Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | UVB_NHEK1_C6 |
| Enrichment Score (ES) | -0.37699905 |
| Normalized Enrichment Score (NES) | -1.309166 |
| Nominal p-value | 0.10696518 |
| FDR q-value | 0.5594779 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 213 | 0.311 | 0.0495 | No |
| 2 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 496 | 0.183 | 0.0667 | No |
| 3 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 535 | 0.175 | 0.1008 | No |
| 4 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 561 | 0.171 | 0.1349 | No |
| 5 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 1434 | 0.097 | 0.0896 | No |
| 6 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 1465 | 0.096 | 0.1075 | No |
| 7 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 1672 | 0.086 | 0.1100 | No |
| 8 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 1956 | 0.074 | 0.1044 | No |
| 9 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 2068 | 0.071 | 0.1110 | No |
| 10 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 2113 | 0.069 | 0.1223 | No |
| 11 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 2118 | 0.069 | 0.1366 | No |
| 12 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 2366 | 0.063 | 0.1312 | No |
| 13 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 2512 | 0.059 | 0.1328 | No |
| 14 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 2697 | 0.055 | 0.1306 | No |
| 15 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 3006 | 0.048 | 0.1176 | No |
| 16 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 3268 | 0.043 | 0.1071 | No |
| 17 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 3509 | 0.038 | 0.0971 | No |
| 18 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 3699 | 0.035 | 0.0903 | No |
| 19 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 5083 | 0.014 | -0.0108 | No |
| 20 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 5084 | 0.014 | -0.0078 | No |
| 21 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 5268 | 0.012 | -0.0191 | No |
| 22 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 5288 | 0.011 | -0.0182 | No |
| 23 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 5743 | 0.005 | -0.0513 | No |
| 24 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 5864 | 0.004 | -0.0595 | No |
| 25 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 6476 | -0.004 | -0.1046 | No |
| 26 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 7339 | -0.015 | -0.1664 | No |
| 27 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 7445 | -0.016 | -0.1709 | No |
| 28 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 7447 | -0.016 | -0.1676 | No |
| 29 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 7775 | -0.020 | -0.1879 | No |
| 30 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 7999 | -0.023 | -0.1998 | No |
| 31 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 8235 | -0.027 | -0.2118 | No |
| 32 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 8296 | -0.028 | -0.2104 | No |
| 33 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 8456 | -0.030 | -0.2160 | No |
| 34 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 8872 | -0.036 | -0.2397 | No |
| 35 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9154 | -0.040 | -0.2525 | No |
| 36 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 9209 | -0.040 | -0.2481 | No |
| 37 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 9252 | -0.041 | -0.2427 | No |
| 38 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9826 | -0.051 | -0.2751 | No |
| 39 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 10303 | -0.059 | -0.2986 | No |
| 40 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 10615 | -0.065 | -0.3084 | No |
| 41 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 10816 | -0.069 | -0.3090 | No |
| 42 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 10997 | -0.073 | -0.3071 | No |
| 43 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 11543 | -0.088 | -0.3297 | No |
| 44 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 12173 | -0.110 | -0.3538 | Yes |
| 45 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 12235 | -0.113 | -0.3346 | Yes |
| 46 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 12321 | -0.117 | -0.3163 | Yes |
| 47 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 12371 | -0.119 | -0.2949 | Yes |
| 48 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 12402 | -0.121 | -0.2716 | Yes |
| 49 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 12612 | -0.135 | -0.2588 | Yes |
| 50 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 12870 | -0.161 | -0.2442 | Yes |
| 51 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 12877 | -0.162 | -0.2105 | Yes |
| 52 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 13037 | -0.195 | -0.1814 | Yes |
| 53 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 13051 | -0.198 | -0.1407 | Yes |
| 54 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 13154 | -0.226 | -0.1009 | Yes |
| 55 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 13200 | -0.255 | -0.0506 | Yes |
| 56 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 13243 | -0.291 | 0.0075 | Yes |
