Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | TAKEDA_NUP8_HOXA9_8D_DN |
| Enrichment Score (ES) | 0.533977 |
| Normalized Enrichment Score (NES) | 1.9388367 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.010356268 |
| FWER p-Value | 0.423 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CD24 | CD24 Entrez, Source | CD24 molecule | 17 | 0.726 | 0.0573 | Yes |
| 2 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 22 | 0.685 | 0.1123 | Yes |
| 3 | DAB2 | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 31 | 0.661 | 0.1651 | Yes |
| 4 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 44 | 0.606 | 0.2131 | Yes |
| 5 | IL1R2 | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 46 | 0.599 | 0.2614 | Yes |
| 6 | RAB30 | RAB30 Entrez, Source | RAB30, member RAS oncogene family | 55 | 0.564 | 0.3062 | Yes |
| 7 | MAF | MAF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | 73 | 0.484 | 0.3441 | Yes |
| 8 | TSPAN2 | TSPAN2 Entrez, Source | tetraspanin 2 | 168 | 0.349 | 0.3651 | Yes |
| 9 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 171 | 0.348 | 0.3930 | Yes |
| 10 | RNASE1 | RNASE1 Entrez, Source | ribonuclease, RNase A family, 1 (pancreatic) | 175 | 0.341 | 0.4203 | Yes |
| 11 | CD9 | CD9 Entrez, Source | CD9 molecule | 299 | 0.250 | 0.4313 | Yes |
| 12 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 330 | 0.237 | 0.4481 | Yes |
| 13 | AKAP13 | AKAP13 Entrez, Source | A kinase (PRKA) anchor protein 13 | 336 | 0.235 | 0.4667 | Yes |
| 14 | JUN | JUN Entrez, Source | jun oncogene | 458 | 0.194 | 0.4732 | Yes |
| 15 | CUTL1 | CUTL1 Entrez, Source | cut-like 1, CCAAT displacement protein (Drosophila) | 516 | 0.180 | 0.4834 | Yes |
| 16 | IFNGR1 | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 529 | 0.177 | 0.4968 | Yes |
| 17 | RAB3C | RAB3C Entrez, Source | RAB3C, member RAS oncogene family | 549 | 0.172 | 0.5092 | Yes |
| 18 | NIPBL | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 578 | 0.167 | 0.5206 | Yes |
| 19 | TDO2 | TDO2 Entrez, Source | tryptophan 2,3-dioxygenase | 581 | 0.167 | 0.5340 | Yes |
| 20 | ENC1 | ENC1 Entrez, Source | ectodermal-neural cortex (with BTB-like domain) | 1029 | 0.119 | 0.5098 | No |
| 21 | IL3RA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 1257 | 0.107 | 0.5013 | No |
| 22 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 1312 | 0.104 | 0.5055 | No |
| 23 | IL10 | IL10 Entrez, Source | interleukin 10 | 1329 | 0.102 | 0.5126 | No |
| 24 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 1345 | 0.102 | 0.5197 | No |
| 25 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 1541 | 0.092 | 0.5124 | No |
| 26 | MS4A2 | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 1555 | 0.091 | 0.5187 | No |
| 27 | IL5RA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 1677 | 0.086 | 0.5165 | No |
| 28 | SLC16A6 | SLC16A6 Entrez, Source | solute carrier family 16, member 6 (monocarboxylic acid transporter 7) | 1775 | 0.081 | 0.5158 | No |
| 29 | LCP2 | LCP2 Entrez, Source | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 1811 | 0.080 | 0.5196 | No |
| 30 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 1832 | 0.079 | 0.5244 | No |
| 31 | LGMN | LGMN Entrez, Source | legumain | 2054 | 0.071 | 0.5135 | No |
| 32 | ITGAM | ITGAM Entrez, Source | integrin, alpha M (complement component 3 receptor 3 subunit) | 2172 | 0.068 | 0.5101 | No |
| 33 | CD14 | CD14 Entrez, Source | CD14 molecule | 2182 | 0.068 | 0.5149 | No |
| 34 | PADI4 | PADI4 Entrez, Source | peptidyl arginine deiminase, type IV | 2199 | 0.067 | 0.5191 | No |
| 35 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 2324 | 0.064 | 0.5149 | No |
| 36 | SLC25A27 | SLC25A27 Entrez, Source | solute carrier family 25, member 27 | 2374 | 0.063 | 0.5163 | No |
| 37 | C7ORF10 | C7ORF10 Entrez, Source | chromosome 7 open reading frame 10 | 2497 | 0.060 | 0.5119 | No |
| 38 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 2584 | 0.058 | 0.5101 | No |
| 39 | ADORA3 | ADORA3 Entrez, Source | adenosine A3 receptor | 2867 | 0.051 | 0.4929 | No |
| 40 | CLU | CLU Entrez, Source | clusterin | 3299 | 0.043 | 0.4638 | No |
| 41 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 3304 | 0.042 | 0.4669 | No |
| 42 | HRH4 | HRH4 Entrez, Source | histamine receptor H4 | 3333 | 0.042 | 0.4682 | No |
| 43 | ALOX5 | ALOX5 Entrez, Source | arachidonate 5-lipoxygenase | 3663 | 0.036 | 0.4462 | No |
| 44 | ZDHHC19 | ZDHHC19 Entrez, Source | zinc finger, DHHC-type containing 19 | 3720 | 0.035 | 0.4448 | No |
| 45 | CAPZA2 | CAPZA2 Entrez, Source | capping protein (actin filament) muscle Z-line, alpha 2 | 3750 | 0.034 | 0.4454 | No |
| 46 | HTRA1 | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 3790 | 0.034 | 0.4451 | No |
| 47 | ST8SIA1 | ST8SIA1 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 3901 | 0.032 | 0.4394 | No |
| 48 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 4037 | 0.030 | 0.4316 | No |
| 49 | ABI1 | ABI1 Entrez, Source | abl-interactor 1 | 4112 | 0.029 | 0.4283 | No |
| 50 | CLEC4A | CLEC4A Entrez, Source | C-type lectin domain family 4, member A | 4129 | 0.028 | 0.4294 | No |
| 51 | S100A8 | S100A8 Entrez, Source | S100 calcium binding protein A8 | 4260 | 0.026 | 0.4217 | No |
| 52 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 4610 | 0.021 | 0.3970 | No |
| 53 | LFNG | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 4798 | 0.018 | 0.3843 | No |
| 54 | RHOH | RHOH Entrez, Source | ras homolog gene family, member H | 4918 | 0.016 | 0.3767 | No |
| 55 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 5202 | 0.013 | 0.3563 | No |
| 56 | MMP12 | MMP12 Entrez, Source | matrix metallopeptidase 12 (macrophage elastase) | 5434 | 0.009 | 0.3396 | No |
| 57 | CD200R1 | CD200R1 Entrez, Source | CD200 receptor 1 | 5446 | 0.009 | 0.3395 | No |
| 58 | CYBB | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 5548 | 0.008 | 0.3325 | No |
| 59 | PADI2 | PADI2 Entrez, Source | peptidyl arginine deiminase, type II | 5592 | 0.007 | 0.3298 | No |
| 60 | PPBP | PPBP Entrez, Source | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 5643 | 0.006 | 0.3266 | No |
| 61 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 6016 | 0.002 | 0.2986 | No |
| 62 | CDH8 | CDH8 Entrez, Source | cadherin 8, type 2 | 6230 | -0.001 | 0.2826 | No |
| 63 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 6410 | -0.003 | 0.2694 | No |
| 64 | UHMK1 | UHMK1 Entrez, Source | U2AF homology motif (UHM) kinase 1 | 6453 | -0.004 | 0.2665 | No |
| 65 | RAP2A | RAP2A Entrez, Source | RAP2A, member of RAS oncogene family | 6516 | -0.005 | 0.2622 | No |
| 66 | SRPX | SRPX Entrez, Source | sushi-repeat-containing protein, X-linked | 6552 | -0.005 | 0.2600 | No |
| 67 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 6734 | -0.007 | 0.2469 | No |
| 68 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 6827 | -0.008 | 0.2406 | No |
| 69 | ADAM19 | ADAM19 Entrez, Source | ADAM metallopeptidase domain 19 (meltrin beta) | 7040 | -0.011 | 0.2255 | No |
| 70 | ME1 | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 7060 | -0.011 | 0.2250 | No |
| 71 | OLIG1 | OLIG1 Entrez, Source | oligodendrocyte transcription factor 1 | 7100 | -0.012 | 0.2230 | No |
| 72 | RAP1A | RAP1A Entrez, Source | RAP1A, member of RAS oncogene family | 7119 | -0.012 | 0.2226 | No |
| 73 | CORO2A | CORO2A Entrez, Source | coronin, actin binding protein, 2A | 7394 | -0.015 | 0.2032 | No |
| 74 | HTR2C | HTR2C Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 2C | 7488 | -0.017 | 0.1975 | No |
| 75 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 7540 | -0.017 | 0.1950 | No |
| 76 | S100B | S100B Entrez, Source | S100 calcium binding protein B | 8430 | -0.030 | 0.1303 | No |
| 77 | GJA4 | GJA4 Entrez, Source | gap junction protein, alpha 4, 37kDa (connexin 37) | 8471 | -0.031 | 0.1297 | No |
| 78 | HSD11B1 | HSD11B1 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 1 | 8552 | -0.031 | 0.1262 | No |
| 79 | PPP1R1B | PPP1R1B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) | 8670 | -0.033 | 0.1201 | No |
| 80 | ETS1 | ETS1 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 8706 | -0.034 | 0.1202 | No |
| 81 | KCNMA1 | KCNMA1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 8797 | -0.035 | 0.1162 | No |
| 82 | UTS2 | UTS2 Entrez, Source | urotensin 2 | 9152 | -0.040 | 0.0926 | No |
| 83 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 9179 | -0.040 | 0.0939 | No |
| 84 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 9594 | -0.047 | 0.0664 | No |
| 85 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 9869 | -0.051 | 0.0498 | No |
| 86 | COLEC12 | COLEC12 Entrez, Source | collectin sub-family member 12 | 9996 | -0.053 | 0.0446 | No |
| 87 | CTSB | CTSB Entrez, Source | cathepsin B | 10352 | -0.059 | 0.0226 | No |
| 88 | S100A9 | S100A9 Entrez, Source | S100 calcium binding protein A9 | 10706 | -0.066 | 0.0013 | No |
| 89 | CEBPE | CEBPE Entrez, Source | CCAAT/enhancer binding protein (C/EBP), epsilon | 10710 | -0.066 | 0.0064 | No |
| 90 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 10939 | -0.072 | -0.0050 | No |
| 91 | ENTPD1 | ENTPD1 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 1 | 10967 | -0.073 | -0.0012 | No |
| 92 | PYGL | PYGL Entrez, Source | phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) | 11176 | -0.078 | -0.0106 | No |
| 93 | ABP1 | ABP1 Entrez, Source | amiloride binding protein 1 (amine oxidase (copper-containing)) | 11324 | -0.082 | -0.0151 | No |
| 94 | PCSK5 | PCSK5 Entrez, Source | proprotein convertase subtilisin/kexin type 5 | 11336 | -0.082 | -0.0093 | No |
| 95 | C1ORF24 | C1ORF24 Entrez, Source | chromosome 1 open reading frame 24 | 12389 | -0.121 | -0.0790 | No |
| 96 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 12406 | -0.122 | -0.0704 | No |
| 97 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 12642 | -0.137 | -0.0771 | No |
| 98 | SLC30A7 | SLC30A7 Entrez, Source | solute carrier family 30 (zinc transporter), member 7 | 12803 | -0.153 | -0.0768 | No |
| 99 | FCGR2B | FCGR2B Entrez, Source | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 13073 | -0.203 | -0.0808 | No |
| 100 | PPP1R3B | PPP1R3B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3B | 13075 | -0.203 | -0.0645 | No |
| 101 | NDRG2 | NDRG2 Entrez, Source | NDRG family member 2 | 13082 | -0.204 | -0.0485 | No |
| 102 | SLCO2B1 | SLCO2B1 Entrez, Source | solute carrier organic anion transporter family, member 2B1 | 13208 | -0.258 | -0.0371 | No |
| 103 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 13328 | -0.584 | 0.0011 | No |
