Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | MANALO_HYPOXIA_UP |
| Enrichment Score (ES) | 0.59461075 |
| Normalized Enrichment Score (NES) | 2.019544 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0043388736 |
| FWER p-Value | 0.147 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 3 | 1.046 | 0.1364 | Yes |
| 2 | ADM | ADM Entrez, Source | adrenomedullin | 34 | 0.649 | 0.2189 | Yes |
| 3 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 50 | 0.578 | 0.2932 | Yes |
| 4 | LOX | LOX Entrez, Source | lysyl oxidase | 82 | 0.465 | 0.3517 | Yes |
| 5 | EDN1 | EDN1 Entrez, Source | endothelin 1 | 113 | 0.410 | 0.4030 | Yes |
| 6 | ANGPTL4 | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 147 | 0.365 | 0.4481 | Yes |
| 7 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 332 | 0.236 | 0.4651 | Yes |
| 8 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 375 | 0.218 | 0.4904 | Yes |
| 9 | GRK5 | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 401 | 0.209 | 0.5158 | Yes |
| 10 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 496 | 0.183 | 0.5326 | Yes |
| 11 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 567 | 0.170 | 0.5495 | Yes |
| 12 | LEPR | LEPR Entrez, Source | leptin receptor | 711 | 0.149 | 0.5583 | Yes |
| 13 | RGS3 | RGS3 Entrez, Source | regulator of G-protein signalling 3 | 762 | 0.144 | 0.5733 | Yes |
| 14 | TNFRSF14 | TNFRSF14 Entrez, Source | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 852 | 0.134 | 0.5841 | Yes |
| 15 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1045 | 0.118 | 0.5850 | Yes |
| 16 | PLCG2 | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 1116 | 0.114 | 0.5946 | Yes |
| 17 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 1404 | 0.098 | 0.5858 | No |
| 18 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 1730 | 0.083 | 0.5722 | No |
| 19 | STC2 | STC2 Entrez, Source | stanniocalcin 2 | 2009 | 0.073 | 0.5608 | No |
| 20 | HES1 | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 2278 | 0.065 | 0.5491 | No |
| 21 | HIF3A | HIF3A Entrez, Source | hypoxia inducible factor 3, alpha subunit | 2328 | 0.064 | 0.5537 | No |
| 22 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 2597 | 0.058 | 0.5411 | No |
| 23 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 2881 | 0.051 | 0.5265 | No |
| 24 | COL18A1 | COL18A1 Entrez, Source | collagen, type XVIII, alpha 1 | 3249 | 0.044 | 0.5045 | No |
| 25 | STC1 | STC1 Entrez, Source | stanniocalcin 1 | 3324 | 0.042 | 0.5044 | No |
| 26 | TRIO | TRIO Entrez, Source | triple functional domain (PTPRF interacting) | 3491 | 0.039 | 0.4970 | No |
| 27 | ZNF292 | ZNF292 Entrez, Source | zinc finger protein 292 | 3872 | 0.032 | 0.4726 | No |
| 28 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 3975 | 0.031 | 0.4689 | No |
| 29 | NFATC4 | NFATC4 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 4051 | 0.029 | 0.4671 | No |
| 30 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 4288 | 0.026 | 0.4527 | No |
| 31 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 4596 | 0.021 | 0.4323 | No |
| 32 | ERO1L | ERO1L Entrez, Source | ERO1-like (S. cerevisiae) | 4604 | 0.021 | 0.4345 | No |
| 33 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 4610 | 0.021 | 0.4369 | No |
| 34 | AK3 | AK3 Entrez, Source | adenylate kinase 3 | 4820 | 0.018 | 0.4235 | No |
| 35 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 5501 | 0.008 | 0.3733 | No |
| 36 | PTGS1 | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 5536 | 0.008 | 0.3718 | No |
| 37 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 5649 | 0.006 | 0.3642 | No |
| 38 | PTPRR | PTPRR Entrez, Source | protein tyrosine phosphatase, receptor type, R | 6102 | 0.001 | 0.3302 | No |
| 39 | COL9A1 | COL9A1 Entrez, Source | collagen, type IX, alpha 1 | 6489 | -0.004 | 0.3017 | No |
| 40 | NOTCH4 | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 6512 | -0.005 | 0.3006 | No |
| 41 | ITPR2 | ITPR2 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 2 | 6591 | -0.006 | 0.2955 | No |
| 42 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 6962 | -0.010 | 0.2689 | No |
| 43 | EPOR | EPOR Entrez, Source | erythropoietin receptor | 7361 | -0.015 | 0.2409 | No |
| 44 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 7447 | -0.016 | 0.2366 | No |
| 45 | ADORA2A | ADORA2A Entrez, Source | adenosine A2a receptor | 7525 | -0.017 | 0.2330 | No |
| 46 | CUBN | CUBN Entrez, Source | cubilin (intrinsic factor-cobalamin receptor) | 7631 | -0.019 | 0.2276 | No |
| 47 | NPR1 | NPR1 Entrez, Source | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) | 7769 | -0.020 | 0.2199 | No |
| 48 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 7852 | -0.021 | 0.2165 | No |
| 49 | TCF8 | TCF8 Entrez, Source | transcription factor 8 (represses interleukin 2 expression) | 8084 | -0.025 | 0.2023 | No |
| 50 | PPARG | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 8513 | -0.031 | 0.1741 | No |
| 51 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 8731 | -0.034 | 0.1622 | No |
| 52 | PTGIS | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 9012 | -0.038 | 0.1461 | No |
| 53 | EGLN1 | EGLN1 Entrez, Source | egl nine homolog 1 (C. elegans) | 9099 | -0.039 | 0.1447 | No |
| 54 | HIVEP2 | HIVEP2 Entrez, Source | human immunodeficiency virus type I enhancer binding protein 2 | 9216 | -0.040 | 0.1412 | No |
| 55 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9350 | -0.043 | 0.1368 | No |
| 56 | PTPRF | PTPRF Entrez, Source | protein tyrosine phosphatase, receptor type, F | 9495 | -0.045 | 0.1318 | No |
| 57 | RLN1 | RLN1 Entrez, Source | relaxin 1 | 9596 | -0.047 | 0.1304 | No |
| 58 | CDH2 | CDH2 Entrez, Source | cadherin 2, type 1, N-cadherin (neuronal) | 9642 | -0.048 | 0.1332 | No |
| 59 | FKBP9 | FKBP9 Entrez, Source | FK506 binding protein 9, 63 kDa | 10052 | -0.054 | 0.1095 | No |
| 60 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 10686 | -0.066 | 0.0704 | No |
| 61 | GDF10 | GDF10 Entrez, Source | growth differentiation factor 10 | 10910 | -0.071 | 0.0629 | No |
| 62 | SHOX2 | SHOX2 Entrez, Source | short stature homeobox 2 | 11349 | -0.083 | 0.0407 | No |
| 63 | ENPP1 | ENPP1 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 11362 | -0.083 | 0.0507 | No |
| 64 | CASK | CASK Entrez, Source | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 12276 | -0.115 | -0.0031 | No |
| 65 | ZBTB1 | ZBTB1 Entrez, Source | zinc finger and BTB domain containing 1 | 12766 | -0.148 | -0.0205 | No |
| 66 | INSR | INSR Entrez, Source | insulin receptor | 12948 | -0.173 | -0.0116 | No |
| 67 | VLDLR | VLDLR Entrez, Source | very low density lipoprotein receptor | 13265 | -0.315 | 0.0058 | No |
