Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | TGF_BETA_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.59981936 |
| Normalized Enrichment Score (NES) | 1.8282888 |
| Nominal p-value | 0.0017361111 |
| FDR q-value | 0.02772794 |
| FWER p-Value | 0.922 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 12 | 0.803 | 0.1815 | Yes |
| 2 | FST | FST Entrez, Source | follistatin | 132 | 0.388 | 0.2607 | Yes |
| 3 | FOS | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 142 | 0.371 | 0.3442 | Yes |
| 4 | LTBP1 | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 372 | 0.219 | 0.3768 | Yes |
| 5 | JUN | JUN Entrez, Source | jun oncogene | 458 | 0.194 | 0.4144 | Yes |
| 6 | TGFBR3 | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 577 | 0.168 | 0.4437 | Yes |
| 7 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 618 | 0.162 | 0.4776 | Yes |
| 8 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 631 | 0.160 | 0.5131 | Yes |
| 9 | LIF | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 1037 | 0.118 | 0.5095 | Yes |
| 10 | SMAD9 | SMAD9 Entrez, Source | SMAD, mothers against DPP homolog 9 (Drosophila) | 1075 | 0.116 | 0.5331 | Yes |
| 11 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 1105 | 0.114 | 0.5570 | Yes |
| 12 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 1389 | 0.099 | 0.5582 | Yes |
| 13 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 1621 | 0.088 | 0.5609 | Yes |
| 14 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 1729 | 0.083 | 0.5718 | Yes |
| 15 | LEF1 | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 1786 | 0.081 | 0.5860 | Yes |
| 16 | BMP4 | BMP4 Entrez, Source | bone morphogenetic protein 4 | 1840 | 0.078 | 0.5998 | Yes |
| 17 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 2079 | 0.071 | 0.5980 | No |
| 18 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 2770 | 0.053 | 0.5582 | No |
| 19 | SMAD6 | SMAD6 Entrez, Source | SMAD, mothers against DPP homolog 6 (Drosophila) | 2842 | 0.052 | 0.5647 | No |
| 20 | IFNG | IFNG Entrez, Source | interferon, gamma | 2940 | 0.050 | 0.5687 | No |
| 21 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 3485 | 0.039 | 0.5367 | No |
| 22 | ZFHX1B | ZFHX1B Entrez, Source | zinc finger homeobox 1b | 3802 | 0.033 | 0.5205 | No |
| 23 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 4596 | 0.021 | 0.4657 | No |
| 24 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 5298 | 0.011 | 0.4155 | No |
| 25 | RUNX3 | RUNX3 Entrez, Source | runt-related transcription factor 3 | 5356 | 0.010 | 0.4136 | No |
| 26 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 6001 | 0.002 | 0.3657 | No |
| 27 | FKBP1A | FKBP1A Entrez, Source | FK506 binding protein 1A, 12kDa | 6282 | -0.002 | 0.3450 | No |
| 28 | RUNX2 | RUNX2 Entrez, Source | runt-related transcription factor 2 | 6625 | -0.006 | 0.3207 | No |
| 29 | SMAD1 | SMAD1 Entrez, Source | SMAD, mothers against DPP homolog 1 (Drosophila) | 6658 | -0.007 | 0.3198 | No |
| 30 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 6788 | -0.008 | 0.3119 | No |
| 31 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 7440 | -0.016 | 0.2666 | No |
| 32 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 7568 | -0.018 | 0.2610 | No |
| 33 | ENG | ENG Entrez, Source | endoglin (Osler-Rendu-Weber syndrome 1) | 8089 | -0.025 | 0.2276 | No |
| 34 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 8847 | -0.035 | 0.1787 | No |
| 35 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 9252 | -0.041 | 0.1577 | No |
| 36 | NOG | NOG Entrez, Source | noggin | 9451 | -0.044 | 0.1528 | No |
| 37 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 10803 | -0.068 | 0.0668 | No |
| 38 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 11240 | -0.080 | 0.0521 | No |
| 39 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12666 | -0.139 | -0.0235 | No |
| 40 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 12737 | -0.145 | 0.0042 | No |
| 41 | SMAD5 | SMAD5 Entrez, Source | SMAD, mothers against DPP homolog 5 (Drosophila) | 12988 | -0.181 | 0.0266 | No |
