Details for gene set REGULATION_OF_SIGNAL

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_72h_repos
Upregulated in class	double_gel_8d
GeneSet	REGULATION_OF_SIGNAL_TRANSDUCTION
Enrichment Score (ES)	0.47237086
Normalized Enrichment Score (NES)	1.7715099
Nominal p-value	0.0
FDR q-value	0.03628903
FWER p-Value	0.995

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CD24	CD24 Entrez, Source	CD24 molecule	17	0.726	0.0546	Yes
2	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	37	0.635	0.1021	Yes
3	RGS2	RGS2 Entrez, Source	regulator of G-protein signalling 2, 24kDa	42	0.616	0.1492	Yes
4	LGALS1	LGALS1 Entrez, Source	lectin, galactoside-binding, soluble, 1 (galectin 1)	47	0.597	0.1949	Yes
5	F2R	F2R Entrez, Source	coagulation factor II (thrombin) receptor	89	0.456	0.2268	Yes
6	PLCE1	PLCE1 Entrez, Source	phospholipase C, epsilon 1	114	0.408	0.2564	Yes
7	RGS16	RGS16 Entrez, Source	regulator of G-protein signalling 16	126	0.391	0.2857	Yes
8	CDH13	CDH13 Entrez, Source	cadherin 13, H-cadherin (heart)	128	0.391	0.3158	Yes
9	CITED2	CITED2 Entrez, Source	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	145	0.367	0.3428	Yes
10	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	196	0.324	0.3640	Yes
11	RGS4	RGS4 Entrez, Source	regulator of G-protein signalling 4	219	0.308	0.3860	Yes
12	RGS5	RGS5 Entrez, Source	regulator of G-protein signalling 5	306	0.247	0.3985	Yes
13	SLC35B2	SLC35B2 Entrez, Source	solute carrier family 35, member B2	383	0.215	0.4093	Yes
14	GRK5	GRK5 Entrez, Source	G protein-coupled receptor kinase 5	401	0.209	0.4242	Yes
15	PLK2	PLK2 Entrez, Source	polo-like kinase 2 (Drosophila)	414	0.206	0.4391	Yes
16	CD40	CD40 Entrez, Source	CD40 molecule, TNF receptor superfamily member 5	467	0.191	0.4499	Yes
17	SLC20A1	SLC20A1 Entrez, Source	solute carrier family 20 (phosphate transporter), member 1	543	0.173	0.4575	Yes
18	OTX2	OTX2 Entrez, Source	orthodenticle homolog 2 (Drosophila)	708	0.150	0.4566	Yes
19	RGS3	RGS3 Entrez, Source	regulator of G-protein signalling 3	762	0.144	0.4637	Yes
20	TAX1BP3	TAX1BP3 Entrez, Source	Tax1 (human T-cell leukemia virus type I) binding protein 3	791	0.140	0.4724	Yes
21	IL17F	IL17F Entrez, Source	interleukin 17F	946	0.125	0.4704	No
22	RIC8B	RIC8B Entrez, Source	resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)	1253	0.107	0.4555	No
23	EDG2	EDG2 Entrez, Source	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2	1468	0.095	0.4466	No
24	IL22RA2	IL22RA2 Entrez, Source	interleukin 22 receptor, alpha 2	1762	0.082	0.4308	No
25	ABRA	ABRA Entrez, Source	actin-binding Rho activating protein	1785	0.081	0.4353	No
26	TAOK2	TAOK2 Entrez, Source	TAO kinase 2	1868	0.078	0.4351	No
27	PTPRC	PTPRC Entrez, Source	protein tyrosine phosphatase, receptor type, C	2044	0.071	0.4273	No
28	TGFB1	TGFB1 Entrez, Source	transforming growth factor, beta 1 (Camurati-Engelmann disease)	2079	0.071	0.4302	No
29	THY1	THY1 Entrez, Source	Thy-1 cell surface antigen	2131	0.069	0.4317	No
30	ADRB3	ADRB3 Entrez, Source	adrenergic, beta-3-, receptor	2242	0.066	0.4284	No
31	CLCF1	CLCF1 Entrez, Source	cardiotrophin-like cytokine factor 1	2268	0.065	0.4316	No
32	MAPK8IP2	MAPK8IP2 Entrez, Source	mitogen-activated protein kinase 8 interacting protein 2	2493	0.060	0.4192	No
33	CASP8	CASP8 Entrez, Source	caspase 8, apoptosis-related cysteine peptidase	2697	0.055	0.4081	No
34	ECM1	ECM1 Entrez, Source	extracellular matrix protein 1	2924	0.050	0.3949	No
35	GIT1	GIT1 Entrez, Source	G protein-coupled receptor kinase interactor 1	2932	0.050	0.3982	No
36	LGALS9	LGALS9 Entrez, Source	lectin, galactoside-binding, soluble, 9 (galectin 9)	2995	0.049	0.3973	No
37	EREG	EREG Entrez, Source	epiregulin	2999	0.049	0.4008	No
38	AMBP	AMBP Entrez, Source	alpha-1-microglobulin/bikunin precursor	3026	0.048	0.4025	No
39	GRM4	GRM4 Entrez, Source	glutamate receptor, metabotropic 4	3042	0.048	0.4050	No
40	RHOA	RHOA Entrez, Source	ras homolog gene family, member A	3147	0.045	0.4006	No
41	NDFIP1	NDFIP1 Entrez, Source	Nedd4 family interacting protein 1	3203	0.045	0.3999	No
42	CARD9	CARD9 Entrez, Source	caspase recruitment domain family, member 9	3230	0.044	0.4013	No
43	SQSTM1	SQSTM1 Entrez, Source	sequestosome 1	3270	0.043	0.4017	No
44	GRK1	GRK1 Entrez, Source	G protein-coupled receptor kinase 1	3340	0.042	0.3997	No
45	MYD88	MYD88 Entrez, Source	myeloid differentiation primary response gene (88)	3471	0.039	0.3929	No
46	CDKN2B	CDKN2B Entrez, Source	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	3476	0.039	0.3956	No
47	HCLS1	HCLS1 Entrez, Source	hematopoietic cell-specific Lyn substrate 1	3587	0.037	0.3901	No
48	LITAF	LITAF Entrez, Source	lipopolysaccharide-induced TNF factor	3654	0.036	0.3879	No
49	RALBP1	RALBP1 Entrez, Source	ralA binding protein 1	3689	0.035	0.3881	No
50	NUP62	NUP62 Entrez, Source	nucleoporin 62kDa	3799	0.033	0.3824	No
51	ATP2C1	ATP2C1 Entrez, Source	ATPase, Ca++ transporting, type 2C, member 1	3896	0.032	0.3776	No
52	PPP5C	PPP5C Entrez, Source	protein phosphatase 5, catalytic subunit	4060	0.029	0.3675	No
53	ZIC1	ZIC1 Entrez, Source	Zic family member 1 (odd-paired homolog, Drosophila)	4145	0.028	0.3633	No
54	CBLC	CBLC Entrez, Source	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	4320	0.025	0.3520	No
55	ACVR2A	ACVR2A Entrez, Source	activin A receptor, type IIA	4325	0.025	0.3537	No
56	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	4525	0.022	0.3403	No
57	MFN2	MFN2 Entrez, Source	mitofusin 2	4545	0.022	0.3406	No
58	RGS12	RGS12 Entrez, Source	regulator of G-protein signalling 12	4561	0.022	0.3411	No
59	INHBA	INHBA Entrez, Source	inhibin, beta A (activin A, activin AB alpha polypeptide)	4596	0.021	0.3401	No
60	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	4794	0.018	0.3266	No
61	CFLAR	CFLAR Entrez, Source	CASP8 and FADD-like apoptosis regulator	4863	0.017	0.3228	No
62	RHOH	RHOH Entrez, Source	ras homolog gene family, member H	4918	0.016	0.3200	No
63	GRK4	GRK4 Entrez, Source	G protein-coupled receptor kinase 4	5401	0.010	0.2842	No
64	TSC1	TSC1 Entrez, Source	tuberous sclerosis 1	5410	0.010	0.2844	No
65	LTBR	LTBR Entrez, Source	lymphotoxin beta receptor (TNFR superfamily, member 3)	5429	0.009	0.2837	No
66	ZDHHC13	ZDHHC13 Entrez, Source	zinc finger, DHHC-type containing 13	5460	0.009	0.2821	No
67	NF2	NF2 Entrez, Source	neurofibromin 2 (bilateral acoustic neuroma)	5466	0.009	0.2824	No
68	FASLG	FASLG Entrez, Source	Fas ligand (TNF superfamily, member 6)	5984	0.002	0.2435	No
69	GIT2	GIT2 Entrez, Source	G protein-coupled receptor kinase interactor 2	6006	0.002	0.2421	No
70	RGS9	RGS9 Entrez, Source	regulator of G-protein signalling 9	6017	0.002	0.2414	No
71	TMEM101	TMEM101 Entrez, Source	transmembrane protein 101	6093	0.001	0.2358	No
72	RAC1	RAC1 Entrez, Source	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	6128	0.000	0.2333	No
73	ATP6AP2	ATP6AP2 Entrez, Source	ATPase, H+ transporting, lysosomal accessory protein 2	6241	-0.001	0.2249	No
74	RELA	RELA Entrez, Source	v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)	6260	-0.001	0.2236	No
75	FKBP1A	FKBP1A Entrez, Source	FK506 binding protein 1A, 12kDa	6282	-0.002	0.2222	No
76	BCL10	BCL10 Entrez, Source	B-cell CLL/lymphoma 10	6386	-0.003	0.2146	No
77	GLI1	GLI1 Entrez, Source	glioma-associated oncogene homolog 1 (zinc finger protein)	6483	-0.004	0.2077	No
78	FGD1	FGD1 Entrez, Source	FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia)	6676	-0.007	0.1937	No
79	VAPA	VAPA Entrez, Source	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	6685	-0.007	0.1936	No
80	SMAD4	SMAD4 Entrez, Source	SMAD, mothers against DPP homolog 4 (Drosophila)	6788	-0.008	0.1865	No
81	RGS14	RGS14 Entrez, Source	regulator of G-protein signalling 14	6865	-0.009	0.1814	No
82	IL12A	IL12A Entrez, Source	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	6887	-0.009	0.1806	No
83	ARHGAP27	ARHGAP27 Entrez, Source	Rho GTPase activating protein 27	6907	-0.010	0.1798	No
84	TFG	TFG Entrez, Source	TRK-fused gene	7017	-0.011	0.1724	No
85	TRADD	TRADD Entrez, Source	TNFRSF1A-associated via death domain	7123	-0.012	0.1654	No
86	GRK6	GRK6 Entrez, Source	G protein-coupled receptor kinase 6	7131	-0.012	0.1658	No
87	CASP1	CASP1 Entrez, Source	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	7177	-0.013	0.1634	No
88	SHC1	SHC1 Entrez, Source	SHC (Src homology 2 domain containing) transforming protein 1	7269	-0.014	0.1576	No
89	TGFA	TGFA Entrez, Source	transforming growth factor, alpha	7317	-0.014	0.1551	No
90	TAOK3	TAOK3 Entrez, Source	TAO kinase 3	8026	-0.024	0.1034	No
91	ENG	ENG Entrez, Source	endoglin (Osler-Rendu-Weber syndrome 1)	8089	-0.025	0.1006	No
92	NF1	NF1 Entrez, Source	neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)	8226	-0.027	0.0924	No
93	NEK6	NEK6 Entrez, Source	NIMA (never in mitosis gene a)-related kinase 6	8247	-0.027	0.0929	No
94	UBE2N	UBE2N Entrez, Source	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	8325	-0.028	0.0893	No
95	CDC42BPA	CDC42BPA Entrez, Source	CDC42 binding protein kinase alpha (DMPK-like)	8396	-0.029	0.0862	No
96	PLEKHG5	PLEKHG5 Entrez, Source	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	8414	-0.030	0.0872	No
97	PPM1A	PPM1A Entrez, Source	protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform	8630	-0.033	0.0735	No
98	RASGRP4	RASGRP4 Entrez, Source	RAS guanyl releasing protein 4	8642	-0.033	0.0752	No
99	CDKN1C	CDKN1C Entrez, Source	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	8731	-0.034	0.0711	No
100	SMAD2	SMAD2 Entrez, Source	SMAD, mothers against DPP homolog 2 (Drosophila)	8847	-0.035	0.0651	No
101	SMAD3	SMAD3 Entrez, Source	SMAD, mothers against DPP homolog 3 (Drosophila)	8872	-0.036	0.0661	No
102	SOCS1	SOCS1 Entrez, Source	suppressor of cytokine signaling 1	8877	-0.036	0.0685	No
103	RPL17	RPL17 Entrez, Source	ribosomal protein L17	9114	-0.039	0.0537	No
104	FADD	FADD Entrez, Source	Fas (TNFRSF6)-associated via death domain	9128	-0.039	0.0557	No
105	SIGIRR	SIGIRR Entrez, Source	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	9143	-0.039	0.0577	No
106	ARF6	ARF6 Entrez, Source	ADP-ribosylation factor 6	9627	-0.047	0.0248	No
107	ACVR1	ACVR1 Entrez, Source	activin A receptor, type I	9665	-0.048	0.0257	No
108	HGS	HGS Entrez, Source	hepatocyte growth factor-regulated tyrosine kinase substrate	9709	-0.049	0.0262	No
109	MAP3K7IP2	MAP3K7IP2 Entrez, Source	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	9752	-0.049	0.0268	No
110	BIRC2	BIRC2 Entrez, Source	baculoviral IAP repeat-containing 2	9826	-0.051	0.0252	No
111	CXXC5	CXXC5 Entrez, Source	CXXC finger 5	10086	-0.055	0.0098	No
112	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	10373	-0.060	-0.0073	No
113	PTEN	PTEN Entrez, Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	10692	-0.066	-0.0263	No
114	ALS2	ALS2 Entrez, Source	amyotrophic lateral sclerosis 2 (juvenile)	10708	-0.066	-0.0223	No
115	CDC42BPB	CDC42BPB Entrez, Source	CDC42 binding protein kinase beta (DMPK-like)	10758	-0.067	-0.0208	No
116	CANT1	CANT1 Entrez, Source	calcium activated nucleotidase 1	10903	-0.071	-0.0262	No
117	EEF1D	EEF1D Entrez, Source	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	11131	-0.077	-0.0375	No
118	FGD4	FGD4 Entrez, Source	FYVE, RhoGEF and PH domain containing 4	11381	-0.084	-0.0500	No
119	FRZB	FRZB Entrez, Source	frizzled-related protein	11835	-0.097	-0.0768	No
120	CENTD2	CENTD2 Entrez, Source	centaurin, delta 2	11845	-0.097	-0.0700	No
121	LYN	LYN Entrez, Source	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	12283	-0.115	-0.0942	No
122	HTR2B	HTR2B Entrez, Source	5-hydroxytryptamine (serotonin) receptor 2B	12292	-0.116	-0.0859	No
123	ACVR2B	ACVR2B Entrez, Source	activin A receptor, type IIB	12294	-0.116	-0.0770	No
124	HMOX1	HMOX1 Entrez, Source	heme oxygenase (decycling) 1	12319	-0.117	-0.0698	No
125	BST2	BST2 Entrez, Source	bone marrow stromal cell antigen 2	12353	-0.119	-0.0632	No
126	TSPAN6	TSPAN6 Entrez, Source	tetraspanin 6	12432	-0.123	-0.0596	No
127	ADRB2	ADRB2 Entrez, Source	adrenergic, beta-2-, receptor, surface	12708	-0.142	-0.0695	No
128	SECTM1	SECTM1 Entrez, Source	secreted and transmembrane 1	12728	-0.144	-0.0598	No
129	EGF	EGF Entrez, Source	epidermal growth factor (beta-urogastrone)	12737	-0.145	-0.0493	No
130	SOST	SOST Entrez, Source	sclerosteosis	12868	-0.161	-0.0467	No
131	MAPK8IP3	MAPK8IP3 Entrez, Source	mitogen-activated protein kinase 8 interacting protein 3	12902	-0.165	-0.0365	No
132	RIPK2	RIPK2 Entrez, Source	receptor-interacting serine-threonine kinase 2	13131	-0.220	-0.0368	No
133	NOTCH2	NOTCH2 Entrez, Source	Notch homolog 2 (Drosophila)	13133	-0.220	-0.0200	No
134	RGN	RGN Entrez, Source	regucalcin (senescence marker protein-30)	13314	-0.464	0.0021	No