Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | MENSE_HYPOXIA_UP |
| Enrichment Score (ES) | 0.5548492 |
| Normalized Enrichment Score (NES) | 1.8347859 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.027021622 |
| FWER p-Value | 0.905 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | BHLHB3 | BHLHB3 Entrez, Source | basic helix-loop-helix domain containing, class B, 3 | 23 | 0.682 | 0.1098 | Yes |
| 2 | ADM | ADM Entrez, Source | adrenomedullin | 34 | 0.649 | 0.2151 | Yes |
| 3 | LOX | LOX Entrez, Source | lysyl oxidase | 82 | 0.465 | 0.2877 | Yes |
| 4 | ANGPTL4 | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 147 | 0.365 | 0.3425 | Yes |
| 5 | SLC6A6 | SLC6A6 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 201 | 0.321 | 0.3910 | Yes |
| 6 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 218 | 0.309 | 0.4404 | Yes |
| 7 | NOL3 | NOL3 Entrez, Source | nucleolar protein 3 (apoptosis repressor with CARD domain) | 325 | 0.238 | 0.4714 | Yes |
| 8 | ADFP | ADFP Entrez, Source | adipose differentiation-related protein | 550 | 0.172 | 0.4826 | Yes |
| 9 | RAB40C | RAB40C Entrez, Source | RAB40C, member RAS oncogene family | 902 | 0.129 | 0.4773 | Yes |
| 10 | WSB1 | WSB1 Entrez, Source | WD repeat and SOCS box-containing 1 | 1023 | 0.119 | 0.4878 | Yes |
| 11 | KLF4 | KLF4 Entrez, Source | Kruppel-like factor 4 (gut) | 1086 | 0.116 | 0.5021 | Yes |
| 12 | PPFIA4 | PPFIA4 Entrez, Source | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 1099 | 0.115 | 0.5199 | Yes |
| 13 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 1177 | 0.111 | 0.5322 | Yes |
| 14 | INSIG1 | INSIG1 Entrez, Source | insulin induced gene 1 | 1616 | 0.089 | 0.5138 | Yes |
| 15 | HCFC1R1 | HCFC1R1 Entrez, Source | host cell factor C1 regulator 1 (XPO1 dependent) | 1668 | 0.086 | 0.5240 | Yes |
| 16 | CEBPB | CEBPB Entrez, Source | CCAAT/enhancer binding protein (C/EBP), beta | 1774 | 0.082 | 0.5294 | Yes |
| 17 | BNIP3L | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 1863 | 0.078 | 0.5355 | Yes |
| 18 | STC2 | STC2 Entrez, Source | stanniocalcin 2 | 2009 | 0.073 | 0.5365 | Yes |
| 19 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 2068 | 0.071 | 0.5437 | Yes |
| 20 | P4HA1 | P4HA1 Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | 2075 | 0.071 | 0.5548 | Yes |
| 21 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 2881 | 0.051 | 0.5026 | No |
| 22 | CTTN | CTTN Entrez, Source | cortactin | 3493 | 0.039 | 0.4630 | No |
| 23 | ERO1L | ERO1L Entrez, Source | ERO1-like (S. cerevisiae) | 4604 | 0.021 | 0.3829 | No |
| 24 | KLHL24 | KLHL24 Entrez, Source | kelch-like 24 (Drosophila) | 4739 | 0.019 | 0.3759 | No |
| 25 | SCD | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 5035 | 0.015 | 0.3561 | No |
| 26 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 5268 | 0.012 | 0.3406 | No |
| 27 | ALDOC | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 5585 | 0.007 | 0.3179 | No |
| 28 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 5788 | 0.005 | 0.3035 | No |
| 29 | NADSYN1 | NADSYN1 Entrez, Source | NAD synthetase 1 | 5953 | 0.003 | 0.2916 | No |
| 30 | ELL2 | ELL2 Entrez, Source | elongation factor, RNA polymerase II, 2 | 6213 | -0.001 | 0.2722 | No |
| 31 | ENO2 | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 6221 | -0.001 | 0.2718 | No |
| 32 | CLK3 | CLK3 Entrez, Source | CDC-like kinase 3 | 6374 | -0.003 | 0.2608 | No |
| 33 | GPI | GPI Entrez, Source | glucose phosphate isomerase | 6561 | -0.005 | 0.2477 | No |
| 34 | PFKFB3 | PFKFB3 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 6724 | -0.007 | 0.2367 | No |
| 35 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 6962 | -0.010 | 0.2205 | No |
| 36 | PPP3CA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 7318 | -0.014 | 0.1962 | No |
| 37 | MTAC2D1 | MTAC2D1 Entrez, Source | membrane targeting (tandem) C2 domain containing 1 | 7403 | -0.015 | 0.1924 | No |
| 38 | GOSR2 | GOSR2 Entrez, Source | golgi SNAP receptor complex member 2 | 7546 | -0.017 | 0.1845 | No |
| 39 | NFIL3 | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 7648 | -0.019 | 0.1800 | No |
| 40 | HK2 | HK2 Entrez, Source | hexokinase 2 | 7823 | -0.021 | 0.1703 | No |
| 41 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 7852 | -0.021 | 0.1717 | No |
| 42 | EGLN1 | EGLN1 Entrez, Source | egl nine homolog 1 (C. elegans) | 9099 | -0.039 | 0.0843 | No |
| 43 | PGK1 | PGK1 Entrez, Source | phosphoglycerate kinase 1 | 9144 | -0.039 | 0.0874 | No |
| 44 | PDK1 | PDK1 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 1 | 9256 | -0.041 | 0.0858 | No |
| 45 | RNASE4 | RNASE4 Entrez, Source | ribonuclease, RNase A family, 4 | 9382 | -0.043 | 0.0834 | No |
| 46 | PTDSR | PTDSR Entrez, Source | phosphatidylserine receptor | 9851 | -0.051 | 0.0565 | No |
| 47 | SPAG4 | SPAG4 Entrez, Source | sperm associated antigen 4 | 9870 | -0.051 | 0.0635 | No |
| 48 | SLC2A3 | SLC2A3 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 3 | 9985 | -0.053 | 0.0637 | No |
| 49 | ABCB6 | ABCB6 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 6 | 10040 | -0.054 | 0.0685 | No |
| 50 | PBEF1 | PBEF1 Entrez, Source | pre-B-cell colony enhancing factor 1 | 10279 | -0.058 | 0.0601 | No |
| 51 | CLPB | CLPB Entrez, Source | ClpB caseinolytic peptidase B homolog (E. coli) | 10465 | -0.061 | 0.0562 | No |
| 52 | GBE1 | GBE1 Entrez, Source | glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV) | 10501 | -0.062 | 0.0638 | No |
| 53 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 10686 | -0.066 | 0.0607 | No |
| 54 | PRPSAP1 | PRPSAP1 Entrez, Source | phosphoribosyl pyrophosphate synthetase-associated protein 1 | 10740 | -0.067 | 0.0677 | No |
| 55 | PFKFB4 | PFKFB4 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 10770 | -0.068 | 0.0766 | No |
| 56 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 12736 | -0.145 | -0.0476 | No |
| 57 | WDR5B | WDR5B Entrez, Source | WD repeat domain 5B | 13007 | -0.186 | -0.0375 | No |
| 58 | PPP1R3C | PPP1R3C Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 13293 | -0.383 | 0.0037 | No |
