Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | TGFBETA_ALL_UP |
| Enrichment Score (ES) | 0.621364 |
| Normalized Enrichment Score (NES) | 1.9861528 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0065540546 |
| FWER p-Value | 0.253 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 3 | 1.046 | 0.1593 | Yes |
| 2 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 12 | 0.803 | 0.2811 | Yes |
| 3 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 15 | 0.737 | 0.3934 | Yes |
| 4 | MARCKSL1 | MARCKSL1 Entrez, Source | MARCKS-like 1 | 122 | 0.399 | 0.4464 | Yes |
| 5 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 200 | 0.321 | 0.4895 | Yes |
| 6 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 234 | 0.297 | 0.5323 | Yes |
| 7 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 350 | 0.230 | 0.5588 | Yes |
| 8 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 567 | 0.170 | 0.5685 | Yes |
| 9 | PXN | PXN Entrez, Source | paxillin | 617 | 0.163 | 0.5896 | Yes |
| 10 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 710 | 0.149 | 0.6054 | Yes |
| 11 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 785 | 0.141 | 0.6214 | Yes |
| 12 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 1312 | 0.104 | 0.5976 | No |
| 13 | CDH6 | CDH6 Entrez, Source | cadherin 6, type 2, K-cadherin (fetal kidney) | 1405 | 0.098 | 0.6056 | No |
| 14 | EFNA5 | EFNA5 Entrez, Source | ephrin-A5 | 1436 | 0.097 | 0.6181 | No |
| 15 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 1975 | 0.074 | 0.5888 | No |
| 16 | FN1 | FN1 Entrez, Source | fibronectin 1 | 2637 | 0.057 | 0.5477 | No |
| 17 | IGFBP5 | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 2713 | 0.055 | 0.5504 | No |
| 18 | RHOG | RHOG Entrez, Source | ras homolog gene family, member G (rho G) | 2819 | 0.052 | 0.5505 | No |
| 19 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 3143 | 0.046 | 0.5332 | No |
| 20 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 3147 | 0.045 | 0.5399 | No |
| 21 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 3256 | 0.044 | 0.5384 | No |
| 22 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 3714 | 0.035 | 0.5093 | No |
| 23 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 3764 | 0.034 | 0.5108 | No |
| 24 | WNT2B | WNT2B Entrez, Source | wingless-type MMTV integration site family, member 2B | 3814 | 0.033 | 0.5122 | No |
| 25 | NEO1 | NEO1 Entrez, Source | neogenin homolog 1 (chicken) | 3835 | 0.033 | 0.5157 | No |
| 26 | BSG | BSG Entrez, Source | basigin (Ok blood group) | 3928 | 0.031 | 0.5136 | No |
| 27 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 3978 | 0.031 | 0.5145 | No |
| 28 | SMO | SMO Entrez, Source | smoothened homolog (Drosophila) | 4364 | 0.024 | 0.4893 | No |
| 29 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 4794 | 0.018 | 0.4598 | No |
| 30 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 5051 | 0.015 | 0.4428 | No |
| 31 | DSP | DSP Entrez, Source | desmoplakin | 5452 | 0.009 | 0.4140 | No |
| 32 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 6001 | 0.002 | 0.3731 | No |
| 33 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 6128 | 0.000 | 0.3637 | No |
| 34 | NID1 | NID1 Entrez, Source | nidogen 1 | 6133 | 0.000 | 0.3634 | No |
| 35 | ITGB2 | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 6196 | -0.001 | 0.3588 | No |
| 36 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 6676 | -0.007 | 0.3238 | No |
| 37 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 6786 | -0.008 | 0.3168 | No |
| 38 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 6969 | -0.010 | 0.3047 | No |
| 39 | ZYX | ZYX Entrez, Source | zyxin | 7461 | -0.016 | 0.2702 | No |
| 40 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 8198 | -0.027 | 0.2189 | No |
| 41 | ARHGDIA | ARHGDIA Entrez, Source | Rho GDP dissociation inhibitor (GDI) alpha | 9058 | -0.038 | 0.1601 | No |
| 42 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 9179 | -0.040 | 0.1572 | No |
| 43 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 9270 | -0.041 | 0.1567 | No |
| 44 | DVL1 | DVL1 Entrez, Source | dishevelled, dsh homolog 1 (Drosophila) | 9309 | -0.042 | 0.1602 | No |
| 45 | JUP | JUP Entrez, Source | junction plakoglobin | 10241 | -0.057 | 0.0989 | No |
| 46 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 10417 | -0.061 | 0.0950 | No |
| 47 | MTA1 | MTA1 Entrez, Source | metastasis associated 1 | 10421 | -0.061 | 0.1040 | No |
| 48 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 10559 | -0.063 | 0.1034 | No |
| 49 | RHOQ | RHOQ Entrez, Source | ras homolog gene family, member Q | 11086 | -0.075 | 0.0753 | No |
| 50 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 11121 | -0.076 | 0.0843 | No |
| 51 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 12663 | -0.138 | -0.0105 | No |
| 52 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 12996 | -0.183 | -0.0076 | No |
| 53 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 13133 | -0.220 | 0.0157 | No |
