Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | UVB_NHEK1_DN |
| Enrichment Score (ES) | -0.319805 |
| Normalized Enrichment Score (NES) | -1.2563372 |
| Nominal p-value | 0.09620253 |
| FDR q-value | 0.6139517 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 213 | 0.311 | 0.0163 | No |
| 2 | RAPGEF5 | RAPGEF5 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 5 | 313 | 0.244 | 0.0342 | No |
| 3 | ADORA2B | ADORA2B Entrez, Source | adenosine A2b receptor | 482 | 0.186 | 0.0408 | No |
| 4 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 496 | 0.183 | 0.0588 | No |
| 5 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 535 | 0.175 | 0.0742 | No |
| 6 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 561 | 0.171 | 0.0901 | No |
| 7 | PER2 | PER2 Entrez, Source | period homolog 2 (Drosophila) | 566 | 0.171 | 0.1076 | No |
| 8 | CEP170 | CEP170 Entrez, Source | centrosomal protein 170kDa | 575 | 0.168 | 0.1245 | No |
| 9 | NIPBL | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 578 | 0.167 | 0.1418 | No |
| 10 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 806 | 0.139 | 0.1391 | No |
| 11 | CBLB | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 858 | 0.133 | 0.1492 | No |
| 12 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 1001 | 0.121 | 0.1511 | No |
| 13 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 1173 | 0.111 | 0.1497 | No |
| 14 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 1434 | 0.097 | 0.1401 | No |
| 15 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 1465 | 0.096 | 0.1478 | No |
| 16 | ATRX | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 1606 | 0.089 | 0.1465 | No |
| 17 | AKAP9 | AKAP9 Entrez, Source | A kinase (PRKA) anchor protein (yotiao) 9 | 1625 | 0.088 | 0.1543 | No |
| 18 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 1672 | 0.086 | 0.1597 | No |
| 19 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 1676 | 0.086 | 0.1684 | No |
| 20 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 1781 | 0.081 | 0.1690 | No |
| 21 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 1956 | 0.074 | 0.1637 | No |
| 22 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 2068 | 0.071 | 0.1626 | No |
| 23 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 2113 | 0.069 | 0.1665 | No |
| 24 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 2118 | 0.069 | 0.1735 | No |
| 25 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 2366 | 0.063 | 0.1613 | No |
| 26 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 2512 | 0.059 | 0.1566 | No |
| 27 | PSCD1 | PSCD1 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) | 2579 | 0.058 | 0.1576 | No |
| 28 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 2697 | 0.055 | 0.1545 | No |
| 29 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 3006 | 0.048 | 0.1363 | No |
| 30 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 3268 | 0.043 | 0.1210 | No |
| 31 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 3396 | 0.041 | 0.1157 | No |
| 32 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 3485 | 0.039 | 0.1131 | No |
| 33 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 3509 | 0.038 | 0.1153 | No |
| 34 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 3699 | 0.035 | 0.1047 | No |
| 35 | CTCF | CTCF Entrez, Source | CCCTC-binding factor (zinc finger protein) | 3967 | 0.031 | 0.0877 | No |
| 36 | CCDC131 | CCDC131 Entrez, Source | coiled-coil domain containing 131 | 4154 | 0.028 | 0.0766 | No |
| 37 | PTPN3 | PTPN3 Entrez, Source | protein tyrosine phosphatase, non-receptor type 3 | 4204 | 0.027 | 0.0757 | No |
| 38 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 5083 | 0.014 | 0.0108 | No |
| 39 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 5084 | 0.014 | 0.0123 | No |
| 40 | CEP350 | CEP350 Entrez, Source | centrosomal protein 350kDa | 5212 | 0.012 | 0.0040 | No |
| 41 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 5268 | 0.012 | 0.0010 | No |
| 42 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 5288 | 0.011 | 0.0008 | No |
| 43 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 5296 | 0.011 | 0.0014 | No |
| 44 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 5743 | 0.005 | -0.0318 | No |
| 45 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 5864 | 0.004 | -0.0404 | No |
| 46 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 6142 | 0.000 | -0.0614 | No |
| 47 | BAZ1B | BAZ1B Entrez, Source | bromodomain adjacent to zinc finger domain, 1B | 6350 | -0.002 | -0.0768 | No |
| 48 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 6476 | -0.004 | -0.0858 | No |
| 49 | UBE2G1 | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 6486 | -0.004 | -0.0860 | No |
| 50 | TAF11 | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 6619 | -0.006 | -0.0954 | No |
| 51 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 7339 | -0.015 | -0.1482 | No |
| 52 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 7445 | -0.016 | -0.1544 | No |
| 53 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 7447 | -0.016 | -0.1528 | No |
| 54 | SERTAD2 | SERTAD2 Entrez, Source | SERTA domain containing 2 | 7501 | -0.017 | -0.1551 | No |
| 55 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 7715 | -0.020 | -0.1692 | No |
| 56 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 7775 | -0.020 | -0.1715 | No |
| 57 | AHR | AHR Entrez, Source | aryl hydrocarbon receptor | 7804 | -0.021 | -0.1715 | No |
| 58 | ZNF148 | ZNF148 Entrez, Source | zinc finger protein 148 | 7943 | -0.023 | -0.1795 | No |
| 59 | NUP153 | NUP153 Entrez, Source | nucleoporin 153kDa | 7992 | -0.023 | -0.1807 | No |
| 60 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 7999 | -0.023 | -0.1787 | No |
| 61 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 8235 | -0.027 | -0.1937 | No |
| 62 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 8296 | -0.028 | -0.1953 | No |
| 63 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 8456 | -0.030 | -0.2042 | No |
| 64 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 8872 | -0.036 | -0.2318 | No |
| 65 | DTX2 | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 8976 | -0.037 | -0.2357 | No |
| 66 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9154 | -0.040 | -0.2450 | No |
| 67 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 9209 | -0.040 | -0.2449 | No |
| 68 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 9252 | -0.041 | -0.2438 | No |
| 69 | SH2B3 | SH2B3 Entrez, Source | SH2B adaptor protein 3 | 9274 | -0.041 | -0.2411 | No |
| 70 | PHC2 | PHC2 Entrez, Source | polyhomeotic homolog 2 (Drosophila) | 9654 | -0.048 | -0.2647 | No |
| 71 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9826 | -0.051 | -0.2724 | No |
| 72 | KEAP1 | KEAP1 Entrez, Source | kelch-like ECH-associated protein 1 | 9860 | -0.051 | -0.2696 | No |
| 73 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 9891 | -0.052 | -0.2664 | No |
| 74 | NFE2L2 | NFE2L2 Entrez, Source | nuclear factor (erythroid-derived 2)-like 2 | 10005 | -0.054 | -0.2694 | No |
| 75 | BRD8 | BRD8 Entrez, Source | bromodomain containing 8 | 10036 | -0.054 | -0.2660 | No |
| 76 | TAF5L | TAF5L Entrez, Source | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | 10163 | -0.056 | -0.2697 | No |
| 77 | DMTF1 | DMTF1 Entrez, Source | cyclin D binding myb-like transcription factor 1 | 10179 | -0.056 | -0.2650 | No |
| 78 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 10303 | -0.059 | -0.2682 | No |
| 79 | NAGK | NAGK Entrez, Source | N-acetylglucosamine kinase | 10368 | -0.060 | -0.2668 | No |
| 80 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 10615 | -0.065 | -0.2786 | No |
| 81 | PUM2 | PUM2 Entrez, Source | pumilio homolog 2 (Drosophila) | 10701 | -0.066 | -0.2782 | No |
| 82 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 10816 | -0.069 | -0.2796 | No |
| 83 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 10997 | -0.073 | -0.2856 | No |
| 84 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 11340 | -0.083 | -0.3029 | No |
| 85 | ADNP | ADNP Entrez, Source | activity-dependent neuroprotector | 11378 | -0.083 | -0.2970 | No |
| 86 | NCOA3 | NCOA3 Entrez, Source | nuclear receptor coactivator 3 | 11477 | -0.086 | -0.2954 | No |
| 87 | MTIF2 | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 11529 | -0.087 | -0.2902 | No |
| 88 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 11543 | -0.088 | -0.2820 | No |
| 89 | MTM1 | MTM1 Entrez, Source | myotubularin 1 | 11733 | -0.093 | -0.2866 | No |
| 90 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 12173 | -0.110 | -0.3083 | Yes |
| 91 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 12235 | -0.113 | -0.3012 | Yes |
| 92 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 12321 | -0.117 | -0.2954 | Yes |
| 93 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 12371 | -0.119 | -0.2867 | Yes |
| 94 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 12402 | -0.121 | -0.2763 | Yes |
| 95 | USP1 | USP1 Entrez, Source | ubiquitin specific peptidase 1 | 12463 | -0.125 | -0.2678 | Yes |
| 96 | AURKA | AURKA Entrez, Source | aurora kinase A | 12546 | -0.131 | -0.2603 | Yes |
| 97 | ANKRD15 | ANKRD15 Entrez, Source | ankyrin repeat domain 15 | 12561 | -0.132 | -0.2476 | Yes |
| 98 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 12612 | -0.135 | -0.2373 | Yes |
| 99 | SKAP2 | SKAP2 Entrez, Source | src kinase associated phosphoprotein 2 | 12646 | -0.138 | -0.2255 | Yes |
| 100 | ADRB2 | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 12708 | -0.142 | -0.2153 | Yes |
| 101 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 12743 | -0.146 | -0.2027 | Yes |
| 102 | DYRK1A | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 12862 | -0.160 | -0.1949 | Yes |
| 103 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 12866 | -0.161 | -0.1784 | Yes |
| 104 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 12870 | -0.161 | -0.1618 | Yes |
| 105 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 12877 | -0.162 | -0.1454 | Yes |
| 106 | SMAD5 | SMAD5 Entrez, Source | SMAD, mothers against DPP homolog 5 (Drosophila) | 12988 | -0.181 | -0.1348 | Yes |
| 107 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 13037 | -0.195 | -0.1181 | Yes |
| 108 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 13051 | -0.198 | -0.0985 | Yes |
| 109 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 13154 | -0.226 | -0.0827 | Yes |
| 110 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 13200 | -0.255 | -0.0596 | Yes |
| 111 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 13243 | -0.291 | -0.0325 | Yes |
| 112 | PPP1R3C | PPP1R3C Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 13293 | -0.383 | 0.0037 | Yes |
