Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | SHEPARD_CRASH_AND_BURN_MUT_VS_WT_DN |
| Enrichment Score (ES) | -0.43449676 |
| Normalized Enrichment Score (NES) | -1.6453689 |
| Nominal p-value | 0.002538071 |
| FDR q-value | 0.18645747 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 323 | 0.239 | 0.0075 | No |
| 2 | UCP2 | UCP2 Entrez, Source | uncoupling protein 2 (mitochondrial, proton carrier) | 344 | 0.231 | 0.0368 | No |
| 3 | DPYSL3 | DPYSL3 Entrez, Source | dihydropyrimidinase-like 3 | 499 | 0.182 | 0.0494 | No |
| 4 | POU3F1 | POU3F1 Entrez, Source | POU domain, class 3, transcription factor 1 | 689 | 0.151 | 0.0553 | No |
| 5 | OTX2 | OTX2 Entrez, Source | orthodenticle homolog 2 (Drosophila) | 708 | 0.150 | 0.0739 | No |
| 6 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 1234 | 0.108 | 0.0487 | No |
| 7 | SFRP1 | SFRP1 Entrez, Source | secreted frizzled-related protein 1 | 1367 | 0.100 | 0.0521 | No |
| 8 | RTKN | RTKN Entrez, Source | rhotekin | 1476 | 0.095 | 0.0566 | No |
| 9 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 1499 | 0.094 | 0.0675 | No |
| 10 | NELL2 | NELL2 Entrez, Source | NEL-like 2 (chicken) | 1551 | 0.091 | 0.0758 | No |
| 11 | AKAP9 | AKAP9 Entrez, Source | A kinase (PRKA) anchor protein (yotiao) 9 | 1625 | 0.088 | 0.0820 | No |
| 12 | NEUROG1 | NEUROG1 Entrez, Source | neurogenin 1 | 1887 | 0.077 | 0.0726 | No |
| 13 | LGMN | LGMN Entrez, Source | legumain | 2054 | 0.071 | 0.0696 | No |
| 14 | DIO2 | DIO2 Entrez, Source | deiodinase, iodothyronine, type II | 3326 | 0.042 | -0.0207 | No |
| 15 | GOLGB1 | GOLGB1 Entrez, Source | golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 | 3455 | 0.040 | -0.0251 | No |
| 16 | POU3F2 | POU3F2 Entrez, Source | POU domain, class 3, transcription factor 2 | 3514 | 0.038 | -0.0243 | No |
| 17 | ARNT2 | ARNT2 Entrez, Source | aryl-hydrocarbon receptor nuclear translocator 2 | 3702 | 0.035 | -0.0337 | No |
| 18 | CTSL | CTSL Entrez, Source | cathepsin L | 3892 | 0.032 | -0.0437 | No |
| 19 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 3898 | 0.032 | -0.0399 | No |
| 20 | SMTN | SMTN Entrez, Source | smoothelin | 3924 | 0.031 | -0.0376 | No |
| 21 | SOX11 | SOX11 Entrez, Source | SRY (sex determining region Y)-box 11 | 4318 | 0.025 | -0.0639 | No |
| 22 | POU3F3 | POU3F3 Entrez, Source | POU domain, class 3, transcription factor 3 | 4509 | 0.022 | -0.0752 | No |
| 23 | PTPRO | PTPRO Entrez, Source | protein tyrosine phosphatase, receptor type, O | 4511 | 0.022 | -0.0723 | No |
| 24 | TACC3 | TACC3 Entrez, Source | transforming, acidic coiled-coil containing protein 3 | 4550 | 0.022 | -0.0723 | No |
| 25 | ATP1A1 | ATP1A1 Entrez, Source | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 4640 | 0.020 | -0.0763 | No |
| 26 | MYH8 | MYH8 Entrez, Source | myosin, heavy chain 8, skeletal muscle, perinatal | 4751 | 0.019 | -0.0820 | No |
| 27 | CRYBB1 | CRYBB1 Entrez, Source | crystallin, beta B1 | 4816 | 0.018 | -0.0845 | No |
| 28 | GPSM1 | GPSM1 Entrez, Source | G-protein signalling modulator 1 (AGS3-like, C. elegans) | 4927 | 0.016 | -0.0906 | No |
| 29 | HMGN3 | HMGN3 Entrez, Source | high mobility group nucleosomal binding domain 3 | 5092 | 0.014 | -0.1011 | No |
| 30 | CDCA2 | CDCA2 Entrez, Source | cell division cycle associated 2 | 5699 | 0.006 | -0.1460 | No |
| 31 | NUMA1 | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 5787 | 0.005 | -0.1520 | No |
| 32 | LHX1 | LHX1 Entrez, Source | LIM homeobox 1 | 6116 | 0.000 | -0.1767 | No |
| 33 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 6164 | -0.000 | -0.1802 | No |
| 34 | TMPO | TMPO Entrez, Source | thymopoietin | 6281 | -0.002 | -0.1887 | No |
| 35 | HMGA1 | HMGA1 Entrez, Source | high mobility group AT-hook 1 | 6574 | -0.005 | -0.2100 | No |
| 36 | FOXM1 | FOXM1 Entrez, Source | forkhead box M1 | 6751 | -0.008 | -0.2222 | No |
| 37 | TTN | TTN Entrez, Source | titin | 6911 | -0.010 | -0.2330 | No |
| 38 | SLIT3 | SLIT3 Entrez, Source | slit homolog 3 (Drosophila) | 7586 | -0.018 | -0.2814 | No |
| 39 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 7602 | -0.018 | -0.2801 | No |
| 40 | NFIL3 | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 7648 | -0.019 | -0.2810 | No |
| 41 | DEK | DEK Entrez, Source | DEK oncogene (DNA binding) | 7668 | -0.019 | -0.2799 | No |
| 42 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 8004 | -0.024 | -0.3020 | No |
| 43 | RHO | RHO Entrez, Source | rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant) | 8035 | -0.024 | -0.3011 | No |
| 44 | HEY1 | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 8303 | -0.028 | -0.3175 | No |
| 45 | NDE1 | NDE1 Entrez, Source | nudE nuclear distribution gene E homolog 1 (A. nidulans) | 8334 | -0.028 | -0.3160 | No |
| 46 | BMS1L | BMS1L Entrez, Source | BMS1-like, ribosome assembly protein (yeast) | 8437 | -0.030 | -0.3197 | No |
| 47 | OTP | OTP Entrez, Source | orthopedia homolog (Drosophila) | 9009 | -0.038 | -0.3577 | No |
| 48 | PLEKHF1 | PLEKHF1 Entrez, Source | pleckstrin homology domain containing, family F (with FYVE domain) member 1 | 9023 | -0.038 | -0.3537 | No |
| 49 | ENO3 | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 9266 | -0.041 | -0.3664 | No |
| 50 | CRYBA4 | CRYBA4 Entrez, Source | crystallin, beta A4 | 9477 | -0.045 | -0.3763 | No |
| 51 | ZP2 | ZP2 Entrez, Source | zona pellucida glycoprotein 2 (sperm receptor) | 9541 | -0.046 | -0.3750 | No |
| 52 | GRIK3 | GRIK3 Entrez, Source | glutamate receptor, ionotropic, kainate 3 | 10240 | -0.057 | -0.4199 | No |
| 53 | SYNCRIP | SYNCRIP Entrez, Source | synaptotagmin binding, cytoplasmic RNA interacting protein | 10434 | -0.061 | -0.4264 | Yes |
| 54 | FZD5 | FZD5 Entrez, Source | frizzled homolog 5 (Drosophila) | 10462 | -0.061 | -0.4202 | Yes |
| 55 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 10615 | -0.065 | -0.4231 | Yes |
| 56 | DDX17 | DDX17 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 10688 | -0.066 | -0.4197 | Yes |
| 57 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 10692 | -0.066 | -0.4112 | Yes |
| 58 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 10730 | -0.067 | -0.4051 | Yes |
| 59 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 10765 | -0.068 | -0.3986 | Yes |
| 60 | KHDRBS1 | KHDRBS1 Entrez, Source | KH domain containing, RNA binding, signal transduction associated 1 | 10794 | -0.068 | -0.3916 | Yes |
| 61 | GDF10 | GDF10 Entrez, Source | growth differentiation factor 10 | 10910 | -0.071 | -0.3909 | Yes |
| 62 | TRIM39 | TRIM39 Entrez, Source | tripartite motif-containing 39 | 10945 | -0.072 | -0.3838 | Yes |
| 63 | MDK | MDK Entrez, Source | midkine (neurite growth-promoting factor 2) | 10954 | -0.072 | -0.3748 | Yes |
| 64 | ADARB2 | ADARB2 Entrez, Source | adenosine deaminase, RNA-specific, B2 (RED2 homolog rat) | 10977 | -0.073 | -0.3668 | Yes |
| 65 | PRIM2A | PRIM2A Entrez, Source | primase, polypeptide 2A, 58kDa | 10979 | -0.073 | -0.3572 | Yes |
| 66 | ANP32B | ANP32B Entrez, Source | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 11023 | -0.074 | -0.3506 | Yes |
| 67 | DDX20 | DDX20 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 | 11083 | -0.075 | -0.3450 | Yes |
| 68 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 11187 | -0.078 | -0.3424 | Yes |
| 69 | PTPRN | PTPRN Entrez, Source | protein tyrosine phosphatase, receptor type, N | 11537 | -0.088 | -0.3570 | Yes |
| 70 | SLC34A1 | SLC34A1 Entrez, Source | solute carrier family 34 (sodium phosphate), member 1 | 11754 | -0.094 | -0.3608 | Yes |
| 71 | TM7SF2 | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 11819 | -0.096 | -0.3528 | Yes |
| 72 | AURKB | AURKB Entrez, Source | aurora kinase B | 11998 | -0.103 | -0.3526 | Yes |
| 73 | GFAP | GFAP Entrez, Source | glial fibrillary acidic protein | 12025 | -0.104 | -0.3407 | Yes |
| 74 | FGFR4 | FGFR4 Entrez, Source | fibroblast growth factor receptor 4 | 12369 | -0.119 | -0.3507 | Yes |
| 75 | HES6 | HES6 Entrez, Source | hairy and enhancer of split 6 (Drosophila) | 12756 | -0.147 | -0.3602 | Yes |
| 76 | FUBP1 | FUBP1 Entrez, Source | far upstream element (FUSE) binding protein 1 | 13083 | -0.205 | -0.3575 | Yes |
| 77 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 13133 | -0.220 | -0.3319 | Yes |
| 78 | PPP1R3C | PPP1R3C Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 13293 | -0.383 | -0.2929 | Yes |
| 79 | PON1 | PON1 Entrez, Source | paraoxonase 1 | 13297 | -0.394 | -0.2406 | Yes |
| 80 | ASCL1 | ASCL1 Entrez, Source | achaete-scute complex-like 1 (Drosophila) | 13340 | -0.915 | -0.1219 | Yes |
| 81 | EDG1 | EDG1 Entrez, Source | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | 13341 | -0.915 | 0.0001 | Yes |
