Details for gene set SMOOTH_MUSCLE

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_72h_repos
Upregulated in class	double_gel_8d
GeneSet	SMOOTH_MUSCLE_CONTRACTION
Enrichment Score (ES)	0.5952329
Normalized Enrichment Score (NES)	2.208427
Nominal p-value	0.0
FDR q-value	2.6800236E-4
FWER p-Value	0.0020

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ADM	ADM Entrez, Source	adrenomedullin	34	0.649	0.0540	Yes
2	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	37	0.635	0.1093	Yes
3	RGS2	RGS2 Entrez, Source	regulator of G-protein signalling 2, 24kDa	42	0.616	0.1627	Yes
4	PRKAR2B	PRKAR2B Entrez, Source	protein kinase, cAMP-dependent, regulatory, type II, beta	69	0.494	0.2038	Yes
5	RGS16	RGS16 Entrez, Source	regulator of G-protein signalling 16	126	0.391	0.2338	Yes
6	RGS1	RGS1 Entrez, Source	regulator of G-protein signalling 1	140	0.372	0.2653	Yes
7	FOS	FOS Entrez, Source	v-fos FBJ murine osteosarcoma viral oncogene homolog	142	0.371	0.2975	Yes
8	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	196	0.324	0.3218	Yes
9	ATF3	ATF3 Entrez, Source	activating transcription factor 3	218	0.309	0.3472	Yes
10	RGS4	RGS4 Entrez, Source	regulator of G-protein signalling 4	219	0.308	0.3741	Yes
11	PKIB	PKIB Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor beta	237	0.292	0.3982	Yes
12	RGS5	RGS5 Entrez, Source	regulator of G-protein signalling 5	306	0.247	0.4146	Yes
13	RAMP3	RAMP3 Entrez, Source	receptor (calcitonin) activity modifying protein 3	329	0.237	0.4336	Yes
14	GRK5	GRK5 Entrez, Source	G protein-coupled receptor kinase 5	401	0.209	0.4465	Yes
15	JUN	JUN Entrez, Source	jun oncogene	458	0.194	0.4592	Yes
16	PRKAR1B	PRKAR1B Entrez, Source	protein kinase, cAMP-dependent, regulatory, type I, beta	512	0.181	0.4709	Yes
17	IGFBP1	IGFBP1 Entrez, Source	insulin-like growth factor binding protein 1	531	0.177	0.4850	Yes
18	CRH	CRH Entrez, Source	corticotropin releasing hormone	541	0.173	0.4995	Yes
19	IGFBP3	IGFBP3 Entrez, Source	insulin-like growth factor binding protein 3	567	0.170	0.5124	Yes
20	CREB3	CREB3 Entrez, Source	cAMP responsive element binding protein 3	731	0.146	0.5129	Yes
21	RGS3	RGS3 Entrez, Source	regulator of G-protein signalling 3	762	0.144	0.5231	Yes
22	NOS3	NOS3 Entrez, Source	nitric oxide synthase 3 (endothelial cell)	867	0.132	0.5268	Yes
23	RGS10	RGS10 Entrez, Source	regulator of G-protein signalling 10	1009	0.121	0.5267	Yes
24	IL1B	IL1B Entrez, Source	interleukin 1, beta	1014	0.121	0.5369	Yes
25	RGS7	RGS7 Entrez, Source	regulator of G-protein signalling 7	1078	0.116	0.5423	Yes
26	PLCG2	PLCG2 Entrez, Source	phospholipase C, gamma 2 (phosphatidylinositol-specific)	1116	0.114	0.5494	Yes
27	YWHAQ	YWHAQ Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	1140	0.113	0.5575	Yes
28	ITPR1	ITPR1 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 1	1235	0.108	0.5598	Yes
29	GNAQ	GNAQ Entrez, Source	guanine nucleotide binding protein (G protein), q polypeptide	1323	0.103	0.5622	Yes
30	ADMR	ADMR Entrez, Source	adrenomedullin receptor	1390	0.099	0.5659	Yes
31	ACTA2	ACTA2 Entrez, Source	actin, alpha 2, smooth muscle, aorta	1439	0.096	0.5707	Yes
32	EDG2	EDG2 Entrez, Source	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2	1468	0.095	0.5769	Yes
33	PKIG	PKIG Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	1533	0.092	0.5801	Yes
34	GNG3	GNG3 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 3	1604	0.089	0.5826	Yes
35	GNB4	GNB4 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 4	1624	0.088	0.5888	Yes
36	RAMP2	RAMP2 Entrez, Source	receptor (calcitonin) activity modifying protein 2	1641	0.087	0.5952	Yes
37	ATP2A3	ATP2A3 Entrez, Source	ATPase, Ca++ transporting, ubiquitous	1800	0.080	0.5903	No
38	PLCD1	PLCD1 Entrez, Source	phospholipase C, delta 1	1899	0.077	0.5896	No
39	PRKCQ	PRKCQ Entrez, Source	protein kinase C, theta	2087	0.070	0.5815	No
40	RYR2	RYR2 Entrez, Source	ryanodine receptor 2 (cardiac)	2487	0.060	0.5566	No
41	CALM3	CALM3 Entrez, Source	calmodulin 3 (phosphorylase kinase, delta)	2619	0.057	0.5517	No
42	GNG5	GNG5 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 5	2680	0.056	0.5520	No
43	PKIA	PKIA Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	2727	0.054	0.5533	No
44	CRHR1	CRHR1 Entrez, Source	corticotropin releasing hormone receptor 1	2844	0.052	0.5490	No
45	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	2895	0.051	0.5497	No
46	PRKAR1A	PRKAR1A Entrez, Source	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	2902	0.051	0.5536	No
47	OXT	OXT Entrez, Source	oxytocin, prepro- (neurophysin I)	3031	0.048	0.5481	No
48	GUCY1A3	GUCY1A3 Entrez, Source	guanylate cyclase 1, soluble, alpha 3	3107	0.046	0.5465	No
49	GNB3	GNB3 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 3	3360	0.041	0.5310	No
50	PRKCD	PRKCD Entrez, Source	protein kinase C, delta	3396	0.041	0.5319	No
51	GUCA2B	GUCA2B Entrez, Source	guanylate cyclase activator 2B (uroguanylin)	3484	0.039	0.5287	No
52	YWHAB	YWHAB Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	3679	0.036	0.5172	No
53	GNB5	GNB5 Entrez, Source	guanine nucleotide binding protein (G protein), beta 5	4018	0.030	0.4942	No
54	RCP9	RCP9 Entrez, Source	-	4102	0.029	0.4905	No
55	GNB2	GNB2 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 2	4268	0.026	0.4802	No
56	ITPR3	ITPR3 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 3	4344	0.025	0.4767	No
57	CAMK2D	CAMK2D Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II delta	4524	0.022	0.4651	No
58	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	4525	0.022	0.4671	No
59	CACNB3	CACNB3 Entrez, Source	calcium channel, voltage-dependent, beta 3 subunit	4613	0.021	0.4623	No
60	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	4662	0.020	0.4604	No
61	CALM2	CALM2 Entrez, Source	calmodulin 2 (phosphorylase kinase, delta)	4699	0.020	0.4594	No
62	MYLK2	MYLK2 Entrez, Source	myosin light chain kinase 2, skeletal muscle	4719	0.019	0.4597	No
63	ADCY2	ADCY2 Entrez, Source	adenylate cyclase 2 (brain)	4922	0.016	0.4458	No
64	IL6	IL6 Entrez, Source	interleukin 6 (interferon, beta 2)	4953	0.016	0.4449	No
65	RYR1	RYR1 Entrez, Source	ryanodine receptor 1 (skeletal)	5034	0.015	0.4402	No
66	CAMK2G	CAMK2G Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma	5201	0.013	0.4287	No
67	GRK4	GRK4 Entrez, Source	G protein-coupled receptor kinase 4	5401	0.010	0.4145	No
68	OXTR	OXTR Entrez, Source	oxytocin receptor	5412	0.010	0.4146	No
69	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	5457	0.009	0.4120	No
70	ACTA1	ACTA1 Entrez, Source	actin, alpha 1, skeletal muscle	5464	0.009	0.4123	No
71	PRKCE	PRKCE Entrez, Source	protein kinase C, epsilon	5796	0.005	0.3877	No
72	YWHAH	YWHAH Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	5809	0.004	0.3872	No
73	PLCB3	PLCB3 Entrez, Source	phospholipase C, beta 3 (phosphatidylinositol-specific)	5900	0.003	0.3807	No
74	RGS9	RGS9 Entrez, Source	regulator of G-protein signalling 9	6017	0.002	0.3721	No
75	ADCY6	ADCY6 Entrez, Source	adenylate cyclase 6	6028	0.002	0.3715	No
76	CAMK2A	CAMK2A Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha	6240	-0.001	0.3556	No
77	SP1	SP1 Entrez, Source	Sp1 transcription factor	6295	-0.002	0.3517	No
78	IGFBP6	IGFBP6 Entrez, Source	insulin-like growth factor binding protein 6	6428	-0.004	0.3420	No
79	CALCA	CALCA Entrez, Source	calcitonin/calcitonin-related polypeptide, alpha	6521	-0.005	0.3355	No
80	CREBL1	CREBL1 Entrez, Source	cAMP responsive element binding protein-like 1	6581	-0.006	0.3315	No
81	ITPR2	ITPR2 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 2	6591	-0.006	0.3313	No
82	ADCY5	ADCY5 Entrez, Source	adenylate cyclase 5	6683	-0.007	0.3250	No
83	CAMK2B	CAMK2B Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II beta	6851	-0.009	0.3132	No
84	RGS14	RGS14 Entrez, Source	regulator of G-protein signalling 14	6865	-0.009	0.3130	No
85	GRK6	GRK6 Entrez, Source	G protein-coupled receptor kinase 6	7131	-0.012	0.2940	No
86	NOS1	NOS1 Entrez, Source	nitric oxide synthase 1 (neuronal)	7163	-0.013	0.2927	No
87	ARRB2	ARRB2 Entrez, Source	arrestin, beta 2	7277	-0.014	0.2854	No
88	RGS6	RGS6 Entrez, Source	regulator of G-protein signalling 6	7652	-0.019	0.2588	No
89	CALM1	CALM1 Entrez, Source	calmodulin 1 (phosphorylase kinase, delta)	7735	-0.020	0.2543	No
90	GNB1	GNB1 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 1	7870	-0.022	0.2460	No
91	ARRB1	ARRB1 Entrez, Source	arrestin, beta 1	8078	-0.025	0.2325	No
92	ADCY8	ADCY8 Entrez, Source	adenylate cyclase 8 (brain)	8194	-0.026	0.2262	No
93	CORIN	CORIN Entrez, Source	corin, serine peptidase	8486	-0.031	0.2068	No
94	SLC8A1	SLC8A1 Entrez, Source	solute carrier family 8 (sodium/calcium exchanger), member 1	8530	-0.031	0.2063	No
95	ADCY3	ADCY3 Entrez, Source	adenylate cyclase 3	8531	-0.031	0.2090	No
96	PRKCH	PRKCH Entrez, Source	protein kinase C, eta	8644	-0.033	0.2034	No
97	PLCG1	PLCG1 Entrez, Source	phospholipase C, gamma 1	8898	-0.036	0.1874	No
98	ATF1	ATF1 Entrez, Source	activating transcription factor 1	9168	-0.040	0.1706	No
99	CNN1	CNN1 Entrez, Source	calponin 1, basic, smooth muscle	9196	-0.040	0.1720	No
100	NFKB1	NFKB1 Entrez, Source	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)	9252	-0.041	0.1714	No
101	PDE4B	PDE4B Entrez, Source	phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)	9537	-0.046	0.1540	No
102	RLN1	RLN1 Entrez, Source	relaxin 1	9596	-0.047	0.1537	No
103	GNG12	GNG12 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 12	9617	-0.047	0.1563	No
104	PRKACA	PRKACA Entrez, Source	protein kinase, cAMP-dependent, catalytic, alpha	9662	-0.048	0.1572	No
105	ATP2A2	ATP2A2 Entrez, Source	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	9899	-0.052	0.1438	No
106	PDE4D	PDE4D Entrez, Source	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	10269	-0.058	0.1210	No
107	PRKCZ	PRKCZ Entrez, Source	protein kinase C, zeta	10325	-0.059	0.1220	No
108	PRKD1	PRKD1 Entrez, Source	protein kinase D1	10693	-0.066	0.1000	No
109	GUCA2A	GUCA2A Entrez, Source	guanylate cyclase activator 2A (guanylin)	10897	-0.071	0.0908	No
110	RGS19	RGS19 Entrez, Source	regulator of G-protein signalling 19	10966	-0.073	0.0920	No
111	PRKAR2A	PRKAR2A Entrez, Source	protein kinase, cAMP-dependent, regulatory, type II, alpha	10971	-0.073	0.0980	No
112	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	10982	-0.073	0.1036	No
113	ATF5	ATF5 Entrez, Source	activating transcription factor 5	11103	-0.076	0.1012	No
114	IGFBP2	IGFBP2 Entrez, Source	insulin-like growth factor binding protein 2, 36kDa	11121	-0.076	0.1065	No
115	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	11531	-0.087	0.0832	No
116	ADCY4	ADCY4 Entrez, Source	adenylate cyclase 4	12124	-0.108	0.0479	No
117	ATF2	ATF2 Entrez, Source	activating transcription factor 2	12173	-0.110	0.0539	No
118	GSTO1	GSTO1 Entrez, Source	glutathione S-transferase omega 1	12328	-0.117	0.0525	No
119	DGKZ	DGKZ Entrez, Source	diacylglycerol kinase, zeta 104kDa	12638	-0.137	0.0411	No
120	IGFBP4	IGFBP4 Entrez, Source	insulin-like growth factor binding protein 4	12663	-0.138	0.0514	No