Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | MANALO_HYPOXIA_DN |
| Enrichment Score (ES) | -0.52377796 |
| Normalized Enrichment Score (NES) | -1.7077918 |
| Nominal p-value | 0.013422819 |
| FDR q-value | 0.2030935 |
| FWER p-Value | 0.998 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HNRPD | HNRPD Entrez, Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 389 | 0.213 | 0.0308 | No |
| 2 | BARD1 | BARD1 Entrez, Source | BRCA1 associated RING domain 1 | 832 | 0.136 | 0.0359 | No |
| 3 | ZWINT | ZWINT Entrez, Source | ZW10 interactor | 1485 | 0.095 | 0.0136 | No |
| 4 | POLG | POLG Entrez, Source | polymerase (DNA directed), gamma | 3170 | 0.045 | -0.1003 | No |
| 5 | CCNF | CCNF Entrez, Source | cyclin F | 4470 | 0.023 | -0.1916 | No |
| 6 | MFN2 | MFN2 Entrez, Source | mitofusin 2 | 4545 | 0.022 | -0.1910 | No |
| 7 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 5296 | 0.011 | -0.2442 | No |
| 8 | HNRPDL | HNRPDL Entrez, Source | heterogeneous nuclear ribonucleoprotein D-like | 5830 | 0.004 | -0.2831 | No |
| 9 | UCHL5 | UCHL5 Entrez, Source | ubiquitin carboxyl-terminal hydrolase L5 | 7725 | -0.020 | -0.4199 | No |
| 10 | MLLT10 | MLLT10 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 7737 | -0.020 | -0.4152 | No |
| 11 | SFRS2 | SFRS2 Entrez, Source | splicing factor, arginine/serine-rich 2 | 8111 | -0.025 | -0.4361 | No |
| 12 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 8663 | -0.033 | -0.4682 | No |
| 13 | ATIC | ATIC Entrez, Source | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 8726 | -0.034 | -0.4633 | No |
| 14 | UMPS | UMPS Entrez, Source | uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) | 8780 | -0.035 | -0.4576 | No |
| 15 | BOP1 | BOP1 Entrez, Source | block of proliferation 1 | 8881 | -0.036 | -0.4550 | No |
| 16 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 9276 | -0.041 | -0.4729 | No |
| 17 | TRIP13 | TRIP13 Entrez, Source | thyroid hormone receptor interactor 13 | 9335 | -0.042 | -0.4654 | No |
| 18 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 9651 | -0.048 | -0.4756 | No |
| 19 | GTPBP4 | GTPBP4 Entrez, Source | GTP binding protein 4 | 9786 | -0.050 | -0.4716 | No |
| 20 | PSME3 | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 9831 | -0.051 | -0.4606 | No |
| 21 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 9891 | -0.052 | -0.4504 | No |
| 22 | MRPL40 | MRPL40 Entrez, Source | mitochondrial ribosomal protein L40 | 9957 | -0.053 | -0.4404 | No |
| 23 | ORC6L | ORC6L Entrez, Source | origin recognition complex, subunit 6 like (yeast) | 10103 | -0.055 | -0.4358 | No |
| 24 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 11274 | -0.081 | -0.5011 | Yes |
| 25 | MRPL46 | MRPL46 Entrez, Source | mitochondrial ribosomal protein L46 | 11292 | -0.081 | -0.4795 | Yes |
| 26 | DDX18 | DDX18 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 11433 | -0.085 | -0.4661 | Yes |
| 27 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11628 | -0.090 | -0.4555 | Yes |
| 28 | DHFR | DHFR Entrez, Source | dihydrofolate reductase | 11751 | -0.094 | -0.4382 | Yes |
| 29 | NOL5A | NOL5A Entrez, Source | nucleolar protein 5A (56kDa with KKE/D repeat) | 11821 | -0.096 | -0.4163 | Yes |
| 30 | PSME4 | PSME4 Entrez, Source | proteasome (prosome, macropain) activator subunit 4 | 12096 | -0.107 | -0.4068 | Yes |
| 31 | TFAM | TFAM Entrez, Source | transcription factor A, mitochondrial | 12152 | -0.109 | -0.3801 | Yes |
| 32 | ELK1 | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 12168 | -0.110 | -0.3501 | Yes |
| 33 | PA2G4 | PA2G4 Entrez, Source | proliferation-associated 2G4, 38kDa | 12425 | -0.123 | -0.3348 | Yes |
| 34 | HNRPU | HNRPU Entrez, Source | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 12429 | -0.123 | -0.3005 | Yes |
| 35 | NOLC1 | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 12447 | -0.123 | -0.2669 | Yes |
| 36 | USP1 | USP1 Entrez, Source | ubiquitin specific peptidase 1 | 12463 | -0.125 | -0.2329 | Yes |
| 37 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 12520 | -0.130 | -0.2006 | Yes |
| 38 | ILF3 | ILF3 Entrez, Source | interleukin enhancer binding factor 3, 90kDa | 12652 | -0.138 | -0.1716 | Yes |
| 39 | NEK4 | NEK4 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 4 | 12883 | -0.162 | -0.1432 | Yes |
| 40 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 13067 | -0.201 | -0.1003 | Yes |
| 41 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 13114 | -0.214 | -0.0434 | Yes |
| 42 | RPL39 | RPL39 Entrez, Source | ribosomal protein L39 | 13115 | -0.215 | 0.0171 | Yes |
