Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | V$NFKAPPAB_01 |
| Enrichment Score (ES) | -0.3105226 |
| Normalized Enrichment Score (NES) | -1.2474391 |
| Nominal p-value | 0.07908163 |
| FDR q-value | 0.6162007 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 27 | 0.668 | 0.0544 | No |
| 2 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 32 | 0.660 | 0.1098 | No |
| 3 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 118 | 0.402 | 0.1374 | No |
| 4 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 121 | 0.401 | 0.1711 | No |
| 5 | MSN | MSN Entrez, Source | moesin | 248 | 0.285 | 0.1856 | No |
| 6 | DDR1 | DDR1 Entrez, Source | discoidin domain receptor family, member 1 | 257 | 0.276 | 0.2084 | No |
| 7 | GRK5 | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 401 | 0.209 | 0.2152 | No |
| 8 | CPD | CPD Entrez, Source | carboxypeptidase D | 565 | 0.171 | 0.2173 | No |
| 9 | CXCL16 | CXCL16 Entrez, Source | chemokine (C-X-C motif) ligand 16 | 683 | 0.152 | 0.2214 | No |
| 10 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 806 | 0.139 | 0.2239 | No |
| 11 | HCST | HCST Entrez, Source | hematopoietic cell signal transducer | 935 | 0.126 | 0.2249 | No |
| 12 | OPCML | OPCML Entrez, Source | opioid binding protein/cell adhesion molecule-like | 1010 | 0.121 | 0.2295 | No |
| 13 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1045 | 0.118 | 0.2369 | No |
| 14 | ZFP36L2 | ZFP36L2 Entrez, Source | zinc finger protein 36, C3H type-like 2 | 1206 | 0.109 | 0.2340 | No |
| 15 | BDNF | BDNF Entrez, Source | brain-derived neurotrophic factor | 1267 | 0.106 | 0.2384 | No |
| 16 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 1268 | 0.106 | 0.2474 | No |
| 17 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 1832 | 0.079 | 0.2115 | No |
| 18 | RBMS1 | RBMS1 Entrez, Source | RNA binding motif, single stranded interacting protein 1 | 1934 | 0.075 | 0.2102 | No |
| 19 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 1982 | 0.074 | 0.2128 | No |
| 20 | STC2 | STC2 Entrez, Source | stanniocalcin 2 | 2009 | 0.073 | 0.2170 | No |
| 21 | NFKBIB | NFKBIB Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 2046 | 0.071 | 0.2203 | No |
| 22 | SAMSN1 | SAMSN1 Entrez, Source | SAM domain, SH3 domain and nuclear localisation signals, 1 | 2103 | 0.070 | 0.2220 | No |
| 23 | GPHN | GPHN Entrez, Source | gephyrin | 2121 | 0.069 | 0.2265 | No |
| 24 | GABRB1 | GABRB1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 1 | 2142 | 0.069 | 0.2308 | No |
| 25 | CCL5 | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 2447 | 0.061 | 0.2130 | No |
| 26 | AGC1 | AGC1 Entrez, Source | aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) | 2474 | 0.060 | 0.2161 | No |
| 27 | GREM1 | GREM1 Entrez, Source | gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) | 2542 | 0.059 | 0.2160 | No |
| 28 | RALGDS | RALGDS Entrez, Source | ral guanine nucleotide dissociation stimulator | 2700 | 0.055 | 0.2088 | No |
| 29 | BFSP1 | BFSP1 Entrez, Source | beaded filament structural protein 1, filensin | 2705 | 0.055 | 0.2132 | No |
| 30 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 2770 | 0.053 | 0.2128 | No |
| 31 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 2956 | 0.050 | 0.2031 | No |
| 32 | SDC4 | SDC4 Entrez, Source | syndecan 4 (amphiglycan, ryudocan) | 3195 | 0.045 | 0.1888 | No |
| 33 | SMOC1 | SMOC1 Entrez, Source | SPARC related modular calcium binding 1 | 3292 | 0.043 | 0.1852 | No |
| 34 | SOX10 | SOX10 Entrez, Source | SRY (sex determining region Y)-box 10 | 3353 | 0.041 | 0.1842 | No |
| 35 | IL13 | IL13 Entrez, Source | interleukin 13 | 3501 | 0.039 | 0.1763 | No |
| 36 | SLC6A12 | SLC6A12 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 | 3625 | 0.036 | 0.1701 | No |
| 37 | PCSK2 | PCSK2 Entrez, Source | proprotein convertase subtilisin/kexin type 2 | 3729 | 0.035 | 0.1652 | No |
| 38 | FKHL18 | FKHL18 Entrez, Source | forkhead-like 18 (Drosophila) | 3947 | 0.031 | 0.1515 | No |
| 39 | USP52 | USP52 Entrez, Source | ubiquitin specific peptidase 52 | 3994 | 0.030 | 0.1506 | No |
| 40 | ASCL3 | ASCL3 Entrez, Source | achaete-scute complex (Drosophila) homolog-like 3 | 4333 | 0.025 | 0.1271 | No |
| 41 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 4347 | 0.025 | 0.1282 | No |
| 42 | GNAO1 | GNAO1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 4514 | 0.022 | 0.1175 | No |
| 43 | MSX1 | MSX1 Entrez, Source | msh homeobox homolog 1 (Drosophila) | 4536 | 0.022 | 0.1178 | No |
| 44 | AGPAT1 | AGPAT1 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) | 4698 | 0.020 | 0.1073 | No |
| 45 | BLR1 | BLR1 Entrez, Source | Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) | 4764 | 0.019 | 0.1040 | No |
| 46 | ATP1B1 | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 4788 | 0.018 | 0.1038 | No |
| 47 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 5051 | 0.015 | 0.0852 | No |
| 48 | IL1A | IL1A Entrez, Source | interleukin 1, alpha | 5162 | 0.013 | 0.0780 | No |
| 49 | LTA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 5175 | 0.013 | 0.0782 | No |
| 50 | IL23A | IL23A Entrez, Source | interleukin 23, alpha subunit p19 | 5247 | 0.012 | 0.0738 | No |
| 51 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 5681 | 0.006 | 0.0416 | No |
| 52 | CLCN1 | CLCN1 Entrez, Source | chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) | 5834 | 0.004 | 0.0305 | No |
| 53 | MAG | MAG Entrez, Source | myelin associated glycoprotein | 5839 | 0.004 | 0.0305 | No |
| 54 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 6008 | 0.002 | 0.0180 | No |
| 55 | NTN1 | NTN1 Entrez, Source | netrin 1 | 6053 | 0.001 | 0.0148 | No |
| 56 | IL2RA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 6388 | -0.003 | -0.0102 | No |
| 57 | UBD | UBD Entrez, Source | ubiquitin D | 6622 | -0.006 | -0.0273 | No |
| 58 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 6860 | -0.009 | -0.0445 | No |
| 59 | IER5 | IER5 Entrez, Source | immediate early response 5 | 6896 | -0.009 | -0.0464 | No |
| 60 | BMP2K | BMP2K Entrez, Source | BMP2 inducible kinase | 6985 | -0.011 | -0.0521 | No |
| 61 | MADCAM1 | MADCAM1 Entrez, Source | mucosal vascular addressin cell adhesion molecule 1 | 7042 | -0.011 | -0.0554 | No |
| 62 | DCAMKL1 | DCAMKL1 Entrez, Source | doublecortin and CaM kinase-like 1 | 7197 | -0.013 | -0.0659 | No |
| 63 | PFN1 | PFN1 Entrez, Source | profilin 1 | 7229 | -0.013 | -0.0672 | No |
| 64 | PTMS | PTMS Entrez, Source | parathymosin | 7316 | -0.014 | -0.0724 | No |
| 65 | FBXL12 | FBXL12 Entrez, Source | F-box and leucine-rich repeat protein 12 | 7391 | -0.015 | -0.0767 | No |
| 66 | GNB1 | GNB1 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 7870 | -0.022 | -0.1110 | No |
| 67 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 8006 | -0.024 | -0.1192 | No |
| 68 | JAK3 | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 8402 | -0.029 | -0.1466 | No |
| 69 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 8408 | -0.029 | -0.1445 | No |
| 70 | ZBTB9 | ZBTB9 Entrez, Source | zinc finger and BTB domain containing 9 | 8502 | -0.031 | -0.1489 | No |
| 71 | ZNF403 | ZNF403 Entrez, Source | zinc finger protein 403 | 8532 | -0.031 | -0.1485 | No |
| 72 | SMPD3 | SMPD3 Entrez, Source | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | 8573 | -0.032 | -0.1488 | No |
| 73 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 8858 | -0.036 | -0.1673 | No |
| 74 | EIF5A | EIF5A Entrez, Source | eukaryotic translation initiation factor 5A | 8947 | -0.037 | -0.1708 | No |
| 75 | ENO3 | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 9266 | -0.041 | -0.1914 | No |
| 76 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 9565 | -0.046 | -0.2100 | No |
| 77 | IFNB1 | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 9678 | -0.048 | -0.2144 | No |
| 78 | SLC11A2 | SLC11A2 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 9701 | -0.049 | -0.2119 | No |
| 79 | G3BP | G3BP Entrez, Source | - | 9801 | -0.050 | -0.2152 | No |
| 80 | IL1RN | IL1RN Entrez, Source | interleukin 1 receptor antagonist | 10196 | -0.057 | -0.2402 | No |
| 81 | FGF1 | FGF1 Entrez, Source | fibroblast growth factor 1 (acidic) | 10275 | -0.058 | -0.2411 | No |
| 82 | ARHGAP5 | ARHGAP5 Entrez, Source | Rho GTPase activating protein 5 | 10392 | -0.060 | -0.2449 | No |
| 83 | ARHGAP8 | ARHGAP8 Entrez, Source | Rho GTPase activating protein 8 | 10506 | -0.062 | -0.2481 | No |
| 84 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 10548 | -0.063 | -0.2459 | No |
| 85 | RIMS2 | RIMS2 Entrez, Source | regulating synaptic membrane exocytosis 2 | 10612 | -0.065 | -0.2452 | No |
| 86 | SHOX2 | SHOX2 Entrez, Source | short stature homeobox 2 | 11349 | -0.083 | -0.2938 | No |
| 87 | GATA4 | GATA4 Entrez, Source | GATA binding protein 4 | 11355 | -0.083 | -0.2872 | No |
| 88 | EDN2 | EDN2 Entrez, Source | endothelin 2 | 11417 | -0.084 | -0.2847 | No |
| 89 | SEC14L2 | SEC14L2 Entrez, Source | SEC14-like 2 (S. cerevisiae) | 11482 | -0.086 | -0.2823 | No |
| 90 | BCKDK | BCKDK Entrez, Source | branched chain ketoacid dehydrogenase kinase | 11511 | -0.087 | -0.2771 | No |
| 91 | DAP3 | DAP3 Entrez, Source | death associated protein 3 | 11558 | -0.088 | -0.2731 | No |
| 92 | EDG5 | EDG5 Entrez, Source | endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 | 12054 | -0.105 | -0.3016 | Yes |
| 93 | TCEA2 | TCEA2 Entrez, Source | transcription elongation factor A (SII), 2 | 12088 | -0.107 | -0.2951 | Yes |
| 94 | CHD4 | CHD4 Entrez, Source | chromodomain helicase DNA binding protein 4 | 12144 | -0.109 | -0.2901 | Yes |
| 95 | CREB1 | CREB1 Entrez, Source | cAMP responsive element binding protein 1 | 12322 | -0.117 | -0.2936 | Yes |
| 96 | C1ORF24 | C1ORF24 Entrez, Source | chromosome 1 open reading frame 24 | 12389 | -0.121 | -0.2883 | Yes |
| 97 | FGF17 | FGF17 Entrez, Source | fibroblast growth factor 17 | 12498 | -0.128 | -0.2857 | Yes |
| 98 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12596 | -0.134 | -0.2817 | Yes |
| 99 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 12642 | -0.137 | -0.2735 | Yes |
| 100 | BMF | BMF Entrez, Source | Bcl2 modifying factor | 12660 | -0.138 | -0.2631 | Yes |
| 101 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 12718 | -0.143 | -0.2554 | Yes |
| 102 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 12737 | -0.145 | -0.2445 | Yes |
| 103 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 12780 | -0.150 | -0.2350 | Yes |
| 104 | ACTN3 | ACTN3 Entrez, Source | actinin, alpha 3 | 12811 | -0.154 | -0.2242 | Yes |
| 105 | SLC12A2 | SLC12A2 Entrez, Source | solute carrier family 12 (sodium/potassium/chloride transporters), member 2 | 12841 | -0.158 | -0.2131 | Yes |
| 106 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 12996 | -0.183 | -0.2092 | Yes |
| 107 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 12999 | -0.184 | -0.1938 | Yes |
| 108 | GRIN2D | GRIN2D Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2D | 13034 | -0.194 | -0.1800 | Yes |
| 109 | VCAM1 | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 13085 | -0.205 | -0.1665 | Yes |
| 110 | CXCL9 | CXCL9 Entrez, Source | chemokine (C-X-C motif) ligand 9 | 13299 | -0.402 | -0.1486 | Yes |
| 111 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 13311 | -0.439 | -0.1123 | Yes |
| 112 | LTB | LTB Entrez, Source | lymphotoxin beta (TNF superfamily, member 3) | 13327 | -0.568 | -0.0655 | Yes |
| 113 | CXCL11 | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 13337 | -0.787 | 0.0004 | Yes |
