Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | NETPATH_NOTCH_PATHWAY |
| Enrichment Score (ES) | -0.34480277 |
| Normalized Enrichment Score (NES) | -1.2086271 |
| Nominal p-value | 0.16129032 |
| FDR q-value | 0.64305633 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 323 | 0.239 | 0.0338 | No |
| 2 | APH1A | APH1A Entrez, Source | anterior pharynx defective 1 homolog A (C. elegans) | 511 | 0.181 | 0.0636 | No |
| 3 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 521 | 0.179 | 0.1064 | No |
| 4 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 631 | 0.160 | 0.1371 | No |
| 5 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 888 | 0.130 | 0.1495 | No |
| 6 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 1729 | 0.083 | 0.1066 | No |
| 7 | LEF1 | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 1786 | 0.081 | 0.1221 | No |
| 8 | HES1 | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 2278 | 0.065 | 0.1009 | No |
| 9 | PSENEN | PSENEN Entrez, Source | presenilin enhancer 2 homolog (C. elegans) | 2434 | 0.061 | 0.1041 | No |
| 10 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 2479 | 0.060 | 0.1155 | No |
| 11 | NOTCH3 | NOTCH3 Entrez, Source | Notch homolog 3 (Drosophila) | 3209 | 0.044 | 0.0714 | No |
| 12 | SKP1A | SKP1A Entrez, Source | S-phase kinase-associated protein 1A (p19A) | 3287 | 0.043 | 0.0761 | No |
| 13 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 3298 | 0.043 | 0.0857 | No |
| 14 | HES5 | HES5 Entrez, Source | hairy and enhancer of split 5 (Drosophila) | 3931 | 0.031 | 0.0457 | No |
| 15 | ADAM10 | ADAM10 Entrez, Source | ADAM metallopeptidase domain 10 | 4533 | 0.022 | 0.0058 | No |
| 16 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 4608 | 0.021 | 0.0054 | No |
| 17 | NUMB | NUMB Entrez, Source | numb homolog (Drosophila) | 4620 | 0.021 | 0.0096 | No |
| 18 | LFNG | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 4798 | 0.018 | 0.0007 | No |
| 19 | GATA1 | GATA1 Entrez, Source | GATA binding protein 1 (globin transcription factor 1) | 5136 | 0.013 | -0.0214 | No |
| 20 | JAG2 | JAG2 Entrez, Source | jagged 2 | 5167 | 0.013 | -0.0205 | No |
| 21 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 5266 | 0.012 | -0.0251 | No |
| 22 | DLL1 | DLL1 Entrez, Source | delta-like 1 (Drosophila) | 5403 | 0.010 | -0.0330 | No |
| 23 | PCAF | PCAF Entrez, Source | p300/CBP-associated factor | 5716 | 0.005 | -0.0551 | No |
| 24 | NOTCH1 | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 6141 | 0.000 | -0.0870 | No |
| 25 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 6260 | -0.001 | -0.0955 | No |
| 26 | POFUT1 | POFUT1 Entrez, Source | protein O-fucosyltransferase 1 | 6279 | -0.002 | -0.0965 | No |
| 27 | NOTCH4 | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 6512 | -0.005 | -0.1128 | No |
| 28 | SMAD1 | SMAD1 Entrez, Source | SMAD, mothers against DPP homolog 1 (Drosophila) | 6658 | -0.007 | -0.1221 | No |
| 29 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 6769 | -0.008 | -0.1285 | No |
| 30 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 6788 | -0.008 | -0.1279 | No |
| 31 | CNTN1 | CNTN1 Entrez, Source | contactin 1 | 6807 | -0.008 | -0.1272 | No |
| 32 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 7440 | -0.016 | -0.1709 | No |
| 33 | MFNG | MFNG Entrez, Source | manic fringe homolog (Drosophila) | 8066 | -0.024 | -0.2120 | No |
| 34 | HEY1 | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 8303 | -0.028 | -0.2230 | No |
| 35 | NCSTN | NCSTN Entrez, Source | nicastrin | 8510 | -0.031 | -0.2310 | No |
| 36 | PSEN1 | PSEN1 Entrez, Source | presenilin 1 (Alzheimer disease 3) | 8599 | -0.032 | -0.2298 | No |
| 37 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 8872 | -0.036 | -0.2415 | No |
| 38 | NUMBL | NUMBL Entrez, Source | numb homolog (Drosophila)-like | 9040 | -0.038 | -0.2449 | No |
| 39 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 9252 | -0.041 | -0.2508 | No |
| 40 | PSEN2 | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 9416 | -0.044 | -0.2524 | No |
| 41 | NCOR1 | NCOR1 Entrez, Source | nuclear receptor co-repressor 1 | 9602 | -0.047 | -0.2550 | No |
| 42 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 9995 | -0.053 | -0.2715 | No |
| 43 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 10765 | -0.068 | -0.3129 | No |
| 44 | RBX1 | RBX1 Entrez, Source | ring-box 1 | 10833 | -0.069 | -0.3011 | No |
| 45 | RING1 | RING1 Entrez, Source | ring finger protein 1 | 11366 | -0.083 | -0.3209 | Yes |
| 46 | YY1 | YY1 Entrez, Source | YY1 transcription factor | 11474 | -0.086 | -0.3082 | Yes |
| 47 | ADAM17 | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 11962 | -0.101 | -0.3202 | Yes |
| 48 | APH1B | APH1B Entrez, Source | anterior pharynx defective 1 homolog B (C. elegans) | 12016 | -0.104 | -0.2990 | Yes |
| 49 | WDR12 | WDR12 Entrez, Source | WD repeat domain 12 | 12091 | -0.107 | -0.2786 | Yes |
| 50 | HES6 | HES6 Entrez, Source | hairy and enhancer of split 6 (Drosophila) | 12756 | -0.147 | -0.2929 | Yes |
| 51 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 13133 | -0.220 | -0.2678 | Yes |
| 52 | JAK2 | JAK2 Entrez, Source | Janus kinase 2 (a protein tyrosine kinase) | 13193 | -0.251 | -0.2113 | Yes |
| 53 | ASCL1 | ASCL1 Entrez, Source | achaete-scute complex-like 1 (Drosophila) | 13340 | -0.915 | 0.0002 | Yes |
