
| 15 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 559 | 0.171 | 0.6229 | Yes |
| 16 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 888 | 0.130 | 0.6146 | Yes |
| 17 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 920 | 0.127 | 0.6282 | Yes |
| 18 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1045 | 0.118 | 0.6337 | Yes |
| 19 | PER1 | PER1 Entrez, Source | period homolog 1 (Drosophila) | 1347 | 0.101 | 0.6238 | No |
| 20 | RRAS2 | RRAS2 Entrez, Source | related RAS viral (r-ras) oncogene homolog 2 | 1399 | 0.099 | 0.6324 | No |
| 21 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 1781 | 0.081 | 0.6139 | No |
| 22 | MFAP4 | MFAP4 Entrez, Source | microfibrillar-associated protein 4 | 2115 | 0.069 | 0.5976 | No |
| 23 | FSTL3 | FSTL3 Entrez, Source | follistatin-like 3 (secreted glycoprotein) | 2235 | 0.066 | 0.5970 | No |
| 24 | HYAL2 | HYAL2 Entrez, Source | hyaluronoglucosaminidase 2 | 2389 | 0.062 | 0.5933 | No |
| 25 | CLU | CLU Entrez, Source | clusterin | 3299 | 0.043 | 0.5302 | No |
| 26 | CHST3 | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 3649 | 0.036 | 0.5085 | No |
| 27 | RGC32 | RGC32 Entrez, Source | - | 3775 | 0.034 | 0.5034 | No |
| 28 | PPAP2A | PPAP2A Entrez, Source | phosphatidic acid phosphatase type 2A | 3851 | 0.033 | 0.5018 | No |
| 29 | CSDC2 | CSDC2 Entrez, Source | cold shock domain containing C2, RNA binding | 4031 | 0.030 | 0.4921 | No |
| 30 | CDC37L1 | CDC37L1 Entrez, Source | CDC37 cell division cycle 37 homolog (S. cerevisiae)-like 1 | 5099 | 0.014 | 0.4136 | No |
| 31 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 5266 | 0.012 | 0.4025 | No |
| 32 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 5268 | 0.012 | 0.4039 | No |
| 33 | CYP4B1 | CYP4B1 Entrez, Source | cytochrome P450, family 4, subfamily B, polypeptide 1 | 5380 | 0.010 | 0.3968 | No |
| 34 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 5464 | 0.009 | 0.3917 | No |
| 35 | NID1 | NID1 Entrez, Source | nidogen 1 | 6133 | 0.000 | 0.3414 | No |
| 36 | MYOM1 | MYOM1 Entrez, Source | myomesin 1 (skelemin) 185kDa | 6209 | -0.001 | 0.3359 | No |
| 37 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 6220 | -0.001 | 0.3352 | No |
| 38 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 6769 | -0.008 | 0.2950 | No |
| 39 | IER5 | IER5 Entrez, Source | immediate early response 5 | 6896 | -0.009 | 0.2867 | No |
| 40 | AREG | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 7265 | -0.014 | 0.2607 | No |
| 41 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 7542 | -0.017 | 0.2421 | No |
| 42 | NFIL3 | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 7648 | -0.019 | 0.2366 | No |
| 43 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 7976 | -0.023 | 0.2149 | No |
| 44 | RERE | RERE Entrez, Source | arginine-glutamic acid dipeptide (RE) repeats | 9139 | -0.039 | 0.1323 | No |
| 45 | CNN1 | CNN1 Entrez, Source | calponin 1, basic, smooth muscle | 9196 | -0.040 | 0.1332 | No |
| 46 | SLCO4A1 | SLCO4A1 Entrez, Source | solute carrier organic anion transporter family, member 4A1 | 9411 | -0.044 | 0.1226 | No |
| 47 | ZBTB16 | ZBTB16 Entrez, Source | zinc finger and BTB domain containing 16 | 10088 | -0.055 | 0.0786 | No |
| 48 | GLUL | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 10574 | -0.064 | 0.0501 | No |
| 49 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 11340 | -0.083 | 0.0029 | No |
| 50 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 12195 | -0.111 | -0.0474 | No |
| 51 | DIXDC1 | DIXDC1 Entrez, Source | DIX domain containing 1 | 12665 | -0.138 | -0.0653 | No |
| 52 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 12743 | -0.146 | -0.0528 | No |
| 53 | INSR | INSR Entrez, Source | insulin receptor | 12948 | -0.173 | -0.0464 | No |
| 54 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 13037 | -0.195 | -0.0284 | No |
| 55 | GADD45G | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 13302 | -0.408 | 0.0030 | No |
