Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | TUMOR_SUPRESSOR |
| Enrichment Score (ES) | -0.43104813 |
| Normalized Enrichment Score (NES) | -1.2579128 |
| Nominal p-value | 0.15367965 |
| FDR q-value | 0.6126653 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | VHL | VHL Entrez, Source | von Hippel-Lindau tumor suppressor | 1336 | 0.102 | -0.0267 | No |
| 2 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 1676 | 0.086 | 0.0097 | No |
| 3 | MSH2 | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 3405 | 0.040 | -0.0909 | No |
| 4 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 3485 | 0.039 | -0.0688 | No |
| 5 | ACTB | ACTB Entrez, Source | actin, beta | 4714 | 0.019 | -0.1470 | No |
| 6 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 5298 | 0.011 | -0.1827 | No |
| 7 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 5466 | 0.009 | -0.1889 | No |
| 8 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 6748 | -0.008 | -0.2796 | No |
| 9 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 6859 | -0.009 | -0.2815 | No |
| 10 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 7218 | -0.013 | -0.2987 | No |
| 11 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 7440 | -0.016 | -0.3038 | No |
| 12 | LCMT2 | LCMT2 Entrez, Source | leucine carboxyl methyltransferase 2 | 7654 | -0.019 | -0.3063 | No |
| 13 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 8731 | -0.034 | -0.3625 | No |
| 14 | APC | APC Entrez, Source | adenomatosis polyposis coli | 9645 | -0.048 | -0.3967 | Yes |
| 15 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 9813 | -0.050 | -0.3729 | Yes |
| 16 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 10456 | -0.061 | -0.3769 | Yes |
| 17 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 10692 | -0.066 | -0.3469 | Yes |
| 18 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11628 | -0.090 | -0.3524 | Yes |
| 19 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12666 | -0.139 | -0.3302 | Yes |
| 20 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 12718 | -0.143 | -0.2309 | Yes |
| 21 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 12999 | -0.184 | -0.1192 | Yes |
| 22 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 13067 | -0.201 | 0.0206 | Yes |
